scholarly journals Sero-surveillance and sero-monitoring of locally produced PPR vaccine in the field and experimental level

2016 ◽  
Vol 2 (1) ◽  
pp. 33-37 ◽  
Author(s):  
Md Ehsanul Kabir ◽  
Md Mokbul Hossain ◽  
Md Ershaduzzaman ◽  
Md Abu Yousuf ◽  
Md Rafiqul Islam
Keyword(s):  
Immune Response ◽  
Viral Disease ◽  
High Morbidity ◽  
Live Attenuated Vaccine ◽  
Antibody Titres ◽  
Immunization Study ◽  
Group A ◽  
The Mean ◽  
One Year ◽  
Group B

Peste des Petits Ruminants (PPR) is a highly contagious, economically important viral disease of goats with high morbidity and mortality. To control the disease effectively a live attenuated vaccine is available in Bangladesh which is produced by Livestock Research Institute (LRI), Mohakhali, Dhaka. The study was carried out to determine the immune status and immune response against PPR in field and experimental Black Bengal goats. Sero-surveillance of PPR was conducted by using c-ELISA in non-vaccinated 240 goats in Gazipur, Sirajgonj and Barisal. Out of the 240 goats tested, of which only 39 (20.31%) goats had positive level of PPR antibodies while 16.25% (13 out of 80 goats) in Gazipur, 28.75% (23 out of 80 goats) in Barisal and 3.75% ((3 out of 80 goats)) in Sirajgonj. In case of sero-monitoring of PPR, the result revealed that vaccinated goats from Rajshahi showed high positive result and have higher seroprevalence where 75% (60 out of 80 goats) were seropositive and only 25% (20 out of 80 goats) are seronegative. These result indicated that vaccinated Rajshahi goats is more resistant for PPR virus than non vaccinated goats. In experimentally to perform sero-monitoring, 10 seronegative goats were selected and divided into two equal groups (A and B).The immunization study against PPR with a commercial PPR vaccine was conducted on 5 goats of group A by inoculating @ 1.0 ml vaccine / animal subcutaneously and group B kept as non-vaccinated. The antibody titres against PPR in goats were determined at 0 day on vaccination and after 21DPV, 180DPV and 365DPV. The results found that 100% (5 out 5goats) seronegative in both vaccinated goats of group A and non-vaccinated goats of group B at 0 day on vaccination. The mean negative titres± SD were 79.285±13.921 and 76.707±9.265 in vaccinated group A and group B, respectively. The mean positive titers ±SD were 20.201±2.480, 8.630±4.970 and 11.382±1.419 at 21DPV, 180DPV an 365DPV, respectively in group A (100% seropositive). In case of non-vaccinated group B, the mean negative titres±SD were 74.258±7.793, 77.726±9.142 and 82.965±7.492 at 21DPV, 180DPV and 365DPV, respectively (100% seronegative). As it is observed, the antibody titres remain at the level over the period of time that indicates the immune response against PPR. From this finding, it is said that PPR vaccine could produce immune response in goats for about one year or 365 days.Asian J. Med. Biol. Res. March 2016, 2(1): 33-37

Outcome of Partial Nail Avulsion Followed by Matricectomy Either With Phenol (80-88%) or With Electro Cautery for Toenails

2021 ◽  
Vol 15 (8) ◽  
pp. 2043-2045
Author(s):  
Tahir Hamid ◽  
Muhammad Rizwan Qadir ◽  
Ahmad Raza Nsar ◽  
Rizwan Saleem ◽  
Abdur Rehman ◽  
...  
Keyword(s):  
Late Complications ◽  
Purulent Discharge ◽  
P Value ◽  
Serous Discharge ◽  
Group A ◽  
The Mean ◽  
One Year ◽  
Group B ◽  
Ingrown Toenails

Aim: To compare partial nail avulsion followed by matricectomy either with phenol (80-88%) or with electro cautery for Stage 2 & 3 ingrown toenails for early and late postoperative complications. Methods: This study was conducted at department of surgery Nawaz Sharif social security teaching hospital Lahore for one year from 01-01-2018 to 31-12-2018. One hundred patients full filling inclusion criteria were included in the study and divided into two equal groups A and B. Partial nail avulsion done in both groups followed by chemical matricectomy with phenol (80-88%) in group A and patients in group B matricectomy done with electrocautry. Results: The mean age in group A is 19.7± 8.08 years and in group B is 20.20± 6.9 years, both groups comparable p-value (0.74).In early post-operative complications in group A 17(34%) patients and 14(28%) patients in group B experienced mild pain p-value is (0.66). 6(12%) of group A patients and 6(12%) of group B patients experienced moderate pain p-value (01). 1(2%) of group A patient and 2(4%) of group B patients experienced severe pain p-value (01). 02(4%) patients of group A and 02(4%) patients of group B had serous discharge p-value(01). 1(2%) of group B patients have purulent discharge, however, no patients in group A patients have purulent discharge p-value (01). 1(2%) patients of group A and 2(4%) patients of group B had recurrence at three months follow up p-value (01). 2(4%) patients of group A and 4(8%) patients of group B had recurrence at six months follow up p-value (0.68). Conclusion: Partial nail avulsion followed by matricectomy either with Phenol 80-88% or with electrocautry are comparable in early and late complications. Keywords: Ingrown toenails, partial matricectomy

scholarly journals Immediate Post-Operative Outcomesof Stapled and Hand Sewn Techniques during Oesophagogastrostomy: A Randomized Clinical Trial

2020 ◽  
Vol 6 (1) ◽  
pp. 43-47
Author(s):  
Mohammad Zakir Hossain Bhuiyan ◽  
Syed Aminul Haque ◽  
Mohammad Ahtashamul Haque ◽  
Farhana Tarannum
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Single Centre ◽  
Anastomotic Complications ◽  
Operative Outcomes ◽  
Group A ◽  
Cardia Carcinoma ◽  
The Mean ◽  
One Year ◽  
Group B

Background: Oesophagogastrostomy is a very crucial surgical management. Objective:The purpose of the present study was to observe the immediate post-operative outcomes of stapled and hand sewn techniques during oesophagogastrostomy. Methodology: This single centre, parallel randomized clinical trial was conducted in the Department of Thoracic Surgery at National institute of Diseases of the Chest and Hospital, Dhaka, Bangladesh from January 2011 to December 2011 for a period of one year. Prior to commencement of this study the study protocol was approved by the thesis committee of NIDCH. Patients were purposefully selected from different surgery ward of NIDCH irrespective of age and sex of patients for the study.Patients were divided into two groups designated as group A and B.Stapled oesophagogastric anastomosis was performed in group A and hand sewn anastomosis was done in group B.Immediate post-operative complication were recorded. Result: A total of 60 patients of oesophageal or gastric cardia carcinoma were recruited for this study. Of them 32 cases were assigned to Stapler method and 28 cases to Hand-sewn method of oesophagogastrostomy. The mean age of the patients of group A and group B were 56.1±12.7 years and 55.3±8.3 years respectively. Regarding blood loss during operation, the table shows that in group A mean + SD were 430.4±63.2 ml and in group B mean + SD were 529.6 +86.9 ml. In one stage operation in group A it was mean + SD i.e. 362.2±38.3 ml and in group B it was mean + SD 529.6±86.9 ml. In two stage operation in group A it was mean 466.2±39.7 ml and in group B it was mean±SD 585.6±62.2 ml. Respiratory complication developed in 9.4% of the patients in group A and 17.9% patients in group B. Cardiac complication developed in 3.1 % of the patients in group A and 7.1 % of patients in group B. Wound infection developed in 12.5% of the patients in group A and 10.7% of the patients in group B. Conclusion: In conclusion most of the immediate anastomotic complications are less in stapled anastomotic technique than hand sewn technique Journal of National Institute of Neurosciences Bangladesh, 2020;6(1): 43-47

scholarly journals Comparison of suture technique (interrupted vs. continuous) with respect to wound dehiscence

2020 ◽  
Vol 72 ◽  
pp. 191-194
Author(s):  
Gopal Sharma ◽  
Nivedita Prashar ◽  
Nikita Gandotra
Keyword(s):  
Wound Infection ◽  
Wound Dehiscence ◽  
Suture Technique ◽  
Emergency Laparotomy ◽  
High Morbidity ◽  
Continuous Suture ◽  
Midline Laparotomy ◽  
Group A ◽  
The Mean ◽  
Group B

Objectives: Post-operative complete wound dehiscence, being an unfortunate and also a very serious complication, is associated with a high morbidity and mortality rate despite the most sophisticated intensive care these patients receive today. The quest for the best closure technique for abdominal incisions continues. To achieve this goal, several modifications in opening the abdomen and closing the wound have been tried. There are many studies in the literature comparing various methods of wound closure, with conflicting results. The aim of the present study was to assess the proportion of wound infection and wound dehiscence in the post-midline laparotomy patients, using interrupted X suture versus continuous suture technique in sheath closure. Material and Methods: A total of 80 patients undergoing vertical midline emergency laparotomy at one of the gynecology units were recruited randomly after taking written informed consent and were equally divided into 40 cases each group (interrupted X suture) and (continuous suture) they were randomized into two groups depending on whether the patient registration number was odd or even. Results: The age of the patients varied from 16 years to 82 years. In Group A, the mean age was 36.75 ± 13.78 years, and in Group B, the mean age of the patients was 38.37 ± 12.56 years. In Group A, 8 (20%) patients had comorbidity, whereas, in Group B, 10 (25%) patients had comorbidity. In Group A, 12 patients had wound infection, while in Group B, ten patients had wound infection (P = 0.001 [statistically significant]). In Group A, two patients had wound dehiscence, while none of the patients in Group B had wound dehiscence (P = 0.001 [statistically significant]). There was no incisional hernia in both the groups. Conclusion: Emergency laparotomy is associated with a higher rate of burst abdomen as compared to elective laparotomy, but using interrupted X suture technique in sheath closure, wound dehiscence can be prevented up to some extent.

scholarly journals Can Repeat Injection Provide Clinical Benefit in Patients with Lumbosacral Diseases When First Epidural Injection Results Only in Partial Response?

2016 ◽  
Vol 19 (2;2) ◽  
pp. E283-E290 ◽  
Author(s):  
Jung Hwan Lee
Keyword(s):  
Clinical Benefit ◽  
Pain Reduction ◽  
Radicular Pain ◽  
Lower Back ◽  
Group A ◽  
The Mean ◽  
One Year ◽  
Group B ◽  
Epidural Steroid ◽  
Mean Time

Background: Epidural steroid injection (ESI) is known to be an effective treatment for lower back or radicular pain due to herniated intervertebral disc (HIVD) and spinal stenosis (SS). Although repeat ESI has generally been indicated to provide more pain relief in partial responders after a single ESI, there has been little evidence supporting the usefulness of repeat injections in cumulative clinical pain reduction. Objectives: The purpose of this study was to determine whether repeat ESI at a prescribed interval of 2 to 3 weeks after the first injection would provide greater clinical benefit in patients with partial pain reduction than that provided by intermittent injection performed only when pain was aggravated. Study Design: An Institutional Review Board (IRB)-approved retrospective chart review. Setting: Spine hospital. Methods: Two hundred and four patients who had underwent transforaminal ESI (TFESI) for treatment of lower back and radicular pain due to HIVD or SS and could be followed-up for one year were enrolled. We divided the patients into 2 groups. Group A (N = 108) comprised partial responders (NRS ≥ 3 after first injection) who underwent repeat injection at a prescribed interval of 2 to 3 weeks after the first injection. Group B (N = 96) comprised partial responders who did not receive a repeat injection at the prescribed interval, but received repeat injections only for aggravation of pain. Various clinical data including total number of injections during one year, duration of NRS < 3 during one year (NRS < 3 duration), and time interval until aggravation of pain required additional injections after repeat injection in group A, or after first injection in group B (time to reinjection), were assessed. These data were compared between groups A and B in terms of total population, HIVD, and SS. Results: In the whole population, the mean time to reinjection was 6.09 ± 3.02 months in group A and 3.69 ± 2.07 months in group B. The NRS < 3 duration was 9.72 ± 2.86 months and 6.2 ± 2.61 months in groups A and B, respectively. In HIVD patients, the mean time to reinjection was 5.82 ± 3.23 months in group A and 3.84 ± 2.34 months in group B, and NRS < 3 duration was 9.40 ± 3.34 months and 7.15 ± 2.40 months in groups A and B, respectively. In SS patients, the mean time to reinjection was 6.40 ± 2.85 months in group A and 3.59 ± 1.88 months in group B, and NRS < 3 duration was 9.98 ± 2.41 months and 5.52 ± 2.55 months in groups A and B, respectively. Group A had a significantly longer time to reinjection and longer NRS < 3 duration than group B in the whole population, HIVD, and SS. Limitation: Retrospective design. Conclusions: Repeat TFESI conducted at 2- to 3-week intervals after the first injection in partial responders contributed to greater clinical benefit compared to intermittent TFESI performed only upon pain aggravation. These benefits were observed in patients with HIVD and in those with SS, irrespective of severity or location of disease. Key words: Epidural steroid injection, transforaminal approach, repeat injection, numeric rating scale, lumbar spine, herniated intervertebral disc, spinal stenosis, partial pain reduction

scholarly journals Field Investigation on the Efficacy of Salmonella Vaccine Prepared at Bangladesh Agricultural University

2015 ◽  
Vol 13 (1) ◽  
pp. 5-9
Author(s):  
MAS Bag ◽  
MM Amin ◽  
MB Rahman ◽  
YA Arafat ◽  
M Salim ◽  
...  
Keyword(s):  
Research Work ◽  
Booster Vaccination ◽  
Primary Vaccination ◽  
Field Investigation ◽  
Unvaccinated Control ◽  
Antibody Titres ◽  
Group A ◽  
The Mean ◽  
Group B ◽  
On Farm

The research work was performed to investigate the immunogenicity of Salmonella vaccine produced at LPVRPC, BAU Mymensingh. The vaccination was performed at the Phenix Hatchery Ltd. Gazipur in Hy-sex brown and HY-sex white chicken designated as group A and group B respectively. Group A and B were subdivided into A1, A2, A3, B1, B2 and B3 groups containing eight birds each. Group C was maintained as unvaccinated control. Birds were immunized following schedule of the LPVRPC. Each bird was vaccinated SC at six weeks of age followed by a subsequent booster dose after 45 days. After four weeks of primary vaccination the mean PHA antibody titres were 96.00±34.21 in group A1 and 96.00±34.21 in B1 group. Prebooster vaccination the mean PHA antibody titres were 88.00±33.12 in group A2 and 88.00±33.12 in B2 group. At four weeks of booster vaccination the mean PHA antibody titres were 104.00±33.12 in group A3 and 104.00±33.12 in B3 group. The mean ± PHA antibody titre in chickens of group C was ? 4.0±0.00. Salmonella vaccine prepared at (LPVRPC) Department of Microbiology and Hygiene, BAU induces satisfactory level of antibody in chickens determined by PHA test conducted in an on-farm study of layer chickens.DOI: http://dx.doi.org/10.3329/bjvm.v13i1.23705Bangl. J. Vet. Med. (2015). 13 (1): 5-9

scholarly journals Association between hypokalemia and cardiovascular diseases among hospitalized patients in tertiary care teaching hospital in North Karnataka: a retrospective study

2017 ◽  
Vol 4 (4) ◽  
pp. 998
Author(s):  
Raju H. Badiger ◽  
Santosh B. Desai ◽  
Ravindra Kantamanenin ◽  
Chetana K. Kavatkopp ◽  
Joel George ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Cardiovascular Diseases ◽  
Tertiary Care ◽  
Positive Association ◽  
Plasma Potassium ◽  
Control Group ◽  
Group A ◽  
The Mean ◽  
One Year ◽  
Group B

Background: Potassium is an extremely crucial element in maintaining the normal charge between intracellular and extracellular space. Normal cellular function is maintained through potassium homeostasis. The normal range of plasma potassium is 3.5 to 5.1 mmol/L. The deviation both hypo and hyperkalaemia are associated with cardiovascular diseases especially cardiac arrhythmia. The objective was to study the association of hypokalaemia on cardiovascular diseases.Methods: During this one year of retrospective study socio-demographic profile of the patients were collected from the medical record section of hospital. The participants were grouped into four classes based on the serum potassium levels as, Group A: < 2 mmol/L, group B: 2-2.49 mmol/l, group C: 2.5 - 2.9 mmol/L, group D: 3 - 3.49 mmol/L and group E (control group) 3.5 to 5.1 mmol/L. The participants were also grouped as those suffering from cardiovascular diseases and those with non-cardiovascular diseases.Results: In our study 4818 records were categorized into 5 groups including control group. Males (61.35%) were slightly more than female (38.65%). The mean age group was 43±4 years. Results revealed that there was positive association between the sexes. Females were more commonly associated as compared to males. Hypokalaemia among cardiovascular diseases was only 22.2% as compared to non-cardiovascular diseases. The mean systolic (142±8) and diastolic Blood pressure (92±2) among cardiovascular diseases was slightly higher as compared with the non-cardiovascular diseases.Conclusions: Hypokalaemia is significantly associated with myocardial infarction when compared with other disorders. Hypokalaemia was more commonly associated with cardiovascular diseases as compared with non-cardiovascular diseases.  

scholarly journals Comparison of Short Term Outcomes of De Vega Repair versus Ring Annuloplasty in Cases of Functional Tricuspid Regurgitation

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M A Ibrahim ◽  
W A Saber ◽  
H A Abdelhamid ◽  
S A Mansour ◽  
M G Mostafa
Keyword(s):  
Tricuspid Valve ◽  
P Value ◽  
Optimal Method ◽  
Functional Tricuspid Regurgitation ◽  
Ring Annuloplasty ◽  
Group A ◽  
The Mean ◽  
Serious Disease ◽  
One Year ◽  
Group B

Abstract Background functional tricuspid valve regurgitation (FTR) is a common problem accompanying left-sided heart lesions e.g. mitral stenosis. FTR is a serious disease which affects survival and quality of life if left untreated. Many techniques can be used to repair the tricuspid valve (TV), but the optimal method for repair is still controversial. The aim of our study is to compare ring annuloplasty and De Vega repair of TV as regard effectiveness and durability. Patients and Methods sixty patients who are candidate for mitral valve (MV) replacement and TV repair were randomized into two groups, 30 patients each. Group (A) underwent ring annuloplasty, and group (B) underwent De Vega repair of TV. Patients from both groups were followed up after the operation for one year. Results Ring annuloplasty was more effective as the mean grade of TR in this group (1.6 ± 1.2) was significantly lower than that in De Vega group (2.2 ± 1.0), p value 0.041. After one year of follow up, no significant increase was present in the mean grade of TR in the ring annuloplasty group. However, grade of TR increased significantly in the De Vega group from 2.2 to 2.6, p value &lt; 0.001. Conclusion Ring annuloplasty provides more effective and durable reduction of FTR compared to De Vega repair of TV.

scholarly journals COMPARISON OF EFFICACY OF COMBINATION OF METFORMIN PLUS MODIFIED-RELEASE GLICLAZIDE WITH COMBINATION OF METFORMIN PLUS SITAGLIPTIN IN PATIENTS WITH TYPE-2 DIABETES MELLITUS

2021 ◽  
Vol 6 (5) ◽  
pp. 38-44
Author(s):  
Atta Khan ◽  
Nowsherwan Nowsherwan ◽  
Muhammad Abbass ◽  
Amjad Ali ◽  
Hussain Afridi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Controlled Trial ◽  
Modified Release ◽  
Group A ◽  
The Mean ◽  
One Year ◽  
Group B

Introduction: Diabetes Mellitus (DM) is one of the leading causes of morbidity and mortality around the world and is responsible for 3.8 million deaths per year. Its prevalence had shown an exponential rise worldwide in the last two decades, from 30 million cases in 1985 to 177 million in 2000 Objective: To compare the efficacy of the combination of Metformin plus modified-release Gliclazide with a variety of Metformin plus Sitagliptin in patients with type-2 diabetes mellitus. Methodology: This study was conducted at the Department of Medicine, Lady Reading Hospital Peshawar. The study design was a randomized controlled trial conducted for one year from May 2017 to May 2018, in which 62 patients in each group were observed. All patients with type 2 Diabetes Mellitus with baseline HbA1c ≥ 8% and duration >1 year, either gender with age range 35 to 65 years, were included. All patients were subjected to detailed history and clinical examinations. All patients were randomly allocated in two groups by lottery method. Patients in Group A were subjected to the combination of Metformin (1gm twice daily) with modified-release Gliclazide (60mg), and patients in Group B were subjected to the variety of Metformin (1 gm twice daily) with Sitagliptin (50 mg twice daily). All patients were followed up after three months, and blood samples for HbA1c levels were obtained. The analysis was done in SPSS version 20. Results: The Study showed that the mean age in Group A was 58 years ± 12.78, and the mean age in Group B was 55 years ± 13.12. In Group A, 44% of patients were male, and 56% of patients were female, while in Group B, 45% of patients were male, and 55% of patients were female. Moreover, Group A (Metformin (1gm twice daily) + Gliclazide (60mg)  was effective in 45% of patients while Group B Metformin (1 gm twice daily) + Sitagliptin (50 mg twice daily) was effective in 71% of patients. Conclusion: Our study concludes that Metformin plus Sitagliptin is more effective than Metformin plus modified-release Gliclazide.

scholarly journals Comparative efficacy of BAU-Fowl cholera and DLS-Fowl cholera vaccines in indigenous ducks

2019 ◽  
Author(s):  
S. Akter ◽  
C. N. Shampa ◽  
M. A. Islam ◽  
A. U. Alam ◽  
M. Hadiuzzaman ◽  
...  
Keyword(s):  
Pasteurella Multocida ◽  
Booster Vaccination ◽  
Significant Loss ◽  
Challenge Infection ◽  
Fowl Cholera ◽  
Antibody Titres ◽  
Group A ◽  
The Mean ◽  
Group B ◽  
Cholera Vaccines

Background: Duck cholera is an acute, fatal, septicemic disease of domestic ducks which is responsible for significant loss in duck population. The present study was conducted to compare the immunogenicity of two formalin killed fowl cholera vaccines (BAU-FCV and DLS-FCV) in indigenous ducks. Methods: The experimental ducks were divided into three groups (A=15, B=15 and C =10 ducks) of which birds of Group A and Group B were inoculated with 0.5 ml of BAU-FCV and DLS-FCV, respectively through subcutaneous route at the age of 10 weeks whereas ducks of group C were kept as unvaccinated control. Booster vaccination was done with same dose and route at 14 weeks of age. Challenge infection was conducted after 2 weeks of booster vaccination. Results: The mean PHA antibody titres on 15 days post vaccination (DPPV), 28 DPPV, 15 days postsecondary vaccination (DPSV), 28 DPSV and 15 days post challenge were 25.60 ± 3.92, 51.20 ± 7.84, 89.60 ± 15.68, 166.40 ± 38.40 and 204.80 ± 31.35, respectively in ducks of Group A whereas, the mean antibody titres in ducks of Group B were 25.60 ± 3.92, 44.80 ± 7.84, 64.00 ± 7.53,102.40 ± 15.68 and 179.20 ± 31.35 at 15 DPPV, 28 DPPV, 15 DPSV, 28 DPSV and 15 days after challenge, respectively. In this investigation, slightly higher immune responses were observed in ducks of Group A vaccinated with BAU-FCV compare to ducks of Group B vaccinated with DLS-FCV. Birds of both vaccinated groups conferred 100% protection against challenge infection with virulent Pasteurella multocida whereas, 100% mortality was observed in control ducks after challenge. Conclusion: Both vaccines were found to be safe and effective for the vaccination of indigenous ducks against duck cholera.

Comparison of one-year prognosis of patients classified as chronic critical lower limb ischaemia according to TASC II or European consensus definition in the COPART cohort

VASA ◽  
2015 ◽  
Vol 44 (3) ◽  
pp. 0220-0228 ◽  
Author(s):  
Marion Vircoulon ◽  
Carine Boulon ◽  
Ileana Desormais ◽  
Philippe Lacroix ◽  
Victor Aboyans ◽  
...  
Keyword(s):  
Medical Treatment ◽  
Critical Limb Ischaemia ◽  
Limb Ischaemia ◽  
Medical Group ◽  
Consensus Definition ◽  
Transcutaneous Oxygen ◽  
European Consensus ◽  
Group A ◽  
One Year ◽  
Group B

Background: We compared one-year amputation and survival rates in patients fulfilling 1991 European consensus critical limb ischaemia (CLI) definition to those clas, sified as CLI by TASC II but not European consensus (EC) definition. Patients and methods: Patients were selected from the COPART cohort of hospitalized patients with peripheral occlusive arterial disease suffering from lower extremity rest pain or ulcer and who completed one-year follow-up. Ankle and toe systolic pressures and transcutaneous oxygen pressure were measured. The patients were classified into two groups: those who could benefit from revascularization and those who could not (medical group). Within these groups, patients were separated into those who had CLI according to the European consensus definition (EC + TASC II: group A if revascularization, group C if medical treatment) and those who had no CLI by the European definition but who had CLI according to the TASC II definition (TASC: group B if revascularization and D if medical treatment). Results: 471 patients were included in the study (236 in the surgical group, 235 in the medical group). There was no difference according to the CLI definition for survival or cardiovascular event-free survival. However, major amputations were more frequent in group A than in group B (25 vs 12 %, p = 0.046) and in group C than in group D (38 vs 20 %, p = 0.004). Conclusions: Major amputation is twice as frequent in patients with CLI according to the historical European consensus definition than in those classified to the TASC II definition but not the EC. Caution is required when comparing results of recent series to historical controls. The TASC II definition of CLI is too wide to compare patients from clinical trials so we suggest separating these patients into two different stages: permanent (TASC II but not EC definition) and critical ischaemia (TASC II and EC definition).

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