scholarly journals Maternal and Perinatal Outcome in Gestational Diabetes Mellitus Compared to Pregestational Diabetes Mellitus

2019 ◽  
Vol 9 (2) ◽  
pp. 127-132
Author(s):  
Faryal Mustary ◽  
TA Chowdhury ◽  
Ferdousi Begum ◽  
Nusrat Mahjabeen
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Perinatal Outcome ◽  
Birth Asphyxia ◽  
Adverse Outcomes ◽  
Intrauterine Death ◽  
Perinatal Complications ◽  
Pregestational Diabetes

Background: Diabetes mellitus is the most frequently encountered endocrine disorder in pregnancy and is associated with adverse outcomes if remain undiagnosed or untreated. This study was done to compare the maternal and perinatal outcome of pregestational diabetes mellitus (PGDM) with that of gestational diabetes (GDM). Methods: This observational analytical study with group comparison was carried out in the Department of Obstetrics and Gynaecology, BIRDEM General Hospital, Dhaka from July 2015 to June 2016. This study was conducted on two groups of pregnant women: group A (PGDM) and group B (GDM). A total of 100 cases were selected and in each group 50 pregnant women were enrolled. Singleton pregnancy and age 18 to 45 years were included. Pregnancy with hypertension, heart disease, renal disease and other metabolic disorders were excluded. Results: In this study mean gestational age of the study subjects were 35.72 ± 2.61 weeks and 36.58 ± 2.34 weeks in PGDM and GDM groups. History of GDM [34.0% vs 16.0%], intrauterine death (IUD) [14.0% vs 2.0%] and abortion [22.0% vas 6.0%] were significantly higher among PGDM patients than GDM patients. Regarding present pregnancy complications, polyhydramnios [32.0% vs 14.0%], preterm delivery [38.0% vs 20.0%], vulvovaginitis [28.0% vs 12.0%] and premature rupture of membrane (PROM) [24.0% vs 8.0%] were significantly higher in PGDM than GDM patients. Wound infection was significantly high in PGDM groups [35.7% vs 11.1%] among the patients delivered by lower uterine Cesarean section (LUCS). Regarding perinatal complications, hypoglycemia [22.0% vs 8.0%], birth asphyxia [24.0% vs 8.0%], RDS [24.0% vs 8.0%] were significantly higher among PGDM comparing GDM patients. Conclusion: The maternal and perinatal outcomes of pregestational diabetes mellitus were less favorable than those of gestational diabetes mellitus. Birdem Med J 2019; 9(2): 127-132

scholarly journals Pregnancy course and outcome peculiarities in women with gestational diabetes mellitus

2018 ◽  
Vol 26 (1) ◽  
pp. 96-105 ◽  
Author(s):  
S. V. Yankina ◽  
N. V. Shatrova ◽  
S. V. Berstneva ◽  
D. N. Pavlov
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Adverse Outcomes ◽  
Chronic Pyelonephritis ◽  
Oral Glucose ◽  
Threatened Miscarriage ◽  
Perinatal Center ◽  
Adverse Pregnancy

Gestational diabetes mellitus (GDM) is a serious medical and social problem, because it greatly increases the frequency of adverse pregnancy outcomes for mother and fetus. The frequency of GDM in the general population of different countries varies from 1% to 14% and average 7%, in Russia this figure is estimated at 4.5%. Aim. To evaluate the prevalence of GDM in Ryazan Regional clinical perinatal center for the last 3 years and examine its influence on the course and outcome of pregnancy. Materials and Methods. The analysis of the birth history data and exchange cards of 1690 pregnant women from 2015 to 2017 at Ryazan Regional clinical perinatal center. Results. GDM was diagnosed in 193 women (prevalence – 11.4%), with 62 pregnant women on the basis of the results of oral glucose tolerance test performed in the period of 24-30 weeks. It was established that the course of pregnancy and delivery in patients with GDM was characterized by a high percentage of complications (late gestosis – 18.1%, anemia – 11.3%, swelling – 11.9%, early toxicosis – 4.6%, poly-hydramnios – 12.4%, chronic pyelonephritis – 5.1% and threatened miscarriage – 3.6%). Pregnancy outcome study revealed that the majority – 60.6% of pregnancies ended in natural births. Preterm birth was noted in 15% of cases, of which 2 cases were of perinatal fetal death. The frequency of delivery by cesarean section – 39.4%. The frequency of childbirth large fetus was 21.8%, higher than in women with normal blood glucose levels. Conclusions. The prevalence of GDM in Ryazan Regional clinical perinatal center for the last 3 years was 11.4%. Complications during pregnancy were observed in 153 women (79.2%) of with GDM. The most frequent complications were; late gestosis, pregnancy anemia, edema, early toxemia, polyhydramnios, chronic pyelonephritis, and threatened miscarriage. In pregnant women with GDM, adverse outcomes of pregnancy were more common than in women with normoglycemia. Significant differences were obtained in the frequency of premature birth, macrosomia of the fetus and asphyxia during childbirth.

scholarly journals Consumption of multiple sources of protein is associated with gestational diabetes mellitus in the Chinese population

2021 ◽  
Author(s):  
Wei-Qin Wang ◽  
Vic Shao-Chih Chiang ◽  
Jing-Yuan Wen ◽  
Ji-Fen Hu ◽  
Rong-Xian Xu
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Dairy Products ◽  
Chinese Population ◽  
Adverse Outcomes ◽  
Smoking History ◽  
Oral Glucose ◽  
Multiple Sources

Background: Gestational diabetes mellitus (GDM) is a hyperglycemic state during pregnancy that results in disruptions of insulin sensitivity and secretion. It affects 7% of all pregnancies and lead to adverse maternal and offspring outcomes. GDM has many risk factors, such as ethnicity special, hereditary. However Nutritional factors offer key strategies against GDM, but this is less characterized for the Chinese population. Methods: A case control study of GDM pregnant women (n=49, 29.88+/-3.92 years of age) and healthy pregnant women (n=77, 27.63+/-4.83 years of age) from 1st Affiliated Hospital of Fujian Medical University were studied. Diagnosis was made using oral glucose tolerance test. Dietary data were collected using food frequency questionnaires. Data for use of dietary supplements, occupation, education, income, meal expenditure and smoking history were also recorded. Results: No differences were found between GDM and control subjects for their age, education, occupation, monthly income, grocery expenditure and smoking (p>0.05). GDM subjects were associated with higher quantities of dairy products (p<0.05) and seafood (p<0.01) intake. There were also higher number of GDM subjects using protein powder supplementation (p<0.05). Conclusions: Dietary recommendation guidelines for pregnant Chinese women should consider possible risks with excessive consumption of dairy products, seafood and protein powder. They should also assess the quality of the nutrition factor, other dietary interactions and their nutritional status further to minimize adverse outcomes caused by GDM .

scholarly journals Association of WISP1/CCN4 with Risk of Overweight and Gestational Diabetes Mellitus in Chinese Pregnant Women

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Lei Liu ◽  
Jiajin Hu ◽  
Liu Yang ◽  
Ningning Wang ◽  
Yang Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Fasting Blood Glucose ◽  
Adverse Outcomes ◽  
Obese Women ◽  
Complement C1q

Background. Obese women with gestational diabetes mellitus (GDM) have a higher risk of adverse outcomes than women with obesity or GDM alone. Our study is aimed at investigating the discriminatory power of circulatory Wnt1-inducible signaling pathway protein-1 (WISP1), a novel adipocytokine, on the copresence of prepregnancy overweight/obesity and GDM and at clarifying the relationship between the WISP1 level and clinical cardiometabolic parameters. Methods. A total of 313 participants were screened from a multicenter prospective prebirth cohort: Born in Shenyang Cohort Study (BISCS). Subjects were examined with a 2×2 factorial design for body mass index BMI≥24 and GDM. Between 24 and 28 weeks of pregnancy, follow-up individuals underwent an OGTT and blood sampling for cardiometabolic characterization. Results. We observed that the WISP1 levels were elevated in prepregnancy overweight/obesity patients with GDM, compared with nonoverweight subjects with normal blood glucose (3.45±0.89 vs. 2.91±0.75 ng/mL). Multilogistic regression analyses after adjustments for potential confounding factors revealed that WISP1 was a strong and independent risk factor for prepregnancy overweight/obesity with GDM (all ORs>1). In addition, the results of the ROC analysis indicated that WISP1 exhibited the capability to identify individuals with prepregnancy overweight/obesity and GDM (all AUC>0.5). Finally, univariate and multivariate linear regression showed that WISP1 level was positively and independently correlated with fasting blood glucose, systolic blood pressure, and aspartate aminotransferase and was negatively correlated with HDL-C and complement C1q. Conclusions. WISP1 may be critical for the prediction, diagnosis, and therapeutic strategies against obesity and GDM in pregnant women.

Assessment of Gestational Diabetes Mellitus Outcomes for Hispanic Women Living in the Rio Grande Valley

2019 ◽  
Vol 17 (3) ◽  
pp. 111-117 ◽  
Author(s):  
Norma Somohano-Mendiola ◽  
Jane Dimmitt Champion ◽  
Kristina Vatcheva
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Hispanic Women ◽  
Adverse Outcomes ◽  
Neonatal Outcomes ◽  
Oral Glucose ◽  
Mexican Origin ◽  
Adverse Neonatal Outcomes

Introduction: Gestational diabetes mellitus (GDM) among women living along the U.S.–Mexico border are approximately twice that of the general population of pregnant U.S. women. This study compared outcomes for Hispanic pregnant women diagnosed and treated for GDM (i.e., two abnormal 3-hour oral glucose tolerance tests [OGTT]) with those who were screened but had only one abnormal 3-hour OGTT and therefore received no treatment. Methods: Retrospective chart review of pregnant Hispanic women of Mexican origin ( N = 95), with GDM ( N = 41) or one abnormal 3-hour OGTT value ( N = 54) who delivered between January 1, 2015, and December 31, 2017. Results: No significant differences were found between the two groups with regard to sociodemographic variables, hyperbilirubinemia, or other adverse neonatal outcomes. Comparisons identified differences between women with and without adverse neonatal outcomes concerned type of delivery; there were more C-sections among women with GDM. Conclusion: Pregnant women with one abnormal 3-hour OGTT value are at risk of giving birth to neonates with biomarkers similar to those diagnosed and treated for GDM. The treatment of hyperglycemia in Hispanic women of Mexican origin with one abnormal 3-hour OGTT value may improve the health outcomes and quality of life of the mother and the neonate. More research is warranted to clarify the risk of adverse outcomes of diverse pregnant women who do not meet guidelines for diagnosis of GDM.

scholarly journals Maternal and foetal outcome in patients of gestational diabetes mellitus

2018 ◽  
Vol 7 (9) ◽  
pp. 3831
Author(s):  
Priyanka Priyanka
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
White Women ◽  
Fetal Outcome ◽  
Intrauterine Death ◽  
Indian Women ◽  
High Prevalence ◽  
Nicu Admission

Background: Indian women have high Prevalence of diabetes and their relative risk of developing gestational diabetes mellitus (GDM) is 11.3 times compared to white women. The metabolic adaptations during pregnancy are designed to maintain a continuous availability of substrate to accommodate the fetal growth. Aims of present study were the antenatal screening of Gestational diabetes mellitus and its pregnancy outcome.Methods: The present study is a type of prospective study in this study 6000 pregnant women were randomly selected for screening irrespective of gestational age and any of the risk factor. All consenting pregnant, who came for first absolute neutrophil count in outpatient department, pregnant women of any parity, and singleton pregnancies were included.Results: Out of 6000 women screened 200 were found positive for GDM. The study indicated that GDM was 3.33%. The incidence of GDM was found to be more in women > 25 years age. Fetal outcome was satisfactory in well controlled GDM, only 7 babies were macrosomic, 13 intrauterine death and 5 still birth, 10 babies required NICU admission for hypoglycemia, respiratory distress syndrome, septicemia.Conclusions: Fetal outcome was satisfactory in well controlled GDM. There was no neonatal mortality. Hence, GDM and its complications are preventable.

scholarly journals DETERMINANTS OF GESTATIONAL DIABETES MELLITUS

2021 ◽  
Vol 17 (37) ◽  
pp. 48-56
Author(s):  
Yuli Puspita DEVI ◽  
Rumaisah ABDILLAH ◽  
Muthmainnah MUTHMAINNAH
Keyword(s):  
Diabetes Mellitus ◽  
Birth Weight ◽  
Family History ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Secondary Data ◽  
Perinatal Complications ◽  
Family History Of Diabetes ◽  
History Of

Background: Gestational Diabetes Mellitus (GDM) is a glucose tolerance disorder that first appears during pregnancy. GDM can cause a variety of obstetric and perinatal complications for pregnant women and their fetuses. The prevalence of GDM in the city of Surabaya in 2015 amounted to 2.29%, increasing to 3.88% in 2018. Aim: The purpose of this study was to analyze the determinants (family history of diabetes mellitus, BMI, history of birth weight, parity, and the age of the pregnant woman) that influence the GDM. Methods: This research is an analytical study with an observational approach. The research design was carried out using a case-control study. In this study, the number of samples was 36 people, 6 cases, and 30 people as controls, and were taken randomly. The data source obtained from secondary data (medical records of pregnant women) at Mulyorejo Health Center Surabaya. The analysis used in this study was a simple logistic regression test. Results and Discussion: The result showed an effect of a family history of diabetes mellitus (p = 0.035) on the incidence of GDM. Parity was a potential variable (p = 0.077) on the incidence of GDM. Meanwhile, BMI, history of birth weight, and mother's age did not affect the incidence of GDM. Conclusion: Pregnant women with a family history of diabetes who are not balanced with maintaining a good lifestyle can experience complications of developing GDM.

scholarly journals Myoinositol in the Prevention of Gestational Diabetes Mellitus: Is It Sensible?

2019 ◽  
Vol 2019 ◽  
pp. 1-5 ◽  
Author(s):  
Angelika Sobota-Grzeszyk ◽  
Mariusz Kuźmicki ◽  
Jacek Szamatowicz
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Sensitivity ◽  
Side Effects ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Adverse Outcomes ◽  
Diagnosis And Treatment

Gestational diabetes mellitus (GDM) is a complication that increasingly affects pregnant women. Due to the risk of adverse outcomes in the mother as well as in the fetus which is caused by GDM, appropriate diagnosis and treatment is very essential. Nevertheless, it is important to find new, effective ways of prevention of GDM to avoid side effects. A promising example of such an action may be supplementation of myoinositol. As shown in studies, myoinositol may reduce the risk of developing gestational diabetes mellitus by improving insulin sensitivity.

The Prevalence of Gestational Diabetes Mellitus in Pregnant Women Referred to Amir al-Mu'minin Hospital of Gerash City, Fars Province, Iran

2021 ◽  
Author(s):  
Elham Rezaee ◽  
Fariba Mohammadi ◽  
Mohammad Javad Boozhmehrani ◽  
Parisa Bagheri
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Health Care Providers ◽  
Adverse Outcomes ◽  
Screening Tests ◽  
Fars Province ◽  
Care Providers ◽  
Significant Difference

Background and Aims: The increasing number of pregnant women being diagnosed as having gestational diabetes mellitus (GDM) and  lead health care providers to develop reliable screening protocols and know the exact worldwide epidemiology of the disease. This study seeks to obtain data that will help to improve the epidemiologic knowledge about this disease. Materials and Methods: This cross-sectional study was performed on 953 pregnant women seeking routine prenatal screening tests. Participants participate with using Carpenter-Coustan criteria in the study. Statistical analysis was performed using SPSS software. Results and Conclusions: Among 953 pregnant women , 38 participants (4%) were detected to have GDM . Fifty percent of patients in the study were overweight .The data showed a significant difference in the mean age between the diabetic and non-diabetic groups. The high prevalence of GDM in young Iranian pregnant women may emphasize the need for early diagnosis and treatment to avoid adverse outcomes associated with GDM.

scholarly journals DETERMINANTS OF GESTATIONAL DIABETES MELLITUS

2021 ◽  
Vol 18 (37) ◽  
pp. 48-56
Author(s):  
Yuli Puspita DEVI ◽  
Rumaisah ABDILLAH ◽  
Muthmainnah MUTHMAINNAH
Keyword(s):  
Diabetes Mellitus ◽  
Birth Weight ◽  
Family History ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Secondary Data ◽  
Perinatal Complications ◽  
Family History Of Diabetes ◽  
History Of

Background: Gestational Diabetes Mellitus (GDM) is a glucose tolerance disorder that first appears during pregnancy. GDM can cause a variety of obstetric and perinatal complications for pregnant women and their fetuses. The prevalence of GDM in the city of Surabaya in 2015 amounted to 2.29%, increasing to 3.88% in 2018. Aim: The purpose of this study was to analyze the determinants (family history of diabetes mellitus, BMI, history of birth weight, parity, and the age of the pregnant woman) that influence the GDM. Methods: This research is an analytical study with an observational approach. The research design was carried out using a case-control study. In this study, the number of samples was 36 people, 6 cases, and 30 people as controls, and were taken randomly. The data source obtained from secondary data (medical records of pregnant women) at Mulyorejo Health Center Surabaya. The analysis used in this study was a simple logistic regression test. Results and Discussion: The result showed an effect of a family history of diabetes mellitus (p = 0.035) on the incidence of GDM. Parity was a potential variable (p = 0.077) on the incidence of GDM. Meanwhile, BMI, history of birth weight, and mother's age did not affect the incidence of GDM. Conclusion: Pregnant women with a family history of diabetes who are not balanced with maintaining a good lifestyle can experience complications of developing GDM.

scholarly journals I/D Polymorphism Gene ACE and Risk of Preeclampsia in Women with Gestational Diabetes Mellitus

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
O. P. Dmitrenko ◽  
N. S. Karpova ◽  
M. K. Nurbekov ◽  
O. V. Papysheva
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Venous Blood ◽  
Adverse Outcomes ◽  
Blood Samples ◽  
Ace Gene ◽  
Large Patient ◽  
D Region

Preeclampsia (PE) and gestational diabetes mellitus (GDM) are the most common complications of pregnancy, which result in adverse outcomes for the mother and the fetus. GDM is regarded as a separate independent risk factor for PE development, as evidenced by a higher preeclampsia rate in gestational diabetes mellitus than in the general population. The role the endothelial cell dysfunction plays is considered to be the most reasonable one in the origin of these diseases. The activity of plasma and tissue angiotensin converting enzyme (ACE) is believed to be genetically controlled. The available data suggests that increased ACE activity due to deletion (D)/insertion (I) in the 16th intron of ACE gene, which is called ACE gene I/D polymorphism, is associated with preeclampsia and varies depending on the studied population and the geography. We did not find any literature data that estimates the influence of ACE gene I/D polymorphism on PE rate in pregnant women with GDM. Therefore, the present study aimed to investigate a relationship between ACE gene I/D polymorphism and preeclampsia development in the case of GDM in the Russian population. The study used the genomic DNA derived by phenol-chloroform extraction method from venous blood samples in 137 pregnant women, including samples of 74 women with GDM accompanied with PE and the blood samples of 63 women with GDM w/o preeclampsia. Genotyping of insertion/deletion in the I/D region (16 intron of АСЕ gene) was conducted by real-time PCR using the TaqMan competing probe technology. The particular features in the frequency array of alleles and genotypes of the ACE gen I/D polymorphism under review, as associated with preeclampsia development risk in pregnant women with GDM, were identified. The acquired data testify to the need to further study of ACE gene I/D region polymorphism association in a large patient sample taking into account the PE and GDM risk factors estimated in the clinical practice.

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