Syringocystadenoma Papilliferum of the Scalp in an Adult Male

2020 ◽  
Vol 22 (2) ◽  
pp. 139-141
Author(s):  
Abdullah Al Tarique ◽  
Nabila Khanduker
Keyword(s):  
Cell Carcinoma ◽  
Early Life ◽  
Neck Region ◽  
Excision Biopsy ◽  
Primary Defect ◽  
Syringocystadenoma Papilliferum ◽  
Apocrine Sweat Gland ◽  
Clinical Variants ◽  
Naevus Sebaceous ◽  
Head Neck

Syringocystadenoma papilliferum is a rare skin tumour developing from eccrine or apocrine sweat gland. Though it usually appears in early life, it may occur in adult also. The clinical variants are plaques, linear and nodular. Head-neck region is affected most. Associations with naevus sebaceous, basal cell carcinoma or even squamous cell carcinoma have been described. Diagnosis is suspected clinically and confirmed by histopathology. Rapid growth, bleeding and ulceration indicate possible malignant transformation. Excision biopsy followed by reconstruction of the primary defect is the treatment of choice. Journal of Surgical Sciences (2018) Vol. 22 (2) : 139-141

scholarly journals Immunohistochemical Assessment of the Tumour-Associated Epitopes CD44v6 and E48 in Tumour-Free Lymph Nodes from Patients with Squamous Cell Carcinoma in the Head-Neck Region

2000 ◽  
Vol 20 (2-3) ◽  
pp. 115-129 ◽  
Author(s):  
Eva-Maria Fabricius ◽  
Michael Guschmann ◽  
Angelika Langford ◽  
Berthold Hell ◽  
Jürgen Bier
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Mononuclear Cells ◽  
Single Cells ◽  
Neck Region ◽  
Peptide Sequence ◽  
Activated T Cells ◽  
Head Neck

We examined immunohistochemically 370 tumour‐free lymph nodes from 41 patients with a head and neck squamous cell carcinoma (HNSCC) to clarify whether the tumour‐associated epitopes CD44v6 and E48 are suitable for adjuvant postoperative immunotherapy. All the positively immunostained cells found were single cells.CD44v6+cells were found in 55% of the lymph nodes, with their numbers increasing in pN>0‐patients (62%). Only pN>0‐patients had abundant to massive CD44v6+cells. A comparison with mononuclear cells in lymphatic tissue from control patients suggested a similarity with activated T‐cells. In the 41 cancer patients there were significantly fewer lymph nodes with E48+cells (11%), but the number of E48+cells increased in pN>1‐patients (29%) with predominantly abundant E48+cells. We conclude from the comparison with the epithelial marker EMA that the E48+single cells are epithelial in origin. Only a specific E48 peptide sequence appears suitable for adjuvant immunotherapy in patients with head‐neck tumours.

scholarly journals BASAL CELL CARCINOMA

2007 ◽  
Vol 14 (02) ◽  
pp. 204-211
Author(s):  
MUHAMMAD FARRUKH AFTAB ◽  
IRFAN AHMAD ◽  
ABDUL MANAN
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Neck Region ◽  
Excision Biopsy ◽  
Skin Defect ◽  
Reconstructive Procedures ◽  
Direct Closure ◽  
Study Results ◽  
One Year

Introduction:- Basal cell carcinoma is the most common skinmalignancy, accounting for about 80% of all skin cancers and may be lethal. Its recognition and management shouldbe familiar to all the general surgeons. Objective:- To describe the prevalence, mode of presentation and varioussurgical options of reconstruction in the management of basal cell carcinoma (BCC) with a local perspective. Setting:-Nishtar Hospital, Multan. Duration:- One year (October 2002 to September 2003). Sample size:- 60 patients. Studydesign:- Descriptive study. Results:- Out of sixty cases, 50 (83%) were male and 10 (17%) were female. Majority ofthe patients presented to us above the age of 45 years and the incidence of BCC increases with the age. The male tofemale ratio was 5:1. Out of 60 cases 26 (20 male, 6 female) 43.3% were farmer, 16 (all male) 26.6% was constructionworkers, 10 (8 male, 2 female) 16.6% were unemployed and 8 (all female) 13.3% were household. No patient presentedbefore 5 years after the development of the lesion. 34 (30 male, 4 female) 56.6% for the last 6-10 years, 20 (16 male,4 female) 33.3% for the last 11-15 years, 2 (all male) 3.3% for 16-20 years and 4 (2 male, 2 female) 6.6% had lesionsfor > 20 years. All the lesions encountered in present study occurred on exposed head and neck region as is evidentfrom the table-III. Most of the patients had the nodular pigmented type of BCC and majority of them were male. Noneof them have Gorlin’s syndrome (Table-IV). Common variant on histopathology was found to be solid type withadenocystic type being the commonest lesion. After the excision of the lesion the skin defect most of the time wasclosed by the mean of split skin graft. Direct closure was done in quarter of the patients. A number of postoperativecomplications were observed after various reconstructive procedures. Wound was found to be commonest complication;with majority of cases getting only minor wound infection. Conclusion:- Delay in presentation has an overall negativeeffect on the outcome. A simple excision, excision biopsy with adequate margin clearance gives surgeon more freedomfor reconstruction.

scholarly journals Oncology gold standard® practical consensus recommendations for the use of monoclonal antibodies in the management of squamous cell carcinoma of head and neck

2017 ◽  
Vol 06 (04) ◽  
pp. 154-160
Author(s):  
Govind Babu ◽  
Ankur Bahl ◽  
G. S. Bhattacharya ◽  
K. T. Bhowmik ◽  
P. S. Dattatraya ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Monoclonal Antibodies ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Gold Standard ◽  
Neck Region ◽  
Advanced Squamous Cell Carcinoma ◽  
Consensus Recommendation ◽  
Head Neck

AbstractWe present the 2017 Oncology Gold Standard Practical Consensus Recommendation for use of monoclonal antibodies in the management of advanced squamous cell carcinoma of head neck region.

Spontaneous regression of Markel cell carcinoma in anterior mediastinum without cutaneous involvement

2020 ◽  
pp. 1-2
Author(s):  
My-Lien Nguyen ◽  
M. Kole Melton ◽  
Salahuddin Ahmad ◽  
Christina Henson
Keyword(s):  
Cell Carcinoma ◽  
Spontaneous Regression ◽  
Intensity Modulated Radiation Therapy ◽  
Neck Region ◽  
Neck Mass ◽  
Anterior Mediastinum ◽  
Cutaneous Involvement ◽  
First Case ◽  
Pet Ct ◽  
Head Neck

Abstract Background: Merkel cell carcinoma (MCC) is a rare and highly aggressive neuroendocrine malignancy typically involving the skin. The majority of MCC involves the head/neck region and the extremities. Despite the aggressive nature of the disease, there have been several case studies that report spontaneous regression. We report a unique case of spontaneous regression of an MCC in a peculiar region in the anterior mediastinum with no cutaneous involvement. Methods: A 50-year-old man who presented with a mobile low anterior neck mass, proven by biopsy, to be MCC. Subsequent PET/CT confirmed an FDG (Flurodeoxyglucose)-avid upper mediastinal mass. The mass gradually regressed over the course of 1 month subsequent to biopsy and was no longer palpable on exam or visible on subsequent CT scans. The patient was treated with intensity modulated radiation therapy with a total dose of 6,160 cGy in 28 fractions to the site of previously visible primary disease. At-risk nodal basins were also treated. On subsequent follow-up, the patient continued to have no clinical or radiographic signs of disease. Discussion: Spontaneous regression of an MCC is rare but has been reported mostly in the head/neck region following biopsy. It is unknown why spontaneous regression occurs. There is a possibility that biopsy may stimulate T-lymphocytes resulting in spontaneous regression. Conclusion: This is the first case to our knowledge of spontaneous regression of an MCC in the anterior mediastinum with no cutaneous involvement. Most MCC are seen clinically due to skin changes with a majority of cases occurring in the head/neck region.

The DNA methylation landscape of PD-1 (PDCD1) and adjacent lncRNA AC131097.3 in head & neck squamous cell carcinoma

Epigenomics ◽  
2020 ◽  
Author(s):  
Christopher Bockhorst ◽  
Jörn Dietrich ◽  
Timo J Vogt ◽  
Roland H Stauber ◽  
Sebastian Strieth ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Head Neck

CD44v6-targeted CAR T-cells specifically eliminate CD44 isoform 6 expressing head/neck squamous cell carcinoma cells

Oral Oncology ◽  
2021 ◽  
Vol 116 ◽  
pp. 105259
Author(s):  
Corinna Haist ◽  
Elena Schulte ◽  
Nina Bartels ◽  
Arthur Bister ◽  
Zoe Poschinski ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
T Cells ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma Cells ◽  
Neck Squamous Cell Carcinoma ◽  
Car T Cells ◽  
Car T ◽  
Head Neck

scholarly journals Leiomyosarcoma of the Tracheostomy Site in a Patient with History of Laryngeal Squamous Cell Carcinoma

2021 ◽  
pp. 912-917
Author(s):  
Zainub Ajmal ◽  
Abdul Moiz Khan ◽  
Lezah McCarthy ◽  
Allison Lupinetti ◽  
Syed Mehdi
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
English Literature ◽  
Neck Region ◽  
Multiple Risk Factors ◽  
History Of ◽  
Rare Malignancy

Leiomyosarcoma (LMS) of the trachea is an extremely rare malignancy with only a few reported cases in English literature. As such the diagnosis can be frequently missed or delayed. We present a case of a 69-year-old male who underwent tracheostomy for airway obstruction secondary to glottic squamous cell carcinoma and treated definitely with radiation therapy. Subsequently, the patient developed LMS of the tracheostomy site. The case further details multiple risk factors that could contribute to development of LMS including radiation exposure, prior malignancy, and chronic inflammation. These risk factors have been well established for LMS in other sites but less so in the head and neck region, which is the subject of our discussion. We also review the current guidelines for head and neck as well as limb sarcomas and discussed role of surgery or radiation and their accompanying challenges in management of this rare malignancy.

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