scholarly journals Syndrome of intrahepatic cholestasis in patients with acute and chronic intoxication with pesticides

2018 ◽  
Vol 81 (1) ◽  
pp. 39-48
Author(s):  
N.M. Bubalo ◽  
G.M. Balan
Keyword(s):  
Ursodeoxycholic Acid ◽  
Liver Damage ◽  
Intrahepatic Cholestasis ◽  
Toxic Hepatitis ◽  
Combined Therapy ◽  
Acute Poisoning ◽  
Synthetic Pyrethroids ◽  
Chronic Intoxication ◽  
Toxic Liver Damage ◽  
2,4 Dichlorophenoxyacetic Acid

Objective. To study the incidence and peculiarities of intrahepatic cholestasis (IHC) syndrome in patients with toxic liver damage in acute and chronic intoxications with pesticides and to substantiate rational methods of diagnosis and treatment. Material and methods. The incidence has been analysed with the description of IHC syndrome peculiarities in acute and remote periods in 238patients with acute poisoning with pesticides: 162 — herbicides based on 2,4-dichlorophenoxyacetic acid (2,4-D), 62 — phosphororganic pesticides (POP), 14 — synthetic pyrethroids (SP) and 70 — with chronic intoxication with pesticides (CIP). Clinical-instrumental, biochemical and statistical methods of the study have been used. Results and conclusions. Along with neurological disorders, the toxic liver damage was observed in 35,8 % of cases of acute poisoning with 2,4-D-based herbicides, in 51,6 % of cases — with POP poisoning, in 64,2 % of cases — with SP poisoning and in 84,2 % of cases — with CIP. IHC syndrome was detected in 22,8 % of cases in patients with pesticide intoxication against toxic hepatitis and in 18,0 % of cases — without signs of hepatitis. The therapeutic efficacy of ursodeoxycholic acid has been established when it is included in the combined therapy of patients with IHC upon intoxication with pesticides. Key words: pesticides, acute and chronic intoxications, toxic hepatitis, intrahepatic cholestasis syndrome, ursodeoxycholic acid.

scholarly journals Metabolic disorders, effects of obese genes and imbalance of fatty tissue hormones in patients after acute and chronic intoxication with pesticides

2018 ◽  
Vol 82-83 (2-3) ◽  
pp. 51-70 ◽  
Author(s):  
N.M. Bubalo ◽  
G.M. Balan
Keyword(s):  
Liver Damage ◽  
Metabolic Disorders ◽  
Acute Poisoning ◽  
Synthetic Pyrethroids ◽  
Fatty Tissue ◽  
Chronic Intoxication ◽  
Increased Risk ◽  
Tnf Α ◽  
Toxic Liver Damage ◽  
Tissue Hormones

The objective is to study the incidence of metabolic disorders and effects of obese genes in patients after acute and chronic intoxication with pesticides and to justify methods for evaluating their severity to optimize differentiated therapy and prevention. Material and methods. In 104 agricultural workers after acute poisoning with 2,4-D based herbicides, organophosphorus pesticides and synthetic pyrethroids, and 66 patients with chronic intoxication with pesticides in the initial period and a year later, parameters of oxidative stress, carbohydrate and fat metabolism were studied, depending on the development of toxic liver damage syndrome. In patients after acute poisoning with 2,4-D-based herbicides, imbalance of fatty tissue hormones — leptin, resistin, adiponectin and TNF-α — has also been studied. Conclusion. Dynamic observation has made it possible to establish that in those who have had acute and chronic intoxication with pesticides with toxic liver damage syndrome, metabolic disorders and effects of obese genes develop as the progression of hepatosteatosis develops. The increased level of fatty tissue hormones in the blood — leptin, resistin and TNF-α, at the background of a slight decrease in adiponectin levels in patients who have had poisoning with 2,4-D-based herbicides, allows predicting an increased risk of a progressive course of steatohepatosis and obesity, prevention of which is based on the long-term use of metformin and statins. Key words: metabolic disorders, effects of obese genes, imbalance of fatty tissue, acute and chronic intoxications, pesticides.

scholarly journals Complex Therapy of Acute Poisoning by Thallium Compounds (Literature review and data from own research)

2020 ◽  
Vol 89 (2) ◽  
pp. 32-39
Author(s):  
G.M. Balan ◽  
A.G. Bogomol ◽  
O.P. Kravchuk ◽  
P.G. Zhminko ◽  
A.H. Kudriavtseva
Keyword(s):  
Neuropathic Pain ◽  
Literature Review ◽  
Liver Damage ◽  
Pain Syndrome ◽  
Acute Poisoning ◽  
Neuropathic Pain Syndrome ◽  
Complex Therapy ◽  
Toxic Liver Damage ◽  
Thallium Compounds ◽  
High Doses

The Aim of the Research. Based on the analysis of modern literature data and our own research to substantiate the principles of rational complex therapy with acute poisoning by thallium compounds (Tl+) at different stages of intoxication. Materials and Methods. The analysis of literature data and our own researches is carried out and the principles of rational complex therapy with acute poisoning by thallium compounds at different stages of intoxication development are substantiated and the algorithm of doctors’ actions at suspicion of acute Tl+ poisoning is defined. Results and Conclusions. The principles of complex therapy of acute Tl+ poisonings substantiated, which includes antidote therapy, methods of extracorporeal treatment (plasmapheresis, hemosorption, hemodialysis), treatment of toxic encephalopolyradiculoneuropathy, neuropathic pain syndrome and toxic liver damage. The sequence of appearance of the main symptoms of intoxication at low and high doses of Tl+ is determined, which allows to assume poisoning by this toxicant. Key Words: thallium, acute poisoning, complex therapy.

scholarly journals PROBLEMS OF TREATMENT OF TOXIC HEPATITIS ON THE BACKGROUND OF CHRONIC VIRAL LESION OF HCV-ETIOLOGY. CLINICAL EXAMPLE OF SUCCESSFUL THERAPY

2018 ◽  
Vol 23 (1) ◽  
pp. 50-56
Author(s):  
Marina G. Avdeeva ◽  
M. I Kulbuzheva ◽  
Ye. I Kolod’ko ◽  
N. V Chernikova ◽  
O. V Zapashnyaya
Keyword(s):  
Liver Damage ◽  
Clinical Observation ◽  
Toxic Hepatitis ◽  
Clinical Laboratory ◽  
Chronic Viral Hepatitis ◽  
Successful Therapy ◽  
Drug Induced ◽  
Viral Hepatitis C ◽  
Toxic Liver Damage ◽  
Chronic Viral Hepatitis C

Epidemiological and clinical-laboratory features of the course of drug-induced and viral liver damage are considered. Clinical observation of severe toxic liver damage in a patient suffering from chronic viral hepatitis “C” is given. The authors share the experience of successful therapy.

scholarly journals CHANGE OF THE PROFILE OF EXPRESSION OF ADAPTIVE RESPONSE GENES IN TOXIC HEPATITIS OF DIFFERENT ETIOLOGY

2019 ◽  
Vol 98 (9) ◽  
pp. 1021-1025
Author(s):  
Denis O. Karimov ◽  
T. G. Kutlina ◽  
G. F. Mukhammadiyeva ◽  
Y. V. Valova ◽  
E. F. Repina ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Toxic Hepatitis ◽  
Alcohol Intoxication ◽  
Expression Profiles ◽  
Molecular Genetic ◽  
Liver Homogenate ◽  
Control Group ◽  
Mrna Levels ◽  
Toxic Liver Damage

Introduction. In Russia, the problem of toxic hepatitis is of great importance and relevance. The etiology of toxic hepatitis (industrial toxicants, drugs, ethanol) and, as a consequence, pathogenesis may have significant differences at the molecular genetic level. The aim of the study was to analyze the expression of genes involved in the response to toxic liver damage of various etiologies. Material and methods. Toxic hepatitis was modulated in male albino mongrel rats weighing 180-200 grams assigned to four groups (control group, carbon tetrachloride, paracetamol, ethanol). After 24 and 72 hours of paracetamol administration, rats were anesthetized and the mRNA levels of the Chek1, Gclc, Gstm1, Gstp1, Gstt1, Nfe2l2, Nqo1, Ripk1 genes in the liver homogenate were examined. Results. As a result of the analysis of the genes expression studied, the expression profile was found TO be differed depending on the etiology of toxic hepatitis. With carbon tetrachloride poisoning, an increase in the expression of the Nqo1 genes (p = 0.001), Gstm1 (p = 0.037) and a decrease in the expression of the Nfe2l2 genes (p = 0.004), Ripk1 (p = 0.004) was observed. With the liver damage by paracetamol and its metabolites, opposite to the expression of the Gstm1 gene (p = 0.001) decreased, and the expression of the Nfe2l2 (p = 0.009), Gclc (p = 0.001), Chek1 (p = 0.011) genes increased. During alcohol intoxication, there were no statistically significant changes in the expression profiles of the genes studied. Conclusion. the results obtained may indicate the involvement of various molecular genetic mechanisms in the process of response to toxic liver damage, depending on the etiology.

scholarly journals Influence of Pancreo-Plant on the histological parameters of the liver in conditions of acute toxic hepatitis

2021 ◽  
Vol 14 (3) ◽  
pp. 328-335
Author(s):  
L. M. Trutaieva
Keyword(s):  
Liver Damage ◽  
Toxic Hepatitis ◽  
Herbal Remedy ◽  
Diagnostic Methods ◽  
Histological Structure ◽  
Plant Materials ◽  
Hydropic Degeneration ◽  
White Rats ◽  
Wide Range ◽  
Toxic Liver Damage

Toxic liver damage is the most problematic for pharmacotherapy and, accordingly, the normalization of the patient’s condition. Most often, hepatotoxins include alcohol, drugs, household and industrial toxins, the effect of which on the liver leads to the development of hepatocyte necrosis. The peculiarity of drug toxic hepatitis is a wide range of clinical manifestations, the absence of unambiguous diagnostic methods, frequent poor prognosis, which makes toxic hepatitis one of the most difficult problems in clinical practice. A promising drug for the treatment of toxic liver damage is a multicomponent herbal remedy, which is currently produced by a domestic manufacturer in the form of a dietary supplement. The aim of the work is to study the effect of the herbal remedy Pancreo-Plant on the histological structure of the liver of rats, under conditions of subacute ethanol-tetrachloromethane intoxication. Materials and methods. A model of poisoning was formed and liver samples from nonlinear white rats were examined. The slides were examined under the light microscope Granum, photographing of microscopic images was carried out with Granum DCM 310 digital video camera. The photographs were processed on a computer using the Toup View program. Results. Micropreparations obtained from liver samples of rats under the condition of subacute ethanol-tetrachloromethane intoxication, were investigated. It has been proven that Pancreo-Plant helps to reduce necrotic manifestations, hydropic degeneration of hepatocytes, manifestations of steatosis, and signs of inflammation; it also stimulates carbohydrate metabolism in hepatocytes and improves regenerative manifestations. Conclusions. It was found that the investigated agent based on medicinal plant materials, when using the model of subacute ethanol-tetrachloromethane intoxication, exhibits a significant hepatoprotective effect. It normalizes the histological structure of hepatocytes, restores the processes of glycogen accumulation, and prevents the development of fatty degeneration of the liver.

scholarly journals A Toxic Hepatitis Caused the Kombucha Tea – Case Report

2014 ◽  
Vol 2 (1) ◽  
pp. 128-131 ◽  
Author(s):  
Zoran Kovacevic ◽  
Goran Davidovic ◽  
Jelena Vuckovic-Filipovic ◽  
Mirjana A. Janicijevic-Petrovic ◽  
Katarina Janicijevic ◽  
...  
Keyword(s):  
Case Report ◽  
Ursodeoxycholic Acid ◽  
Female Patient ◽  
Liver Damage ◽  
Toxic Hepatitis ◽  
Effective Therapy ◽  
Differential Diagnoses ◽  
Hepatic Toxicity ◽  
Kombucha Tea

Background: Toxic hepatitis may clinically manifest as other diseases of the liver, where it must always be considered in differential diagnoses of unexplained liver damage, such as poisoning with kombucha tea.Case report: 47-year old female patient was hospitalized and has consumed daily ounces of kombucha tea. During hospitalization patient was diagnosed with toxic hepatitis and treated with intravenous solutions of hepatic protective and ursodeoxycholic-acid (effective therapy). Conclusion: Examinations showed that kombucha tea has potential to revert the CCl4-induced hepatic toxicity, but used in overdose can induce toxicity himself.

Evaluation of the Effectiveness and Safety of Combination Therapy Using Drugs Vazonat and Entrop in Patients with Chronic Toxic Liver Damage

2016 ◽  
pp. 98-102
Author(s):  
Valentyna Velichko ◽  
Halyna Cornovan ◽  
Svitlana Kovalenko ◽  
Halyna Danilchuk
Keyword(s):  
Liver Damage ◽  
Cognitive Abilities ◽  
Liver Toxicity ◽  
Positive Impact ◽  
Combined Therapy ◽  
Diet Therapy ◽  
Homogeneous Groups ◽  
Integrated Therapy ◽  
Toxic Liver Damage ◽  
And Control

The objective: to study the efficacy and safety of using in the complex treatment of cytoprotector Vazonat in combination with the nootropic medicine of entropy in patients with chronic toxic liver damage. Patients and methods. There were examined 60 patients (36 men and 24 women) with signs of liver toxicity in age from 35 to 63 years. The average age of the examined was 43.2±1.3 years. All patients were divided into two statistically homogeneous groups (main and control) for 30 people in each. Patients in both groups received diet therapy, hepatoprotective, according to indications – antispasmodic, choleretic, antisecretory drugs, and enzymes. The main group of patients in the combined therapy was additionally appointed Vazonat 500 mg per day (2 capsules per day) and Entrop 100 mg per day in the first half of day for 1 month. Results. Analysis of the obtained results testifies the effectiveness of additional use of drugs Vazonat and Entrop in combination with a standard hepatoprotective therapy in patients with chronic toxic liver in comparison of using only basic therapy. There was a positive dynamics of the main clinical syndromes. It was proved the positive impact of integrated therapy on the functional activity of the liver and also improving of cognitive abilities. Conclusion. Inclusion in comprehensive standard hepatoprotective therapy of patients with chronic toxic liver damage drugs Vazonat and Entrop accelerates the normalization of the functional state of the liver.

EFFECT OF MMSC AND HSC ON REPARATIVE REGENERATION OF THE LIVER UNDER CONDITIONS OF ITS TOXIC DAMAGE

2020 ◽  
Vol 17 (3) ◽  
pp. 243-248
Author(s):  
I.Yu. Maklakova ◽  
◽  
V.V. Bazarniy ◽  
D.Yu. Grebnev ◽  
◽  
...  
Keyword(s):  
Dna Repair ◽  
Carbon Tetrachloride ◽  
Mitotic Activity ◽  
Liver Damage ◽  
Inflammatory Activity ◽  
Control Group ◽  
Nacl Solution ◽  
Repair Enzymes ◽  
Toxic Liver Damage ◽  
Hsc Transplantation

The aim of this study was to study the effect of combined MMSC and HSC transplantation on liver regeneration under conditions of toxic carbon tetrachloride damage. Materials and methods. The study was performed on white male mice with toxic liver damage by intraperitoneal administration of carbon tetrachloride at a dose of 50 µl per mouse once. An hour after modeling liver damage, placental MMSCs and HSCs were administered intravenously at a dose of 4 million cells/kg and 330 thousand cells/kg, respectively, suspended in 0.2 ml of 0.9% NaCl solution. Control group animals were given 0.9% NaCl solution-0.2 ml intravenously. On days 1, 3, and 7 after cell transplantation, changes in inflammatory activity in the liver were evaluated, and mitotic and apoptotic indices were determined. On the 7th day after the introduction of cells, the activity of DNA repair enzymes of the PARP family was analyzed. Results. Combined MMSC and HSC transplantation leads to a decrease in the index of inflammatory activity in the liver due to a decrease in necrosis, hepatocyte dystrophy, and a decrease in infiltration. As a result of the study, an increase in the activity of PARP repair enzymes was found, which led to a decrease in programmed cell death. Also, cotransplantation of MMSCs and HSCs was accompanied by increased mitotic activity of hepatocytes. Conclusion. Cotransplantation of MMSCs and HSCs under conditions of toxic liver damage reduces the inflammatory response, stimulates the mitotic activity of hepatocytes, and increases the activity of enzymes of the DNA repair system. Activation of the liver's reparative system, in turn, reduces the programmed death of hepatocytes.

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