scholarly journals Serum Lipid Profile, Serum Magnesium and Fasting Serum Glucose in Newly Diagnosed Type 2 Diabetic Subjects

2014 ◽  
Vol 7 (1) ◽  
pp. 4-8
Author(s):  
R Karim ◽  
W Nargis ◽  
KA Begum ◽  
SS Subhan ◽  
MN Uddin
Keyword(s):  
Lipid Profile ◽  
Serum Magnesium ◽  
Serum Glucose ◽  
Reference Ranges ◽  
Newly Diagnosed ◽  
Fasting Serum ◽  
Fasting Serum Glucose ◽  
Group I ◽  
Type 2 Diabetic

Type 2 diabetes is considered as a major health burden due to its rising prevalence and disabling, life threatening complications. Dyslipidemia, often coexisting with T2DM as a feature of insulin resistance, is hypothesized to be linked with altered magnesium homeostasis. This study was designed to evaluate the serum magnesium levels and its influence on serum lipids in type 2 diabetics. Lipid profile, serum magnesium (Mg) and fasting serum glucose (FSG) were measured in 30 newly diagnosed normotensive type 2 diabetic patients chosen as cases (Group II) just before introducing any treatment, and was compared with that of 30 healthy controls (Group I). The serum magnesium was found to be significantly lower (p<0.001) and LDL-c was found to be significantly higher (p<0.01) in cases. The correlation analysis revealed a significant negative association of FSG to serum magnesium (r= -0.720), total cholesterol (r=-0.483) and a positive correlation to HDL-c (r=-0.440). However, serum magnesium showed a significant positive relation only with serum HDL-c (r =0.372, p<0.05). Serum magnesium and lipid fractions showed wide range of variation within the normal reference ranges in the newly diagnosed T2D subjects. Further large scale studies are needed to elucidate the association of serum magnesium with lipid profile changes. Estimation of serum magnesium level may prove useful in T2DM with normal or abnormal lipid levels or in those who are prone to develop dyslipidemia or certain complications associated with dyslipidemia. DOI: http://dx.doi.org/10.3329/bjmb.v7i1.18572 Bangladesh J Med Biochem 2014; 7(1): 4-8

scholarly journals Comparative Study on Antidiabetic Effect of Ethanolic Extract of Jute Leaf on Neonatal Streptozotocin- Induced Type-2 Diabetic Model Rat

2020 ◽  
pp. 60-71
Author(s):  
Md. Mahabub Ali ◽  
Md. Asrafuzzaman ◽  
Md. Mahedi Hassan Tusher ◽  
Md. Hafizur Rahman ◽  
Md. Tanvir Rahman ◽  
...  
Keyword(s):  
Body Weight ◽  
Lipid Profile ◽  
Ethanolic Extract ◽  
Liver Glycogen ◽  
Serum Glucose ◽  
Water Control ◽  
Citrate Buffer ◽  
Diabetic Model ◽  
Type 2 Diabetic

Aim: Functional food and their bioactive compounds have been considered as a new approach for the prevention and management of type 2 diabetes and its complications. According to this approach current study was carried out as an elucidation of antidiabetic properties of Corchorus capsularis and Corchorus olitorius varieties of jute leaf (ethanolic extract) on nSTZ-induced type-2 diabetic rats. Methodology: The type-2 diabetic model rat was developed by a single intraperitoneal injection of freshly prepared STZ (90 mg/kg/10 ml) in sterile citrate buffer (0.1 M, pH 4.5) to rat pups (48 hour old). After three months, OGTT was performed to select diabetic (FSG > 6.5mmol/L and after 90 min of glucose load > 14 mmol/L) experimental rats. The rats were randomly divided into four groups [DWC, GT, Ext-1 and Ext-2 represent, diabetic water control, glybenclamide treated (20 mg/5 ml/kg body weight), C. capsularis treated and C. olitorius treated group (1.25 g/10 ml/kg body weight) respectively]. One group was kept with normal rats [normal water control, NWC]. The treatment was given once daily or 28 consecutive days. Fasting serum glucose, liver glycogen and lipid profile were estimated by using standard methods. Results: The results showed that Ext-1 and Ext-2 treated groups gradually decreased serum glucose level (7.15 ±0.67 to 5.94 ± 1.19 and 7.20 ± 0.93 to 5.28 ±1.03 respectively) and reducing effect by Ext-2 was significant (p=0.001). Both extract showed lower liver glycogen level compared with GT group [5.0±2.5 Vs 17.7±6.5 (Ext-1 vs GT) and 7.5±6.4 Vs 17.7±6.5 (Ext-2 vs GT)] and even Ext-1 manifested significant effect (p=0.05). Additionally, lipid profile estimation revealed no significant improvement by the consumption of both the extracts. Conclusion: On the basis of current investigations, it may be concluded that both variety of jute’s leaf demonstrated hypoglycemic properties in Type 2 diabetic model rats; further in-depth studies are recommended to explore the exact mechanism(s) of hypoglycemic effect.

scholarly journals Serum Levels of Zinc and Magnesium in Newly Diagnosed Type-2 Diabetic Subjects

2013 ◽  
Vol 3 (2) ◽  
pp. 46-49 ◽  
Author(s):  
S Ferdousi ◽  
FH Mollah ◽  
MAR Mia
Keyword(s):  
Diabetes Mellitus ◽  
Protein Metabolism ◽  
Serum Zinc ◽  
Serum Levels ◽  
Newly Diagnosed ◽  
Group I ◽  
Strong Relation ◽  
Type 2 Diabetic ◽  
Group 1

Diabetes mellitus is a chronic metabolic disorder which affects carbohydrate, lipid and protein metabolism. There is a strong relation between some specific oligoelements and diabetes mellitus. The study was undertaken to determine serum levels of zinc and magnesium in 60 newly diagnosed uncomplicated type 2 diabetic (group I) and 60 healthy non-diabetic subjects (group II). Serum zinc and magnesium were estimated by Atomic Absorption Spectrophotometer (AAS). The serum zinc and magnesium levels were (72.70±8.43 ?g/dl) and (1.85±0.17 mg/dl) respectively in group-1 and (75.92±8.20 ?g/dl) and (2.00±0.17 mg/dl) respectively in group-11. The levels were significantly decreased in group-1. Study showed that type 2 diabetes mellitus can result in changes in zinc and magnesium levels and supplementation of both zinc and magnesium may be considered in those cases.DOI: http://dx.doi.org/10.3329/bjmb.v3i2.13811 Bangladesh J Med Biochem 2010; 3(2): 46-49

scholarly journals Effects of NonPharmacological Interventions on Dietary Practices, Energy Expenditure and Biochemical Parameters of Hypercholesterolemic Type 2 Diabetic Subjects

1970 ◽  
Vol 3 (2) ◽  
pp. 75-77
Author(s):  
Fadia Afnan ◽  
Farzana Saleh ◽  
Shirin Jahan Mumu ◽  
Afroza Akhter ◽  
Kazi Rumana Ahmed ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Total Cholesterol ◽  
Daily Intake ◽  
Serum Glucose ◽  
Activity Level ◽  
Fasting Serum ◽  
Dietary Practices ◽  
Significant Difference ◽  
Type 2 Diabetic

Nonpharmacological interventions play an important role in the management of diabetes and its complications. This study analyzed the effect of nonpharmacological interventions on dietary practices, energy expenditure and management outcome in terms of glycemic and lipidemic status of type 2 diabetic subjects with hypercholesterolemia. These interventions included dietary advice, leaflets, televised lectures, booklets, posters and a bimonthly publication in Bangla. Eighty newly diagnosed type 2 diabetic subjects (male: female ratio 47:33, age 46 ± 8 years) with hypercholesterolemia (fasting serum total cholesterol >200 mg/dl) were selected from BIRDEM by purposive sampling. The first interview was taken before any intervention while the second interview was taken after a minimum interval of 8 weeks. The daily intake of macro- and micro- nutrients was assessed by 24- hr recall method. Energy expenditure of the subjects was calculated by factorial method using physical activity level (WHO/FAO/UNU 1985). After intervention, the proportion of carbohydrate, protein and fat intake of the study subjects did not differ significantly compared to values before intervention. The daily intake of micronutrients also did not differ compared to those before intervention. No significant difference was found between pre and post intervention values of per day energy intake (kcal, 1621 ± 426 vs 1645 ± 623). Total energy expenditure after intervention was significantly higher (1649 ± 340) compared to before intervention (1519 ± 353, p<0.002). After intervention, fasting serum glucose level (7 ± 1.43 mmol/l), serum glucose 2 hrs after breakfast (11 ± 4.1 mmol/l) and total cholesterol (217 ± 35 mg/dl) were significantly reduced compared to before intervention values (9 ± 4, 16 ± 7, 231 ± 32 respectively; p=0.001 for FSG, p=0.001 for SGABF, p<0.001 for total cholesterol). Nonpharmacological intervention was found to be effective in improving the management of diabetes and its complications. Ibrahim Med. Coll. J. 2009; 3(2): 75-77 DOI: 10.3329/imcj.v3i2.4222

scholarly journals Serum Lipids and Diabetic Retinopathy in Newly Diagnosed Type 2 Diabetic Subjects

2012 ◽  
Vol 1 (2) ◽  
pp. 63-66
Author(s):  
Md Rezwanur Rahman ◽  
M Iqbal Arslan ◽  
Md Mozammel Hoque ◽  
Forhadul Hoque Mollah ◽  
Shahana Shermin
Keyword(s):  
Diabetic Retinopathy ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
Serum Triglyceride ◽  
Vascular Complication ◽  
Lipoprotein Cholesterol ◽  
Newly Diagnosed ◽  
Significant Difference ◽  
Type 2 Diabetic

Background: Diabetic retinopathy is the commonest and usually the first observable vascular complication of diabetes mellitus. Along with hyperglycaemia, dyslipidaemia is a contributing factor for the occurrence of diabetic retinopathy. It is postulated that dyslipidaemia results in formation of hard exudate by increasing blood viscosity and altering the fibrinolytic system. A case control study was carried out in the department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka during the period of January 2006 to December 2007 to evaluate the serum lipid profile in newly diagnosed type 2 diabetic subjects with diabetic retinopathy.Materials and Methods: Total 85 newly diagnosed type 2 diabetic subjects were included in this study, 40 were cases having retinopathy and 45 were age and sex matched controls without retinopathy. Serum triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were compared between cases and controls. Unpaired t-test and chi-square test were done between groups as tests of significance.Results: All the parameters of lipid profile showed dyslipidaemic trend both in cases and controls. In the cases TG was significantly higher and HDL-C was significantly lower than that of controls (p < 0.05) whereas no significant difference was found between cases and controls with respect to serum TC and LDL-C.Conclusion: It can be concluded that high TG and low HDL-C are associated with diabetic retinopathy in newly diagnosed type 2 diabetes. DOI: http://dx.doi.org/10.3329/jemc.v1i2.11464 J Enam Med Col 2011; 1(2): 63-66

Effect of Jaman Fruit Extract on Serum Glucose and Lipid Profile in Type 2 Diabetic Individuals

2006 ◽  
Vol 5 (6) ◽  
pp. 573-576 ◽  
Author(s):  
Mahpara Safdar . ◽  
Alam Khan . ◽  
Habibullah .
Keyword(s):  
Lipid Profile ◽  
Serum Glucose ◽  
Fruit Extract ◽  
Type 2 Diabetic

scholarly journals Status of some Trace Elements in Type-2 Diabetic Patients and its Relationship with Lipid Profile

2016 ◽  
Vol 40 (1) ◽  
pp. 79-85 ◽  
Author(s):  
Roksana Yeasmin ◽  
MA Muttalib ◽  
Naznin Sultana ◽  
Nizamul Hoque Bhuiyan ◽  
Rashedul Alam
Keyword(s):  
Lipid Profile ◽  
Serum Magnesium ◽  
Control Group ◽  
P Value ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Serum Zn ◽  
And Control ◽  
Type 2 Diabetic

Investigation of the serum level of copper, zinc, magnesium and manganese in type-2 diabetes mellitus and their possible association with lipid profile was carried out. The comparative study included 100 type-2 diabetic patients in Gr-II and 100 non-diabetic as control in (Gr-I). Results indicated that there is a significant lower level (p < .001) of serum Zn, Cu, Mg and Mn in diabetic patients compared with the control group, showing p value < .001. In type-2 DM patients (Gr-II) there were significant correlations between serum Zn and TAG (r = 0.209) and between Zn and HDL-C level (r = .199) showing p value <.05. Non significant relationships were found in between Zn and lipid profile (TAG, Cholesterol, HDL-C and LDL-C) of control (Gr-I) group. Significant correlation was found between serum magnesium and TAG of control (Gr-I) where p < .01 and non significant correlations were found in serum Mg and total cholesterol, HDL-C, LDL-C of both type-2 diabetic (Gr-II) and control (Gr-I). Significant correlations were also found in between serum of Cu and Mn and TAG of control (Gr-I) where p < .05 and non significant correlations were found in other component of lipid profile of both cases (Gr-II) and control (Gr-I).Journal of Bangladesh Academy of Sciences, Vol. 40, No. 1, 79-85, 2016

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