scholarly journals Microalbumin: Urinary Biomarker of Cardiovascular Risk Assessment

2016 ◽  
Vol 5 (2) ◽  
pp. 98-103
Author(s):  
Tabassum Samad ◽  
Wasim Md Mohosin ul Haque
Keyword(s):  
Risk Assessment ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Risk ◽  
Independent Predictor ◽  
Urinary Biomarker ◽  
Cardiovascular Risk Assessment ◽  
Normal Range ◽  
Incident Coronary Heart Disease ◽  
All Cause Mortality

Microalbuminuria is an early sign of vascular damage. Now-a-days it is considered as a predictor of worse outcome for both renal and cardiac patients. In this review we investigate the magnitude of relationship between microalbuminuria and incident coronary heart disease and mortality. Microalbuminuria is an independent predictor of coronary heart disease and all cause mortality. It is demonstrated that cardiovascular and renal risk is elevated even in the high normal range of microalbuminuria. Early detection of microalbuminuria, or therapies that prevent or delay the development of microalbuminuria, and all measures that prevent it, may help to prevent or delay cardiovascular eventsBirdem Med J 2015; 5(2): 98-103

Comparison of coronary heart disease genetic assessment with conventional cardiovascular risk assessment in primary care: reflections on a feasibility study

2015 ◽  
Vol 16 (06) ◽  
pp. 607-617
Author(s):  
Nadeem Qureshi ◽  
Joe Kai ◽  
Jo Middlemass ◽  
Paula Dhiman ◽  
Laura Cross-Bardell ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Primary Care ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Risk ◽  
Genetic Test ◽  
Average Risk ◽  
Cardiovascular Risk Assessment ◽  
Direct To Consumer ◽  
Genetic Assessment

AimThis study assesses the feasibility of collecting genetic samples and self-reported outcome measures after cardiovascular risk assessment, and presenting the genetic test results to participants.BackgroundCoronary heart disease (CHD) genetic tests are increasingly available through direct-to-consumer marketing, but their potential clinical impact on cardiovascular risk assessment is unclear.MethodsObservational study in 10 British general practices in Central England. A total of 320 individuals, who had completed conventional cardiovascular risk assessment, were offered CHD genetic test, with follow-up outcome questionnaire at eight months for lifestyle change and State-Trait Anxiety.FindingsA total of 119 (37%) participants returned genetic test specimens, with over a third reporting family history of CHD in a specified relative; 79 (66.4%) were categorized above-average risk on conventional cardiovascular risk assessment, 65 of whom (82.3%) were only average risk on genetic assessment. The dietary fat questionnaire was poorly completed while study participation was not associated with increased anxiety (mean increase in anxiety score=2.1; 95% CI −0.1–4.3;P=0.06).ConclusionAs a feasibility study, over a third of individuals offered genetic testing in primary care, as part of CVD risk assessment, took up the offer. Although intervention did not appear to increase anxiety, this needs further evaluation. To improve generalizability and effect size, future studies should actively engage individuals from wider socio-economic backgrounds who may not have already contemplated lifestyle change. The current research suggests general practitioners will face the clinical challenge of patients presenting with direct-to-consumer genetic results that are inconsistent with conventional cardiovascular risk assessment.

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