scholarly journals Comparative Study on Antidiabetic Effect of Ethanolic Extract of Jute Leaf on Neonatal Streptozotocin- Induced Type-2 Diabetic Model Rat

2020 ◽  
pp. 60-71
Author(s):  
Md. Mahabub Ali ◽  
Md. Asrafuzzaman ◽  
Md. Mahedi Hassan Tusher ◽  
Md. Hafizur Rahman ◽  
Md. Tanvir Rahman ◽  
...  
Keyword(s):  
Body Weight ◽  
Lipid Profile ◽  
Ethanolic Extract ◽  
Liver Glycogen ◽  
Serum Glucose ◽  
Water Control ◽  
Citrate Buffer ◽  
Diabetic Model ◽  
Type 2 Diabetic

Aim: Functional food and their bioactive compounds have been considered as a new approach for the prevention and management of type 2 diabetes and its complications. According to this approach current study was carried out as an elucidation of antidiabetic properties of Corchorus capsularis and Corchorus olitorius varieties of jute leaf (ethanolic extract) on nSTZ-induced type-2 diabetic rats. Methodology: The type-2 diabetic model rat was developed by a single intraperitoneal injection of freshly prepared STZ (90 mg/kg/10 ml) in sterile citrate buffer (0.1 M, pH 4.5) to rat pups (48 hour old). After three months, OGTT was performed to select diabetic (FSG > 6.5mmol/L and after 90 min of glucose load > 14 mmol/L) experimental rats. The rats were randomly divided into four groups [DWC, GT, Ext-1 and Ext-2 represent, diabetic water control, glybenclamide treated (20 mg/5 ml/kg body weight), C. capsularis treated and C. olitorius treated group (1.25 g/10 ml/kg body weight) respectively]. One group was kept with normal rats [normal water control, NWC]. The treatment was given once daily or 28 consecutive days. Fasting serum glucose, liver glycogen and lipid profile were estimated by using standard methods. Results: The results showed that Ext-1 and Ext-2 treated groups gradually decreased serum glucose level (7.15 ±0.67 to 5.94 ± 1.19 and 7.20 ± 0.93 to 5.28 ±1.03 respectively) and reducing effect by Ext-2 was significant (p=0.001). Both extract showed lower liver glycogen level compared with GT group [5.0±2.5 Vs 17.7±6.5 (Ext-1 vs GT) and 7.5±6.4 Vs 17.7±6.5 (Ext-2 vs GT)] and even Ext-1 manifested significant effect (p=0.05). Additionally, lipid profile estimation revealed no significant improvement by the consumption of both the extracts. Conclusion: On the basis of current investigations, it may be concluded that both variety of jute’s leaf demonstrated hypoglycemic properties in Type 2 diabetic model rats; further in-depth studies are recommended to explore the exact mechanism(s) of hypoglycemic effect.

scholarly journals The Antidiabetic and Antilipidemic Activity of Aqueous Extract of Urtica dioica L. on Type2 Diabetic Model Rats

1970 ◽  
Vol 17 ◽  
pp. 1-6 ◽  
Author(s):  
M Das ◽  
BP Sarma ◽  
AKA Khan ◽  
M Mosihuzzaman ◽  
N Nahar ◽  
...  
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Water Extract ◽  
Treated Group ◽  
Serum Glucose ◽  
Urtica Dioica ◽  
Male Rats ◽  
Diabetic Model ◽  
Type 2 Diabetic

Context: To evaluate the anti-diabetic activity of Urtica dioica L. in type 2 diabetic model rats.Objectives: The aim of this study is to explore the effect of water extract of U. dioica on glycemic status, body weight and lipidemic status in type2 diabetic model ratsMaterials and Methods: The mature and fresh leaves of U. dioica was collected from the mountain range of Assam in India and the leaves extract was used at a dose of 1.25 g-kg body weight. Type2 diabetes was induced by a single intraperitoneal injection of STZ to 48 hours old pups of Long Evans. Experiments for semi-chronic effects were done with continuous feeding of aqueous extract for 14 days at a dose of 1.25 g-kg body weight type 2 diabetic male rats. Serum glucose was estimated by GOD-POD method, serum triglyceride and cholesterol by enzymatic-colorimetric methods.  Results: Water extract showed significant effect on lowering fasting serum glucose levels in type 2 diabetic model rats on 14th day (14.05 ± 3.4 mmol/l in control vs 8.3 ± 1.4 mmol/l in treated group, p = 0.04). There was significant increase in the body weight of treated group in comparison to the control group (175 ± 8 g in control vs in 168 ± 9 g in treated group on 0 day, p = ns; 193 ± 26 g in control vs in 185 ± 25 g in treated group on 14th day, p=0.002]. Beneficial effect was observed in lipid although the change was not statistically significant.Conclusion:  The results obtained in this study suggests that U. dioica has hypoglycemic and hypo-lipidemic activity in type 2 diabetic model rats. This may be due to the histological and functional improvement of b-cells with the consequence of improved insulinemic status.Key words: hypoglycemic; hypolipidemic; Urtica dioica; diabetes mellitusDOI: 10.3329/jbs.v17i0.7092J. bio-sci. 17: 1-6, 2009

scholarly journals Hypoglycemic effect of Irvingia gabonensis (Aubry-Lacomate Ex. Ororke), Baill in Type 2 Diabetic Long-Evans Rats

2012 ◽  
Vol 11 (1) ◽  
pp. 19-24 ◽  
Author(s):  
M S Hossain ◽  
S Sokeng ◽  
M Shoeb ◽  
K Hasan ◽  
M Mosihuzzaman ◽  
...  
Keyword(s):  
Glucose Level ◽  
Serum Insulin ◽  
Liver Glycogen ◽  
Treated Group ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Bush Mango ◽  
Irvingia Gabonensis ◽  
Type 2 Diabetic

Irvingia gabonensis (Aubry-Lacomate Ex. Ororke), Baill (African wild mango/bush mango) seeds are   widely used in cooking as a sauce in Cameroon and in most parts of tropical Africa for the treatment of a number of ailments. In this study normal rat food was incorporated with I. gabonensis seed powder (10%) and oil free seed powder (5%) and their chronic effects on streptozotocin induced Type 2 diabetic rats were studied. Oral consumption of food incorporated with seed powder significantly reduced serum glucose level on the 28th day (p<0.01) which was   comparable with glibenclamide treated group. Food with oil free seed powder showed 24% fall in glucose level on the 28th day. Fasting serum insulin increased significantly (p<0.001) in glibenclamide and oil free seed powder treated (p<0.008) groups. No effect was observed in the seed powder treated group. Liver glycogen content increased in the glibenclamide treated group but no significant change was observed in both powder and oil free seed powder   treated groups. On the 28th day seed powder treated group significantly lowered serum TG level (p<0.033) and 48% was lowered by oil free seed powder. It is concluded that seed powder as well as oil free seed powder lowered blood glucose level in Type 2 diabetic model rats. It seems to act as an insulinomimetic and/or insulin sensitizing agent. DOI: http://dx.doi.org/10.3329/dujps.v11i1.12482 Dhaka Univ. J. Pharm. Sci. 11(1): 19-24, 2012 (June)

scholarly journals Serum Lipid Profile, Serum Magnesium and Fasting Serum Glucose in Newly Diagnosed Type 2 Diabetic Subjects

2014 ◽  
Vol 7 (1) ◽  
pp. 4-8
Author(s):  
R Karim ◽  
W Nargis ◽  
KA Begum ◽  
SS Subhan ◽  
MN Uddin
Keyword(s):  
Lipid Profile ◽  
Serum Magnesium ◽  
Serum Glucose ◽  
Reference Ranges ◽  
Newly Diagnosed ◽  
Fasting Serum ◽  
Fasting Serum Glucose ◽  
Group I ◽  
Type 2 Diabetic

Type 2 diabetes is considered as a major health burden due to its rising prevalence and disabling, life threatening complications. Dyslipidemia, often coexisting with T2DM as a feature of insulin resistance, is hypothesized to be linked with altered magnesium homeostasis. This study was designed to evaluate the serum magnesium levels and its influence on serum lipids in type 2 diabetics. Lipid profile, serum magnesium (Mg) and fasting serum glucose (FSG) were measured in 30 newly diagnosed normotensive type 2 diabetic patients chosen as cases (Group II) just before introducing any treatment, and was compared with that of 30 healthy controls (Group I). The serum magnesium was found to be significantly lower (p<0.001) and LDL-c was found to be significantly higher (p<0.01) in cases. The correlation analysis revealed a significant negative association of FSG to serum magnesium (r= -0.720), total cholesterol (r=-0.483) and a positive correlation to HDL-c (r=-0.440). However, serum magnesium showed a significant positive relation only with serum HDL-c (r =0.372, p<0.05). Serum magnesium and lipid fractions showed wide range of variation within the normal reference ranges in the newly diagnosed T2D subjects. Further large scale studies are needed to elucidate the association of serum magnesium with lipid profile changes. Estimation of serum magnesium level may prove useful in T2DM with normal or abnormal lipid levels or in those who are prone to develop dyslipidemia or certain complications associated with dyslipidemia. DOI: http://dx.doi.org/10.3329/bjmb.v7i1.18572 Bangladesh J Med Biochem 2014; 7(1): 4-8

scholarly journals A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects

2016 ◽  
Vol 23 (3) ◽  
pp. 427-440 ◽  
Author(s):  
Saswata Talukdar ◽  
Yingjiang Zhou ◽  
Dongmei Li ◽  
Michelle Rossulek ◽  
Jennifer Dong ◽  
...  
Keyword(s):  
Body Weight ◽  
Lipid Profile ◽  
Long Acting ◽  
Type 2 Diabetic

Effect of Jaman Fruit Extract on Serum Glucose and Lipid Profile in Type 2 Diabetic Individuals

2006 ◽  
Vol 5 (6) ◽  
pp. 573-576 ◽  
Author(s):  
Mahpara Safdar . ◽  
Alam Khan . ◽  
Habibullah .
Keyword(s):  
Lipid Profile ◽  
Serum Glucose ◽  
Fruit Extract ◽  
Type 2 Diabetic

scholarly journals Lipid profile in type 2 diabetic subjects aged 40 years and over living in Benin

2015 ◽  
Vol 6 (10) ◽  
pp. 805
Author(s):  
Casimir D. Akpovi ◽  
Segbo A.G. Julien ◽  
Medehouenou T.C. Marc ◽  
Anago A.A. Eugénie ◽  
Akakpo B. Huguette ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Type 2 Diabetic

scholarly journals Ethanol extract of mulberry leaves partially restores the composition of intestinal microbiota and strengthens liver glycogen fragility in type 2 diabetic rats

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zhan-Zhong Liu ◽  
Qing-Hua Liu ◽  
Zhao Liu ◽  
Jia-Wei Tang ◽  
Eng-Guan Chua ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Intestinal Microbiota ◽  
Ethanol Extract ◽  
Liver Glycogen ◽  
Diabetic Rats ◽  
Size Exclusion ◽  
Mulberry Leaves ◽  
Positive Effects ◽  
Type 2 Diabetic

Abstract Background Mulberry leaf as a traditional Chinese medicine is able to treat obesity, diabetes, and dyslipidemia. It is well known that diabetes leads to intestinal microbiota dysbiosis. It is also recently discovered that liver glycogen structure is impaired in diabetic animals. Since mulberry leaves are able to improve the diabetic conditions through reducing blood glucose level, it would be interesting to investigate whether they have any positive effects on intestinal microbiota and liver glycogen structure. Methods In this study, we first determined the bioactive components of ethanol extract of mulberry leaves via high-performance liquid chromatography (HPLC) and liquid chromatography/mass spectrometry (LC/MS). Murine animal models were divided into three groups, normal Sprague-Dawley (SD) rats, high-fat diet (HFD) and streptozotocin (STZ) induced type 2 diabetic rats, and HFD/STZ-induced rats administered with ethanol extract of mulberry leaves (200 mg/kg/day). Composition of intestinal microbiota was analyzed via metagenomics by sequencing the V3-V4 region of 16S rDNAs. Liver glycogen structure was characterized through size exclusion chromatography (SEC). Both Student’s t-test and Tukey’s test were used for statistical analysis. Results A group of type 2 diabetic rat models were successfully established. Intestinal microbiota analysis showed that ethanol extract of mulberry leaves could partially change intestinal microbiota back to normal conditions. In addition, liver glycogen was restored from fragile state to stable state through administration of ethanol extract of mulberry leaves. Conclusions This study confirms that the ethanol extract of mulberry leaves (MLE) ameliorates intestinal microbiota dysbiosis and strengthens liver glycogen fragility in diabetic rats. These finding can be helpful in discovering the novel therapeutic targets with the help of further investigations.

Angiotensin II causes endothelial dysfunction via the GRK2/Akt/eNOS pathway in aortas from a murine type 2 diabetic model

2011 ◽  
Vol 64 (5) ◽  
pp. 535-546 ◽  
Author(s):  
Kumiko Taguchi ◽  
Tsuneo Kobayashi ◽  
Yasuhiro Takenouchi ◽  
Takayuki Matsumoto ◽  
Katsuo Kamata
Keyword(s):  
Angiotensin Ii ◽  
Endothelial Dysfunction ◽  
Diabetic Model ◽  
Type 2 Diabetic
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