scholarly journals Effects of Hyperuricemia on Fetal Outcome in Preeclamptic Patients

2019 ◽  
Vol 9 (2) ◽  
pp. 117-120
Author(s):  
Nusrat Mahjabeen ◽  
Sk Zinnat Ara Nasreen ◽  
Ferdousi Begum ◽  
Faryl Mustary
Keyword(s):  
Uric Acid ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Fetal Outcome ◽  
Group A ◽  
Group B

Background: A raised serum uric acid is recognized as an unfavourable fetal outcome of pre-eclampsia. The objective of this study was to determine the relationship between hyperuricemia and fetal outcome in preeclamptic patients. Methods: This observational study was carried out in the Department of Gynecology and Obstetrics of BIRDEM General Hospital from July 2015 to June 2016. Fifty pre eclamptic pregnant women with hyperuricemia (group A) and 50 preeclamptic pregnant women with normal serum uric acid level (group B) were taken as study subjects. Data were analyzed by SPSS where p value less than 0.05 was considered significant. Results: Mean age of the patients was 25.88 ± 4.52 years and 24.30 ± 5.09 years in group A and group B respectively. Mean serum uric acid level was 7.19±0.62 mg/dl in group A and 4.83±0.73 mg/dl in group B. Maximum (66%) patients were primigravida in group A and 34% in group B. In this study, intra-uterine death (IUD) occurred in 4 (8%) cases in group A and in 1 (2%) case in group B, intra-uterine growth retardation (IUGR) was 20 (40%) cases in group A and 4 (8%) cases in group B, low birth weight was in 38 (76%) cases in group A and 21(42%) cases in group B. Occurrence of IUGR and low birth weight was significantly higher in group A than group B. APGAR score was significantly lower in group A (5.10±1.61) than that of group B (6.36±1.32). Neonatal intensive care unit (NICU) referral was more in group A (60%) than group B (20%). Conclusion: It can be concluded that hyperuricemia is a predictor of poor fetal outcome in pre-eclamptic women. Birdem Med J 2019; 9(2): 117-120

scholarly journals An Observational Study to Assess Outcome of NSTEMI Patients with Raised Serum Uric Acid Level in a Tertiary Care Hospital of Bangladesh

2020 ◽  
Vol 5 (2) ◽  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Normal Serum ◽  
Group A ◽  
The Mean ◽  
Group B ◽  
Level Group

Background: Non-ST segment elevation myocardial infarction (NSTEMI) is the commonest form of ACS and a leading global cause of premature morbidity and mortality. Evidences link serum uric acid with short and long-term major adverse outcomes (MACE) in patients with NSTEMI. Objective: To see in-hospital outcome of NSTEMI patients with raised serum uric acid level. Methodology: This cross-sectional observational study was conducted in the Department of Cardiology, Sylhet MAG Osmani Medical College Hospital, Sylhet during the period from July, 2017 to June, 2019. Fifty NSTEMI patients with raised serum uric acid (>7mg/dl in male; >6mg/dl in female) level (Group A) and fifty NSTEMI patients with normal serum uric acid level (group B) admitted within 24 hours of symptom onset were consequently enrolled. In-hospital complications and mortality were recorded while continuing standard treatment for the event. Results: The mean age was 60.82 (SD 9.62) years in group A and 49.90 (SD 10.40) years in group B. The mean age of the patients of group A was significantly higher than patients of Group B (p<0.001). Male preponderance was in both groups (84.0% versus 80.0%; p=0.603). Diabetes mellitus (52.0% versus 22.0%; p=0.002), hypertension (78.0% versus 52.0%; p=0.039) and dyslipidaemia (48.0% versus 12.0%; p<0.001) were more frequent in group A than that of group B. But smoking status (70.0% versus 66.0%; p=0.668), family history of CAD (10.0% versus 26.0%; p=0.476) did not differ significantly. Killip class did not differ significantly between group A and group B (p=0.127). In-hospital mortality was 5 (10.0%) patients in group A and 2 (4.0%) patients in group B; did not reach the level of significance (p>0.05) and complications such as post MI angina, cardiogenic shock, acute left ventricular failure, re-infarction, sinus tachycardia, sinus bradycardia, atrial flutter, atrial fibrillation, bundle branch block, ventricular tachycardia, ventricular fibrillation did not differ significantly between the two groups (p>0.05). Conclusion: There is no significant difference between in-hospital outcome (mortality and complications) of NSTEMI patients with raised and normal serum uric acid level.

scholarly journals Effect of raised serum uric acid level on perinatal and maternal outcome in cases of pregnancy-induced hypertension

2017 ◽  
Vol 10 (2) ◽  
pp. 58 ◽  
Author(s):  
Qumrun Nassa Ahmed ◽  
Farhana Dewan
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Pregnancy Induced Hypertension ◽  
Maternal Complications ◽  
Induced Hypertension ◽  
Group A ◽  
Group B

<p>The aim of this study was to find out the effects of raised serum uric acid level on perinatal and maternal outcome in cases of pregnancy-induced hypertension. One hundred pregnant women with gestational period beyond 28 weeks with pregnancy-induced hypertension-preeclampsia and eclampsia were included in this study and divided into two groups. Group A (n=65) patients with a serum uric acid level &gt;6 mg/dL was compared to Group B (n=35) patients with a uric acid level &lt;6 gm/dL. It revealed that high uric acid level in patients with pregnancy-induced hypertension was a risk factor for several maternal complications like postpartum hemorrhage (Group A, 17.4%; Group B, 22.6%), postpartum eclampsia (Group A, 10.1%; Group B, 9.7%), abruptio placentae (Group A, 8.7%; Group B, 6.4%), HELLP syndrome (Group A, 2.9%; Group B, 0%) and pulmonary edema (Group A, 4.3%; Group B, 0%). In case of perinatal outcome, the birth weight, intrauterine growth retardation, intrauterine death, stillbirth and neonatal death rate were worse in Group A 1.9 kg, 66.7, 19, 7 and 8% in comparison to Group B, where those were 2.1, 13, 6, 2, and 2% respectively. In conclusion, high uric acid in blood in patient with hypertensive disorders in pregnancy is a risk factor for several maternal complications.</p>

Comparison of Fetal Outcome in Pre-eclampsia with Hyperuricemia and Normal Uricemic Patients

2020 ◽  
Vol 10 (2) ◽  
Author(s):  
Saima Ayub ◽  
Shamshad Begum ◽  
Nudrat Ayub ◽  
Rukhsana Karim ◽  
Nadia Rasheed
Keyword(s):  
Uric Acid ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Uric Acid Level ◽  
Birth Rate ◽  
Acid Level ◽  
Fetal Outcome ◽  
Intrauterine Death ◽  
Cesarean Sections ◽  
Term Delivery

Background: Pre-eclampsia with hyperuricemia is a complication of pregnancy associated with fetal mortality and morbidity. The main complications are preterm delivery, low birth weight and intrauterine demise of the fetus along with higher rate of cesarean section.Objective: To compare fetal outcome in pre-eclampsia with hyperuricemia and with normal uricemic controlMaterial and Methods: Study was conducted at department of the Gynecology “B” Hayatabad Medical Complex Peshawar from 1st August 2016 to 31st July 2017. Patients with pre-eclampsia were divided in two groups “A” and “B”. In group “A” patients with serum uric acid level > 6mg/dl and in group “B” patients with uric acid level of < 6mg/dl were included. The low birth weight, preterm birth, rate of cesarean sections and intrauterine death were observed in the two groups. Results: Among the 60 patients with hyperuricemia 34 (56.66%) babies born with low birth weight, rate of cesarean section was 53.33% (32), pre-term delivery 48.33% (29) and intrauterine deaths 6.66% (4). While in 60 patients with normal uricemic control 7 (11.66%) babies born with low birth weight, rate of cesarean section was 13 (21.66%), pre-term delivery 16 (26.66%) and intrauterine deaths 0 (0.00%).Conclusion: Increased uric acid level is a poor predictor for fetal outcome in terms of low birth weight, preterm birth, rate of cesarean sections and intrauterine death.

scholarly journals Raised Uric Acid Level and Fetal Outcome in Hypertensive Disorders of Pregnancy

2014 ◽  
Vol 9 (1) ◽  
pp. 78-81
Author(s):  
A Singh ◽  
P Sharma ◽  
R Malla ◽  
S Singh
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Fetal Outcome ◽  
Morbidity And Mortality ◽  
Perinatal Morbidity ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders

Aims: This study was done to find the relation of raised uric acid with fetal outcome in hypertensive disorders of pregnancy and to compare the fetal outcome with normal and raised uric acid level . Methods: This was a hospital based cross-sectional prospective comparative study done in Paropakar maternity and Women’s hospital conducted over three month period. Results: During the study period, a total of 126 cases of hypertensive disorders of pregnancy were identified among 3819 obstetric cases. The incidence of hypertensive disorders of pregnancy in this study was 3.3%. Fifty seven of them were found to have serum uric acid level <5.5 mg% (Group A), 43 of them were found to have serum uric acid level ≥5.5mg% (Group B). In those developing hyperuricemia 54.81% had mild hypertension, 40.91% had severe hypertension. Adverse perinatal outcome with serum uric acid level ≥5.5mg/dl had stillbirth in 7%, had low birth weight in 27.9%, 11.6 % were admitted in special care baby unit and 18.6 % had apgar <7 at five minute. Conclusions: Perinatal morbidity and mortality was increased in women with raised uric acid level except admission to special baby care unit Hypertensive disorders of pregnancy are associated with high maternal and perinatal morbidity and mortality. DOI: http://dx.doi.org/10.3126/njog.v9i1.11196 NJOG 2014 Jan-Jun; 2(1):78-81

scholarly journals Fetal Outcome of Pre-eclamptic Mothers with Hyperuricemia

2012 ◽  
Vol 17 (1) ◽  
pp. 41-43 ◽  
Author(s):  
SS Hussain ◽  
MBK Choudhury ◽  
J Akhter ◽  
S Begum ◽  
FR Mowsumi ◽  
...  
Keyword(s):  
Uric Acid ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Serum Uric Acid ◽  
Serum Uric Acid Level ◽  
Study Groups ◽  
Fetal Outcome ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

Pre-eclampsia (PE) is considered as a major cause of maternal and fetal morbidity and mortality. When a pre-eclamptic woman develops associated hyperuricemia then fetal outcome may become worse. To observe the fetal outcome of hyperuricemic pre-eclamptic pregnancy in relation to normo-uricemic pre-eclamptic pregnancy in a hospital based comparative and cross-sectional study 62 pre-eclamptic patients were selected purposively. PE was diagnosed by hypertension and proteinuria. PE patients were divided into two groups by there serum uric acid level - Hyperuricemic & Normo-uricemic. Then fetal outcome markers (Stillbirth and low birth weight fetus) of the study groups were observed. In this study significant increased number of low birth weight fetuses was observed in babies born to hyperuricemic pre-eclamptic mothers in comparison with babies born to normo-uricemic pre-eclamptic mothers. According to the observation the estimation of serum uric acid may be considered in management of pre-eclamptic mothers, especially in lowering the rate of poor fetal outcome. DOI: http://dx.doi.org/10.3329/jdnmch.v17i1.12192 J. Dhaka National Med. Coll. Hos. 2011; 17 (01): 41-43

A STUDY OF SERUM URIC ACID LEVELS IN PREECLAMPSIA

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Sushma Goad ◽  
Anita Verma ◽  
Subhash Chandra
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Control Group ◽  
Age Group ◽  
Hypertensive Disorders Of Pregnancy ◽  
Level Elevation ◽  
The Mean

Background: To Study Serum Uric Acid level elevation in Hypertensive Disorders of Pregnancy. Methods: 50 Patients diagnosed as having Pre-eclampsia with age between 18-37 years and 50 controls with similar age group. Results: The mean serum uric acid level in control group was 3.41 ± 0.62 and in patient 7.01 ± 0.58 which was statistically significant (p =0.001). Conclusion: Serum uric acid levels were significantly higher in preeclampsia could be a useful indicator of fetal complication in preeclampsia patients. Keywords: serum uric acid, preeclampsia, laboratory.

scholarly journals Synergic effect in the reduction of serum uric acid level between ethanol extract of Aster glehni and vitamin B6

2018 ◽  
Vol 27 (5) ◽  
pp. 1439-1444 ◽  
Author(s):  
Eun Hye Han ◽  
Mi Kyung Lim ◽  
Sang Ho Lee ◽  
Hyoung Ja Kim ◽  
Dahyun Hwang
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Vitamin B6 ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Ethanol Extract ◽  
Synergic Effect
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