scholarly journals Cholesterotic Fibrous Histiocytoma in a Patient with Metabolic Syndrome

2017 ◽  
Vol 9 (2) ◽  
pp. 136-140 ◽  
Author(s):  
Masatoshi Deguchi ◽  
Setsuya Aiba
Keyword(s):  
Metabolic Syndrome ◽  
Skin Biopsy ◽  
Male Patient ◽  
Rare Case ◽  
Fibrous Histiocytoma ◽  
Giant Cells ◽  
Lower Leg ◽  
Multinucleated Giant Cells ◽  
First Report ◽  
The Many

Among the many variants of dermatofibroma, dermatofibroma with cholesterol cleft (cholesterotic fibrous histiocytoma) is extremely rare. Here, we describe the case of a 50-year-old male patient with a cholesterotic fibrous histiocytoma on his left lower leg. He presented with a hyperkeratotic nodule 6 mm in diameter with a brown surface on the extensor surface of his left lower leg. The lesion had developed over the course of a few years without any tendency to heal. A skin biopsy performed on the tumor showed histopathological findings compatible with those of dermatofibroma. Interestingly, the lesion included many cholesterol clefts, as well as foamy histiocytes and multinucleated giant cells around them. He had had metabolic syndrome for years. To the best of our knowledge, this is the first report of a cholesterotic fibrous histiocytoma in a patient with metabolic syndrome. We conclude that the altered microenvironment caused by metabolic syndrome, as well as hyperlipoproteinemia itself, may play a role in the pathogenesis of this rare case.

scholarly journals Lupus Vulgaris: A Rare Case of Cutaneous Tuberculosis

2014 ◽  
Vol 41 (2) ◽  
pp. 57-58
Author(s):  
MA Chowdhury ◽  
TK Sikdar
Keyword(s):  
Medical Journal ◽  
Rare Case ◽  
Giant Cells ◽  
Multinucleated Giant Cells ◽  
Lupus Vulgaris ◽  
Cutaneous Tuberculosis ◽  
Histological Sections ◽  
Epithelioid Granuloma ◽  
Affected Tissue ◽  
Anti Tubercular Therapy

Lupus vulgaris is an extremely chronic, progressive form of cutaneous tuberculosis. The earliest description of lupus vulgaris was given by Erasmus Wilson in 1865. It usually occurs through contagious extension of the disease from underlying affected tissue or hematogenous or lymphatic spread. A 55 years male, non diabetic, non hypertensive, non smoker, got himself admitted into Dermatology and Venereology Department of DMCH with the complaints of multiple ulcerated lesions over the left lower thigh and upper leg including knee for 8 years. Histological sections of skin revealed multiple epithelioid granuloma, multinucleated giant cells and infiltration of lymphocytes with areas of fibrosis and ESR was 80 in 1st hour. The patient was treated with anti tubercular therapy and cured completely. DOI: http://dx.doi.org/10.3329/bmj.v41i2.18811 Bangladesh Medical Journal 2012 Vol. 41 No. 2: 57-58

Pleomorphic Carcinoma of the Gallbladder: Report of a Case

1991 ◽  
Vol 77 (6) ◽  
pp. 523-526 ◽  
Author(s):  
Rosario A. Caruso ◽  
Ciro Familiari ◽  
Giuseppe Giuffré ◽  
Giovanni Mazzeo
Keyword(s):  
Tumor Cell ◽  
Rare Case ◽  
Epithelial Membrane Antigen ◽  
Giant Cells ◽  
Pleomorphic Carcinoma ◽  
Multinucleated Giant Cells ◽  
General Lack ◽  
Carcinoma Of The Gallbladder ◽  
Extensive Necrosis ◽  
Polypoid Tumor

The authors report a rare case of primary pleomorphic carcinoma of the gallbladder in a 70-year-old woman. A polypoid tumor protruded into the lumen from the fundus of the gallbladder. Characteristic histologic findings Included a general lack of architectural cohesiveness, marked pleomorphism, presence of mononucleated and multinucleated giant cells, extensive necrosis, leukocyte-tumor cell phagocytosis or cannibalism. Immunoreactivity for cytokeratin, carclnoembryonic antigen and epithelial membrane antigen as well as histochemical positivity for mucins demonstrated the epithelial nature of the tumor. The neoplasm behaved aggressively; the patient died of metastases 9 months after the operation.

Benign Fibrous Histiocytoma: Report of Case

2003 ◽  
Vol 4 (2) ◽  
pp. 74-79 ◽  
Author(s):  
Ümit Ertaş ◽  
M. Cemil Büyükkurt ◽  
Yasin Çiçek
Keyword(s):  
Soft Tissue ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Panoramic Radiograph ◽  
Giant Cells ◽  
Benign Fibrous Histiocytoma ◽  
Multinucleated Giant Cells ◽  
Caucasian Male ◽  
Storiform Pattern ◽  
Radiolucent Lesion

Abstract Benign fibrous histiocytoma is a rare and usually painless oral neoplasm found in adults that may affect either soft tissue or bone typically noted in their fifth decade. This case was found in a 32 year-old Caucasian male who presented with a fairly well circumscribed unilocular radiolucent lesion extending from the mandibular right first incisor to the left first premolar and reaching the inferior mandible on a panoramic radiograph. A bony window was created and the intrabony lesion was curetted. Multiple sections revealed a cellular tumor composed of uniform spindle-shaped cells arranged in a prominent whorled or storiform pattern. Scattered xanthoma cells, multinucleated giant cells, lymphocytes, and deposits of hemosiderin were noted throughout the lesional stroma. Although malignant fibrous histiocytoma of the bone is relatively well known, benign fibrous histiocytoma of the bone is very rare. Citation Ertas U, Büyükkurt MC. Benign Fibrous Histiocytoma: Report of Case. J Contemp Dent Pract 2003 May;(4)2:074-079.

scholarly journals A Rare Case of Lateral Canthal Gouty Tophus Presenting as an Eyelid Mass

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Austin S. Nakatsuka ◽  
Timothy F. McDevitt ◽  
Pamela S. Tauchi-Nishi
Keyword(s):  
Clinical Examination ◽  
Rare Case ◽  
Histopathological Examination ◽  
Giant Cells ◽  
Crystalline Material ◽  
Multinucleated Giant Cells ◽  
Lateral Canthus ◽  
History Of ◽  
Gouty Tophus

A 41-year-old man with a history of gout presented with an enlarging eyelid growth. Clinical examination revealed a mildly indurated nodule at the lateral canthus. Following resection, histopathological examination revealed needle-shaped, crystalline material surrounded by multinucleated giant cells, findings consistent with gouty tophus. This represents just the sixth case of gouty tophus of the eyelid reported in the literature.

The Ultrastructure of Malignant Fibrous Histiocytoma (Case Report)

1977 ◽  
Vol 63 (4) ◽  
pp. 387-396 ◽  
Author(s):  
Luciano Lombardi ◽  
Silvana Pilotti ◽  
Antonino Carbone ◽  
Franco Rilke
Keyword(s):  
Electron Microscopy ◽  
Stem Cells ◽  
Case Report ◽  
Soft Tissue ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Light And Electron Microscopy ◽  
Giant Cells ◽  
Multinucleated Giant Cells ◽  
Cellular Types

A soft tissue malignant fibrous histiocytoma was studied by light and electron microscopy. The presence of fibroblast-like cells, histiocyte-like cells, undifferentiated stem cells, and xanthomatous cells was confirmed. Fibroblast- and histiocyte-like multinucleated giant cells were also observed. The observation of lysosomes in some fibroblast-like cells, the features of undifferentiated stem cells, and the presence of cells with intermediate characteristics common to xanthomatous, histiocytic, and stem cells suggest a strict relationship among these cellular types.

scholarly journals Ultrastructure of a Feline Extraskeletal Giant Cell Tumor (Malignant Fibrous Histiocytoma)

1981 ◽  
Vol 18 (6) ◽  
pp. 738-744 ◽  
Author(s):  
A. W. Confer ◽  
F. M. Enright ◽  
G. B. Beard
Keyword(s):  
Endoplasmic Reticulum ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Rough Endoplasmic Reticulum ◽  
Malignant Fibrous Histiocytoma ◽  
Mononuclear Cells ◽  
Fibrous Histiocytoma ◽  
Giant Cells ◽  
Cell Tumor ◽  
Multinucleated Giant Cells

A subcutaneous extraskeletal giant cell tumor (malignant fibrous histiocytoma) was excised repeatedly from a 9-year-old Domestic Shorthair cat. Ultrastructurally, the mass was composed of fibroblast-like, histiocyte-like, and multinucleated giant cells, and some undifferentiated cells and mononuclear cells intermediate between the fibroblast-like and histiocyte-like cells. Fibroblast-like cells were characterized by abundant well-developed rough endoplasmic reticulum, relatively smooth cytoplasmic membranes, few lysosomal structures, and finely granular chromatin. Histiocyte-like cells resembled immature macrophages. The cell membranes had many villous projections. Rough endoplasmic reticulum varied in quantity. Lysosomes were numerous. Multinucleated giant cells had characteristics of both the fibroblast-like and histiocyte-like cells. No viral particles were seen.

scholarly journals A Case of Granulomatosis with Polyangiitis (Wegener’s Granulomatosis) Presenting with Marked Inflamed Tracheobronchial Mucosa

2013 ◽  
Vol 2013 ◽  
pp. 1-5
Author(s):  
Teruaki Nishiuma ◽  
Hisashi Ohnishi ◽  
Sho Yoshimura ◽  
Saori Kinami ◽  
Susumu Sakamoto
Keyword(s):  
Weight Loss ◽  
Wegener’S Granulomatosis ◽  
Rare Case ◽  
Granulomatosis With Polyangiitis ◽  
Giant Cells ◽  
Wegener's Granulomatosis ◽  
Transbronchial Biopsy ◽  
Multinucleated Giant Cells ◽  
Diffuse Erythema ◽  
Localized Form

A 70-year-old man was admitted to our hospital because of weight loss and persistent dry cough. Chest radiograph and CT showed multiple infiltrates in the bilateral upper lobes and the remarkably thickened bronchial walls. Bronchoscopy revealed diffuse erythema and edema of the tracheobronchial mucosa without any ulcerous legions. Serum MPO-ANCA was positive (155 EU). Transbronchial biopsy was performed and revealed necrotic granulomas with multinucleated giant cells in the bronchial/bronchiolar and parenchymal lesions. Thus, we diagnosed it as a localized form of granulomatosis with polyangiitis (GPA, Wegener’s granulomatosis). After treatment with corticosteroid and cyclophosphamide, the bronchial findings were entirely resolved. We report here a rare case of GPA presenting with markedly inflamed tracheobronchial mucosa.

Spontaneous Osteosarcoma in a Rabbit (Oryctolagus cuniculus)

2007 ◽  
Vol 44 (5) ◽  
pp. 691-694 ◽  
Author(s):  
H. Kondo ◽  
M. Ishikawa ◽  
H. Maeda ◽  
M. Onuma ◽  
M. Masuda ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Case Report ◽  
Oryctolagus Cuniculus ◽  
Rare Case ◽  
Giant Cells ◽  
Helical Computed Tomography ◽  
Multinucleated Giant Cells ◽  
Computed Tomography Images ◽  
Rare Case Report ◽  
The Right

A 6-year-old male cross-breed rabbit ( Oryctolagus cuniculus) was presented with lameness and severe swelling from the right shoulder to brachium. On 16-detector helical computed tomography images of the amputated right forelimb after being fixed in formalin, evident proliferative and destructive lesions of bone were observed. On histologic examination, the tumor was composed of proliferating neoplastic cells that resembled histiocytes, with abundant osteoid production. A large number of multinucleated giant cells were found throughout. This case was diagnosed as osteosarcoma by clinical, radiographic, and histologic findings. This is a rare case report of osteosarcoma in a rabbit consistent with canine predilection sites.

Origin of histiocyte‐like cells and multinucleated giant cells in malignant fibrous histiocytoma: Neoplastic or reactive?

1999 ◽  
Vol 49 (1) ◽  
pp. 14-22 ◽  
Author(s):  
Hiroshi Hatano ◽  
Kunihiko Tokunaga ◽  
Akira Ogose ◽  
Satoshi Imaizumi ◽  
Tadashi Hayami ◽  
...  
Keyword(s):  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Giant Cells ◽  
Multinucleated Giant Cells
Sign in / Sign up

Export Citation Format

Share Document