Pleomorphic Carcinoma of the Gallbladder: Report of a Case

The authors report a rare case of primary pleomorphic carcinoma of the gallbladder in a 70-year-old woman. A polypoid tumor protruded into the lumen from the fundus of the gallbladder. Characteristic histologic findings Included a general lack of architectural cohesiveness, marked pleomorphism, presence of mononucleated and multinucleated giant cells, extensive necrosis, leukocyte-tumor cell phagocytosis or cannibalism. Immunoreactivity for cytokeratin, carclnoembryonic antigen and epithelial membrane antigen as well as histochemical positivity for mucins demonstrated the epithelial nature of the tumor. The neoplasm behaved aggressively; the patient died of metastases 9 months after the operation.

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Lupus Vulgaris: A Rare Case of Cutaneous Tuberculosis

Bangladesh Medical Journal ◽

10.3329/bmj.v41i2.18811 ◽

2014 ◽

Vol 41 (2) ◽

pp. 57-58

Author(s):

MA Chowdhury ◽

TK Sikdar

Keyword(s):

Medical Journal ◽

Rare Case ◽

Giant Cells ◽

Multinucleated Giant Cells ◽

Lupus Vulgaris ◽

Cutaneous Tuberculosis ◽

Histological Sections ◽

Epithelioid Granuloma ◽

Affected Tissue ◽

Anti Tubercular Therapy

Lupus vulgaris is an extremely chronic, progressive form of cutaneous tuberculosis. The earliest description of lupus vulgaris was given by Erasmus Wilson in 1865. It usually occurs through contagious extension of the disease from underlying affected tissue or hematogenous or lymphatic spread. A 55 years male, non diabetic, non hypertensive, non smoker, got himself admitted into Dermatology and Venereology Department of DMCH with the complaints of multiple ulcerated lesions over the left lower thigh and upper leg including knee for 8 years. Histological sections of skin revealed multiple epithelioid granuloma, multinucleated giant cells and infiltration of lymphocytes with areas of fibrosis and ESR was 80 in 1st hour. The patient was treated with anti tubercular therapy and cured completely. DOI: http://dx.doi.org/10.3329/bmj.v41i2.18811 Bangladesh Medical Journal 2012 Vol. 41 No. 2: 57-58

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A Rare Case of Lateral Canthal Gouty Tophus Presenting as an Eyelid Mass

Case Reports in Ophthalmological Medicine ◽

10.1155/2016/9786810 ◽

2016 ◽

Vol 2016 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Austin S. Nakatsuka ◽

Timothy F. McDevitt ◽

Pamela S. Tauchi-Nishi

Keyword(s):

Clinical Examination ◽

Rare Case ◽

Histopathological Examination ◽

Giant Cells ◽

Crystalline Material ◽

Multinucleated Giant Cells ◽

Lateral Canthus ◽

History Of ◽

Gouty Tophus

A 41-year-old man with a history of gout presented with an enlarging eyelid growth. Clinical examination revealed a mildly indurated nodule at the lateral canthus. Following resection, histopathological examination revealed needle-shaped, crystalline material surrounded by multinucleated giant cells, findings consistent with gouty tophus. This represents just the sixth case of gouty tophus of the eyelid reported in the literature.

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Cholesterotic Fibrous Histiocytoma in a Patient with Metabolic Syndrome

Case Reports in Dermatology ◽

10.1159/000478923 ◽

2017 ◽

Vol 9 (2) ◽

pp. 136-140 ◽

Cited By ~ 2

Author(s):

Masatoshi Deguchi ◽

Setsuya Aiba

Keyword(s):

Metabolic Syndrome ◽

Skin Biopsy ◽

Male Patient ◽

Rare Case ◽

Fibrous Histiocytoma ◽

Giant Cells ◽

Lower Leg ◽

Multinucleated Giant Cells ◽

First Report ◽

The Many

Among the many variants of dermatofibroma, dermatofibroma with cholesterol cleft (cholesterotic fibrous histiocytoma) is extremely rare. Here, we describe the case of a 50-year-old male patient with a cholesterotic fibrous histiocytoma on his left lower leg. He presented with a hyperkeratotic nodule 6 mm in diameter with a brown surface on the extensor surface of his left lower leg. The lesion had developed over the course of a few years without any tendency to heal. A skin biopsy performed on the tumor showed histopathological findings compatible with those of dermatofibroma. Interestingly, the lesion included many cholesterol clefts, as well as foamy histiocytes and multinucleated giant cells around them. He had had metabolic syndrome for years. To the best of our knowledge, this is the first report of a cholesterotic fibrous histiocytoma in a patient with metabolic syndrome. We conclude that the altered microenvironment caused by metabolic syndrome, as well as hyperlipoproteinemia itself, may play a role in the pathogenesis of this rare case.

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A Case of Granulomatosis with Polyangiitis (Wegener’s Granulomatosis) Presenting with Marked Inflamed Tracheobronchial Mucosa

Case Reports in Medicine ◽

10.1155/2013/208194 ◽

2013 ◽

Vol 2013 ◽

pp. 1-5

Author(s):

Teruaki Nishiuma ◽

Hisashi Ohnishi ◽

Sho Yoshimura ◽

Saori Kinami ◽

Susumu Sakamoto

Keyword(s):

Weight Loss ◽

Wegener’S Granulomatosis ◽

Rare Case ◽

Granulomatosis With Polyangiitis ◽

Giant Cells ◽

Wegener's Granulomatosis ◽

Transbronchial Biopsy ◽

Multinucleated Giant Cells ◽

Diffuse Erythema ◽

Localized Form

A 70-year-old man was admitted to our hospital because of weight loss and persistent dry cough. Chest radiograph and CT showed multiple infiltrates in the bilateral upper lobes and the remarkably thickened bronchial walls. Bronchoscopy revealed diffuse erythema and edema of the tracheobronchial mucosa without any ulcerous legions. Serum MPO-ANCA was positive (155 EU). Transbronchial biopsy was performed and revealed necrotic granulomas with multinucleated giant cells in the bronchial/bronchiolar and parenchymal lesions. Thus, we diagnosed it as a localized form of granulomatosis with polyangiitis (GPA, Wegener’s granulomatosis). After treatment with corticosteroid and cyclophosphamide, the bronchial findings were entirely resolved. We report here a rare case of GPA presenting with markedly inflamed tracheobronchial mucosa.

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Spontaneous Osteosarcoma in a Rabbit (Oryctolagus cuniculus)

Veterinary Pathology ◽

10.1354/vp.44-5-691 ◽

2007 ◽

Vol 44 (5) ◽

pp. 691-694 ◽

Cited By ~ 16

Author(s):

H. Kondo ◽

M. Ishikawa ◽

H. Maeda ◽

M. Onuma ◽

M. Masuda ◽

...

Keyword(s):

Computed Tomography ◽

Case Report ◽

Oryctolagus Cuniculus ◽

Rare Case ◽

Giant Cells ◽

Helical Computed Tomography ◽

Multinucleated Giant Cells ◽

Computed Tomography Images ◽

Rare Case Report ◽

The Right

A 6-year-old male cross-breed rabbit ( Oryctolagus cuniculus) was presented with lameness and severe swelling from the right shoulder to brachium. On 16-detector helical computed tomography images of the amputated right forelimb after being fixed in formalin, evident proliferative and destructive lesions of bone were observed. On histologic examination, the tumor was composed of proliferating neoplastic cells that resembled histiocytes, with abundant osteoid production. A large number of multinucleated giant cells were found throughout. This case was diagnosed as osteosarcoma by clinical, radiographic, and histologic findings. This is a rare case report of osteosarcoma in a rabbit consistent with canine predilection sites.

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Cell cycle regulatory protein expression in multinucleated giant cells: Do they proliferate?

10.26226/morressier.596dfd5bd462b80292387f76 ◽

2017 ◽

Author(s):

Tibor Krenacs

Keyword(s):

Cell Cycle ◽

Protein Expression ◽

Regulatory Protein ◽

Giant Cells ◽

Multinucleated Giant Cells ◽

Cell Cycle Regulatory Protein

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Three cases of breast carcinoma with osteoclastic multinucleated giant cells: Clinicopathological and imunohistochemical study of osteoclastic multinucleated giant cells

10.26226/morressier.596cd2b7d462b80292386fb3 ◽

2017 ◽

Author(s):

Robert Ondrussek

Keyword(s):

Breast Carcinoma ◽

Giant Cells ◽

Multinucleated Giant Cells

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CLINICAL AND MORPHOLOGICAL CORRELATIONS AND HISTOPATHOLOGY OF JOINT DAMAGE IN PATIENTS WITH DIFFUSE-TYPE TENOSYNOVIAL GIANT CELL TUMOR

Wiadomości Lekarskie ◽

10.36740/wlek201912102 ◽

2019 ◽

Vol 72 (12) ◽

Author(s):

Olena O Dyadyk ◽

Anastasiia Hryhorovska

Keyword(s):

Giant Cell Tumor ◽

Giant Cell ◽

Cell Size ◽

Giant Cells ◽

Cell Tumor ◽

Multinucleated Giant Cells ◽

Diffuse Type ◽

Association Coefficient ◽

Mean Values ◽

Tenosynovial Giant Cell Tumor

Introduction: Tenosynovial giant cell tumor (TSGCT) (synonym – pigmented villonodular synovitis) – is a rare benign proliferative lesion of the synovial sheath, localized in the joint capsule, bursa or tendon sheath and characterized by locally destructive growth. Depending on the prevalence within the joint elements, the presence of a capsule around the tumor, histophotographic features of cell structure and clinical behavior TSGCT can be divided to localized or diffuse type. The aim of the study was researching of histopathological properties of diffuse-type TSGCT, determine the parameters its morphological indicators and to find out the correlation between these morphological and clinical parameters. Materials and methods: The research material was used biopsy (resect) of pathological lesions from 50 patients who were diagnosed and histologically verified diffuse-type TSGCT. Microscopic examinations of the stained sections and their photo archiving were carried out with use of a Olympus-CX 41 light optical microscope. Group measurable parameters (mean values and Pearson tetrachoric index (association coefficient) were calculated in groups of comparison for morphological and clinical indices of TSGCT. The mean values were compared by Student’s test, P value of ≤0.1 was considered statistically significant. Results:Correlation analysis of indicators that accounted for the pairs of cases «clinic – morphology» revealed the relationships, that had the highest parameters of the association coefficient between such indicators: «presence of villous growths» - «severity of hemosiderosis» (if hypertrophied synovial villi available, with vascular injection and pronounced proliferation of synovial cells, there is also a significant accumulation of hemosiderin pigment); «presence of villous growths» - «type of predominant cellular proliferates» (if cells of TSGCT diffuse type consists of monotonous sheets of stromal cells, with uniform, oval to reniform nuclei, the proliferation of villi in synovial layer is non-distinctive); «presence of nodes» - «kind of stroma» (if nodes predominate, their histological structure is mainly represented by polymorphic clusters of synovitis cells in the form of cells, strands, chains, solid formations, among immature connective tissue with low hyalinosis); «cell size (area, cm²)» - «severity of haemosiderosis» and «cell size (area, cm²)» - «the number of multinucleated giant cells» (there is a pronounced deposition of pigment and accumulation of osteoclast-like multinucleated giant cells type, although usually their number is relatively small compared to the localized type of TSGCT). Conclusions: Morphological parameters, that we have identified, characterize pathological changes in the tissues of TSGCT; careful analysis of the frequency of their occurrence in the different comparison groups made it possible to establish intergroup differences and correlations between individual indicators, which were previously unknown or not obvious. Our study was determine to analyze of incidence rates and correlation relationships, revealed some previously unknown differences and dependencies that are important for understanding the pathogenesis, improvement of diagnosis and prognosis of diffuse-type TSGCT.

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Kaposiform Hemangioendothelioma: clinicopathological characteristics of 8 cases of a rare vascular tumor and review of literature

Diagnostic Pathology ◽

10.1186/s13000-021-01080-9 ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Qurratulain Chundriger ◽

Muhammad Usman Tariq ◽

Jamshid Abdul-Ghafar ◽

Arsalan Ahmed ◽

Nasir Ud Din

Keyword(s):

Pediatric Population ◽

Adult Population ◽

Correct Diagnosis ◽

Kaposi Sarcoma ◽

Minor Component ◽

Vascular Tumor ◽

Giant Cells ◽

Clinicopathological Characteristics ◽

Multinucleated Giant Cells ◽

Kaposiform Hemangioendothelioma

Abstract Background Kaposiform Hemangioendothelioma (KHE) is a rare vascular tumor of intermediate malignant potential which shows locally aggressive growth but only rarely metastasizes. It is mostly considered to be a tumor of pediatric population but its occurrence in the adults is not uncommon as once considered. Histologically, KHE can mimic other soft tissue neoplasms of different behaviors (e.g. Kaposi Sarcoma, hemangioma) and establishing the correct diagnosis is important for appropriate treatment. Herein, we describe the clinicopathological features of 8 cases of KHE which will be helpful in making their diagnosis. Methods We reviewed pathology reports, microscopy glass slides and obtained follow up information about 8 cases of KHE which were diagnosed at our institution from January 2008 till June 2020. Immunohistochemical stain for HHV8 was also performed. Results Age ranged from 7 months to 25 years. Seven patients were less than 20 years of age and one patient was 25 years old. Equal gender distribution was observed. Extremities were the most common sites of involvement, followed by head and neck, pancreas and ischiorectal region. 2 cases were resection specimen and all others were incisional biopsies. The largest tumor size was 5.5 cm in one of the resections. The incisional/fragmented tissues were all less than 5 cm in aggregate. Most cases showed predominance of nodular growth and a minor component of spindle cell population along with lymphangiomatosis like vascular channels, with evidence of microthrombi in 2 cases. Few multinucleated giant cells were observed in 2 cases. None of the cases exhibited significant nuclear atypia or mitotic activity. One of the cases arising in dermis showed underlying bone involvement. HHV8 was negative in 7/7 cases. Conclusions KHE can also involve adult population and it should always be considered in the differential diagnoses of a vascular lesion. Presence of multinucleated giant cells is a rare finding. Knowledge about histological features and potential mimics is helpful in avoiding misdiagnosis.

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