Antimicrobial Susceptibility Pattern of Bacterial Isolates from Patients with Chronic Suppurative Otitis Media

Background: Chronic suppurative otitis media (CSOM) is one of the common diseases of the middle ear especially in developing countries. Early and effective treatment based on the knowledge of causative micro-organisms and their antimicrobial sensitivity pattern ensures prompt clinical recovery and possible complications may be avoided. Objectives: This study was done to determine the pattern of bacterial isolates and to detect their antibiogram. Methods: A total of 103 patients clinically diagnosed of CSOM were enrolled in the study and the samples were obtained from each patient using sterile cotton swabs and cultured for bacterial isolates. Antimicrobial susceptibility test of the isolates were performed using Kirby- Bauer disc diffusion method. Results: Among the cases females were more affected than males. Out of the 103 cases, bacteriological investigation revealed that Pseudomonas aeruginosa 42 (44.68%) and Staphylococcus aureus 31(32.97%) were the predominant bacteria. Ciprofloxacin and Ceftazidime revealed high level of sensitivity whereas high resistance rates were observed for Amoxycillin, Gentamicin and Cephalexin. Conclusion: The study concluded that an appropriate knowledge of the etiological agents and antibacterial susceptibility of microorganisms would contribute to a rational use of antibiotics, success of treatment and reduce the complications of CSOM. Bangladesh J Otorhinolaryngol; October 2016; 22(2): 90-95.

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Antimicrobial susceptibility pattern of bacterial isolates in patients of chronic suppurative otitis media in a tertiary care hospital in India

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20184434 ◽

2018 ◽

Vol 6 (11) ◽

pp. 3705

Author(s):

R. K. Mahajan ◽

Saumya Agarwal ◽

Hishmi Jeram ◽

R. C. Vashishtha

Keyword(s):

Otitis Media ◽

Antimicrobial Susceptibility ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Chronic Suppurative Otitis Media ◽

Care Hospital ◽

Bacterial Isolates ◽

Susceptibility Pattern ◽

Suppurative Otitis Media ◽

Antimicrobial Susceptibility Pattern

Background: Chronic suppurative otitis media (CSOM) is a massive public health problem in developing countries like India, especially among low socio-economic class because of malnutrition, overcrowding, poor hygiene, inadequate health care and recurrent upper respiratory tract infections. CSOM cases unless managed effectively may land into various complications such as persistent otorrhoea, hearing impairment, mastoiditis, labyrinthitis, facial nerve paralysis to more serious intracranial abscesses.Methods: The study was carried out in a tertiary care hospital from January 2017 to December 2017 with an aim to determine the microbiological profile of ear discharge in patients suffering from CSOM and their antimicrobial susceptibility pattern using Kirby Bauer disc diffusion method.Results: Out of 630 samples processed, 407 (64.6%) samples were culture positive. Most common organism isolated was Pseudomonas spp. (43.2%) followed by S. aureus (39.1%). Most of isolates recovered were multidrug resistant.Conclusions: Management of CSOM consists mainly of eradicating infection and closure of tympanic membrane. Periodic monitoring of bacterial isolates and their antibiotic susceptibility pattern is necessary for administering appropriate antibiotics as empirical treatment and also helps in reducing the potentially disabling and fatal complications of CSOM.

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Bacteriological profile and their antibiotic susceptibility pattern in chronic suppurative otitis media (TTD) in a tertiary care hospital

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20192137 ◽

2019 ◽

Vol 5 (4) ◽

pp. 871

Author(s):

Sriram Govindaraj ◽

Jinu Vadakkanethu Iype ◽

Srinivasa V. ◽

Jayendiran S.

Keyword(s):

Otitis Media ◽

Antimicrobial Susceptibility ◽

Antibiotic Susceptibility ◽

Chronic Suppurative Otitis Media ◽

Care Hospital ◽

Bacterial Isolates ◽

Susceptibility Pattern ◽

Suppurative Otitis Media ◽

Antimicrobial Susceptibility Pattern ◽

The Common

Background: Chronic suppurative otitis media (CSOM) is one of the common infective conditions which can cause many complications if not treated properly. Improper use of antibiotic among the common population has led to many drug resistant organisms; therefore it is necessary to study the antimicrobial susceptibility pattern before treating the patient with CSOM. Aim of the study was to identify the bacterial isolates causing CSOM in tubo tympanic disease and to study their antimicrobial susceptibility pattern.Methods: The study was carried out in ENT department in Vinayaka Mission Medical College, Karaikal from July 2018 till December 2018 for six months. 60 patients of CSOM (TTD) with ear discharge attending the ENT Out Patient Department were included in the study. Swabs were collected for culture and sensitivity. Bacterial isolates were identified using standard methods and antibiotic susceptibility testing were done. Results: Pseudomonas species was the most predominant organism, which was seen in 19 patients (38%) followed by Escherichia coli (22%), Staphylococcus aureus (18%), Klebsiella species (10%).Conclusions: A continuous and periodic evaluation of microbiological pattern and their antibiotic sensitivity pattern prevalent in local area, helps in prescribe proper antibiotics for successful treatment of CSOM and thus minimizing its complications and emergence of resistant strains.

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PREVALENCE AND ANTIMICROBIAL SENSITIVITY PATTERN OF PSEUDOMONAS AERUGINOSA FROM CHRONIC SUPPURATIVE OTITIS MEDIA (CSOM) CASES IN A TERTIARY CARE HOSPITAL OF BIHAR

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2017/1086 ◽

2017 ◽

Vol 6 (70) ◽

pp. 5000-5003

Author(s):

Kumar Ajay ◽

Kumari Namrata ◽

Kumar Shailesh ◽

Kumar Rakesh ◽

Xess Anima ◽

...

Keyword(s):

Pseudomonas Aeruginosa ◽

Otitis Media ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Chronic Suppurative Otitis Media ◽

Care Hospital ◽

Suppurative Otitis Media ◽

Antimicrobial Sensitivity ◽

Sensitivity Pattern

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Bacterial Profile and Antimicrobial Susceptibility Pattern of Chronic Suppurative Otitis Media from a Tertiary Care Hospital in Kannauj, Uttar Pradesh, India

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2021/48334.14770 ◽

2021 ◽

Author(s):

Kiran Yadav ◽

Sandeep Kaushik ◽

Kumkum Rani ◽

Anuj Kumar Tyagi

Keyword(s):

Otitis Media ◽

Antimicrobial Susceptibility ◽

Tertiary Care ◽

Uttar Pradesh ◽

Tympanic Membrane Perforation ◽

Chronic Suppurative Otitis Media ◽

Care Hospital ◽

Susceptibility Pattern ◽

Suppurative Otitis Media ◽

Antimicrobial Susceptibility Pattern

Introduction: Chronic Suppurative Otitis Media (CSOM) is a chronic and persistent inflammation of the mucosal lining of middle ear cleft which presents with recurrent ear discharge through a tympanic membrane perforation. CSOM is a worldwide disease and has higher prevalence in developing countries causing serious local damage and threatening complications. Aim: To determine the profile of CSOM, its causative agents and their antibiotic susceptibility pattern. Materials and Methods: The present study was a retrospective study in which data for culture and antimicrobial susceptibility profile of CSOM cases was retrieved from Microbiology department of Government Medical College, Kannauj, Uttar Pradesh, India, from January 2019 to October 2019 the analysis of data was done in February 2020. Two hundred pus swabs from discharging ears were processed during the study period for aerobic bacterial culture and antimicrobial susceptibility pattern in Microbiology department using standard microbiological techniques. The result analysis of the study was expressed as percentage and proportion for distribution of CSOM cases. Results: Out of 200 patients, 114 (57%) were males and 86 (43%) females. Among the 200 cases, 147 (73.5%) cases showed growth and 53 (26.5%) showed no growth. The most common organism isolated in this study was Pseudomonas aeruginosa, 67 (42.40%) followed by Staphylococcus aureus.48 (30.37%) and Klebsiella spp. 23 (14.55%). Gentamicin (85%) and amikacin (83%) had high level of antibacterial activity on all the isolates. Meropenem was found to be most effective drug for gram negative isolates. All Staphylococcus spp isolates were sensitive to vancomycin (100%). Conclusion:Pseudomonas aeruginosa was the most predominant organism isolated in otitis media patients. Most of the isolates were sensitive to meropenem.

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Aerobic bacteriology of Chronic Suppurative Otitis Media (CSOM) in a tertiary care hospital: A retrospective study

Journal of College of Medical Sciences-Nepal ◽

10.3126/jcmsn.v7i2.6673 ◽

2012 ◽

Vol 7 (2) ◽

pp. 1-8 ◽

Cited By ~ 3

Author(s):

RK Sanjana ◽

YI Singh ◽

NS Reddy

Keyword(s):

Staphylococcus Aureus ◽

Pseudomonas Aeruginosa ◽

Otitis Media ◽

Tertiary Care ◽

Chronic Suppurative Otitis Media ◽

Diffusion Method ◽

National Committee ◽

Care Hospital ◽

Suppurative Otitis Media ◽

Sensitivity Pattern

The present study was carried out to determine the aerobic microorganisms involved and their antibiotic sensitivity pattern in patients with Chronic Suppurative Otitis Media (CSOM) and to provide a guideline for empirical antibiotic therapy.Between March 2009 to February 2011, the ear discharge samples submitted at the microbiology laboratory were processed aerobically and all the isolates were included in this study. All organisms were identified morphologically and biochemically by standard laboratory procedures and antibiotic susceptibility pattern was determined by modified Kirby Bauer disc diffusion method as per National Committee for Clinical Laboratory Standard recommendations.Out of a total of 214 samples, microbiological culture was yielded from 202 (94.3%) specimens. Single organism were isolated from 168 (78.5%) of the culture positive specimens, while the remaining 34 (15.9%) had two or more organisms isolated. Pseudomonas aeruginosa 59 (35.1%) was the most common isolate, followed by Staphylococcus aureus 42 (25.0%) including 5 (3%) of the Methicillin Resistant Staphylococcus Aureus (MRSA). Antibiotic sensitivities of Pseudomonas aeruginosa showed that 93.2% isolates were sensitive to tobramycin, whereas, 91.5% isolates were sensitive to ceftazidime and 77.9% to amikacin.Only 50.8% of the isolates of Pseudomonas aeruginosa were sensitive to ciprofloxacin and 25.4% to gentamicin. For Staphylococcus aureus (other than MRSA) 95.2% were sensitive to cloxacillin, 83.3% to gentamicin and 78.5% to erythromycin. Only 07.1% were sensitive to ampicillin and 26.1% to ciprofloxacin.Pseudomonas aeruginosa was the most common isolate followed by Staphylococcus aureus. More than 90% of Pseudomonas and 90% of Staph aureus were sensitive to tobramycin and cloxacillin respectively. Therefore, these two drugs may be included in the formulary to cover the most common aerobic isolates involved in CSOM.Journal of College of Medical Sciences-Nepal, 2011, Vol-7, No-2, 1-8DOI: http://dx.doi.org/10.3126/jcmsn.v7i2.6673

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Chronic Suppurative Otitis Media (CSOM): Etiological Agents and Antibiotic Sensitivity Pattern of the Isolates

Journal of Medicine ◽

10.3329/jom.v16i2.25431 ◽

2015 ◽

Vol 16 (2) ◽

pp. 79-82

Author(s):

Metri C Basavaraj ◽

P Jyothi

Keyword(s):

Otitis Media ◽

Antibiotic Susceptibility ◽

Clinical Laboratory ◽

Antibiotic Sensitivity ◽

Chronic Suppurative Otitis Media ◽

Diffusion Method ◽

Susceptibility Pattern ◽

Suppurative Otitis Media ◽

Sensitivity Pattern ◽

Microbiological Techniques

Introduction: Chronic suppurative otitis media (CSOM) remains one of the most common childhood chronic infectious diseases worldwide. It is recognized as an important cause of preventable hearing loss in the developing world. The present study was carried out to determine the etiological agent of CSOM and their antibiotic susceptibility pattern at the teaching hospital in North Karnataka.Methods: Samples were collected from patients in accordance with standard protocols. Organisms were identified by conventional microbiological techniques. Antibiotic susceptibility of the isolates was done by disc diffusion method according Clinical Laboratory Standards Institute (CLSI) guidelines.Results: A total of 159 patients were included in the study, out of which 53.5 % were males. Majority of the patients (85/159) were in the age group of 1-20 years. Pseudomonas was the most common organism causing CSOM, closely followed by Staphylococcus aureus. Pseudomonas were more sensitive to piperacilln-tazobactam (91%), followed by amikacin (80%). Among Staphylococcal isolates sensitivity was more to linezolid (93%), closely followed by piperacilln -tazobactam (88%). 73% of the Gram negative bacilli were sensitive to amikacin and 67% to gentamicinConclusion: Due to the easy availability and widespread use of antibiotics the susceptibility pattern of the pathogenic microorganisms are changing, therefore it is imperative to know the local susceptibility pattern of the causative agents, to treat the infection effectively.J MEDICINE July 2015; 16 (2) : 79-82

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Antimicrobial susceptibility pattern of pathogenic bacteria of Chronic Suppurative Otitis Media (CSOM) patients through culture and sensitivity in a tertiary level hospital in Khulna

Mediscope ◽

10.3329/mediscope.v7i1.47133 ◽

2020 ◽

Vol 7 (1) ◽

pp. 1-6

Author(s):

Mitun Kumar Paul ◽

Baishakhi Islam ◽

KM Reza Ul Haq

Keyword(s):

Otitis Media ◽

Antimicrobial Susceptibility ◽

Pathogenic Bacteria ◽

Chronic Suppurative Otitis Media ◽

Susceptibility Pattern ◽

College Hospital ◽

Suppurative Otitis Media ◽

Medical College ◽

Antimicrobial Susceptibility Pattern ◽

Culture And Sensitivity

Background: Chronic Suppurative Otitis Media (CSOM) is a chronic disease associated with irreversible consequences and serious intracranial and extracranial complications. Thereby early & effective treatment must be needed to avoid such complications. Objectives: This study was carried out to know antimicrobial susceptibility pattern of pathogenic bacteria through culture and sensitivity for better management and to reduce resistance & morbidity due to CSOM. Methods: After taking proper approval from hospital administration, this study was conducted on 82 patients of clinically diagnosed cases of both Tubo-tympanic & Attico-antral variety of CSOM attending ENT OPD of Gazi Medical College Hospital, Khulna from January 2018 to June 2018. After proper sample collection by sterile aural swabs, they were immediately sent to the microbiology laboratory of Gazi Medical College Hospital, Khulna for bacterial culture, isolation and identification. Routine antibacterial susceptibility was done as per CLSI guidelines. SPSS 18.0 was used for statistical analysis. Results: The commonest pathogens isolated were Staphylococci, Coagulase Negative Staphylococci (CONS), Pseudomonas aeruginosa, Klebsiella spp. & others; mostly showing susceptibility to high end antibiotics like Ceftriaxone and Amoxiclav for staphylococcal infection & piperacillin-tazobactum for Pseudomonal infection. Conclusion: Antibiotic sensitivity pattern determines the prevalent bacterial organism causing CSOM to start empirical treatment for a successful outcome, and thus to prevent the emergence of resistant strains. Mediscope Vol. 7, No. 1: Jan 2020, Page 1-6

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Chronic Suppurative Otitis Media (CSOM): Evaluation of fungal and aerobic bacterial agents and antibiotic sensitivity pattern of the bacterial isolates

IP International Journal of Medical Microbiology and Tropical Diseases ◽

10.18231/j.ijmmtd.2019.049 ◽

2020 ◽

Vol 5 (4) ◽

pp. 214-217

Author(s):

K Pavani ◽

◽

S Krishnamurthy ◽

Swetha K S ◽

Supriya P S ◽

...

Keyword(s):

Otitis Media ◽

Antibiotic Sensitivity ◽

Chronic Suppurative Otitis Media ◽

Bacterial Isolates ◽

Suppurative Otitis Media ◽

Sensitivity Pattern

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Evaluation of antimicrobial sensitivity pattern of chronic suppurative otitis media in a tertiary care hospital of West Bengal, India

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20171099 ◽

2017 ◽

Vol 6 (4) ◽

pp. 891

Author(s):

Shirsendu Mondal ◽

Manasi Banerjee ◽

Sudip Das

Keyword(s):

Staphylococcus Aureus ◽

Otitis Media ◽

West Bengal ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Chronic Suppurative Otitis Media ◽

Care Hospital ◽

Suppurative Otitis Media ◽

Antimicrobial Sensitivity ◽

Sensitivity Pattern

Background: Chronic suppurative otitis media is a common infectious disease in our country. The micro-organisms commonly causing the disease and their antibiotic sensitivity pattern is important for treatment. This study was conducted to evaluate the antimicrobial sensitivity pattern of the common microorganisms in patients with chronic suppurative otitis media in our tertiary care hospital.Methods: The study was carried out from July 2013 to December 2013 at the ENT out-patient department of a tertiary care hospital in West Bengal. 100 patients aged 18 to 60 years of either sex, with unilateral or bilateral active chronic suppurative otitis media attending the out- patient clinic were included in the study. Pus samples were collected from the discharging ears and sent for isolating the organisms and susceptibility testing.Results: A total number of 108 ear swabs were collected from the 100 recruited patients of which 15 (13.88%) were sterile and 93 (86.11%) showed presence of organisms. Pseudomonas aeruginosa 41(38%) was the commonest organism isolated, followed by Staphylococcus aureus 25(23.15%). The antimicrobial profile of the microorganisms reveals maximum sensitivity of the isolated organisms to piperacillin and levofloxacin.Conclusions: In our study, Pseudomonas aeruginosa (38%) and Staphylococcus aureus (23.15%) are the major pathogens involved in the etiology of CSOM. The isolates showed maximum sensitivity to piperacillin (41%) and levofloxacin (41%). As piperacillin is available only in parenteral form and is also costly, topical levofloxacin can be recommended in empirical treatment of CSOM.

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A prospective study on pattern of microbes in chronic suppurative otitis media

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20210165 ◽

2021 ◽

Vol 7 (2) ◽

pp. 331

Author(s):

Ajaz U. Haq ◽

Rishabh Dogra ◽

Kanika Arora ◽

Fatma Anjum

Keyword(s):

Otitis Media ◽

Antibiotic Sensitivity ◽

Local Area ◽

Multidrug Resistant ◽

Maximum Activity ◽

Chronic Suppurative Otitis Media ◽

Suppurative Otitis Media ◽

Microbial Profile ◽

Antimicrobial Sensitivity ◽

Sensitivity Pattern

Background: Chronic suppurative otitis media (CSOM) is a common chronic ear disease causing serious local damage and complications. Irrational use of antibiotics for its management has led to the emergence of multidrug-resistant strains. This study was conducted to find out the microbial profile and their antimicrobial sensitivity patterns in CSOM patients in Garhwal belt.Methods: A total number of 100 patients of clinically diagnosed CSOM were enrolled over the duration of 1 year. Ear discharge was collected using sterile swabs and processed for the identification of aerobes, anaerobes and fungal isolates. Antimicrobial susceptibility testing of the isolates was performed. Results: Maximum incidence of CSOM was observed in patients of 10–20 years age group with female preponderance. Decreased hearing was the main associated symptom. Out of 100 swabs, microbial growth was obtained in 88 samples amongst which 61 had monomicrobial growth while 39 had polymicrobial growth. Pseudomonas aeruginosa was the most common isolate. Amikacin showed maximum activity to most of the isolates.Conclusions: Evaluation of microbes and their antibiotic sensitivity pattern in local area becomes helpful in prescribing empirical treatment for successful cure of CSOM.

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