Assessment of relationship of lipid and carbon profile indicators with vitamin D supply in children depending on body mass index

Objective: In our study, we aimed to determine vitamin D levels among obese patients registered to Obesity Center and to investigate its relationship with body mass index (BMI). Methods: The study was conducted in the Obesity Center of Health Sciences University Samsun Training and Research Hospital. Records of 102 patients with BMI> 30 kg/m², 18 years of age and over, admitted to the obesity center between 01.12.2018 and 01.12.2019 were retrospectively analyzed. Serum 25-OH D level<20 ng/ml was accepted as severe insufficiency, 20-30 ng/ml insufficiency, >30 ng/ml proficiency. Mann-Whitney U, Pearson chi-squared and Spearman tests were used in the evaluation of the data. The data were evaluated by the SPSS 22.00 program. p<0.05 was considered significant. Results: A total of 102 patients participated. The mean age was 48.82±12.09 years. 62.75% of them were female. 24.51% of participants were class 1 obese, 32.35% of participants were class 2 obese, 43.14% of participants were class 3 obese. The prevalance of severe vitamin D insufficiency was 45.10% and insufficiency in 38.24% of the patients. The mean vitamin D levels of the patients registered to the Obesity Center was 13.26±7.74 ng/ml. The mean BMI was 35.26±4.28 kg/m². Serum 25-(OH)D levels were inversely related to BMI. There was a significant relationship between age and BMI (p=0.036). Conclusion: Vitamin D insufficiency is highly prevalent in obese patients registered to Obesity Center. Serum 25-(OH)D levels were inversely associated with BMI. Obese patients should be evaluated and followed for vitamin D insufficiency.

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Specific cut-off for the 25-OH vitamin D levels to predict the highest Body Mass Index and fat mass: a sex-related analysis in obese patients

Minerva Endocrinologica ◽

10.23736/s0391-1977.20.03177-6 ◽

2020 ◽

Vol 45 (3) ◽

Author(s):

Luigi Barrea ◽

Annamaria Colao ◽

Silvia Savastano ◽

Giovanna Muscogiuri

Keyword(s):

Body Mass Index ◽

Vitamin D ◽

Body Mass ◽

Fat Mass ◽

Obese Patients ◽

Vitamin D Levels ◽

25 Oh Vitamin D

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Prevention of Advanced Cancer by Vitamin D3 Supplementation: Interaction by Body Mass Index Revisited

Nutrients ◽

10.3390/nu13051408 ◽

2021 ◽

Vol 13 (5) ◽

pp. 1408

Author(s):

Hermann Brenner ◽

Sabine Kuznia ◽

Clarissa Laetsch ◽

Tobias Niedermaier ◽

Ben Schöttker

Keyword(s):

Body Mass Index ◽

Vitamin D ◽

Cancer Patients ◽

Body Mass ◽

Advanced Cancer ◽

Vitamin D3 ◽

Normal Weight ◽

The Body ◽

Published Data ◽

Vitamin D3 Supplementation

Meta-analyses of randomized controlled trials (RCTs) have demonstrated a protective effect of vitamin D3 (cholecalciferol) supplementation against cancer mortality. In the VITAL study, a RCT including 25,871 men ≥ 50 years and women ≥ 55 years, protective effects of vitamin D3 supplementation (2000 IU/day over a median of 5.3 years) with respect to incidence of any cancer and of advanced cancer (metastatic cancer or cancer death) were seen for normal-weight participants but not for overweight or obese participants. We aimed to explore potential reasons for this apparent variation of vitamin D effects by body mass index. We conducted complementary analyses of published data from the VITAL study on the association of body weight with cancer outcomes, stratified by vitamin D3 supplementation. Significantly increased risks of any cancer and of advanced cancer were seen among normal-weight participants compared to obese participants in the control group (relative risk (RR), 1.27; 95% confidence interval (CI), 1.07–1.52, and RR, 1.44; 95% CI, 1.04–1.97, respectively). No such patterns were seen in the intervention group. Among those with incident cancer, vitamin D3 supplementation was associated with a significantly reduced risk of advanced cancer (RR, 0.86; 95% CI, 0.74–0.99). The observed patterns point to pre-diagnostic weight loss of cancer patients and preventive effects of vitamin D3 supplementation from cancer progression as plausible explanations for the body mass index (BMI)—intervention interactions. Further research, including RCTs more comprehensively exploring the potential of adjuvant vitamin D therapy for cancer patients, should be pursued with priority.

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Sex and body mass index dependent associations between serum 25-hydroxyvitamin D and pulse pressure in middle-aged and older US adults

Scientific Reports ◽

10.1038/s41598-021-88855-8 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Jung Hyun Kwak ◽

Yoon-Hyeong Choi

Keyword(s):

Body Mass Index ◽

Vitamin D ◽

Body Mass ◽

Pulse Pressure ◽

Lower Risk ◽

Hydroxyvitamin D ◽

Vascular Stiffening ◽

25 Hydroxyvitamin D ◽

Dose Dependent ◽

Overweight Subjects

AbstractHigh pulse pressure (PP) is a valid indicator of arterial stiffness. Many studies have reported that vitamin D concentration is inversely associated with vascular stiffening. This association may differ depending on sex and body mass index (BMI). This study investigated the associations between vitamin D and PP and evaluated whether these associations differ according to sex and BMI, using data for individuals aged ≥ 50 years from the National Health and Nutrition Examination Survey (NHANES) 2007–2010. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were used as biomarkers of vitamin D levels. High PP was defined as ≥ 60 mmHg. Total 25(OH)D concentrations were dose-dependently associated with lower odds ratios (ORs) for high PP (p-trend = 0.01), after controlling for sociodemographic, behavioral, and dietary factors. When stratified by sex, there was a dose-dependent association between total 25(OH)D concentrations and lower risk of high PP (p-trend < 0.001) in females, but not in males. When stratified by BMI, there was a dose-dependent association between total 25(OH)D concentrations and lower risk of high PP (p-trend < 0.001) in non-overweight subjects, but not in overweight subjects. Improving the vitamin D status could delay elevation of PP and vascular stiffening in female and non-overweight subjects.

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