scholarly journals Hubungan Antara Tekanan Darah Sistolik dengan Kadar Kolesterol Total pada Pasien Diabetes Melitus Tipe 2 di Klinik Arafah Lampung Tengah

2021 ◽  
Vol 3 (4) ◽  
pp. 562-569
Author(s):  
Firhat Esfandiari ◽  
Tusy Triwahyuni ◽  
Resti Arania ◽  
Najmi Bias Aysa
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Systolic Blood Pressure ◽  
Total Cholesterol ◽  
Cross Sectional ◽  
Cholesterol Levels ◽  
Diabetes Melitus

ABSTRACT: RELATIONSHIP BETWEEN SYSTOLIC BLOOD PRESSURE AND TOTAL CHOLESTEROL LEVEL IN TYPE 2 DIABETES MELLITUS PATIENTS IN ARAFAH CLINIC, CENTRAL LAMPUNG Background: Diabetes mellitus type 2 is a disease characterized by hyperglycemia, with the underlying cause being an increase in insulin resistance and or an increase in pancreatic beta cell dysfunction (Decroli, 2019). Diabetes mellitus, hypertension and increased cholesterol levels are conditions that are often found to be interrelated. Hypertension and increased cholesterol levels can be comorbid conditions that accompany DM (Noviyanti et al., 2015). Objective: This study aimed to determine the correlation between systolic blood pressure levels and total cholesterol levels in patients with type 2 diabetes mellitus at the Arafah Clinic, Central Lampung. Method: The type of research used in this research is descriptive analytic with aapproach Cross Sectional. As well as samples taken from Arafah Clinic patients diagnosed with type 2 diabetes, as many as 46 patients. Results: Based on the results of thetest, it was fisher exact found that there was no correlation with the p value = 0.735 (p> 0.05). Conclusion: H0 is received, which means there is no significant correlation between systolic blood pressure and total cholesterol levels in type 2 DM patients at the Arafah Clinic, Central Lampung. Keywords: Systolic Blood Pressure, Total Cholesterol Levels, Type 2 Diabetes Mellitus  INTISARI: HUBUNGAN ANTARA TEKANAN DARAH SISTOLIK DENGAN KADAR KOLESTEROL TOTAL PADA PASIEN DIABETES MELITUS TIPE 2 DI KLINIK ARAFAH LAMPUNG TENGAH Latar Belakang: Diabetes Melitus tipe 2 merupakan suatu penyakit dengan karakteristik hiperglikemia, dengan penyebab yang mendasarinya adalah peningkatan resistensi insulin dan atau peningkatan disfungsi sel beta pankreas (Decroli, 2019). Diabetes melitus, hipertensi dan peningkatan kadar kolesterol merupakan keadaan yang sering dijumpai saling berkaitan. Hipertensi dan peningkatan kadar kolesterol bisa menjadi kondisi komorbiditas yang menyertai DM (Noviyanti et al., 2015).Tujuan: Penelitian ini ditujukkan untuk mengetahui hubungn antara kadar tekanan darah sistolik dengan kadar kolesterol total pada pasien diabetes melitus tipe 2 di Klinik Arafah Lampung Tengah.Metodologi: Jenis penelitian yang digunakan pada penelitian ini adalah deskriptif analitik dengan pendekatan Cross Sectional. Serta sampel diambil dari pasien Klinik Arafah yang terdiagnosa DM tipe 2 yaitu sebanyak 46 pasien.Hasil: Berdasarkan dari hasil uji fisher exact didapatkan tidak adanya hubungan dengan nilai p =0,735 (p>0,05).Kesimpulan: Didapatkan H0 yang diterima yang berarti tidak ada hubungan yang signifikan antara tekanan darah sistolik dengan kadar koletesterol total pada pasien DM tipe 2 di Klinik Arafah Lampung Tengah. Kata Kunci:Tekanan Darah Sistolik, Kadar Kolesterol Total, Diabetes Melitus tipe  

scholarly journals Hubungan Antara Tekanan Darah Sistolik Dengan Kadar Hdl Kolesterol Pada Pasien Diabetes Melitus Tipe 2 Di Klinik Arafah Lampung Tengah

2021 ◽  
Vol 1 (4) ◽  
pp. 307-314
Author(s):  
Toni Prasetia ◽  
Firhat Esfandiari ◽  
Sandhy Arya Pratama ◽  
Ikbal Zaenur Ridwan
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Systolic Blood Pressure ◽  
Hdl Cholesterol ◽  
Cross Sectional ◽  
Cholesterol Levels ◽  
Diabetes Melitus

ABSTRACT: RELATIONSHIP BETWEEN SYSTOLIC BLOOD PRESSURE AND HDL CHOLESTEROL LEVELS IN TYPE 2 DIABETES MELLITUS PATIENTS IN ARAFAH CLINIC, CENTRAL LAMPUNG Background: Hypertension is a major risk factor for type 2 Diabetes Mellitus, hypertension can make cells insensitive to insulin, so blood sugar levels can also be disrupted. Dyslipidemia causes constriction in blood vessels or atherosclerosis which can aggravate hypertension or diabetes mellitus. Meanwhile, the function of HDL in transporting bad cholesterol also causes blood vessels to dilate due to increased NO production. Objective: To find out the relationship between systolic blood pressure and HDL cholesterol levels in type 2 diabetes mellitus patients at the Arafah Clinic, Central Lampung, 2020. Method: This type of research used in this research is descriptive-analytic with cross-sectional design. The sampling technique was total sampling. Respondents in this study were patients with Type 2 Diabetes Mellitus at the Arafah Clinic in Central Lampung in 2020 Results: Based on the results of the chi-square statistical test, it was found that there was no relationship with the results of p = 0.898 (p> 0.05). Conclusion: There is no correlation between systolic blood pressure and HDL cholesterol levels in type 2 diabetes mellitus patients at the Arafah Clinic, Central Lampung in 2020. Keywords: Diabetes Mellitus type 2, Systolic Blood Pressure, HDL   INTISARI: HUBUNGAN TEKANAN DARAH SISTOLIK DENGAN KADAR KOLESTEROL HDL PADA PASIEN DIABETES MELLITUS TIPE 2 DI KLINIK ARAFAH LAMPUNG TENGAH Latar Belakang: Hipertensi merupakan faktor risiko utama untuk terjadinya Diabetes Melitus tipe 2, hipertensi dapat membuat sel tidak sensitif terhadap insulin, maka kadar gula di dalam darah juga dapat mengalami gangguan. Dislipidimia menyebabkan terjadinya penyempitan dalam pembuluh darah atau aterosklerosis yang dapat memperberat kondisi hipertensi ataupun diabetes mellitus. Sedangkan fungsi HDL mengangkut kolesterol jahat juga menyebabkan pembuluh darah bisa berdilatasi karena produksi NO yang meningkat.Tujuan: Untuk mengetahui Hubungan Antara Tekanan Darah Sistolik dengan Kadar HDL Kolesterol pada pasien Diabetes Melitus tipe 2 di Klinik Arafah Lampung Tengah Tahun 2020.Metode: Jenis penelitian yang digunakan dalam penelitian ini adalah deskriptif analitik dengan desain cross sectional. Teknik pengambilan sampel berupa total sampling. Responden dalam penelitian ini adalah pasien Diabetes Melitus tipe 2 di Klinik Arafah Lampung Tengah.Hasil: Berdasarkan hasil uji statistic chi-square didapatkan tidak terdapat hubungan dengan hasil p=0,898 (p>0,05).Kesimpulan: Tidak terdapat Hubungan Antara Tekanan Darah Sistolik dengan Kadar HDL Kolesterol pada pasien Diabetes Melitus tipe 2 di Klinik Arafah Lampung Tengah tahun 2020. Kata Kunci     : Diabetes Melitus tipe 2, Tekanan Darah Sistolik, HDL

scholarly journals Pengendalian Diabetes Melitus Tipe 2 pada Pasien di Puskesmas Jayabaru Kota Banda Aceh

2018 ◽  
Vol 28 (4) ◽  
pp. 239-246
Author(s):  
Nur Ramadhan ◽  
Nelly Marissa ◽  
Eka Fitria ◽  
Veny Wilya
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Plasma Glucose ◽  
Good Control ◽  
Cross Sectional ◽  
Banda Aceh ◽  
Diabetes Melitus

Diabetes Mellitus (DM) is a metabolic disease that affects many people of the world, including Indonesia. To prevent complications, a good control of DM is needed by patients, one of them is controlling blood sugar and keeping blood pressure stable. DM is reported in Banda Aceh as one of diseases with the highest number of visits every year. The purpose of this study was to determine the achievements of DM control by patients with type 2 diabetes mellitus in Puskesmas Jayabaru Banda Aceh. The study used a cross sectional design and a sample of 85 patients with type 2 diabetes mellitus in Puskesmas Jayabaru in 2015. The results showed 81.2% HbA1c value ≥ 7%, 80% fasting plasma glucose (FPG) ≥ 100 mg/dl, 85.9% of the value post prandial plasma glucose ≥ 140 mg/dl and 58.8% blood pressure ≥ 130 mmHg. Of the 85 patients only 7 showed good DM control results. This illustrates that DM control achievement is still below the cut-off value set by PERKENI. Counseling to patients and families is needed to improve the management of type 2 DM by patients. Abstrak Abstrak Diabetes Melitus (DM) merupakan penyakit metabolik yang banyak diderita penduduk dunia, termasuk Indonesia. Untuk mencegah terjadi komplikasi diperlukan pengendalian DM yang baik oleh penderita, salah satunya dengan mengontrol gula darah dan menjaga tekanan darah tetap stabil. Penyakit DM dilaporkan di Kota Banda Aceh sebagai salah satu penyakit dengan angka kunjungan terbanyak setiap tahun. Tujuan penelitian ini untuk mengetahui capaian pengendalian DM oleh penderita DM tipe 2 di wilayah kerja Puskesmas Jayabaru Kota Banda Aceh. Penelitian menggunakan desain potong lintang dan sampel berjumlah 85 orang penderita DM tipe 2 di Puskesmas Jayabaru tahun 2015. Hasil penelitian menunjukkan 81,2% nilai HbA1c ≥ 7%, 80% nilai GDP ≥ 100 mg/dl, 85,9% nilai GD 2 jam PP ≥ 140 mg/dl, 58,8% dan tekanan darah ≥ 130. Dari 85 pasien hanya tujuh orang yang menunjukkan hasil pengendalian DM yang baik. Hal ini menggambarkan bahwa capaian pengendalian DM masih di bawah nilai cut off yang ditetapkan Perkumpulan Endokrinologi Indonesia (PERKENI). Penyuluhan kepada pasien dan keluarga sangat dibutuhkan untuk memperbaiki pengelolaan DM tipe 2 oleh penderita.

scholarly journals Hubungan Antara Tekanan Darah Sistolik Dengan Kadar Ldl (Low Density Lipoprotein) Padapasien Diabetes Melitus Tipe 2 Di Klinik Arafah, Lampung Tengah

2021 ◽  
Vol 1 (3) ◽  
pp. 134-141
Author(s):  
Avi Hurriyatus Sholihah ◽  
Firhat Esfandiari ◽  
Sandhy Arya Pratama ◽  
Resti Arania
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Systolic Blood Pressure ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Diabetes Melitus

ABSTRACT: RELATIONSHIP BETWEEN SYSTOLIC BLOOD PRESSURE WITH LDL (LOW DENSITY LIPOPROTEIN) IN DIABETES MELLITUS TYPE 2 PATIENTS IN ARAFAH CLINIC, CENTRAL LAMPUNG  Background: According to the 2017 World Health Organization (WHO), type 2 diabetes mellitus and hypertension ( HT) is a common disease among older adults aged> 60 years in developing and developed countries. One of the factors of hypertension is high levels of fat at high levels of fat, levels of LDL (Low Density Lipoprotein) are very influential and can lead to atherosclerosis that triggers hypertension. Of the 46 subjects, the frequency distribution of the sexes was male as many as 16 people (34.8%), female 30 people (65.2%). According to age <30 years as many as 2 people (4.3%), 30-50 years as many as 8 people (17.4%),> 50 years as many as 36 (78.3%). According to normal systolic blood pressure <140 mmHg as many as 34 people (73.9%), Height> 140 mmHg as many as 12 people (26.1%). And according to normal LDL levels <100 mg / dl as many as 8 people (17.4%), height> 100 mmHg as many as 38 people (2.6%). Objectives: to determine the relationship between systolic blood pressure and LDL (Low Density Lipoprotein) levels in patients with type 2 diabetes mellitus at the Arafah clinic, Central Lampung, 2020. Methods: This study used a cross sectional approach, namely by collecting data at the same time as one time. The data will be processed and analyzed with the help of a computer using the SPSS for Windows version 20.0 program. Results: Based on the Chi-Square analysis, it was found that there was no relationship with the value of p = 0.336 (p> 0.05). Conclusion: There is no relationship between systolic blood pressure and LDL (Low Density Lipoprotein) levels in patients with type 2 diabetes mellitus.                                                                                                 Keywords: Systolic blood pressure, LDL Levels, Diabetes Mellitus type 2.        INTISARI: HUBUNGAN ANTARA TEKANAN DARAH SISTOLIK DENGAN KADAR LDL (LOW DENSITY LIPOPROTEIN) PADA PASIEN DIABETES MELITUS TIPE 2 DI KLINIK ARAFAH, LAMPUNG TENGAH.Latar Belakang: Menurut World Health Organization tahun 2017 (WHO), diabetes melitus tipe 2 dan hipertensi (HT) adalah penyakit yang umum dikalangan orang dewasa tua berusia > 60 tahun di negara berkembang dan negara maju. Salah satu faktor hipertensi ialah tingginya kadar lemak pada tingginya kadar lemak, kadar LDL (Low Density Lipoprotein) sangat berpengaruh dan dapat mengakibatkan sebuah aterosklerosis pemacu hipertensi. Dari 46 subjek didapatkan distribusi frekuensi jenis kelaminnya laki laki sebanyak 16 orang (34,8%), perempuan 30 orang (65,2%). Menurut umurnya <30 tahun sebanyak 2 orang (4,3%), 30 – 50 tahun sebanyak 8 orang (17,4%), >50 tahun sebanyak 36 (78,3%). Menurut Tekanan darah sistoliknya Normal <140 mmHg sebanyak 34 orang (73,9%), Tinggi >140 mmHg sebanyak 12 orang (26,1%). Dan Menurut Kadar LDLnya normal <100 mg/dl sebanyak 8 orang (17,4%), tinggi >100 mmHg sebanyak 38 orang (2,6%).Tujuan: untuk mengetahui hubunganan antara tekanan darah sistolik dengan kadar LDL (Low Density Lipoprotein) pada pasien diabetes melitus tipe 2 di klinik Arafah, Lampung tengah tahun 2020.Metode: Penelitian ini menggunakan pendekatan cross sectional, yaitu dengan cara pengumpulan data sekaligus pada satu waktu. Data akan diolah dan dianalisa dengan bantuan komputer dengan menggunakan program SPSS for Windows versi 20,0.Hasil: Berdasarkan analisa Chi-Square didapatkan tidak adanya hubungan dengan nilai nilai p =0,336 (p>0,05).Kesimpulan: Tidak terdapat hubungan antara tekanan darah sistolik dengan kadar LDL (Low Density Lipoprotein) pada pasien diabetes melitus tipe 2. Kata Kunci : Tekanan darah sistolik, Kadar LDL, Diabetes Melitus tipe 2.

scholarly journals Hubungan Tekanan Darah Sistolik Dengan Kadar Trigliserida Pada Pasien Diabetes Melitus Tipe 2 Di Klinik Arafah Lampung Tengah

2021 ◽  
Vol 1 (3) ◽  
pp. 230-236
Author(s):  
Toni Prasetia ◽  
Firhat Esfandiari ◽  
Sandhy Arya Pratama ◽  
Mohamad Imam Istawa
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Systolic Blood Pressure ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
Diabetes Melitus

ABSTRACT: CORRELATION OF SYSTOLIC BLOOD PRESSURE WITH TRIGLYCERIDE LEVELS IN TYPE 2 DIABETES MELLITUS PATIENTS IN ARAFAH CLINIC, CENTRAL LAMPUNGBackground: Hypertension is the main risk factor for DM. Hypertension can make cells insensitive to insulin. Even though insulin plays a role in increasing glucose uptake in many cells and in this way also regulates carbohydrate metabolism, so that if insulin resistance occurs by cells, the blood sugar levels can also be disrupted. Dyslipidemia is a change in blood lipid profile, one of which is an increase in triglyceride levels. High triglyceride levels can cause thickening of the blood vessels and cause narrowing of the arteries.Objective: To determine the relationship between systolic blood pressure and triglyceride levels in patients with type 2 diabetes mellitus in Klniki Arafah Tengah Lampung.Methodology: This research uses a descriptive-analytic research method with a cross-sectional approach. The sampling technique is Total Sampling. . Respondents in this study were patients with Type 2 Diabetes Mellitus at the Arafah Clinic in Central Lampung in 2020.Results: It is known that in the sex frequency distribution, there were 16 men with 34.8% and 30 women with 65.2%. Distribution of frequency based on age, it was found that the age group 24-45 years numbered 7 patients (15.2%), the age group 46-65 years amounted to 32 patients (69.6%), and the group> 65 years amounted to 7 patients (15.2 %). It is known that the frequency distribution of systolic blood pressure in type II diabetes mellitus patients, it was found that type II diabetes mellitus patients with normal systolic blood pressure levels were 34 patients with 73.9%, while high systolic blood pressure levels were 12 patients with 26.1%. It is known that the frequency distribution of triglyceride levels in patients with type II diabetes mellitus, it was found that 8 patients with normal triglycerides had normal triglyceride levels, and 38 patients (82.6%) had high triglyceride levels. The results of the chi-square statistical test found no relationship with the results of p = 898 (p> 0.05).Conclusion: There is no correlation between systolic blood pressure and cholesterol triglycerides in type 2 diabetes mellitus patients at the Arafah Clinic, Central Lampung in 2020.                 Keywords: Type 2 Diabetes Mellitus, Systolic Blood Pressure Triglierida INTISARI: HUBUNGAN TEKANAN DARAH SISTOLIK DENGAN KADAR TRIGLISERIDA PADA PASIEN DIABETES MELITUS TIPE 2 DI KLINIK ARAFAH LAMPUNG TENGAHLatar Belakang: Hipertensi merupakan faktor risiko untama untuk terjadinya DM. Hipertensi dapat membuat sel tidak sensitif terhadap insulin. Padahal insulin berperan meningkatkan ambilan glukosa di banyak sel dan dengan cara ini juga mengatur metabolisme karbohidrat, sehingga jika terjadi resistensi insulin oleh sel, maka kadar gula di dalam darah juga dapat mengalami gangguan. Dislipidemia adalah perubahan dari profil lipid darah salah satunya adalah peningkatan kadar trigliserida. Kadar trigliserida yang tinggi dapat menyebabkan penebalan pembuluh darah dan menyebabkan penyempitan pembuluh darahTujuan : Untuk mengetahui hubungan tekanan darah sistolik dengan kadar trigliserida pada pasien diabetes melitus tipe 2 di klniki arafah lampung tengahMetode : Jenis penelitian ini menggunakan metode penelitian deskriptif analitik dengan pendekatan cross – sectional. Teknik pengambilan sampel berupa Total Sampling. . Responden dalam penelitian ini adalah pasien Diabetes Melitus tipe 2 di Klinik Arafah Lampung Tengah tahun 2020.Hasil : pada variabel trigliserida dan tekanan darah sistolik diperoleh nilai p Vale = 898 (p>0,05)Kesimpulan: Tidak terdapat Hubungan Antara Tekanan Darah Sistolik dengan Trigliserida Kolesterol pada pasien Diabetes Melitus tipe 2 di Klinik Arafah Lampung Tengah tahun 2020.Kata Kunci     : Diabetes Melitus tipe 2, Tekanan Darah Sistolil Triglierid

Abstract 11267: LX4211, a Dual Inhibitor of Sodium-Glucose Cotransporters 1 and 2, Reduces Systolic Blood Pressure in Patients With Type 2 Diabetes Mellitus and Moderate to Severe Renal Impairment

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Pablo Lapuerta ◽  
Paul Strumph ◽  
Philip Banks ◽  
Ikenna Ogbaa ◽  
Brian Zambrowicz ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Renal Impairment ◽  
Systolic Blood Pressure ◽  
Severe Renal Impairment ◽  
Postprandial Glucose ◽  
Dual Inhibitor

Introduction: Selective sodium-glucose cotransporter 2 (SGLT2) inhibitors target only the kidney, and they have reduced efficacy when patients with type 2 diabetes mellitus (T2DM) have renal impairment (RI). LX4211 blocks sodium and glucose absorption in the gastrointestinal tract by inhibition of SGLT1, and it enhances urinary sodium and glucose excretion in the urine through inhibition of SGLT2. The dual SGLT1/2 action of LX4211 was anticipated to reduce systolic blood pressure (SBP) in addition to improving glucose control in the setting of RI. Methods: This analysis explored the effect of LX4211 on SBP in a clinical trial of patients with T2DM and moderate to severe RI. Patients (N=31) were randomly assigned to be treated with LX4211 (400 mg, N=16) or placebo (N=15) qd for 7 consecutive days. Postprandial glucose levels after a standard high glucose meal served as the primary measure of pharmacodynamic activity. Baseline and Day 8 trough SBP measures were each an average of 3 seated assessments. Results: Mean baseline characteristics included age 66.4 years, estimated glomerular filtration rate (eGFR) 43.4 mL/min/1.73 m 2 , and SBP 130.9 mmHg. Postprandial glucose area under the curve (sampled from pre-dose to 4 hours post meal) was reduced from Baseline to Day 7 by 169.3 mg*hr/dL on LX4211 compared to placebo (p=0.003). Day 8 SBP reductions were 11.4 mmHg on LX4211 and 0.0 mmHg on placebo (p=0.045 for difference between groups). Patients with greater RI (eGFR <45 mL/min/1.73 m2) treated with LX4211 (N=6) had a 10.5 mmHg SBP reduction compared to 0.3 mmHg on placebo (N=9). The difference between seated and standing SBP did not change with LX4211 (0.0 mmHg change, Day 8 vs. Baseline). There were no reports of hypotension, hypovolemia, no serious adverse events, and no patient discontinued due to an adverse event. Mild hypoglycemia was reported in 1 LX4211 patient compared to 2 placebo patients. Conclusions: LX4211 may reduce SBP and enhance glycemic control in T2DM patients with moderate to severe RI.

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