scholarly journals Comparative Study of Evaluation of Efficacy and Safety of Combination of Erythromycin and Benzyl Peroxide with Benzyl Peroxide alone in the Treatment of Acne Vulgaris

2017 ◽  
Vol 35 (4) ◽  
pp. 174-178
Author(s):  
Monira Yeasmin ◽  
AZM Maidul Islam
Keyword(s):  
Acne Vulgaris ◽  
Topical Therapy ◽  
Treatment Modalities ◽  
Base Line ◽  
Efficacy And Safety ◽  
Lesion Count ◽  
Group A ◽  
Group B ◽  
Better Than

Objective: Acne vulgaris is the disease of the teenagers as 90% of them being affected. So many treatment modalities are there - systemic , topical and physical . Among them topical therapy is the main stay of treatment. Our study was to determine the efficacy and safety of combination of erythromycin/benzyl peroxide compared with benzyl peroxide alone in the treatment of mild to moderate acne.Method: Patients attended in a Charity Foundation were enrolled for the study after fulfilling the criteria. Among total 50 patients 25 were selected for group A and another 25 for group B.. Group A were treated with 3% erythromycin and 5% Benzyl peroxide combination and GroupB with 5% Benzyl peroxide only. Total acne lesions were counted at base line and after 4 , 8 and 12 weeks of follow up. Reduction of total no of lesions were seen and analyzed.Result: At baseline mean of total acne score was 33.60 ± 5.98 and 33.53 ± 5.68 in group A and B (p=0.965). After 12 week it was 2.27 ± 1.08 and 6.27 ± 1.57 respectively in group A and B (p=0.001). Percent reduction of acne severity from base line to final follow up was 93.24 ± 3.11 in group A and 81.17 ± 4.22 in group B (p=0.001). So we can see better reduction of lesion count in Group A than Group B.Conclusion: We conclude that Group A is safer and more effective than that of Group B. So the combination of Benzyl peroxide and erythromycin is better than Benzyl peroxide alone.J Bangladesh Coll Phys Surg 2017; 35(4): 174-178

scholarly journals Efficacy and tolerability of 0.1% tazarotene cream and 0.05% tretinoin cream in the treatment of acne vulgaris

2016 ◽  
Vol 8 (1) ◽  
pp. 24
Author(s):  
Mohammad Habibur Rahman ◽  
Md. Shahidullah Sikder ◽  
Lubna Khondker
Keyword(s):  
Treated Patient ◽  
Acne Vulgaris ◽  
Chronic Inflammatory Disease ◽  
Controlled Clinical Trial ◽  
Base Line ◽  
Excellent Response ◽  
Group A ◽  
Group B ◽  
Medical University

<p><strong>Background:</strong> Acne vulgaris is a chronic inflammatory disease of the pilosebaceous follicles that is seen primarily in adolescents.</p><p><strong>Objective:</strong> To compare the efficacy of 0.1 % tazarotene cream and 0.05% tretinoin cream in the treatment of mild to moderate acne vulgaris.</p><p><strong>Methods:</strong> A randomized controlled clinical trial was done in the department of Dermatol­ogy and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.</p><p><strong>Results:</strong> At base line mean number of comedones in group A and group B was 12.77 ± 4.01 and 11.80 ± 3.93 respectively (p=0.350) and at final follow up 4.17 ± 4.02 and 3.47 ± 4.00(p=0.501). At base line mean number ofpapules in group A and group B was 17.30 ± 10.29 and 18.57 ± 13.88 respectively (p=0.690) and at final follow up 7.63 ± 8.08 and 7.73 ± 9.98 (p=0.966). At base line mean number of pustules in group A and group B was 0.50 ± 1.33 and 0.53 ± 1.28 respectively (p=0. 922) and at final follow up 0.07 ± 0.37 and 0.00 (p=0.326). At baseline mean of total acne score was 30.57 ± 13.62 and 30.90 ± 17.17 in group A and B(p=0.934) and at final follow up it was 11.87 ± 12.04 and 11.20 ± 13.85 respectively in group A and B(p=0.846). At 1st follow up 3.3% of both group got excellent response, at 2nd follow up 13.3% of group A and 30.0% of group B got excellent response, and at final follow up 56.7% of group A and 63.3% of group B achieved excel­lent response. About 73.33% oftretinoin treated patient and 60% oftazarotene treated did not experience any side effects.</p><p><strong>Conclusion:</strong> It can be concluded that 0.1 % tazarotene cream and 0.05% tretinoin cream is individually effective and tolerability of 0.1 % tazarotene is comparable to 0.05% tretinoin in the treatment of mild to moderate acne vulgaris.</p>

A Study on Frozen Shoulder and its clinical management through Nasaapana and Nasya

2016 ◽  
Vol 1 (1) ◽  
Author(s):  
Praveenkumar H. Bagali ◽  
A. S. Prashanth
Keyword(s):  
Medical Science ◽  
Frozen Shoulder ◽  
Signs And Symptoms ◽  
Treatment Modalities ◽  
Animal Kingdom ◽  
Shoulder Joints ◽  
Group A ◽  
Group B

The unique position of man as a master mechanic of the animal kingdom is because of skilled movements of his hands and when this shoulder joints get obstructed, we call it as Apabahuka (Frozen shoulder), we do not find satisfactory management in modern medical science. Various effective treatment modalities have been mentioned which reverse the pathogenesis, Shodhana is advised initially followed by Shamana therapies. In the present study 30 patients were selected incidentally and placed randomly into two groups A and B, with 15 subjects in each group. Group A received Amapachana with Panchakola Churna, Jambeera Pinda Sweda and Nasya Karma. Group B received Amapachana with Panchakola Churna, Jambeera pinda Sweda and Nasaapana. In both the groups two months follow up was done. Both groups showed significant improvement in the signs and symptoms of Apabahuka as well as the activities of daily livings, thereby improving the quality of life of the patients. Nasya Karma and Nasaapana provided highly significant results in all the symptoms of Apabahuka. In the present study as per the clinical data, Nasaapana is found to be more effective than Nasya Karma.

scholarly journals A Comparative Study of Efficacy and Safety Between Tamsulosin and Terazosin in the Treatment of Symptomatic Benign Prostatic Hyperplasia

2016 ◽  
Vol 15 (1) ◽  
pp. 17-21
Author(s):  
Sakhawat Mahmud Khan ◽  
Md Matiar Rahaman Khan ◽  
Shahin Akhter ◽  
Md Mizanur Rahman
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Prostatic Hyperplasia ◽  
Common Disease ◽  
Efficacy And Safety ◽  
College Hospital ◽  
Symptomatic Benign Prostatic Hyperplasia ◽  
Group A ◽  
Group B ◽  
A Prospective Study

Background: Lower urinary tract symptoms suggestive of symptomatic Benign Prostatic Hyperplasia (BPH) are a very common disease in elderly men .The incidence of benign prostatic hyperplasia is age related.Objectives: To compare the efficacy and safety of Tamsulosin and Terazosin in the treatment of symptomatic Benign Prostatic Hyperplasia.Methods: This was a prospective study carried out in the Department of Urology, Chittagong Medial College Hospital, Chittagong, Bangladesh during the period of July to December 2014. Total 40 patients of 45-80 years of age were consequently selected according to inclusion criteria. After completion of baseline clinical evaluation and investigations, participants were divided into two groups, group A and group B. Group A (n=20) was given Terazosin 1mg daily for 3 days at bed time and then 2 mg daily at bed time for 2 months. Group B (n=20) was given Tamsulosin, 0.4 mg per day for 2 months. Efficacy was evaluated of each group after 2 month follow up and lastly a comparison was made between them. The parameters monitored were International Prostate Symptoms Score (IPSS) Maximum urine flow rate (Qmax) and Post Voidal Residual Volume (PVR). Tamsulosin 0.4 mg and Terazosin 2 mg once daily for 8 weeks both are effective in relieving symptoms of BPH but Tamsulosin is superior to Terazosin in improvement of total IPSS (p<0.001) and Qmax (p<0.01) PVR (p<0.01) at the end point.Results: Outcome of parameters at follow up after 2 months. Tamsulosin group showed significant improvement of IPSS (p<0.05) PVR (p<0.001) and Qmax (p<0.001) than Terazosin. The incidence of adverse events by administration of Tamsulosin was less than that by Terazosin.Conclusion: Tamsulosin appears to have more efficacy and safety than Terazosin in symptomatic BPH.Chatt  Shi Hosp Med Coll J; Vol.15 (1); Jan 2016; Page 17-21

scholarly journals Comparison of 4% Topical Hydroquinone versus Combination of Oral Tranexamic Acid and 4% Topical Hydroquinone in the Treatment of Epidermal Melasma

2021 ◽  
Vol 15 (10) ◽  
pp. 3406-3409
Author(s):  
Sarah Riaz ◽  
Najia Ahmed ◽  
Ayesha Anwar ◽  
Moizza Tahir ◽  
Farrah Yousaf ◽  
...  
Keyword(s):  
Tranexamic Acid ◽  
Topical Therapy ◽  
Military Hospital ◽  
Ethical Review ◽  
P Value ◽  
Treatment Groups ◽  
Quasi Experimental ◽  
Group A ◽  
Group B ◽  
Better Than

Objective: comparison of efficacy of topical 4% hydroquinone monotherapy with combination of oral tranexamic acid and topical 4% hydroquinone in the treatment of epidermal melasma Study design: Quasi experimental study Study period and place: Dermatology OPD, Pak Emirates Military Hospital Rawalpindi from July 2018 to January 2019. Methodology: Total 80 patients presenting with epidermal melasma were selected from outdoor patient department after applying the inclusion criteria and consent was taken from selected patients. Study was started after getting permission from hospital ethical review board. Two treatment groups were made after dividing patients by using alternate method. Treatment with topical 4% hydroquinone alone was started for group A patients and combination of capsule tranexamic acid (250 mg two times a day) along with topical 4% hydroquinone were started for group B patients for the next 6 months. Evaluation of patients through detailed history, clinical and wood’s light examination before starting therapy and after of 24 weeks of treatment was done for both groups. Efficacy of treatment was assessed via Modified MASI score. Results: Hydroquinone monotherapy was effective in 21 (52.5%) patients among group A while in group B patients, combination treatment i.e. oral tranexamic acid and topical hydroquinone, was effective in 31 (77.5%) patients (p value= 0.01). Conclusion: Effectiveness of Hydroquinone 4% topical therapy combined with oral tranexamic acid for epidermal melasma is better than topical 4% hydroquinone alone. Key words: Epidermal melasma, oral tranexamic acid, topical 4% hydroquinone.

scholarly journals Evaluation of the Efficacy of Excimer Light 308 nm Wavelength Versus Low Level Laser in Treatment of Alopecia Areata

2021 ◽  
pp. 120-129
Author(s):  
Rania Abdelfatah Ali Elnagar ◽  
Doaa Waseem Nada ◽  
Arwa Mohammad Hassan ◽  
Doaa Salah Hegab
Keyword(s):  
Alopecia Areata ◽  
Topical Therapy ◽  
Light Therapy ◽  
Low Level ◽  
Level Laser ◽  
Significant Difference ◽  
Lactating Females ◽  
Group A ◽  
Group B

Background: Alopecia areata (AA) is a non-scaring alopecia which can affect any body hairy area. Excimer light 308 nm is a UVB irradiation with immunosuppressive effects. Low level light therapy (LLLT) emits low energy visible and infrared irradiation to modulate biological processes in cell. This study aimed to evaluate efficacy and safety  of excimer light 308 nm versus LLLT in treatment of AA. Methods: Thirty patients with multilocular AA of the scalp were collected after excluding those with alopecia totalis, universalis, AA in other body sites than scalp, those with other systemic or dermatological diseases, those received topical therapy in the last 2 weeks or systemic therapy for AA in the last three months, pregnant and lactating females. Patients were distributed into two equal groups; group A was treated by excimer lamp and group B was treated by LLLT. Sessions were repeated twice weekly for 3 months and patients were followed for 3 months. Treatment efficacy was evaluated by severity of alopecia tool score (SALT score) and Dermoscopy; at baseline, at end of sessions and at follow up. Results: A statistically significant improvement was detected in treated patches of both groups than control patches at end of sessions and only in group A at follow up. There was no statistically significant difference between both groups according to short vellus hair and regrowing hair at end of sessions and at follow up in dermoscopy. Side effects reported were minimal and transient in both groups. Conclusion: Both excimer light and LLLT are safe and effective in treatment of AA. Apart from its relatively higher cost, Excimer light induced better and more sustained improvement than LLLT.

Is Double Dose of Tamsulosin Monotherapy Superior to Combination of Conventional Dose of Tamsulosin and Finasteride in Symptomatic Benign Prostatic Hyperplasia

2020 ◽  
Vol 20 (2) ◽  
pp. 94-98
Author(s):  
Md Zahid Hussain ◽  
SM Khan ◽  
AKMA Islam ◽  
S Akhter ◽  
Suhel Al Mujahid Reza ◽  
...  
Keyword(s):  
Prostate Volume ◽  
Combination Group ◽  
Double Dose ◽  
Efficacy And Safety ◽  
Symptomatic Benign Prostatic Hyperplasia ◽  
Conventional Dose ◽  
Group A ◽  
Group B ◽  
A Prospective Study

Background: The primary aim of the medical therapy for BPH is to improve quality of life by relieving the lower urinary tract symptoms and prevent complications. Objectives: To compare efficacy and safety of double dose of tamsulosin monotherapy with combination of conventional dose of tamsulosin and finasteride in symptomatic BPH. Methods: This was a prospective study carried out in the Department of Urology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh during the period of July 2005 to June 2006. Total 60 patients of 45-80 years of age were consequently selected according to inclusion criteria. After completion of baseline clinical evaluation and investigations, participants were divided into two groups, group A and group B. Group A were given tamsulosin 0.4 mg for 1 week. Then double dose of tamsulosin (0.8 mg) were given from 2nd week for 12 months. Group B were given tamsulosin 0.4 mg and finasteride 5 mg for the same duration. Efficacy was evaluated at 6 month and 12 month follow up visit and a comparison was made between them. During follow up each was observed for any adverse effect. The parameters monitored were International Prostate Symptom Score (IPSS), Maximum urine flow rate (Qmax), Post Voidal Residual Volume (PVR) and Prostate volume. Results : Both double dose of tamsulosin 0.8 mg and combination of conventional dose of tamsulosin 0.4 mg and finasteride 5 mg are effective in relieving symptoms of BPH but combination dose is superior to double dose monotherapy. Outcome parameters at end point follow up after 12 months showed significant improvement of IPSS (p<0.05), PVR(p<0.001), Q max (p<0.001) and prostate volume (p<0.001) in combination group than double dose group .The incidence of adverse events were also significantly less in combination group (p<0.05). Conclusion: Combination of conventional dose of tamsulosin with finasteride appears to have more efficacy and safety than double dose of tamsulosin in symptomatic BPH. Bangladesh Journal of Urology, Vol. 20, No. 2, July 2017 p.94-98

Cryosurgery as a Single Agent and in Combination with Intralesional Corticosteroids Is Effective on Young, Small Keloids and Induces Characteristic Histological and Immunohistological Changes: A Prospective Randomized Trial

Dermatology ◽  
2020 ◽  
pp. 1-11
Author(s):  
Christos C. Zouboulis ◽  
Eftychia Zouridaki
Keyword(s):  
Treatment Failure ◽  
Normal Skin ◽  
Randomized Study ◽  
Single Agent ◽  
Interferon Γ ◽  
Efficacy And Safety ◽  
Rete Ridge ◽  
Group A ◽  
Group B

<b><i>Background:</i></b> As the pathogenesis of keloids is poorly understood, there is no sound biological basis of keloid management. Few controlled therapeutic studies have been published, and recurrences are a major reason for treatment failure. <b><i>Objective:</i></b> To detect efficacy and safety of cryosurgery regimens on keloids and the occurring biological changes caused by the treatment. <b><i>Methods:</i></b> This prospective randomized study compared efficacy and tolerability as well as histological/immunohistochemical effects of liquid nitrogen contact cryosurgery as a single regimen (group A) and combined with intralesional corticosteroids (group B) on young (&#x3c;2 years old), small (≤10 cm<sup>2</sup>) keloids in 40 patients (2-sided effect, α-error 1%, power 95%). <b><i>Results:</i></b> Marked flattening of the lesions was achieved by both regimens. Median lesional volumes decreased from 106 to 7 mm<sup>3</sup> in group A (<i>p</i> = 0.001) and from 138 to 6 mm<sup>3</sup> in group B (<i>p</i> &#x3c; 0.0001; ns, between groups). Good to excellent responses were registered in 83.3 and 90% of patients in groups A and B, respectively, by evaluating the lesional volume, in 80 and 95% of patients by the physician’s evaluation and in 95% of patients in either group by the patient’s assessment. Follow-up of 6–36 months revealed no further significant changes. Cryosurgery was generally well tolerated, with minor pain during treatment not requiring (27.5%) or requiring local anaesthesia (5%) – but not analgesics –, and hypopigmentation (25%). Histological examination showed increased vessel number and lumen dilatation after treatment in group B and reduction of rete ridge length in both groups with more prominent changes in group A. Tenascin C staining demarcated keloids from normal skin before therapy, while after therapy the entire treated tissue was labelled. Interferon-γ expression was significantly decreased after therapy both regarding positively stained cells and intensity in both groups. <b><i>Conclusion:</i></b> Cryosurgery without and with intralesional corticosteroids is effective and safe on young, small keloids not only as a destructive physical procedure, but also by inducing biochemical and immunological scar rejuvenation.

scholarly journals “A COMPARATIVE CLINICAL STUDY TO EVALUATE THE EFFICACY OF SHEETALA JALA NASYA AND MASHA TAILA NASYA WITH RASNADI GUGGULU IN THE MANAGEMENT OF AVABAHUKA WITH SPECIAL REFERENCE TO FROZEN SHOULDER”

2020 ◽  
Vol 8 (10) ◽  
pp. 4669-4676
Author(s):  
Maitradevi 1 ◽  
Uma Patil
Keyword(s):  
Clinical Study ◽  
Shoulder Joint ◽  
Frozen Shoulder ◽  
Treatment Modalities ◽  
Daily Routine ◽  
Routine Work ◽  
Comparative Clinical Study ◽  
Group A ◽  
Group B

Avabahuka is a disease of Amsa Sandhi (shoulder joint) and it has been described under eighty types of Vata Vyadhi by Acharya Sushruta. Being a disease of shoulder joint, which has greatest range of motion, is of vital importance to the activities of daily routine work. This disease is a hindrance in one’s productivity. Various effective treatment modalities have been mentioned in our classics regarding this disease. In order to reverse the pathogenesis, Shodhana is advised initially followed by Shamana therapies. In the present study 40 patients were selected incidentally and placed randomly into two groups- A and B, with 20 sub-jects in each group. Group- A received Nasya with Sheetala Jala and Group- B received Nasya with Ma-sha Taila followed by Rasnadi Guggulu as Shamanoushadhi for both groups A and B. In both the groups after 7th day of Nasya Karma follow up was done. Assessment was done on the bases of symptomatology. Nasya Karma provided highly significant results in all the symptoms of Avabahuka. In the present study as per the clinical data, ‘Nasya with Masha Taila is found to be more effective than Nasya with Sheetala Jala’.

scholarly journals Comparative study of oral ivermectin, topical permethrin and benzyl benzoate in the treatment of scabies

2019 ◽  
Vol 7 (12) ◽  
pp. 4743
Author(s):  
G. Chitti Babu ◽  
Kavita Dhar Bagati ◽  
Praveen Agarwal ◽  
Jyostna Sharma
Keyword(s):  
Good Alternative ◽  
Benzyl Benzoate ◽  
Effective Treatment Option ◽  
Treatment Groups ◽  
Number Of Patients ◽  
Group A ◽  
Group B ◽  
Clinical Grading ◽  
Better Than

Background: Efficacy of these modalities as shown by various investigations are inconsistent and ambiguous. Thus, evidence based effective treatment option is warranted. Aim of the study was to compare the efficacy of oral ivermectin, topical permethrin and benzyl benzoate in the treatment of uncomplicated scabies.Methods: Patients with confirmed diagnosis of scabies were included in this study. One hundred and ninety-five subjects were included in this investigation as per inclusion and exclusion criteria laid down. Equal numbers of patients were randomly allocated to one of the three treatment groups. Efficacy of three groups [oral ivermectin (Group A), topical permethrin (Group B) and benzyl benzoate (Group C)] of drugs was compared in terms of improvement in clinical grading of disease (%) and improvement in clinical grading of pruritus (%) during follow up visits.Results: Those subjects receiving topical permethrin, at 1st follow up 56.9% showed cure rate which increased to 89.2% at 2nd follow up with respect to clinical improvement in pruritus. Maximum relief in severity of pruritus at the end of 6th week was reported by 58(89.2%) patients receiving group B treatment modality followed by 52 patients (80%) in arm A. Regarding efficacy of three treatment groups in terms of improvement in severity of lesion at the end of 6 weeks, maximum number of patients 57(87.7%), receiving group B treatment reported improvement which is better than other two treatment groups.Conclusions: maximum number of patients receiving topical Permethrin treatment reported improvement better than other Oral Ivermectin therapy and topical benzyl benzoate. Oral ivermectin may serve a good alternative for managing scabies under certain conditions like poor compliance to topical scabicides.

scholarly journals Comparison of the Efficacy and Safety between Doxycycline and Moxifloxacin in the Treatment of Tsutsugamushi Disease

2021 ◽  
Vol 5 (5) ◽  
pp. 73-77
Author(s):  
Qiang Qiu
Keyword(s):  
Liver Function ◽  
Adverse Reactions ◽  
Clinical Symptoms ◽  
Effective Rate ◽  
Clinical Treatment ◽  
Efficacy And Safety ◽  
Tsutsugamushi Disease ◽  
Group A ◽  
Group B ◽  
Better Than

Objective: To explore the efficacy and safety of doxycycline and moxifloxacin in the treatment of tsutsugamushi disease. Methods: There was a total of 80 cases of tsutsugamushi disease that were treated in Jiangsu Sihong Fenjinting Hospital from January 2017 to August 2020. The patients were divided into group A and group B, with 40 cases in each group. The patients in group A were treated with moxifloxacin whereas those in group B were treated with doxycycline. The efficacy and safety of the clinical treatment between the two groups were compared. Results: The effective rate was 72.5% in group A and 95.0% in group B. Compared with group A, group B was better (p < 0.05). The time taken for the resolution of clinical symptoms, the detection indexes of liver function, and the incidence of adverse reactions were also compared between the two groups, in which group B was significantly better than group A (p < 0.05). Conclusion: In the clinical treatment of tsutsugamushi disease, doxycycline has better therapeutic effect and higher safety compared to moxifloxacin. It can significantly improve the patient’s liver function, reduce the probability of adverse reactions, and accelerate the patient’s physical recovery.

Sign in / Sign up

Export Citation Format

Share Document