scholarly journals Evaluation of the effectiveness of the pharmacotherapy scheme “TRIO” in patients with chronic arterial insufficiency of IIb-III degree

2020 ◽  
pp. 241-242
Author(s):  
V.V. Petrushenko
Keyword(s):  
Oxygen Saturation ◽  
Comparison Group ◽  
Ankle Brachial Index ◽  
Lower Extremities ◽  
Walking Distance ◽  
Control Group ◽  
Peripheral Oxygen Saturation ◽  
Significant Difference ◽  
Arterial Insufficiency ◽  
Experimental Group

Background. Occlusive peripheral arterial disease (OPAD) of the lower extremities is a pathological condition; its pathogenetic substrate is an obstruction or narrowing of the lumen of peripheral vessels of various calibres. About 200 million people worldwide suffer from OPAD. The incidence and severity of the disease increase with age. Patients with diabetes are 2-4 times more likely to develop OPAD than those without diabetes. Smoking increases the risk of OPAD by 2.5 times. Objective. To evaluate the effectiveness of the pharmacotherapy regimen “TRIO” in patients with chronic arterial insufficiency of IIb-III degree. Materials and methods. The study included 45 people with confirmed OPAD of the lower extremities and chronic arterial insufficiency of IIb-III degree (62.2 % males, 37.8 % females, mean age – 61 years). Patients in the experimental group (n=20) were prescribed a “TRIO” scheme, which included: 1) a multicomponent isoosmolar solution containing Ringer’s lactate and pentoxifylline (200 ml per day); 2) multicomponent hyperosmolar solution containing sorbitol and sodium lactate (400 ml per day); 3) a solution of L-arginine hydrochloride (100 ml per day). Comparison group was treated by the solution 2 (200 ml per day) and solution 3 (100 ml per day) only. The effectiveness criteria included the distance of painless walking, the intensity of pain according to the visual-analogue scale (VAS), ankle brachial index, and peripheral oxygen saturation. Results and discussion. In the experimental group there was a shorter length of hospital stay (7.9±0.97 days vs. 9.8±1.63 days in the comparison group) and better dynamics of painless walking distance (1st day – 47.50±30.54 m, 7th day – 126.25±72.16 m, in the comparison group: 1st day – 49.00±27.73 m, 7th day – 54.20±33.59 m). Pain syndrome according to VAS also decreased more markedly in the experimental group: from 5.35±1.81 points on day 1 to 3.25±1.68 points on day 7 (in the comparison group – from 5.32±1.63 points on day 1 to 4.80±1.53 points on day 7). There was no significant difference in the ankle brachial index. Peripheral oxygen saturation increased more markedly in the experimental group (from 75.50±7.10 % on day 1 to 90.65±5.07 % on day 7) than in the control group (from 75.72±6.55 % on day 1 to 79.48±6.91 % on day 7). Conclusions. 1. Administration of the pharmacotherapy scheme “TRIO” allows to improve the indicators of the functional state of the vascular bed in patients with chronic arterial insufficiency of IIb-III degree. 2. Manifestations of improvement included lengthening of the distance of painless walking, increase of peripheral blood oxygen saturation, and reduction of the pain severity.

scholarly journals Application of the “Trio” pharmacotherapy regimen in patients with chronic arterial insufficiency IIb-III

2020 ◽  
pp. 61-61
Author(s):  
V.V. Petrushenko ◽  
D.I. Grebeniuk ◽  
O.M. Skupyi ◽  
K.L. Lonskyi ◽  
R.I. Stoika
Keyword(s):  
Comparison Group ◽  
Lower Extremities ◽  
Sodium Lactate ◽  
Walking Distance ◽  
Peripheral Oxygen Saturation ◽  
Pressure Index ◽  
Duration Of Hospital Stay ◽  
Arterial Insufficiency ◽  
Peripheral Arterial ◽  
Experimental Group

Objective. To evaluate the effectiveness of the “Trio” pharmacotherapy regimen in patients with chronic arterial insufficiency IIb-III. Materials and methods. 45 patients with a confirmed diagnosis of peripheral arterial occlusive disease of the lower extremities and chronic arterial insufficiency IIb-III were included in the study. All patients were randomly divided into two groups. Patients from experimental group received “Trio” pharmacotherapy (multicomponent isoosmolar solution containing petoxifyllin; multicomponent hyperosmolar solution containing sodium lactate; L-arginine hydrochloridum solution). Patients from comparison group received medical therapy with multicomponent hyperosmolar solution containing sodium lactate and L-arginine hydrochloridum solution. Results and discussion. The duration of hospital stay was significantly shorter (p<0.01) in the experimental group (7.9±0.97 days) than in the comparison group (9.8±1.63 days). After treatment painless walking distance and peripheral oxygen saturation were significantly greater (p<0.01) in the experimental group (126.25±72.16 m and 90.65±5.07 %) than in the comparison group (54.20±33.59 m and 79.48±6.91 %). At the same time, and intensity of pain was significantly lower (p<0.01) in the experimental group (3.25±1.68 points) than in the comparison group (4,80±1.53 points). The values of the ankle-brachial pressure index were not differing (p<0.05) in both groups (0.49±0.16 and 0.51±0.17 for the experimental group and comparison group, respectively). Conclusions. “Trio” pharmacotherapy regimen in patients with chronic arterial insufficiency IIb-III allows to improve the basic indicators of the functional state of the microvasculature of the lower extremities.

scholarly journals Evaluation of the effectiveness of the “TRIO” pharmacotherapy regimen in patients with chronic arterial insufficiency IIb-III

2020 ◽  
Vol 3 (1) ◽  
pp. 4-9
Author(s):  
Viktoriia Petrushenko ◽  
Dmytro Hrebeniuk ◽  
Oleh Skupyi ◽  
Kostiantyn Lonskyi ◽  
Vadym Stoika
Keyword(s):  
Comparison Group ◽  
Lower Extremities ◽  
Walking Distance ◽  
Peripheral Oxygen Saturation ◽  
New Methods ◽  
Study Population ◽  
Arterial Insufficiency ◽  
Peripheral Arterial ◽  
Methods Of Treatment ◽  
Experimental Group

Background. Despite constant progress in the study of the etiopathogenetic aspects of the disease, the development and implementation of new methods of treatment, the search for optimal pharmacotherapy regimens, the problem of occlusion disease of the peripheral arteries of the lower extremities continues to be extremely relevant. The aim of the study was to evaluate the effectiveness of the “TRIO” pharmacotherapy regimen in patients with chronic arterial insufficiency IIb-III. Materials and methods. According to the aims and objectives, 45 patients with a confirmed diagnosis of peripheral arterial occlusive disease of the lower extremities and chronic arterial insufficiency IIb-III were included in the study. All patients from the study population were randomly divided into two groups. Patients from experimental group received “TRIO” pharmacotherapy (Latren, Rheosorbilact, Tivortin). Patients from comparison group received medical therapy with Rheosorbilact and Tivortin. Results. The duration of hospital stay was significantly shorter (p < 0.01) in the experimental group (7.9 ± 0.97 days) than in the comparison group (9.8 ± 1.63 days). After treatment painless walking distance and peripheral oxygen saturation were significantly greater (p < 0.01) in the experimental group (126.25 ± 72.16 m and 90.65 ± 5.07 %, respectively) than in the comparison group (54.20 ± 33.59 m and 79.48 ± 6.91 %, respectively). At the same time, the intensity of pain was significantly lower (p < 0.01) in the experimental group (3.25 ± 1.68 points) than in the comparison group (4.80 ± 1.53 points). The values of the ankle-brachial pressure index were not differing (p < 0.05) in both groups (0.49 ± 0.16 and 0.51 ± 0.17 for the experimental group and comparison group, respectively). Conclusions. “TRIO” pharmacotherapy regimen in patients with chronic arterial insufficiency IIb–III allows to improve the basic indicators of the functional state of the microvasculature of the lower extremities.

EFFECT OF MOTOR IMAGERY TRAINING IN COMBINATION WITH ELECTROMYOGRAPHY-TRIGGERED ELECTRICAL STIMULATION IN STROKE WITH HEMIPLEGIA PATIENTS: A RANDOMIZED CONTROLLED STUDY

2019 ◽  
Vol 19 (08) ◽  
pp. 1940062
Author(s):  
JI-SU PARK ◽  
JONG-BAE CHOI ◽  
GIHYOUN LEE ◽  
SANG-HOON LEE ◽  
YOUNGJIN JUNG
Keyword(s):  
Electrical Stimulation ◽  
Motor Imagery ◽  
Lower Extremities ◽  
Controlled Study ◽  
Control Group ◽  
Timed Up And Go ◽  
Imagery Training ◽  
Significant Difference ◽  
Experimental Group ◽  
Better Than

Recently, motor imagery training combined with electromyography-triggered electrical stimulation (MIT EMG-ES) has been reported as a remedial treatment for stroke patients. However, the clinical evidence of the effect is still lacking. To investigate the effect of MIT EMG-ES on lower extremities and activities of daily of living (ADL) in patients with stroke, the participants were randomly assigned to an experimental group ([Formula: see text]) or control group ([Formula: see text]). The experimental group underwent MIT EMG-ES, whereas the control group performed underwent motor imagery training. In addition, both groups received the same conventional rehabilitation therapy. All participants underwent treatment for 30[Formula: see text]min a day, 5 sessions per week, for 4 weeks. Lower extremities function was measured by the Fugl–Meyer Assessment Lower Extremity (FMA-LE), Timed Up-and-Go (TUG) test and 10 m Walk (10[Formula: see text]MW) test. ADL were measured by the Korea version of the Modified Barthel Index (K-MBI). The experimental group except for the FMA-LE group showed more improvement in TUG and 10[Formula: see text]MW test scores than the control group ([Formula: see text]). The effect size showed FMA-LE, TUG, and 10[Formula: see text]MW test (0.7, 1.0, 0.7, respectively). However, there was no statistically significant difference between the two groups in K-MBI ([Formula: see text]). Our findings suggest that MIT EMG-ES may be a novel treatment for lower extremities function in patients with stroke better than MIT alone.

scholarly journals The effects of Kinesio taping-combined exercise on the balance and gait ability of hemiplegic patients

2021 ◽  
Vol 12 (3) ◽  
pp. 322-328
Author(s):  
Young-Han Park ◽  
Dae-Hwan Lee ◽  
Youn-Bum Sung
Keyword(s):  
Lower Extremities ◽  
Control Group ◽  
Group Comparison ◽  
Stroke Patients ◽  
Combined Exercise ◽  
Kinesio Taping ◽  
Significant Difference ◽  
Balance Ability ◽  
Stance Time ◽  
Experimental Group

Purpose: This study aims to investigate the effect of the Kinesio taping method on the balance ability and gait ability of hemiplegic stroke patients by applying it to the lower extremities of the ankle on the affected side, addressing instability and asymmetry by improving the stability of the muscles and ankle joint. Methods: This study confirmed the general characteristics of hemiplegic patients diagnosed with stroke. Kinesio taping was applied to the lower extremities of 15 subjects in the experimental group, and they performed mat and treadmill exercises. In addition, basic mat and treadmill exercises were performed by the 15 subjects in the control group. The exercise regimens were performed 18 times: three times a week for six weeks. Results: In the paired-sample T-test used for within-group comparison of BBS, TUG and stance time on nonparetic side value, there was a significant difference between pre- and post-test for experimental group. However, in the control group, there was a statistically significant difference only in TUG. In the inter-group comparison, the experimental group showed a statistically significant improvement in BBS, TUG and stance time on nonparetic side value compared to the control group. Conclusion: The experiment’s results demonstrate that the application of Kinesio taping-combined exercise provides stability of the muscles and ankle joints of the lower extremities during walking by improving balance ability, and improves overall gait stability by increasing the stance phase time of the affected side in hemiplegic stroke patients.

Is perioperative antibiotic necessary in straightforward implant placement procedures?

2020 ◽  
Author(s):  
Elçin Bedeloğlu ◽  
Mustafa Yalçın ◽  
Cenker Zeki Koyuncuoğlu
Keyword(s):  
Clavulanic Acid ◽  
Dental Implant ◽  
Prophylactic Antibiotic ◽  
Antibiotic Use ◽  
Implant Failure ◽  
Control Group ◽  
Implant Placement ◽  
Significant Difference ◽  
Amoxicillin Clavulanic Acid ◽  
Experimental Group

The purpose of this non-random retrospective cohort study was to evaluate the impact of prophylactic antibiotic on early outcomes including postoperative pain, swelling, bleeding and cyanosis in patients undergoing dental implant placement before prosthetic loading. Seventy-five patients (45 males, 30 females) whose dental implant placement were completed, included to the study. Patients used prophylactic antibiotics were defined as the experimental group and those who did not, were defined as the control group. The experimental group received 2 g amoxicillin + clavulanic acid 1 h preoperatively and 1 g amoxicillin + clavulanic acid twice a day for 5 days postoperatively while the control group had received no prophylactic antibiotic therapy perioperatively. Data on pain, swelling, bleeding, cyanosis, flap dehiscence, suppuration and implant failure were analyzed on postoperative days 2, 7, and 14 and week 12. No statistically significant difference was detected between the two groups with regard to pain and swelling on postoperative days 2, 7, and 14 and week 12 ( p &gt;0.05), while the severity of pain and swelling were greater on day 2 compared to day 7 and 14 and week 12 in both groups ( p =0.001 and p &lt;0.05, respectively). Similarly, no significant difference was found between the two groups with regard to postoperative bleeding and cyanosis. Although flap dehiscence was more severe on day 7 in the experimental group, no significant difference was found between the two groups with regard to the percentage of flap dehiscence assessed at other time points. Within limitations of the study, it has been demonstrated that antibiotic use has no effect on implant failure rates in dental implant surgery with a limited number of implants. We conclude that perioperative antibiotic use may not be required in straightforward implant placement procedures. Further randomized control clinical studies with higher numbers of patients and implants are needed to substantiate our findings.

The Effect of Using Students Peer Teaching on Iraqi EFL Students' Achievement in the Course of Library and Research Work

2019 ◽  
Vol 1 (33) ◽  
pp. 693-714
Author(s):  
. Muntaha Sabbar Jebur
Keyword(s):  
Basic Education ◽  
Teaching Method ◽  
Research Work ◽  
Peer Teaching ◽  
Control Group ◽  
College Of Basic Education ◽  
Significant Difference ◽  
Post Test ◽  
Efl Students ◽  
Experimental Group

          Peer teaching is a strategy that allows the students to teach the new content to each other, and they must be accurately guided by instructors.     The researcher proposes that the use of students peer teaching  may promote students' achievement  and ensure the engagement of all the students in the learning process. Therefore, the researcher employs it as a teaching method aiming at investigating its  effect on Iraqi EFL students' achievement in the course of Library and Research Work .      The study hypothesizes that there is no significant difference between the students' achievement who are taught library and research work by students peer teaching  and that of the students taught by the traditional way. The experimental design of the study is Parallel Groups, Random Assignment, posttest. Each group consists of 35 students, chosen randomly from the Third Year Students at the Department of English in the College of Basic Education. Both groups were matched in terms of their age and parents' education. The experiment was fulfilled in the first course for 15 weeks during the academic year 2016-2017.       The same materials were presented to both groups. This included   units from Writing Research Paper by Lester D. . Post-test was constructed and exposed  The t-test for  independent samples was used to analyze the results and it is found out that there is a statistical difference between the two groups in their achievement because the calculated t- value 2.635 is bigger than the tabulated t- value which is 2.000, and also shown the superiority of the experimental group. The results indicate that the experimental group, who was taught Library and Research Work by peer teaching   was better than the control group, who was taught according to the traditional way. So, the null hypothesis is rejected. Finally, some recommendations and suggestions are presented in the light of the study findings. to a jury of experts to verify its validity and it was administered to both groups.

Optimization of postoperative management of patients undergoing functional endoscopic sinus surgery

2018 ◽  
pp. 26-31
Author(s):  
Sergey Bezshapochny ◽  
Andrey Loburets ◽  
Valery Loburets
Keyword(s):  
Nasal Cavity ◽  
Postoperative Period ◽  
Sodium Hyaluronate ◽  
Sinus Surgery ◽  
Control Group ◽  
Nasal Breathing ◽  
Traditional Therapy ◽  
Significant Difference ◽  
Water Salt ◽  
Experimental Group

Topicality: The result of surgical treatment depends largely on the chosen method of management of the postoperative period, the main purpose of which is to reduce the effects of surgical trauma. Despite the wide variety of drugs for local and systemic use, the question of pharmacotherapy of the operated sinus remains open to this day. The main properties that a modern drug should possess are safety and high clinical efficacy. Aim: to study the clinical efficacy of topical application of a complex preparation based on a saline solution containing sodium hyaluronate and dexpanthenol in patients with chronic sinusitis after functional endoscopic sinus surgery (FESS). Materials and Methods: Clinical and laboratory studies were conducted on 47 patients with chronic rhinosinusitis who underwent surgery using the FESS technique. Patients were divided into 2 groups according to the principle of the postoperative period. Patients of research group (n=21), except for traditional therapy, was used locally NASOMER (a preparation based on a water-salt solution containing sodium hyaluronate and dexpanthenol); to the control group (n=26) patients entered, in the postoperative period received traditional therapy. Traditional therapy included a toilet of the nasal cavity, the use of short-course topical decongestants, irrigation of the nasal cavity with water-salt solutions. Criteria of clinical effectiveness: data of endoscopy of the nasal cavity, rhinomanometry, activity of the mucociliary transport system. The effectiveness of functional research methods in the postoperative period was determined on the 7th and 14th day of treatment. Results: On the 3rd day of the study, an increase in the swelling of the nasal cavity was observed in patients of both clinical groups, correlated with difficulty in nasal breathing. On the 7th day, a decrease in edema was observed in patients of both groups, but in the experimental group, the index of nasal breathing, according to rhinomanometry, was significantly (p<0.05) different from the control group, and was respectively 1.54±0.14 and 2.04±0.19 kPa/l*s. On the 14th day of the study, no significant difference was observed between these indicators. When studying the activity of the ciliated epithelium of the mucous membrane of the nasal cavity, it was proved that patients of the experimental group on day 7 after surgery showed a statistically significant difference in this indicator compared to the control group (17.8±1.0 and 22.7±2.1 min. respectively). Conclusions: The use of NASOMER after surgical intervention in patients with chronic rhinosinusitis contributes to more effective treatment compared with traditional therapy, as evidenced by the rapid recovery of the main functional parameters according to active posterior rhinomanometry and mucociliary clearance. Based on the results of the studies performed, the use of NASOMER for pharmacotherapy in the postoperative period is recommended for patients who have undergone rhinosurgical interventions with the aim of reducing the period of postoperative rehabilitation as an effective anti-inflammatory and wound-healing agent.

Thyroid Dysfunction in Pregnant Women with Gestational Diabetes Mellitus

2020 ◽  
Vol 16 (8) ◽  
pp. 895-899 ◽  
Author(s):  
Shahin Safian ◽  
Farzaneh Esna-Ashari ◽  
Shiva Borzouei
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Thyroid Dysfunction ◽  
Control Group ◽  
Thyroid Peroxidase ◽  
Free T4 ◽  
Significant Difference ◽  
Experimental Group

Aims: Investigation thyroid dysfunction and autoimmunity in pregnant women with gestational diabetes mellitus. Background: This article was written to evaluate the thyroid function and anti-thyroid peroxidase (anti- TPO) antibodies in pregnant women with gestational diabetes mellitus (GDM). Method: A total of 252 women with GDM and 252 healthy pregnant women were enrolled. Thyroid tests, including TSH, FreeT3, Free T4, and anti-TPO were performed for all women at 24–28 weeks of gestation. Data analysis was then carried out using SPSS ver. 22. Result: There was a significant difference between the experimental group (38.4%) and the control group (14.06%) in terms of the prevalence of subclinical hypothyroidism (p= 0.016). The frequency of anti-TPO was higher in the experimental group than the control group and positive anti-TPO was observed in 18.6% of women with GDM and 10.3% of healthy pregnant women (P= 0.008). Conclusion: Thyroid disorders are observed in pregnant women with GDM more frequently than healthy individuals and it may be thus reasonable to perform thyroid tests routinely.

EFFECT OF WEB BASED INSTRUCTIONS ON ACHIEVEMENT IN SOCIAL STUDIES

2017 ◽  
Vol 4 (24) ◽  
Author(s):  
Rajwinder Kaur
Keyword(s):  
Social Studies ◽  
Conventional Method ◽  
Traditional Method ◽  
Statistical Techniques ◽  
Control Group ◽  
Web Based ◽  
Significant Difference ◽  
Post Test ◽  
Based Instruction ◽  
Experimental Group

The purpose of the study was to study the Effect of Web based instructions on achievement in Social Studies. The sample consisted of 100 students from Grade 8th of schools affiliated to C.B.S.E of Ferozepur and were randomly split into two groups-control (taught by traditional method) and experimental (taught by Web based instruction) groups. Firstly pre-test was administered on both the groups; then the students in the control group were taught by conventional method while experimental group was taught by Web based instructions. Then post-test was administrated on both the groups. The Statistical techniques were then employed to data collected and analysis and interpretation of the data was done. The result of the study implied that there exists significant difference in achievement in Social Studies based on Web based instructions and conventional method. The study also revealed that there exist significant gender differences in achievement in Social Studies with Web based instructions.

Role of Nutrition Counseling and Lifestyle Modification in Managing Prediabetes

2021 ◽  
pp. 037957212110254
Author(s):  
Harleen Kaur ◽  
Neerja Singla ◽  
Rohini Jain
Keyword(s):  
Hemoglobin A1c ◽  
Lifestyle Modification ◽  
Fasting Blood Glucose ◽  
Nutrition Intervention ◽  
Control Group ◽  
Population Prevalence ◽  
Significant Difference ◽  
And Control ◽  
Experimental Group

Objective: India is the second country after China having the highest population prevalence of diabetes. Several research studies investigating diabetes have been done, but not much work has been done on prediabetes. The purpose of this study was to investigate the effect of nutrition and lifestyle modification on prediabetic females. Methods: A total of 120 prediabetic females from Ludhiana city were divided into 2 matched groups: control group (n = 60) and experimental group (n = 60). Impact of nutrition intervention for dietary and lifestyle modification (for 3 months) was assessed on the anthropometric, dietary, biochemical parameters, and diabetes risk score of the experimental group and control group (no intervention). Results: All the selected 120 subjects completed the study (experimental group = 60; control group = 60). There was significant difference in the changes between the 2 groups throughout the study. The fasting blood glucose and glycated hemoglobin A1c levels of the experimental group subjects reduced significantly ( P ≤ .01). However, no change was observed among the control group subjects. The lipid profile of the experimental group showed a significant improvement ( P ≤ .01). Conclusion: Nutrition counselling of the prediabetics regarding dietary and lifestyle modification is recommended so as to improve their metabolic control, thus preventing them from being diabetics.

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