scholarly journals Prevalence of coronary artery disease and its associated risk factors in Aljouf region of Saudi Arabia

2022 ◽  
Vol 21 (1) ◽  
pp. 201-205
Author(s):  
Md Sayed Ali Sheikh
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Saudi Arabia ◽  
Coronary Artery ◽  
Medical Science ◽  
Laboratory Data ◽  
Individual Risk ◽  
Total Prevalence ◽  
Artery Disease ◽  
Associated Risk Factors

Objective:Toevaluate the prevalence of coronary artery disease (CAD) with its associated risk factors among Saudi population in Aljouf, Sakaka, Saudi Arabia. Methods: This is a retrospective hospital based study conducted at King Abdul Aziz specialized hospital Sakaka Aljouf, Saudi Arabia by selecting participants with diagnosed CAD by coronary angiogram, the meanage 55.1 ± 10.8 yrs ( range 35-75-years)over a period ofJanuary 2019to December 2019. Demographic characteristics included age, sex,diabetes, hypertension, smoking and family history of CAD. Laboratory data included such as total cholesterol, triglyceride, LDL and HDL levels. Collected data were analyzed by using SPSS 20.00software. Results: One hundred two participants, out of eight hundred fifty five were diagnosed CADwhich included 64.7% stable angina and 35.2% unstable angina. The total prevalence of CAD obtained from this study was11.9% among male and female was7.89% and 4.621% respectively (P<0.0001). Diabetes (85.7%) and dyslipidemia 94.2%weremost important risk factors in female compared to male 59.1% and 62.2% respectively, while hypertension 82% higher in male than female 51.4 % considers as a significant (p<0.001). Smoking considered as an individual risk factor of 94% for male coronary artery disease patients. Conclusion:The prevalence of CAD was higher in male 7.89 % than female 4.21% and its associated risk factors including hypertension and cigarette smoking. Bangladesh Journal of Medical Science Vol. 21(1) 2022 Page : 201-205

scholarly journals Silent coronary artery disease in type 2 diabetes: a narrative review on epidemiology, risk factors, and clinical studies

2021 ◽  
Author(s):  
Saula Vigili de Kreutzenberg
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Point Of View ◽  
Narrative Review ◽  
Silent Coronary Artery Disease ◽  
Artery Disease ◽  
Associated Risk Factors

Silent coronary artery disease (CAD) is one of the manifestations of heart disease that particularly affects subjects with type 2 diabetes mellitus (T2DM). From a clinical point of view, silent CAD represents a constant challenge for the diabetologist, who has to decide whether a patient could or could not be screened for this disease. In the present narrative review, several aspects of silent CAD are considered: the epidemiology of the disease, the associated risk factors, and main studies conducted, in the last 20 years, especially aimed to demonstrate the usefulness of the screening of silent CAD, to improve cardiovascular outcomes in type 2 diabetes.

Waist circumference in the assessment of obesity and associated risk factors in coronary artery disease patients

2000 ◽  
Vol 4 (4) ◽  
pp. 179-186 ◽  
Author(s):  
S. Carroll ◽  
C.B. Cooke ◽  
R.J. Butterly ◽  
J.W.D. Moxon ◽  
J.W.A. Moxon ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Waist Circumference ◽  
Artery Disease ◽  
Associated Risk Factors

scholarly journals Convergence of biomarkers and risk factor trait loci of coronary artery disease at 3p21.31 and HLA region

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Majid Nikpay ◽  
Ruth McPherson
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Protein Level ◽  
Human Leukocyte ◽  
Trait Loci ◽  
Artery Disease ◽  
Associated Risk Factors ◽  
The Impact ◽  
Cad Risk

AbstractHere we seek to identify molecular biomarkers that mediate the effect of risk factors on coronary artery disease (CAD). We perform a SNP-based multiomics data analysis to find biomarkers (probes) causally associated with the risk of CAD within known genomic loci for its risk factors. We identify 78 biomarkers, the majority (64%) of which are methylation probes. We detect the convergence of several CNS and lifestyle trait loci and their biomarkers at the 3p21.31 and human leukocyte antigen (HLA) regions. The 3p21.31 locus was the most populated region in the convergence of biomarkers and risk factors. In this region, we noted as the BSN gene becomes methylated the level of stomatin (STOM) in blood increases and this contributes to higher risk of CAD. In the HLA locus, we identify several methylation biomarkers associated with various CAD risk factors. SNPs in the CFB gene display a trans-regulatory impact on the GRIA4 protein level. A methylation site upstream of the APOE gene is associated with a higher protein level of S100A13 which in turn leads to higher LDL-C and greater CAD risk. We find UHRF1BP1 and ILRUN mediate the effect of obesity on CAD whereas methylation sites within NOS3 and CKM mediate the effect of their associated-risk factors on CAD. This study provides further insight into the biology of CAD and identifies a list of biomarkers that mediate the impact of risk factors on CAD. A SNP-based initiative can unite data from various fields of omics into a single network of knowledge.

scholarly journals Epidemiology of coronary artery disease and stroke and associated risk factors in Gaza community –Palestine

PLoS ONE ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. e0211131 ◽  
Author(s):  
Amal Jamee Shahwan ◽  
Yehia Abed ◽  
Ileana Desormais ◽  
Julien Magne ◽  
Pierre Marie Preux ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Artery Disease ◽  
Associated Risk Factors

scholarly journals The smoking-dyslipidaemia dyad: A potent synergistic risk for atherosclerotic coronary artery disease

2021 ◽  
Vol 10 ◽  
pp. 204800402098094
Author(s):  
Vineet Prakash ◽  
Sams Jaker ◽  
Amjad Burgan ◽  
Adam Jacques ◽  
David Fluck ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Reference Group ◽  
Mean Difference ◽  
Individual Risk ◽  
Vessel Disease ◽  
History Of ◽  
Artery Disease ◽  
Never Smokers

Background Smoking and dyslipidaemia are known individual risk factors of coronary artery disease (CAD). The present study examined the combined risk of smoking and dyslipidaemia on coronary atherosclerosis. Methods Coronary artery calcium (CAC), measured by cardiac CT, was used to assess the extent of CAD, which was related to smoking and dyslipidaemia using logistic regression, adjusted for age, sex, hypertension, BMI and family history of ischaemic heart disease. Results Seventy-one patients (46 men, 25 women: median age of 53.7yrs; IQR = 47.0–59.5) were recruited. The mean log10 CAC score in never-smokers without dyslipidaemia (reference group) was 0.37 (SD = 0.73), while the value in those with a history of smoking was 0.44 ± 0.48 (mean difference: 0.07, 95%CI:–0.67 to 0.81, p = 0.844), dyslipidaemia was 1.07 ± 1.08 (mean difference: 0.71, 95%CI: 0.24 to 1.17, p = 0.003), and both risk factors was 1.82 ± 0.64 (mean difference: 1.45, 95%CI:0.88 to 2.02, p < 0.001). For individuals in the reference group, the proportions with none, one and multiple vessel disease were 80.6%, 16.1% and 3.2%; for those with a history of smoking or with dyslipidaemia were 50.0%, 25.0% and 25.0%; and for those with both risk factors were 8.3%, 25.0% and 66.7%. Patients with a history of both risk factors had greater adjusted risks of having one- vessel disease - OR = 14.3 (95%CI = 2.1–98.2) or multiple vessel disease: OR = 51.8 (95%CI = 4.2–609.6). Conclusions Smoking and dyslipidaemia together are associated with high coronary artery calcification and CAD, independent of other major risk factors.

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