scholarly journals A 2-YEAR PRELIMINARY LONGITUDINAL STUDY OF NEUROPSYCHOLOGICAL FUNCTIONING IN HASHIMOTO’S THYROIDITIS UNDER LEVOTHYROXINE TREATMENT: ONLY TRAIL MAKING TEST IS MAKING A DIFFERENCE

2017 ◽  
Vol 11 (1) ◽  
pp. 15-21
Author(s):  
Vaitsa Giannouli ◽  
Nikolaos Syrmos
Keyword(s):  
Verbal Memory ◽  
Hashimoto’S Thyroiditis ◽  
Visual Memory ◽  
Neuropsychological Functioning ◽  
Hashimoto's Thyroiditis ◽  
Neuropsychological Battery ◽  
Impaired Performance ◽  
Making A Difference ◽  
Healthy Control ◽  
Effects Of Aging

Few studies have examined longitudinally depression, stress and cognition in Hashimoto’s Thyroiditis (HT) under levothyroxine (LT4) treatment. Although HT is claimed to cause several mood changes and cognitive deficits in patients who are left untreated, we still know little about the longitudinal profile of these patients when they are under stable treatment. Sixteen middle-aged euthyroid HT women and sixteen healthy control women were examined with a detailed neuropsychological battery covering different cognitive functions (attention, visual and verbal memory, executive functions and mood), and with thyroid functions tests at three time points at one and two years post-baseline. Depression and perceived stress, along with verbal and visual memory were found to be stable at a two-year retesting in euthyroid HT women. Only TMT-Parts A and B deteriorated at one and two years in euthyroid HT. Although impaired performance in attention and executive deficits are linked with heighted levels of depression and stress, here they were not accompanied by changes in mood. The present study failed to detect any noticeable changes longitudinally in the cognitive and emotional function in euthyroid HT women under stable and continuous LT4 treatment. Patients’ restricted deficits may indicate that the decline in attention and executive functioning performance might be related to the effects of a specific progressive degenerative process associated with the disorder, rather than the effects of aging. Keywords: Hashimoto’s Thyroiditis, depression, stress, longitudinal neuropsychological assessment, LT4 treatment.

Vitamin D Treatment in Patients with Hashimoto’s Thyroiditis may Decrease the Development of Hypothyroidism

2016 ◽  
Vol 86 (1-2) ◽  
pp. 9-17 ◽  
Author(s):  
Bekir Ucan ◽  
Mustafa Sahin ◽  
Muyesser Sayki Arslan ◽  
Nujen Colak Bozkurt ◽  
Muhammed Kizilgul ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Hashimoto’S Thyroiditis ◽  
Healthy Control Group ◽  
Hashimoto's Thyroiditis ◽  
Control Group ◽  
Endocrine Society ◽  
Thyroid Autoantibody ◽  
Healthy Control ◽  
The Mean

Abstract.The relationship between Hashimoto’s thyroiditis and vitamin D has been demonstrated in several studies. The aim of the present study was to evaluate vitamin D concentrations in patients with Hashimoto’s thyroiditis, the effect of vitamin D therapy on the course of disease, and to determine changes in thyroid autoantibody status and cardiovascular risk after vitamin D therapy. We included 75 patients with Hashimoto’s thyroiditis and 43 healthy individuals. Vitamin D deficiency is defined as a 25-hydroxy vitamin D (25(OH)D3) concentration less than 20ng/mL. Vitamin D deficient patients were given 50.000 units of 25(OH)D3 weekly for eight weeks in accordance with the Endocrine Society guidelines. All evaluations were repeated after 2 months of treatment. Patients with Hashimoto’s thyroiditis had significantly lower vitamin D concentrations compared with the controls (9.37±0.69 ng/mL vs 11.95±1.01 ng/mL, p < 0.05, respectively). Thyroid autoantibodies were significantly decreased by vitamin D replacement treatment in patients with euthyroid Hashimoto’s thyroiditis. Also, HDL cholesterol concentrations improved in the euthyroid Hashimoto group after treatment. The mean free thyroxine (fT4) concentrations were 0.89±0.02 ng/dL in patients with Hashimoto’s thyroiditis and 1.07±0.03 ng/dL in the healthy control group (p < 0.001). The mean thyroid volumes were 7.71±0.44 mL in patients with Hashimoto’s thyroiditis and 5.46±0.63 mL in the healthy control group (p < 0.01). Vitamin D deficiency is frequent in Hashimoto’s thyroiditis and treatment of patients with this condition with Vitamin D may slow down the course of development of hypothyroidism and also decrease cardiovascular risks in these patients. Vitamin D measurement and replacement may be critical in these patients.

scholarly journals The Relation between Inflammation and Neuropsychological Test Performance

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Valerie H. Balldin ◽  
James R. Hall ◽  
Robert C. Barber ◽  
Linda Hynan ◽  
Ramon Diaz-Arrastia ◽  
...  
Keyword(s):  
Verbal Memory ◽  
Test Performance ◽  
Inflammatory Markers ◽  
Visual Memory ◽  
Longitudinal Research ◽  
Neuropsychological Functioning ◽  
Neuropsychological Test ◽  
Differential Relation ◽  
Markers Of Inflammation ◽  
Anti Inflammatory

Background. Considerable research documents an association between pro- and anti-inflammatory markers and Alzheimer's disease (AD), yet the differential relation between these markers and neuropsychological functioning in AD and nondemented controls has received less attention. The current study sought to evaluate the relationship between peripheral markers of inflammation (both pro- and anti-inflammatory) and neuropsychological functioning through the Texas Alzheimer's Research and Care Consortium (TARCC) cohort.Methods. There were 320 participants (Probable ADn=124, Controlsn=196) in the TARCC Longitudinal Research Cohort available for analysis. Regression analyses were utilized to examine the relation between proinflammatory and anti-inflammatory markers and neuropsychological functioning. Follow-up analyses were conducted separately by case versus control status.Results. Proinflammatory and anti-inflammatory markers were found to be associated with neuropsychological testing. Third tertile proinflammatory markers were negatively associated with measures of attention and language, and anti-inflammatory markers were positively associated with measures of immediate verbal memory and delayed verbal and visual memory.Conclusions. These findings support the link between peripheral inflammatory markers and neuropsychological functioning and suggest the utility of examining profiles of inflammatory markers in the future.

Relationship of cognitive impairment to psychiatric symptoms in multiple sclerosis

2008 ◽  
Vol 14 (8) ◽  
pp. 1084-1090 ◽  
Author(s):  
N Figved ◽  
R Benedict ◽  
G Klevan ◽  
KM Myhr ◽  
HI Nyland ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Verbal Memory ◽  
Psychiatric Symptoms ◽  
Cognitive Tests ◽  
Cognitive Changes ◽  
Impaired Performance ◽  
Impaired Memory ◽  
Healthy Control ◽  
Relationship Of ◽  
The Relationship

Psychiatric and cognitive changes are common in patients with multiple sclerosis (MS), but their relationship has not received much attention. We studied the relationship between psychiatric symptoms and verbal memory, working memory, and mental speed in 78 patients with MS and 40 healthy control subjects using linear regression analyses. The MS group exhibited impaired performance on all cognitive tests. Apathy was associated with intrusions and depression with impaired memory and mental speed. The association between apathy and intrusions supports the hypothesis that lesions in frontal areas or frontal connections contribute to a specific neuropsychiatric syndrome in patients with MS.

Components of Fault-Finding: Symptom Interpretation

1989 ◽  
Vol 31 (4) ◽  
pp. 465-483 ◽  
Author(s):  
Margaret Toms ◽  
John Patrick
Keyword(s):  
Verbal Memory ◽  
Visual Memory ◽  
External Memory ◽  
Impaired Performance ◽  
Memory Aids ◽  
Processing Demands ◽  
Symptom Interpretation ◽  
Improved Performance

The processing demands of two strategies for symptom interpretation in a fault-finding task were considered. It was predicted that a more demanding, eliminative strategy would result in improved performance when supported by an external memory aid, and impaired performance when unsupported, as compared with a less demanding strategy involving tracing backward from bad system outputs. The nature of such demands, whether primarily verbal or visuospatial, was also examined. Results indicated that the eliminative strategy improved symptom interpretation accuracy slightly when supported by a visual memory aid and depressed performance when combined with a verbal memory aid. When no memory aid was permitted, subjects were apparently unable to use this strategy. No difference between visual and verbal memory aids was indicated with the less demanding strategy. These results are discussed with reference to their implications for the manner in which individuals utilize and represent problem information.

scholarly journals Natural Autoimmunity to Selenoprotein P Impairs Selenium Transport in Hashimoto’s Thyroiditis

2021 ◽  
Vol 22 (23) ◽  
pp. 13088
Author(s):  
Qian Sun ◽  
Sebastian Mehl ◽  
Kostja Renko ◽  
Petra Seemann ◽  
Christian L. Görlich ◽  
...  
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Thyroid Autoimmunity ◽  
Hashimoto's Thyroiditis ◽  
Selenoprotein P ◽  
Serum Samples ◽  
Autoimmune Thyroid ◽  
Established Risk Factor ◽  
Quantitative Immunoassay ◽  
Healthy Control ◽  
Se Status

The essential trace element selenium (Se) is needed for the biosynthesis of selenocysteine-containing selenoproteins, including the secreted enzyme glutathione peroxidase 3 (GPX3) and the Se-transporter selenoprotein P (SELENOP). Both are found in blood and thyroid colloid, where they serve protective functions. Serum SELENOP derives mainly from hepatocytes, whereas the kidney contributes most serum GPX3. Studies using transgenic mice indicated that renal GPX3 biosynthesis depends on Se supply by hepatic SELENOP, which is produced in protein variants with varying Se contents. Low Se status is an established risk factor for autoimmune thyroid disease, and thyroid autoimmunity generates novel autoantigens. We hypothesized that natural autoantibodies to SELENOP are prevalent in thyroid patients, impair Se transport, and negatively affect GPX3 biosynthesis. Using a newly established quantitative immunoassay, SELENOP autoantibodies were particularly prevalent in Hashimoto’s thyroiditis as compared with healthy control subjects (6.6% versus 0.3%). Serum samples rich in SELENOP autoantibodies displayed relatively high total Se and SELENOP concentrations in comparison with autoantibody-negative samples ([Se]; 85.3 vs. 77.1 µg/L, p = 0.0178, and [SELENOP]; 5.1 vs. 3.5 mg/L, p = 0.001), while GPX3 activity was low and correlated inversely to SELENOP autoantibody concentrations. In renal cells in culture, antibodies to SELENOP inhibited Se uptake. Our results indicate an impairment of SELENOP-dependent Se transport by natural SELENOP autoantibodies, suggesting that the characterization of health risk from Se deficiency may need to include autoimmunity to SELENOP as additional biomarker of Se status.

scholarly journals Long-Term Follow-Up of Children Treated for High-Grade Gliomas: Children's Oncology Group L991 Final Study Report

2012 ◽  
Vol 30 (9) ◽  
pp. 943-949 ◽  
Author(s):  
Stephen Alan Sands ◽  
Tianni Zhou ◽  
Sharon Helene O'Neil ◽  
Sunita K. Patel ◽  
Jeffrey Allen ◽  
...  
Keyword(s):  
Verbal Memory ◽  
Visual Memory ◽  
Neuropsychological Functioning ◽  
High Grade ◽  
Oncology Group ◽  
Term Survival ◽  
Patient Reported ◽  
High Grade Gliomas

Purpose High-grade gliomas of the CNS are characterized by poor treatment response and prognosis for long-term survival. The Children's Oncology Group (COG) L991 study investigated the neuropsychological, behavioral, and quality of life (QoL) outcomes after treatment on the Children's Cancer Group (CCG) trial for high-grade gliomas (CCG-945). Patients and Methods Fifty-four patients (29 males, 25 females) with a median age of 8.8 years at diagnosis (range, 0.2 to 19.5 years) were enrolled at 25 institutions in North America, representing 81% of available survivors; median length of follow-up was 15.1 years (range, 9.5 to 19.2 years), and median age at study evaluation was 23.6 years (range, 11.3 to 36 years). Standardized tests of neuropsychological functioning and QoL were performed. Descriptive statistics summarized principal findings, and one-way analysis of variance identified potential predictors of outcomes. Results With an average follow-up time of 15 years, survivors demonstrated intellectual functioning within the low-average range. Executive functioning and verbal memory were between the low-average and borderline ranges. In contrast, visual memory and psychomotor processing speed were between the borderline and impaired ranges, respectively. Approximately 75% of patient reported overall QoL within or above normal limits for both physical and psychosocial domains. Nonhemispheric tumor location (midline or cerebellum), female sex, and younger age at treatment emerged as independent risk factors. Conclusion These results serve as a benchmark for comparison with future pediatric high-grade glioma studies, in addition to identifying at-risk cohorts that warrant further research and proactive interventions to minimize late effects while striving to ensure survival.

scholarly journals Differences in Neuropsychological Performance between Refugee and Non-Refugee Children in Palestine

2021 ◽  
Vol 18 (11) ◽  
pp. 5750
Author(s):  
Ahmed F. Fasfous ◽  
María Nieves Pérez-Marfil ◽  
Francisco Cruz-Quintana ◽  
Miguel Pérez-García ◽  
Hala R. Al-Yamani ◽  
...  
Keyword(s):  
School Children ◽  
Verbal Memory ◽  
Visual Memory ◽  
Refugee Children ◽  
Neuropsychological Performance ◽  
Refugee Camps ◽  
Neuropsychological Battery ◽  
Verbal Comprehension ◽  
Palestinian Refugee ◽  
Palestinian Children

Neuropsychological studies on refugee children are scarce, but there are even less in the case of Palestinian children. This work aims to study the neuropsychological performance of Palestinian refugee children in Palestine compared to other Palestinian children living outside refugee camps. A comprehensive Neuropsychological battery was administrated to 584 Palestinian school children (464 refugees and 120 non-refugees) aged 6, 7, and 8 years old. Results showed that non-refugee children outperformed refugee children in sustained attention, verbal comprehension, verbal memory, and visual memory. This study is the first to have performed a comprehensive neuropsychological assessment, based on a standardized and validated battery with the Palestinian refugee children. It supports professionals in their evaluation of neurodevelopment and neuropsychological alterations in refugee and non-refugee children in Palestine.

Neuropsychological Deficits in the Prodromal Phase and Course of an Early-Onset Schizophrenia

2014 ◽  
Vol 42 (3) ◽  
pp. 167-176 ◽  
Author(s):  
Vanessa Puetz ◽  
Thomas Günther ◽  
Berrak Kahraman-Lanzerath ◽  
Beate Herpertz-Dahlmann ◽  
Kerstin Konrad
Keyword(s):  
Verbal Memory ◽  
Early Onset ◽  
Neuropsychological Functioning ◽  
Neuropsychological Testing ◽  
Clinical Situation ◽  
Adolescent Male ◽  
Antipsychotic Treatment ◽  
Early Onset Schizophrenia ◽  
Prodromal Phase ◽  
Illness Onset

Objectives: Although clear advances have been achieved in the study of early-onset schizophrenia (EOS), little is known to date about premorbid and prodromal neuropsychological functioning in EOS. Method: Here, we report on a case of an adolescent male with EOS who underwent neuropsychological testing before and after illness onset. Results: Marked cognitive deficits in the domains of attention, set-shifting, and verbal memory were present both pre-onset and during the course of schizophrenia, though only deficits in verbal memory persisted after illness-onset and antipsychotic treatment. Conclusion: The findings of this case study suggest that impairments in the verbal memory domain are particularly prominent symptoms of cognitive impairment in prodromal EOS and persist in the course of the disorder, which further demonstrates the difficult clinical situation of adequate schooling opportunities for adolescent patients with EOS.

Sign in / Sign up

Export Citation Format

Share Document