scholarly journals Serum Nephrin Levels in Severe Preeclampsia: A Cross-Sectional Study

2021 ◽  
pp. 10-14
Author(s):  
Meice Fitrina ◽  
Sofie R. Krisnadi ◽  
Hartanto Bayuaji
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Normal Pregnancy ◽  
Cross Sectional Study ◽  
Severe Preeclampsia ◽  
Rank Test ◽  
Sectional Study ◽  
Cross Sectional ◽  
Elisa Kit

Abstract Objective: To determine differences in serum nephrin levels in severe preeclampsia compared to normal pregnancy and also its correlation with systolic and diastolic blood pressure and proteinuria.Methods: This study is an analytical observational with cross sectional study. The observation group consisted of severe preeclampsia (n= 30) and normal pregnancy group as a control (n= 30). Both groups measured systolic and diastolic blood pressure, proteinuria and serum nephrin using the Human NPHN (Nephrin) ELISA Kit. Statistical test were performed with Mann-Whitney test and the Spearman’s rank test. A value of p<0.05 was considered significant. The study was conducted in the Obstetric Clinic Inward and Laboratorium Department of Clinical Pathology Dr. Hasan Sadikin General Hospital/Faculty of Medicine Universitas Padjadjaran on March–May 2019.Results: Levels of serum nephrin in the severe preeclampsia group were significantly higher than in normal pregnancies (6.4 ng/mL vs 4.2 ng/mL; p= 0.014). There is a positive weak correlation but statistically significant between serum nephrin with systolic blood pressure (r= 0.36; p= 0.02) but not significant to diastolic blood pressure (r= 0.3; p= 0.05). There is no significant correlation was found between serum nephrin levels and proteinuria (r= 0.18; p= 0.54).Conlusions:  Levels of serum nephrin in the severe preeclampsia group were significantly higher than in normal pregnancies and there is a correlation between serum nephrin with systolic blood pressure. Keywords: blood pressure, proteinuria, serum nephrin, podocyte, severe preeclampsia. Abstrak Tujuan: Untuk mengetahui perbedaan kadar nephrin serum pada preeklamsia berat dibandingkan dengan kehamilan normal dan juga hubungannya dengan tekanan darah sistolik dan diastolik serta proteinuria.Metode: Penelitian ini bersifat analitik observasional dengan pendekatan potong silang. Kelompok pengamatan terdiri dari kelompok preeklamsia berat (n= 30) dan kelompok kehamilan normal sebagai kontrol (n= 30). Pada kedua kelompok dilakukan pengukuran tekanan darah sistolik dan diastolik, proteinuria serta pengukuran kadar nephrin serum menggunakan Human NPHN (Nephrin) ELISA Kit. Uji statistik dilakukan dengan uji Mann-Whitney dan uji rank Spearman. Nilai p<0,05 dianggap bermakna. Penelitian dilakukan di ruang perawatan obstetri FKUP/RSHS dan Laboratorium Patologi Klinik FKUP/RSHS pada bulan Maret-Mei 2019.Hasil: Rerata kadar nephrin serum pada kelompok preeklamsia berat lebih tinggi secara bermakna dibandingkan kehamilan normal (6,4 ng/mL vs 4,2 ng/mL; p= 0,014). Terdapat korelasi positif dengan derajat lemah namun bermakna secara statistik antara nephrin serum dengan tekanan darah sistolik (r= 0,36; p= 0,02) namun tidak signifikan terhadap tekanan darah diastolik (r= 0,3; p= 0,05). Tidak ditemukan korelasi yang bermakna antara kadar nephrin serum dengan proteinuria (r= 0,18; p= 0,54). Kesimpulan: Kadar nephrin serum pada kelompok preeklamsia berat lebih tinggi dibandingkan kehamilan normal dan terdapat korelasi antara nephrin serum dengan tekanan darah sistolik. Kata kunci: nephrin serum, podosit, preeklamsia berat, proteinuria, tekanan darah

scholarly journals HUBUNGAN ASUPAN ASAM LEMAK OMEGA-3 DAN OMEGA-6 DENGAN TEKANAN DARAH WANITA USIA 30 – 50 TAHUN

2017 ◽  
Vol 6 (4) ◽  
pp. 313
Author(s):  
Mega Lucyta Sari ◽  
Enny Probosari ◽  
Hartanti Sandi Wijayanti
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Cross Sectional Study ◽  
Observational Research ◽  
Omega 3 ◽  
Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Omega 6

Background: Hypertension is one of the major risk factors for cardiovascular disease. Decreased intake of omega-3 and increased intake of omega-6 can increase the risk of hypertension. Hypertension cases in Indonesia are highest in women especially aged 30 - 50 years. This study aimed to determine correlation of omega-3 and omega-6 intake with blood pressure in women aged 30-50 years.Method : This was an observational research with cross-sectional study design. Fifty four subjects were selecting using consecutive sampling. Intakes were assessed by food recall 2x24 hours. Blood pressure levels were measured by Sphygmomanometer. Data were analyzed by Chi Square and Fisher Exact.Result : Systolic and diastolic blood pressure mean were 115.92 ± 14.5 mmHg and 75 ± 7.45 mmHg, while omega-3 and omega-6 mean were of 3. 1.03 ± 0.52 g and 14.17 ± 5 , 8 g. More than one third of the subjects (37.9%) with pre-hypertension/hypertension had omega-3 intake less than 1.1 g and 52.7% of them had omega-6 intake less than 12 g.There was correlation of omega-6 intake with systolic blood pressure (p <0.05) but there were no correlation between omega-3 intake with systolic blood pressure, omega-3 and omega-6 intake with diastolic blood pressure (p >0,05). Conclusion: There was correlation of omega-6 intake with systolic blood pressure, there were no correlation between omega-3 intake with systolic blood pressure, omega-3 and omega-6 intake with diastolic blood pressure

scholarly journals Gambaran Perubahan Tekanan Darah Pasca Olahraga Futsal pada Mahasiswa Fakultas Kedokteran Universitas Andalas

2016 ◽  
Vol 5 (2) ◽  
Author(s):  
Akdri Andi ◽  
Afriwardi Afriwardi ◽  
Detty Iryani
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Cross Sectional Study ◽  
Cardiovascular Disorders ◽  
Sectional Study ◽  
Exclusion Criteria ◽  
Cross Sectional ◽  
Initial Blood ◽  
Initial Blood Pressure

AbstrakPada olahraga tertentu seperti futsal,  tekanan darah dapat naik menjadi 150-200 mmHg. Sebuah penelitian menyatakan  60 kematian mendadak pasca olahraga, 58 diantaranya disebabkan oleh kelainan kardiovaskuler. Tujuan penelitian ini adalah untuk mengetahui gambaran perubahan tekanan darah pasca olahraga futsal pada mahasiswa Fakultas Kedokteran Universitas Andalas. Rancangan penelitian yang digunakan adalah deskriptif observasional dengan menggunakan desain cross-sectional study. Subjek yang digunakan adalah 30 orang mahasiswa Fakultas Kedokteran Universitas Andalas yang memenuhi kriteria inklusi dan eklusi pada April 2014. Olahraga futsal dilakukan 30 menit lalu dilakukan pengukuran tekanan darah sesaat, 15, 30 dan 60 menit dengan menggunakan sphygmomanometer air raksa dan stetoskop. Hasil penelitian didapatkan peningkatan tekanan darah sistolik sesaat setelah olahraga futsal pada semua sampel dengan peningkatan sebesar 20 mmHg pada 18 orang (60%) dan 25 orang (83,8%) tidak mengalami perubahan tekanan darah diastolik. Pada 15 menit setelah olahraga futsal, 18 orang (60%) terjadi penurunan tekanan darah sistolik sebesar 20 mmHg dan 26 orang (86,67%) tidak mengalami perubahan tekanan darah diastolik. Pada 30 menit setelah olahraga, 4 orang (13,3%) mengalami penurunan tekanan darah sistolik. Satu jam setelah olahraga, semua subjek telah mencapai tekanan darah awal.Kata kuncl: tekanan darah, olahraga futsal sesaat, 15 menit, 30 menit, satu jam AbstractIn certain exercise such as futsal, blood pressure can raise around 150-200 mmHg. A study has identified 60 sudden deaths after sports and 58 were caused by cardiovascular disorders. The objective of this study was to describe changes in blood pressure after futsal exercise in students of Medical Faculty of Andalas University. The design is descriptive observational using a cross-sectional study. The 30 subjects were taken base on inclusion and exclusion criteria. This study was conducted on April 2014. Subject played futsal for 30 minutes, then the blood pressure was measured right after doing futsal then 15, 30 and 60 minutes later with a sphygmomanometer and stethoscope. This study found an increase in systolic blood pressure shortly after  futsal in all subjects with an increase of 20 mmHg in 18 people (60%) and 25 people (83.8%) had no change in diastolic blood pressure. Fifteen minutes after doing futsal, 18 people (60%) had 20 mmHg decrease in systolic blood pressure and 26 (86.67%) had no change in diastolic blood pressure. Thirty minutes after doing futsal, 4 (13.3%) experienced a decrease in systolic blood pressure and 100%  returned to the initial blood pressure. One hour after exercise, all of subjects  reached the initial blood pressure again.Keywords: blood pressure, right after doing futsal, 15 minutes, 30 minutes, one hour

Lower diastolic blood pressure in healthy subjects with vitamin K deficiency: a preliminary cross-sectional study

10.20883/181 ◽  
2016 ◽  
Vol 85 (4) ◽  
pp. 276
Author(s):  
Jan Krzysztof Nowak ◽  
Andrzej Wykrętowicz ◽  
Patrycja Krzyżanowska ◽  
Agnieszka Górna ◽  
Jarosław Tobolski ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Vitamin K ◽  
Healthy Subjects ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Vitamin K Deficiency ◽  
Cross Sectional ◽  
K Deficiency ◽  
The Relationship

Introduction. There is a growing body of evidence for the role of vitamin K in cardiovascular health. As a cofactor of carboxylation of the matrix Gla protein it prevents arterial calcification. However, the data on the relationship between vitamin K status and the blood pressure are scarce, and particularly so in persons without the burden of cardiovascular risk factors. Material and Methods. We performed a pilot cross‑sectional study, in which we hypothesized that vitamin K deficiency is associated with a higher blood pressure in young, healthy people. The concentration of protein induced by vitamin K absence‑II (PIVKA‑II) larger than 2 ng/mL was chosen as a proxy for vitamin K deficiency; it was assessed in serum using ELISA. Blood pressure was measured using a validated, automated oscillometric monitor in triplicate.Results. Twenty‑three healthy subjects were enrolled (16 female; mean age 21.3 ± 1.6 years; body mass index 20.6 ± 2.4 kg/m2). The diastolic blood pressure (DBP) was lower in vitamin K‑deficient subjects (58 ± 9 vs. 67 ± 5 mmHg, p = 0.01). The mean arterial blood pressure also differed (75 ± 9 vs. 83 ± 6, p = 0.02). PIVKA‑II levels correlated with DBP only (Pearson’s R = -0.41, p < 0.05; Spearman’s ρ ns.). Stepwise regression identified PIVKA‑II concentrations as the only independent parameter associated with DBP (adjusted R2 = 13.1%; PIVKA‑II: β = -0.41; 95%CI -1.87-(-0.00098), t = -2.08, p < 0.05).Conclusions. The relationship between vitamin K deficiency and low DBP in young adults should be investigated further.

scholarly journals HUBUNGAN ASUPAN PROTEIN, LEMAK, KALIUM DAN MAGNESIUM DENGAN TEKANAN DARAH SISTOLIK DAN DIASTOLIK LANJUT USIA

2017 ◽  
Vol 6 (4) ◽  
pp. 385
Author(s):  
Aria Menad M ◽  
Aryu Candra Kusumastuti
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Diastolic Blood Pressure ◽  
Cross Sectional Study ◽  
Bivariate Analysis ◽  
Cross Sectional ◽  
Magnesium Intake ◽  
High Prevalence ◽  
Relationship Of ◽  
Spearman Test

Background : Hypertension is one of the degenerative diseases that has high prevalence an increase. One of the factors that influence blood pressure in hypertensive patients is protein, fat, potassium, and magnesium intake. The purpose of this study was to determine the relationship of protein, fat, potassium, and magnesium intake with blood pressure in elderly.Design : This cross-sectional study was conducted among 42 subjects (aged 60-80 years) of PWRI (Persatuan Wredatama Republik Indonesia) members rating South Semarang, Semarang. Food recall method was used to measure the intake of protein, fat, potassium and magnesium intake. Blood pressure was measured with a mercury sphygmomanometer. Rank- Spearman test was used on bivariate analysis. Results : On the results of this study as many as 83.3% of subjects hypertention. Protein intake (52.4% of subjects), fat intake (100% of subject) potassium intake (54.8%) and magnesium (95.2% of subjects) are lower than needs. Bivariate analysis shows that there were no correlation between protein, fat, potassium, and magnesium intake and systolic blood pressure and diastolic blood pressure. Conclusion : In there were correlation between protein, fat, potassium, and magnesium intake and systolic blood pressure and diastolic blood pressure. 

scholarly journals A Cross-Sectional Study Of The Association Between Skin Tags And Vascular Risk Factors In Patients With Severe And Complicated Obesity

2020 ◽  
Author(s):  
Clarissa Ern Hui Fang ◽  
Catherine Crowe ◽  
Annette Murphy ◽  
Martin O’Donnell ◽  
Francis Martin Finucane
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Antihypertensive Therapy ◽  
Severe Obesity ◽  
Cross Sectional Study ◽  
Lipid Profiles ◽  
Vascular Risk ◽  
Sectional Study ◽  
Cross Sectional ◽  
Skin Tags

Abstract Objective: We sought to determine whether the presence of cervical or axillary skin tags was associated with an adverse cardiovascular risk profile in Irish adults with severe obesity. Results: We conducted a cross-sectional study of patients attending our regional bariatric centre. Of 167 patients, 100 (31% male, 37% with type 2 diabetes, 36% on lipid lowering therapy, 41% on antihypertensive therapy) agreed to participate. 85 patients had cervical or axillary tags while 15 had none. Those with any skin tags had higher systolic blood pressure (138.0±16.0 versus 125.1±8.3 mmHg, p=0.003) and higher glycated haemoglobin (HbA1c) (46.5±13.2 versus 36.8±3.5 mmol/mol, p=0.017). 94.6% of patients with diabetes, compared to 79.4% of those without diabetes had skin tags (p=0.039). 45.8% of patients with skin tags compared to 13.3% with no tags were on antihypertensive therapy (p=0.018). Skin tags were not associated with any differences in lipid profiles. In Irish adults with severe obesity, skin tags are associated with higher systolic blood pressure and HbA1c and a higher prevalence of diabetes and hypertension, consistent with increased vascular risk, though differences in lipid profiles were not found.

scholarly journals Nocturnal systolic blood pressure pattern of type 2 diabetic hypertensive men with erectile dysfunction: a cross sectional study from Northern Sri Lanka

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Thirunavukarasu Kumanan ◽  
Vathulan Sujanitha ◽  
Nadarajah Rajeshkannan ◽  
Balasingam Nisahan
Keyword(s):  
Blood Pressure ◽  
Erectile Dysfunction ◽  
Systolic Blood Pressure ◽  
Cross Sectional Study ◽  
Small Scale ◽  
Sectional Study ◽  
Cross Sectional ◽  
Pressure Pattern ◽  
Type 2 Diabetic

Abstract Objective This small scale cross-sectional study was done to identify the common systolic blood pressure pattern (dipping or non-dipping) among type 2 diabetic men with coexisting hypertension and erectile dysfunction(ED). A recent study in the same setting showed that prevalence of ED was high among diabetic men and co-existing hypertension was identified as an independent risk factor. There was a postulation about an association between ED and non-dipping nocturnal blood pressure pattern. So ambulatory blood pressure measurements (ABPM) was obtained for participants to test this prediction. Data was analysed using SPSS 25 Version. Results Among 29 participants who underwent ABPM, 21 showed non-dipping pattern of nocturnal systolic blood pressure (72.4%; CI 54.3–86.3). Mean SBP of participants was 125.55 +_14.1 and Mean DBP was 81.5 + _12.82. There was no statistical difference observed in mean SBP and DBP between patients with dipping nocturnal SBP and non-dipping pattern (P > 0.05). Variability of SBP was high among the participants (Mean SD-11.96 +/_2.74) and DBP also showed relatively high variability (SD-9.28 +/_2.9). Mean dipping percentage of the SBP during sleep was 5.54 +/_6.66. A significant difference in heart rate (HR) between patients with non-dipping and dipping pattern was noted (P-0.034).

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