scholarly journals The Effect of Hydroethanolic Extract of Pomegranate Peels and High-intense Interval Training on C-reactive Protein, Catalase and Superoxide Dismutase in Rats

2021 ◽  
Vol 27 (2) ◽  
pp. 182-197
Author(s):  
Farah Nameni ◽  
◽  
Roya Aliakbar Alavi ◽  
Keyword(s):  
Superoxide Dismutase ◽  
Immune System ◽  
High Intensity ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
C Reactive Protein ◽  
Statistical Population ◽  
Reactive Protein ◽  
High Intensity Interval ◽  
Hydroethanolic Extract

Aims: Heavy exercise can damage the immune system by oxidative stress. The role of herbal supplements during and after strenuous exercise is unknown. Therefore, the present study aimed to determine hydroethanolic extract of pomegranate peels and a period of high-intensity interval training on the C-reactive protein and antioxidant enzyme activity in rats. Methods & Materials: This research was an experimental study. The statistical population was rats, of which 36 Wistar rats were randomly selected and were divided into 4 groups (control, hydroethanolic extract of pomegranate peels, high-intensity interval training, and hydroethanolic extract of pomegranate peels + high-intensity interval training). After 8 weeks of interval training and supplementation, blood samples were taken from the rats. Then, the C-reactive protein and the activity of the antioxidant enzymes of superoxide dismutase and catalase were assessed by 1-way analysis of variance. Findings: The results showed that in the group of hydroethanolic extract of pomegranate peels + high-intensity interval training, the superoxide dismutase (P=0.000) and catalase (P=0.003) significantly increased, and the C-reactive protein (P=0.002) decreased. Tukey’s test confirmed the significance of these changes in the hydroethanolic extract of pomegranate peels+high-intensity interval training compared to the control group. Conclusion: The combination of high-intensity interval training and hydroethanolic extract of pomegranate peels could strengthen the immune system, potentially enhances athletic performance, and accelerates recovery after exercises. The hydroethanolic extract of pomegranate peels and high-interval training synergistically boost the immune system and increase physical endurance.

scholarly journals Timing of Exercise Affects Glycemic Control in Type 2 Diabetes Patients Treated with Metformin

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Tao Huang ◽  
Chunyan Lu ◽  
Moritz Schumann ◽  
Shenglong Le ◽  
Yifan Yang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Superoxide Dismutase ◽  
Glycemic Control ◽  
High Intensity ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
Acute Effects ◽  
Sod Activity ◽  
High Intensity Interval

Objective. The purpose of the study was to examine the acute effects of the timing of exercise on the glycemic control during and after exercise in T2D. Methods. This study included 26 T2D patients (14 women and 12 men) who were treated with metformin. All patients were tested on four occasions: metformin administration alone (Metf), high-intensity interval training (HIIT) performed at 30 minutes (EX30), 60 minutes (EX60), and 90 minutes (EX90) postbreakfast, respectively. Glucose, insulin, and superoxide dismutase (SOD) activity were examined. Results. Glucose decreased significantly after the exercise in EX30, EX60, and EX90. Compared with Metf, the decline in glucose immediately after the exercise was larger in EX30 (−2.58 mmol/L; 95% CI, −3.36 to −1.79 mmol/L; p<0.001), EX60 (−2.13 mmol/L; 95% CI, −2.91 to −1.34 mmol/L; p<0.001), and EX90 (−1.87 mmol/L; 95% CI, −2.65 to −1.08 mmol/L; p<0.001), respectively. Compared with Metf, the decrease in insulin was larger in EX30 and EX60 (both p<0.001). Conclusions. Timing of exercise is a factor to consider when prescribing exercise for T2D patients treated with metformin. This trial is registered with ChiCTR-IOR-16008469 on 13 May 2016.

scholarly journals Comparing the Effect of Two Methods of High-Intensity Interval Training (HIIT) and High-Intensity Continuous Training (HICT) on Damage and Antioxidant Indices of Liver in Male Wistar Rats

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Aghaali Ghasemnian ◽  
Mozhgan Usefpour ◽  
Ahmad Rahmani ◽  
Zeinab Iddehloei
Keyword(s):  
Superoxide Dismutase ◽  
High Intensity ◽  
Liver Tissue ◽  
Wistar Rats ◽  
Interval Training ◽  
Control Group ◽  
High Intensity Interval Training ◽  
Continuous Training ◽  
Male Wistar Rats ◽  
High Intensity Interval

Background: Nowadays, one of the widely used training methods is high-intensity interval training (HIIT). In addition, researchers have stated that long-term, high-intensity training is associated with the production of free radicals in the body. Free radicals also damage liver cells, resulting in increased liver enzymes. Objectives: The objective of this study was to investigate the effect of HIIT, compared to high-intensity continuous training (HICT), on damage and antioxidant indices of the liver in male Wistar rats. Methods: Twenty-two adult male rats were randomly divided into three groups of control (n = 6), HIIT (n = 8), and HICT (n = 8). Training protocols included HIIT and HICT on a treadmill for eight weeks (five days in a week). Standard water and food were provided for rats ad libitum. Forty-eight hours after the last training session, blood and tissue samples were collected, and serum enzymes were measured by the methods recommended by the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) method. The level of enzyme activity of superoxide dismutase in the liver tissue was measured by Randox Commercial Kit (Cat. No. SD 126). One-way analysis of variance (ANOVA) and Tukey’s post hoc tests were used to analyze the data. Results: The results showed that eight weeks of HIIT and HICT had no effect on the alanine aminotransferase (ALT) level (P = 0.14), but eight weeks of HIIT significantly decreased the serum aspartate aminotransferase (AST) level compared to the control group (P = 0.04). The level of liver superoxide dismutase (SOD) enzyme activity significantly increased in the HIIT and HICT groups compared to the control group (P = 0.001). HICT also led to a significant increase in the SOD level compared to HIIT (P = 0.03). Conclusions: The research results suggested that eight weeks of HIIT led to a significant reduction in serum AST levels, and HIIT had a lower effect on the increased SOD activity in liver tissue compared to HICT. It might be stated that HIIT is safer than HICT, and it has fewer destructive effects on liver tissue.

Abstract 12538: Effect of High Intensity Interval Training on High-sensitivity C-reactive Protein in Breast Cancer Patients Undergoing Anthracycline-based Chemotherapy

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Kyuwan Lee ◽  
Christina Dieli-Conwright
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Interval Training ◽  
High Sensitivity ◽  
Breast Cancer Patients ◽  
High Intensity Interval Training ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
High Intensity Interval ◽  
Circulating Levels

Introduction: Anthracycline-based chemotherapies are widely used chemotherapeutic agents for treatment of breast cancers, but these agents increase inflammation in the cardiovascular system. Circulating levels of high sensitivity C-reactive protein (hsCRP) have been validated to assess the degree of inflammation in adults. While exercise has been shown to reduce hsCRP in patients with coronary artery diseases, it is unclear whether high intensity interval training (HIIT) reduces hsCRP in breast cancer patients undergoing anthracycline-based chemotherapy. Hypothesis: We hypothesized that a group of participants that performed the 8-week HIIT intervention would demonstrate maintenance in hsCRP level compared to a group of participants that did not perform HIIT. Methods: Thirty breast cancer survivors were randomized to either the HIIT or control (CON) group. The HIIT group participated in 8 weeks of supervised exercise sessions 3 times/week. The CON group was asked to maintain their current activity levels. Fasting (≥ 12 hours) blood (∽30 cc) was obtained from the antecubital and hsCRP was measured by immunoturbidimetric assay. A paired t-test and 2x2 (group x time) repeated measures ANOVA were used to evaluate changes in hsCRP. Results: At baseline, there were no group differences in age (46.9±9.8 yrs), BMI (31.0±7.5 kg/m 2 ) and blood pressure (123.4 ± 16.8/72.3.9 ± 5.6 mmHg; p>0.05). Following 8 weeks, hsCRP did not significantly change (7.1±2.7 to 8.7±3.5 mg/L) in the HIIT group (p=0.21). However, there was a significant within-group change in the CON group (6.0±3.2 to 10.9.1±2.3 mg/L; p=0.02). There was no group x time interaction following 8 weeks (P=0.93). Conclusions: An 8-week HIIT intervention maintained circulating levels of hsCRP in breast cancer patients receiving anthracycline-based chemotherapy. Future large randomized controlled trials are warranted to investigate the impact of exercise-induced reductions in inflammation while undergoing anthracycline-based chemotherapy.

scholarly journals Comparing the Effect of Two Methods of High-Intensity Interval Training (HIIT) and High-Intensity Continuous Training (HICT) on Damage and Antioxidant Indices of Liver in Male Wistar Rats

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Aghaali Ghasemnian ◽  
Mozhgan Usefpour ◽  
Ahmad Rahmani ◽  
Zeinab Iddehloei
Keyword(s):  
Superoxide Dismutase ◽  
High Intensity ◽  
Liver Tissue ◽  
Wistar Rats ◽  
Interval Training ◽  
Control Group ◽  
High Intensity Interval Training ◽  
Continuous Training ◽  
Male Wistar Rats ◽  
High Intensity Interval

Background: Nowadays, one of the widely used training methods is high-intensity interval training (HIIT). In addition, researchers have stated that long-term, high-intensity training is associated with the production of free radicals in the body. Free radicals also damage liver cells, resulting in increased liver enzymes. Objectives: The objective of this study was to investigate the effect of HIIT, compared to high-intensity continuous training (HICT), on damage and antioxidant indices of the liver in male Wistar rats. Methods: Twenty-two adult male rats were randomly divided into three groups of control (n = 6), HIIT (n = 8), and HICT (n = 8). Training protocols included HIIT and HICT on a treadmill for eight weeks (five days in a week). Standard water and food were provided for rats ad libitum. Forty-eight hours after the last training session, blood and tissue samples were collected, and serum enzymes were measured by the methods recommended by the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) method. The level of enzyme activity of superoxide dismutase in the liver tissue was measured by Randox Commercial Kit (Cat. No. SD 126). One-way analysis of variance (ANOVA) and Tukey’s post hoc tests were used to analyze the data. Results: The results showed that eight weeks of HIIT and HICT had no effect on the alanine aminotransferase (ALT) level (P = 0.14), but eight weeks of HIIT significantly decreased the serum aspartate aminotransferase (AST) level compared to the control group (P = 0.04). The level of liver superoxide dismutase (SOD) enzyme activity significantly increased in the HIIT and HICT groups compared to the control group (P = 0.001). HICT also led to a significant increase in the SOD level compared to HIIT (P = 0.03). Conclusions: The research results suggested that eight weeks of HIIT led to a significant reduction in serum AST levels, and HIIT had a lower effect on the increased SOD activity in liver tissue compared to HICT. It might be stated that HIIT is safer than HICT, and it has fewer destructive effects on liver tissue.

High-Intensity Interval Training and Hypoglycemia Minimization in Adults with Type 1 Diabetes (HIIT HYPO T1D Study)

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 743-P
Author(s):  
ANGELA S. LEE ◽  
KIMBERLEY L. WAY ◽  
NATHAN A. JOHNSON ◽  
STEPHEN M. TWIGG
Keyword(s):  
Type 1 Diabetes ◽  
High Intensity ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
High Intensity Interval

553-P: Differential Effects of High-Intensity Interval Training on Somatosensory and Autonomic Nerve Function in Patients with Type 2 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 553-P
Author(s):  
GIDON J. BÖNHOF ◽  
ALEXANDER STROM ◽  
MARIA APOSTOLOPOULOU ◽  
DOMINIK PESTA ◽  
MICHAEL RODEN ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
High Intensity ◽  
Interval Training ◽  
Autonomic Nerve ◽  
Nerve Function ◽  
High Intensity Interval Training ◽  
Differential Effects ◽  
Autonomic Nerve Function ◽  
High Intensity Interval
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