scholarly journals Lupus Vulgaris: A Rare Case of Cutaneous Tuberculosis

2014 ◽  
Vol 41 (2) ◽  
pp. 57-58
Author(s):  
MA Chowdhury ◽  
TK Sikdar
Keyword(s):  
Medical Journal ◽  
Rare Case ◽  
Giant Cells ◽  
Multinucleated Giant Cells ◽  
Lupus Vulgaris ◽  
Cutaneous Tuberculosis ◽  
Histological Sections ◽  
Epithelioid Granuloma ◽  
Affected Tissue ◽  
Anti Tubercular Therapy

Lupus vulgaris is an extremely chronic, progressive form of cutaneous tuberculosis. The earliest description of lupus vulgaris was given by Erasmus Wilson in 1865. It usually occurs through contagious extension of the disease from underlying affected tissue or hematogenous or lymphatic spread. A 55 years male, non diabetic, non hypertensive, non smoker, got himself admitted into Dermatology and Venereology Department of DMCH with the complaints of multiple ulcerated lesions over the left lower thigh and upper leg including knee for 8 years. Histological sections of skin revealed multiple epithelioid granuloma, multinucleated giant cells and infiltration of lymphocytes with areas of fibrosis and ESR was 80 in 1st hour. The patient was treated with anti tubercular therapy and cured completely. DOI: http://dx.doi.org/10.3329/bmj.v41i2.18811 Bangladesh Medical Journal 2012 Vol. 41 No. 2: 57-58

scholarly journals Lupus vulgaris mimicking cutaneous leishmaniasis: A case report

2022 ◽  
Vol 13 (1) ◽  
pp. 53-56
Author(s):  
Nouf Faihan Bin Rubaian ◽  
Haya Fahad Alzamami ◽  
Gadah Abdulatif Alhosawi ◽  
Leena Abdulrahman Almuhaish
Keyword(s):  
Delayed Diagnosis ◽  
Punch Biopsy ◽  
Lupus Vulgaris ◽  
Cutaneous Tuberculosis ◽  
Dorsal Aspect ◽  
Skin Punch Biopsy ◽  
Diagnostic Difficulties ◽  
Anti Tubercular Therapy ◽  
The Right ◽  
Saudi Male

Lupus vulgaris (LV) is a progressive, chronic form of cutaneous tuberculosis (CTB). The head and neck regions are the most commonly affected sites, followed by the arms and legs. Occurring in unusual sites may pose diagnostic difficulties. Herein, we report a case of LV present on the dorsal aspect of the right hand in a twenty-year-old Saudi male. It was misdiagnosed as leishmaniasis as the patient lived in an area in which it was endemic, and was treated accordingly with no benefit. A skin punch biopsy was taken and the diagnosis of LV was confirmed. The lesion responded well to anti-tubercular therapy (ATT), yet healed with atrophic scarring. Although rare, clinicians must be aware of the importance of considering CTB as an important differential, as misdiagnosis or delayed diagnosis of this entity may eventually cause prolonged morbidity.

Pleomorphic Carcinoma of the Gallbladder: Report of a Case

1991 ◽  
Vol 77 (6) ◽  
pp. 523-526 ◽  
Author(s):  
Rosario A. Caruso ◽  
Ciro Familiari ◽  
Giuseppe Giuffré ◽  
Giovanni Mazzeo
Keyword(s):  
Tumor Cell ◽  
Rare Case ◽  
Epithelial Membrane Antigen ◽  
Giant Cells ◽  
Pleomorphic Carcinoma ◽  
Multinucleated Giant Cells ◽  
General Lack ◽  
Carcinoma Of The Gallbladder ◽  
Extensive Necrosis ◽  
Polypoid Tumor

The authors report a rare case of primary pleomorphic carcinoma of the gallbladder in a 70-year-old woman. A polypoid tumor protruded into the lumen from the fundus of the gallbladder. Characteristic histologic findings Included a general lack of architectural cohesiveness, marked pleomorphism, presence of mononucleated and multinucleated giant cells, extensive necrosis, leukocyte-tumor cell phagocytosis or cannibalism. Immunoreactivity for cytokeratin, carclnoembryonic antigen and epithelial membrane antigen as well as histochemical positivity for mucins demonstrated the epithelial nature of the tumor. The neoplasm behaved aggressively; the patient died of metastases 9 months after the operation.

scholarly journals A Rare Case of Lateral Canthal Gouty Tophus Presenting as an Eyelid Mass

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Austin S. Nakatsuka ◽  
Timothy F. McDevitt ◽  
Pamela S. Tauchi-Nishi
Keyword(s):  
Clinical Examination ◽  
Rare Case ◽  
Histopathological Examination ◽  
Giant Cells ◽  
Crystalline Material ◽  
Multinucleated Giant Cells ◽  
Lateral Canthus ◽  
History Of ◽  
Gouty Tophus

A 41-year-old man with a history of gout presented with an enlarging eyelid growth. Clinical examination revealed a mildly indurated nodule at the lateral canthus. Following resection, histopathological examination revealed needle-shaped, crystalline material surrounded by multinucleated giant cells, findings consistent with gouty tophus. This represents just the sixth case of gouty tophus of the eyelid reported in the literature.

scholarly journals Clinicohistological Profile of Cutaneous Tuberculosis in Central Nepal

2015 ◽  
Vol 12 (4) ◽  
pp. 238-241 ◽  
Author(s):  
M Mathur ◽  
SN Pandey
Keyword(s):  
Giant Cells ◽  
Medical Sciences ◽  
Lupus Vulgaris ◽  
Internal Organs ◽  
Female Ratio ◽  
Cutaneous Tuberculosis ◽  
The Past ◽  
Central Nepal ◽  
Type Giant ◽  
Male To Female

Background There are few studies on cutaneous tuberculosis in Nepal.Objective To analyse the epidemiological, clinical and histological patterns of cutaneous TB over the past 5 years.Method Patients with cutaneous tuberculosis diagnosed from January 2010 to December 2014 at College of Medical Sciences, Chitwan, Nepal were included in the study. Chest radiography, routine investigations and screening for HIV was performed in all cases.Result A total of 47 clinical cases of cutaneous tuberculosis were diagnosed. The most commonly affected age group was 41-50 years. Male to female ratio was 1.5:1. Duration of cutaneous tuberculosis ranged from 1 month to 33 years. Lupus vulgaris was the most common clinical type (64%), followed by tuberculosis verrucosa cutis (19%). Two cases (4%) were diagnosed as papulonecrotic tuberculid. Overall, the most common site of involvement was extremities (55%) followed by head and neck, trunk, and perianal region. Histopathologic features of epitheloid cell granuloma with Langhans type giant cells were seen in 89% of cases, and in remaining 11% cases, chronic inflammatory dermatitis and nonspecific chronic dermatitis were observed.Conclusion M Tuberculosis is endemic in Nepal and the incidence of cutaneous tuberculosis at our centre was 0.1%. Lupus vulgaris was the most common type followed by tuberculosis verrucosa cutis in our study. Cutaneous tuberculosis can be accompanied by tuberculosis in internal organs and hence should be looked for. Clinicopathologic correlation is necessary to make a proper diagnosis.Kathmandu University Medical Journal Vol.12(4) 2014; 238-241

scholarly journals LUPUS VULGARIS DENGAN LESI DISEMINATA

2015 ◽  
Vol 7 (3) ◽  
Author(s):  
Nana N. Jayadi ◽  
Niken Ernaningtyas ◽  
Nurdjannah J. Niode ◽  
Marthen C. P. Wongkar
Keyword(s):  
Wound Care ◽  
Giant Cells ◽  
Lupus Vulgaris ◽  
Open Wound ◽  
Cutaneous Tuberculosis ◽  
Left Neck ◽  
The Face ◽  
Night Sweats ◽  
History Of ◽  
Erythematous Plaques

Abstract: Lupus vulgaris (LV) is a chronic progressive form of paucibacillary cutaneous tuberculosis. Lesion is usually solitary in the form of nodes or erythematous plaques with an apple-jelly sign on diascopy. Disseminated LV is a rare form of cutanoeus tuberculosis with multiple lesions in several body areas. We reported a male of 40 years old with a suppurative wound on the left neck and reddish nodules on the face, neck, trunk, and limbs along with fever, night sweats, weight loss, and history of previous TB infections. There were multiple erythematous nodules and painful suppurating ulcers with enlargement of several lymph nodes. Apple-jelly sign appeared on diascopy. The FNAB showed specific granulamatous inflammation for TB with lymphocytes, epitheloid macrophages, and multinucleated giant cells. The histopathological finding showed tubercles surrounded by macrophages and lymphocytes. Anti-tuberculosis drugs category I were given for 6 months, ofloxacin, and open wound care compressed with NaCl 0.9%. In the third month of observation, there was significant improvement. Conclusion: This case was diagnosed as lupus vulgaris based on the history of lymphadenitis TB and scrofuloderma, lesions in several body area with positive diascopy test, the FNAB as well as the histopathologic result supporting the diagnosis of tuberculosis, and there was significant improvement after treatment with antiTB drugs.Keywords: lupus vulgaris, diseminata, tuberculosis, ofloksasinAbstrak: Lupus vulgaris (LV) merupakan tuberkulosis (TB) kutis pausibasiler kronis dan progresif. Lesi biasanya soliter, berupa nodus atau plak eritematosa dengan gambaran apple-jelly pada diaskopi. Lupus vulgaris diseminata merupakan bentuk TB kutis yang jarang ditemukan dengan lesi multipel pada beberapa area tubuh secara bersamaan. Kami melaporkan seorang laki-laki, 40 tahun, dengan luka bernanah pada leher kiri dan benjolan-benjolan kemerahan pada wajah, leher, badan, dan tungkai disertai demam, keringat malam, penurunan berat badan dan riwayat infeksi tuberkulosis sebelumnya. Pada pemeriksaan fisik tampak nodus eritematosa multipel disertai ulkus bernanah dan pembesaran beberapa kelenjar getah bening. Gambaran apple-jelly tampak pada diaskopi. Pemeriksaan FNAB menunjukkan gambaran radang granulomatik spesifik TB dengan adanya sel-sel radang limfosit, kelompok makrofag epiteloid, dan sel-sel datia Langhans. Pemeriksaan histopatologis memberikan gambaran tuberkel yang dikelilingi oleh makrofag dan limfosit. Terapi diberikan berupa OAT kategori I selama 6 bulan, ofloksasin, dan kompres terbuka dengan NaCL 0,9%. Pada bulan ketiga tampak perbaikan signifikan. Simpulan: Pada kasus ini, diagnosis lupus vulgaris ditegakkan berdasarkan adanya riwayat limfadenitis TB dan skrofuloderma, lesi di beberapa area tubuh sekaligus dengan pemeriksaan diaskopi positif, gambaran FNAB dan histopatologis menunjang diagnosis TB, dan pengobatan dengan OAT memberikan perbaikan bermakna.Kata kunci: lupus vulgaris, diseminata, OAT, ofloksasin

scholarly journals Cholesterotic Fibrous Histiocytoma in a Patient with Metabolic Syndrome

2017 ◽  
Vol 9 (2) ◽  
pp. 136-140 ◽  
Author(s):  
Masatoshi Deguchi ◽  
Setsuya Aiba
Keyword(s):  
Metabolic Syndrome ◽  
Skin Biopsy ◽  
Male Patient ◽  
Rare Case ◽  
Fibrous Histiocytoma ◽  
Giant Cells ◽  
Lower Leg ◽  
Multinucleated Giant Cells ◽  
First Report ◽  
The Many

Among the many variants of dermatofibroma, dermatofibroma with cholesterol cleft (cholesterotic fibrous histiocytoma) is extremely rare. Here, we describe the case of a 50-year-old male patient with a cholesterotic fibrous histiocytoma on his left lower leg. He presented with a hyperkeratotic nodule 6 mm in diameter with a brown surface on the extensor surface of his left lower leg. The lesion had developed over the course of a few years without any tendency to heal. A skin biopsy performed on the tumor showed histopathological findings compatible with those of dermatofibroma. Interestingly, the lesion included many cholesterol clefts, as well as foamy histiocytes and multinucleated giant cells around them. He had had metabolic syndrome for years. To the best of our knowledge, this is the first report of a cholesterotic fibrous histiocytoma in a patient with metabolic syndrome. We conclude that the altered microenvironment caused by metabolic syndrome, as well as hyperlipoproteinemia itself, may play a role in the pathogenesis of this rare case.

scholarly journals A Case of Granulomatosis with Polyangiitis (Wegener’s Granulomatosis) Presenting with Marked Inflamed Tracheobronchial Mucosa

2013 ◽  
Vol 2013 ◽  
pp. 1-5
Author(s):  
Teruaki Nishiuma ◽  
Hisashi Ohnishi ◽  
Sho Yoshimura ◽  
Saori Kinami ◽  
Susumu Sakamoto
Keyword(s):  
Weight Loss ◽  
Wegener’S Granulomatosis ◽  
Rare Case ◽  
Granulomatosis With Polyangiitis ◽  
Giant Cells ◽  
Wegener's Granulomatosis ◽  
Transbronchial Biopsy ◽  
Multinucleated Giant Cells ◽  
Diffuse Erythema ◽  
Localized Form

A 70-year-old man was admitted to our hospital because of weight loss and persistent dry cough. Chest radiograph and CT showed multiple infiltrates in the bilateral upper lobes and the remarkably thickened bronchial walls. Bronchoscopy revealed diffuse erythema and edema of the tracheobronchial mucosa without any ulcerous legions. Serum MPO-ANCA was positive (155 EU). Transbronchial biopsy was performed and revealed necrotic granulomas with multinucleated giant cells in the bronchial/bronchiolar and parenchymal lesions. Thus, we diagnosed it as a localized form of granulomatosis with polyangiitis (GPA, Wegener’s granulomatosis). After treatment with corticosteroid and cyclophosphamide, the bronchial findings were entirely resolved. We report here a rare case of GPA presenting with markedly inflamed tracheobronchial mucosa.

Spontaneous Osteosarcoma in a Rabbit (Oryctolagus cuniculus)

2007 ◽  
Vol 44 (5) ◽  
pp. 691-694 ◽  
Author(s):  
H. Kondo ◽  
M. Ishikawa ◽  
H. Maeda ◽  
M. Onuma ◽  
M. Masuda ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Case Report ◽  
Oryctolagus Cuniculus ◽  
Rare Case ◽  
Giant Cells ◽  
Helical Computed Tomography ◽  
Multinucleated Giant Cells ◽  
Computed Tomography Images ◽  
Rare Case Report ◽  
The Right

A 6-year-old male cross-breed rabbit ( Oryctolagus cuniculus) was presented with lameness and severe swelling from the right shoulder to brachium. On 16-detector helical computed tomography images of the amputated right forelimb after being fixed in formalin, evident proliferative and destructive lesions of bone were observed. On histologic examination, the tumor was composed of proliferating neoplastic cells that resembled histiocytes, with abundant osteoid production. A large number of multinucleated giant cells were found throughout. This case was diagnosed as osteosarcoma by clinical, radiographic, and histologic findings. This is a rare case report of osteosarcoma in a rabbit consistent with canine predilection sites.

scholarly journals Disseminated Cutaneous Tuberculosis like Fungal Sporotrichosis Successfully Treated With Terbinafine: A Rare Case Report

2021 ◽  
Vol 1 (1) ◽  
pp. 69-72
Author(s):  
Anil Gautam ◽  
Bijay Subedi ◽  
Janak Awasthi ◽  
Suman Adhikari
Keyword(s):  
Case Report ◽  
Cutaneous Leishmaniasis ◽  
Adult Male ◽  
Rare Case ◽  
Lupus Vulgaris ◽  
Diagnostic Dilemma ◽  
Cutaneous Tuberculosis ◽  
Rare Case Report ◽  
Old Adult ◽  
Skin Tuberculosis

Occurrence of Sporotrichosis is uncommon in Nepal. Here, we describe a case of cutaneous Sporotrichosis of 43 years old adult male working as a farmer from Pokhara-30, Nepal with unusual skin tuberculosis like presentation since 3 years, initiating from the unusual location in right pinna. Histopathological observation was suggestive of cutaneous tuberculosis, lupus vulgaris, cutaneous leishmaniasis due to overlapping findings during biopsy. The case was diagnosed by the pharma­cological intervention observing the effect of drugs i.e., terbinafine. The purpose of reporting this serendipitous case is to enhance timely diagnosis, avoid the diagnostic dilemma for future references.

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