scholarly journals Study on Optimization of Wet Milling Process for the Development of Albendazole Containing Nanosuspension with Improved Dissolution

2020 ◽  
Vol 64 (4) ◽  
pp. 401-420
Author(s):  
Viktor Fülöp ◽  
Géza Jakab ◽  
Bence Tóth ◽  
Emese Balogh ◽  
István Antal
Keyword(s):  
Process Parameters ◽  
Dissolution Kinetics ◽  
Polymorphic Transition ◽  
Milling Process ◽  
Process Time ◽  
Wet Milling ◽  
Influence Of Process Parameters ◽  
Freundlich Equation ◽  
Milling Medium ◽  
Kinetics Of

The main objective of this work was to show the potential of the optimization of top-down wet planetary bead milling process parameters (milling speed, process time and size of the milling medium) by Design Of Experiments (DOE) approach for the development of albendazole (ABZ) containing nanosuspension with improved dissolution. In addition, the influence of process parameters (capacity of milling container, applied volume of milling beads, size of the milling medium, milling speed, milling time) on ABZ polymorphic transition has also been investigated. The optimized, milled formula yielded ~ 145.39 times reduction in mean particle size (182.200 ± 1.3130 nm) compared to unmilled dispersion, which demonstrated 13.50 times gain in mean dissolution rate value compared to the unmilled dispersion in medium at pH = 1.2. No lag time values were observed in the dissolution kinetics of the nanosuspension in comparison with the unmilled samples. Moreover, maximal mean solubility value was also improved by 1.45 times compared to the unmilled suspension, in medium at pH = 6.8, supporting the significance of the Ostwald-Freundlich equation. Diffraction pattern comparisons have indicated a polymorphic transition of albendazole to Form II, which was more pronounced in smaller container at high milling speed values and prolonged operations.

Preparation of high-oriented molybdenum thin films using DC reactive magnetronsputtering

2017 ◽  
Vol 31 (07) ◽  
pp. 1750059 ◽  
Author(s):  
Zhengguo Shang ◽  
Dongling Li ◽  
She Yin ◽  
Shengqiang Wang
Keyword(s):  
Thin Film ◽  
Thin Films ◽  
Surface Roughness ◽  
Process Parameters ◽  
Gas Flow ◽  
Lattice Mismatch ◽  
Practical Significance ◽  
Process Time ◽  
Process Conditions ◽  
Influence Of Process Parameters

Since molybdenum (Mo) thin film has been used widely recently, it attracts plenty of attention, like it is a good candidate of back contact material for CuIn[Formula: see text]Ga[Formula: see text]Se[Formula: see text]S[Formula: see text] (CIGSeS) solar cells development; thanks to its more conductive and higher adhesive property. Besides, molybdenum thin film is an ideal material for aluminum nitride (AlN) thin film preparation and attributes to the tiny (−1.0%) lattice mismatch between Mo and AlN. As we know that the quality of Mo thin film is mainly dependent on process conditions, it brings a practical significance to study the influence of process parameters on Mo thin film properties. In this work, various sputtering conditions are employed to explore the feasibility of depositing a layer of molybdenum film with good quality by DC reactive magnetron sputtering. The influence of process parameters such as power, gas flow, substrate temperature and process time on the crystallinity and crystal orientation of Mo thin films is investigated. X-ray diffraction (XRD) measurements and atomic force microscope (AFM) are used to characterize the properties and surface roughness, respectively. According to comparative analysis on the results, process parameters are optimized. The full width at half maximum (FWHM) of the rocking curves of the (110) Mo is decreased to 2.7[Formula: see text], and the (110) Mo peaks reached [Formula: see text] counts. The grain size and the surface roughness have been measured as 20 Å and 3.8 nm, respectively, at 200[Formula: see text]C.

scholarly journals Cylindrical Polyurethane Scaffold Fabricated Using the Phase Inversion Method: Influence of Process Parameters on Scaffolds’ Morphology and Mechanical Properties

Materials ◽  
2021 ◽  
Vol 14 (11) ◽  
pp. 2977
Author(s):  
Aleksandra Kuźmińska ◽  
Dominika Kwarta ◽  
Tomasz Ciach ◽  
Beata A. Butruk-Raszeja
Keyword(s):  
Mechanical Properties ◽  
Polyvinyl Alcohol ◽  
Polymer Solution ◽  
Process Parameters ◽  
Phase Inversion ◽  
Young Modulus ◽  
Process Time ◽  
Inversion Method ◽  
Influence Of Process Parameters ◽  
Phase Inversion Technique

This work presents a method of obtaining cylindrical polymer structures with a given diameter (approx. 5 mm) using the phase inversion technique. As part of the work, the influence of process parameters (polymer hardness, polymer solution concentration, the composition of the non-solvent solution, process time) on the scaffolds’ morphology was investigated. Additionally, the influence of the addition of porogen on the scaffold’s mechanical properties was analyzed. It has been shown that the use of a 20% polymer solution of medium hardness (ChronoFlex C45D) and carrying out the process for 24 h in 0:100 water/ethanol leads to the achievement of repeatable structures with adequate flexibility. Among the three types of porogens tested (NaCl, hexane, polyvinyl alcohol), the most favorable results were obtained for 10% polyvinyl alcohol (PVA). The addition of PVA increases the range of pore diameters and the value of the mean pore diameter (9.6 ± 3.2 vs. 15.2 ± 6.4) while reducing the elasticity of the structure (Young modulus = 3.6 ± 1.5 MPa vs. 9.7 ± 4.3 MPa).

scholarly journals Influence of process parameters and pre-treatments on quality and drying kinetics of apple samples

2009 ◽  
Vol 27 (No. 2) ◽  
pp. 88-94 ◽  
Author(s):  
S. Jokić ◽  
D. Velić ◽  
M. Bilić ◽  
J. Lukinac ◽  
M. Planinić ◽  
...  
Keyword(s):  
Process Parameters ◽  
Drying Kinetics ◽  
Hot Water ◽  
Sodium Metabisulfite ◽  
Mixed Solution ◽  
Influence Of Process Parameters ◽  
Treatment Methods ◽  
Drying Kinetic ◽  
Pre Treatment ◽  
Kinetics Of

The aim of this research was to determine the influence of the process parameters and pre-treatment methods on the quality and drying kinetics of apple samples of the Florina variety using standard analytical methods: thermo-gravimetry, rehydration, colorimetry. The Apple samples were dried in a laboratory tray drier at different temperatures (50, 60, and 70°C), airflow velocities (1.5 m/s and 2.75 m/s), and pre-treatment methods (dipping in 0.5% ascorbic acid solution; 0.3% L-cysteine solution; 0.1% 4-hexyl resorcinol solution; 0.5% sodium metabisulfite solution; mixed solution of 0.05% 4-hexyl resorcinol and 0.5% sodium metabisulfite; blanching in hot water at 85°C). According to the drying time, rehydration and colour characteristics, the optimal drying parameters found were: temperature of 60°C and airflow velocity of 2.75 m/s. The drying kinetic equations were estimated using Page’s mathematical model. The results of the estimation showed a good agreement with the experimental data. The best results were achieved when the samples were pre-treated with 4-hexyl resorcinol. Blanching in hot water resulted in a higher drying rate and higher rehydration ratio, but also in unacceptable changes in the colour appearance of the apple samples.

Optimization of process parameters and dissolution kinetics of nickel and cobalt from lateritic chromite overburden using organic acids

2014 ◽  
Vol 89 (10) ◽  
pp. 1491-1500 ◽  
Author(s):  
Supratim Biswas ◽  
Suparna Chakraborty ◽  
Mahua Ghosh Chaudhuri ◽  
Pataki C Banerjee ◽  
Siddhartha Mukherjee ◽  
...  
Keyword(s):  
Organic Acids ◽  
Process Parameters ◽  
Dissolution Kinetics ◽  
Optimization Of Process Parameters ◽  
Chromite Overburden ◽  
Kinetics Of

scholarly journals Dissolution Kinetics of Milled-Silicate Rock Fertilizers in Organic Acid

2008 ◽  
Vol 13 (1) ◽  
pp. 1-10
Author(s):  
Joko Priyono ◽  
Robert John Gilkes
Keyword(s):  
Dissolution Kinetics ◽  
Silicate Rock ◽  
Solvent Ratio ◽  
Dry Milling ◽  
Wet Milling ◽  
Dissolution Experiment ◽  
Rock Powder ◽  
Soluble Rock ◽  
Milling Condition ◽  
Kinetics Of

A dissolution experiment was carried out to identify the effects of milling condition on dissolution kinetics of silicate rock fertilizers. Initially ground materials (Ø < 250 μm for basalt, dolerite, gneiss, and Ø < 150 μm for K-feldspar) were further milled with a ball mill (Spex 8000) under dry and wet conditions for 10, 60, and 120 minutes. The rock powders were dissolved in a mixture of 0.01M acetic-citric acid at a rock powder/solvent ratio of 1/1000, and the solution was agitated continuously on a rotary shaker at 25o C.  The concentrations of dissolved Na, K, Ca, Mg, Al, and Si from the milled rocks were determined at intervals from 1 hour up to 56 days. Results indicated that the relationships of quantity of dissolved rock and elemental plant nutrients (Et) with time (t) were well described by a power equation: Et = Eo + atn with reaction order (n) of 0.3 – 0.8. Milling increased quantity of total and individual dissolved element (Et ), dissolution rate (Rt), the proportion of rapidly soluble rock or element (Eo), and dissolution constant a. The increases in dissolution due to dry milling were larger than for wet milling. Although further proves should be provided, results of this dissolution experiment clearly indicates that SRFs may be used as multinutrient fertilizers as well as remedial materials for acidic soils; and dry milling may be applied as an appropriate method for manufacturing effective SRFs.

Influence of Process Parameters on Corrosion Resistance of Ceramic Layer Prepared by Micro Arc Oxidation on Aluminum Alloy 6061

2013 ◽  
Vol 591 ◽  
pp. 180-184
Author(s):  
Zong Wei Niu ◽  
Xiu Ting Wei ◽  
Zhi Yong Li ◽  
Li Li ◽  
Hong Fu Liu
Keyword(s):  
Corrosion Resistance ◽  
Aluminum Alloy ◽  
Process Parameters ◽  
Great Influence ◽  
Duty Ratio ◽  
Process Time ◽  
Alumina Ceramics ◽  
Impulse Frequency ◽  
Influence Of Process Parameters ◽  
Micro Arc Oxidation

Alumina ceramics film which has high hardness, wear resistance and erosion resistance can be obtained using micro arc oxidation on the surface of aluminum alloy. The process parameters have great influence on the corrosion resistance of alumina ceramics film prepared by micro arc oxidation. In this research, the alumina ceramics film was gotten using micro arc oxidation with different process parameters. The corrosion resistance of ceramics coating prepared by micro arc oxidation on the surface of aluminum alloy was investigated by putting the samples into sodium chloride solution of the concentration 3.5%.The influence regularity of process parameters such as current density, impulse frequency, duty ratio and process time on the corrosion resistance of alumina ceramics film was researched. This can provide basis for the optimization of process parameters.

Influence of Process Parameters on Surface Morphology of Ceramic Layer Prepared by Micro Arc Oxidation on Aluminum Alloy 6061

2013 ◽  
Vol 591 ◽  
pp. 61-65 ◽  
Author(s):  
Zong Wei Niu ◽  
Xiu Ting Wei ◽  
Zhi Yong Li ◽  
Li Li ◽  
Dong Shan Zhao
Keyword(s):  
Aluminum Alloy ◽  
Surface Morphology ◽  
Process Parameters ◽  
Great Influence ◽  
Duty Ratio ◽  
Process Time ◽  
Alumina Ceramics ◽  
Impulse Frequency ◽  
Influence Of Process Parameters ◽  
Micro Arc Oxidation

Alumina ceramics film which has high hardness, wear resistance and erosion resistance can be obtained using micro arc oxidation on the surface of aluminum alloy. The process parameters have great influence on the surface morphology of alumina ceramics film prepared by micro arc oxidation. In this research, the alumina ceramics film was gotten using micro arc oxidation with different process parameters. The surface morphology of ceramics film was analyzed using scanning electron microscope (SEM). The SEM photograph was processed using ImageJ software. The dimensions of holes diameter and porosity on the surface of ceramics film were investigated. The influence regularity of process parameters such as current density, impulse frequency, duty ratio and process time to the surface morphology of alumina ceramics film was researched. This can provide basis for the optimization of process parameters.

Influence of Process Parameters on the Reaction Kinetics of the Chromium-Catalyzed Trimerization of Ethylene

2010 ◽  
Vol 16 (26) ◽  
pp. 7833-7842 ◽  
Author(s):  
Anina Wöhl ◽  
Wolfgang Müller ◽  
Stephan Peitz ◽  
Normen Peulecke ◽  
Bhaskar R. Aluri ◽  
...  
Keyword(s):  
Reaction Kinetics ◽  
Process Parameters ◽  
Influence Of Process Parameters ◽  
Kinetics Of
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