Study on Clinical Spectrum, Laboratory Profile and Outcome of Dengue Fever in Adults

Mediscope ◽  
2021 ◽  
Vol 8 (1) ◽  
pp. 33-39
Author(s):  
Muhammad Ashraful Kabir ◽  
Syed Didarul Haque ◽  
Baishakhi Islam ◽  
Hasan Imam
Keyword(s):  
Abdominal Pain ◽  
Pleural Effusion ◽  
Dengue Fever ◽  
Laboratory Finding ◽  
Dengue Infection ◽  
Febrile Illness ◽  
Clinical Spectrum ◽  
Structural Protein ◽  
Careful Clinical Examination ◽  
Laboratory Profile

Background: Dengue infection is a major health burden, which can result in mild self-limited febrile illness to highly fatal haemorrhagic disease. Infection is caused by Dengue virus, which is transmitted by the Aedes aegypti mosquito. Objective: The aim of the study was to see the clinical spectrum, laboratory profile and outcome of dengue fever in adult. Methods: This prospective observational study was carried out on 75 patients in the department of medicine of Bangabandhu Sheikh Mujib Medical University, Dhaka from 11/07/2019 to 20/10/2019. All patients above 18 years with confirmed dengue, who were either hospitalized or managed as outdoor patients with NS1 (non-structural protein) antigen and/ or IgM dengue antibody positive were included in the study. The patients with concomitant malaria, typhoid and leptospirosis were excluded from the study. Detailed history and careful clinical examination were performed on each patient. Results: In this study, all patients (100%) had fever. Among them, 70 (93.3%) was suffering from headache, 66 (88.0%) myalgia, 32 (42.7%) abdominal pain, 30 (40.0%) conjuctival suffusion, 29 (38.7%) nausea/vomiting, 27 (36.0%) skin rashes, 14 (18.7%) pleural effusion, 13 (17.3%) ascites, 13 (17.3%) retro-orbital pain, 11 (14.7%) itching, 8 (10.7%) hepatomegaly, 7 (9.3%) splenomegaly. Death occurred in 3 (4.0%) patients. Rate of cure was 58 (77.3%) and ICU admission was required in 14 (18.7%), they were ultimately cured. Conclusion: Fever associated with headache and myalgia were the most common symptoms. Other common clinical features were abdominal pain, conjunctival suffusion, nausea/vomiting, skin rashes and pleural effusion. Regarding laboratory finding, platelet count has little role in management of dengue patients. Mediscope Vol. 8, No. 1: January 2021, Page 33-39

scholarly journals Case Report: False-Positive Dengue Non-Structural Protein 1 Antigen in a Patient with COVID-19 Infection

2020 ◽  
Vol 26 (2) ◽  
Author(s):  
Yohanes Firmansyah ◽  
Jessica Elizabeth ◽  
Hendsun Hendsun ◽  
Darren Gosal
Keyword(s):  
Case Report ◽  
Early Diagnosis ◽  
Dengue Fever ◽  
False Positive ◽  
Dengue Infection ◽  
Antigen Test ◽  
Structural Protein ◽  
Positive Events ◽  
Test Strips ◽  
Endemic Areas

Abstract: Early diagnosis of dengue fever and COVID-19 is made very easy due to technological advancements. The  non-structural protein 1 antigen test strips are widely used in various regions; however, false-positive events have begun to be reported in the dengue-endemic areas with the COVID-19 pandemic, even though statistically non-structural protein 1 antigens are very specific to dengue infection. We reported a case of the false-positive non-structural protein 1 test in a patient with COVID-19 infection.

scholarly journals Clinical and laboratory profile of dengue fever: a retrospective study

2019 ◽  
Vol 6 (4) ◽  
pp. 1254
Author(s):  
Sachin N. Solanke ◽  
Abhay S. Pohekar ◽  
Jayshree A. Pohekar
Keyword(s):  
Platelet Count ◽  
Abdominal Pain ◽  
Dengue Fever ◽  
Dengue Infection ◽  
Recent Decade ◽  
High Morbidity ◽  
Normal Platelet ◽  
Bone Marrow Diseases ◽  
Number Of Patients ◽  
Low Platelet Count

Background: The global incidence of dengue has grown dramatically in recent decade. Half of world’s population is now at risk. India represents significantly a larger burden, accounting for nearly 34% of the global burden of dengue infection. Dengue infection needs to be addressed as a single disease with different clinical presentations ranging from asymptomatic conditions to severe clinical courses that may lead to high morbidity and mortality.Method: This was retrospective observational study carried out during period of July 2017 to April 2018, to study clinical profile and laboratory parameters in dengue fever patients. Confirmed dengue cases having NS1 positive or IgM positive or having both NS1 and IgM positive or dengue ELISA reactive, having minimum one CBC reports done and not having other confounding factor such as co-infection, bone marrow diseases etc. that may altered clinical and laboratory results are included in study. Statistical analysis was done by SPSS software version 18.0.Results: Out of 48 confirmed dengue cases maximum patients 58.33% was from young age group (21 to 40 years) with M:F ratio was 2.43:1. Fever was found in 100% patients, in order of frequency followed by headache, bodyache, abdominal pain, weakness, retro-orbital pain, anorexia, dry cough, back pain, nausea, diarrhoea, vomiting, rash, joint pain, itching and malena.NS1was positive in 41.67% cases, dengue ELISA in 31.25%, IgM was positive in 20.83% cases, and both NS1 and IgM positive were in 4.17% cases. TLC count was low 35.42%, high in 12.50% of cases and remaining had normal TLC count. Platelet count was ranged between normal platelet counts to thrombocytopenia. One case had platelet count less than 20000. Out of 48 patients, 2 (4.17%) had malena.Conclusion: In this study, fever was found in all patients, and headache, body ache and weakness were common symptoms, but significant number of patients also had gastroentstinal and respiratory symptoms like abdominal pain, nausea, diarrhea, vomiting and dry cough. TLC count ranging from normal TLC, leukopenia to leucocytosis. Large number of patients had low platelet count that shows dengue fever had varied clinical presentation. 

scholarly journals Spontaneous splenic rupture in dengue fever with non-fatal outcome in an adult

2012 ◽  
Vol 6 (04) ◽  
pp. 369-372 ◽  
Author(s):  
Emmanuel Bhaskar ◽  
Swathy Moorthy
Keyword(s):  
Abdominal Pain ◽  
Dengue Fever ◽  
Splenic Rupture ◽  
Fatal Outcome ◽  
Severe Dengue ◽  
Structural Protein ◽  
Viremic Phase ◽  
Laboratory Investigations ◽  
Splenic Hematoma

A 26-year-old male presented with fever for five days and abdominal pain for 24 hours. System examination identified a soft abdomen with diffuse tenderness. CT-abdomen findings were consistent with splenic rupture with intra and peri-splenic hematoma. Laboratory investigations showed a platelet count of 40,000 per mm3. In due course he developed hypotension and underwent splenectomy. Non-structural protein 1 (NS1) dengue antigen was positive in the admission sample and IgM dengue antibodies were detected in the follow-up sample. Histopathology of the spleen showed normal architecture with no evidence of hyperplasia, cellular infiltrates or haematological malignancy. Splenic rupture is a rare, but potentially fatal complication of dengue fever and severe dengue which should be suspected when a patient presents with abdominal pain and hypotension. Our case highlights the occurrence of splenic rupture in the viremic phase of dengue illness before the development of IgM antibodies. 

scholarly journals Clinical Profile of Dengue Fever in Children

1970 ◽  
Vol 33 (2) ◽  
pp. 55-58 ◽  
Author(s):  
ABM Shahidul Alam ◽  
S Anwar Sadat ◽  
Zakaria Swapan ◽  
Aftab U Ahmed ◽  
Md Nazmul Karim ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Dengue Fever ◽  
Dengue Infection ◽  
Cross Sectional Study ◽  
Dengue Haemorrhagic Fever ◽  
Published Data ◽  
Haemorrhagic Fever ◽  
Cross Sectional ◽  
Normal Platelet ◽  
The Mean

Background: Dengue infection has become endemic in Bangladesh since it hasbeen broken out in June 2000. Although children are the usual victim of dengueinfection, there is paucity of published data regarding dengue infection in children inour country.Objectives: This study was designed to document the presenting features and outcomeof Dengue infection in children.Materials and Methods: This cross sectional study was done among the childrenhaving Dengue infection. Fifty four consecutive patients were enrolled. Purposivesampling was done. In every patient a detailed history was taken. Clinical examinationsand relevant investigations were done. Data were collected in a predesigned structuredquestionnaire. Data were analyzed with the help of descriptive statistics and Chisquare(x2) Test.Results: The mean age of the patients was 6.5±3.5 years with equal male and femaleratio. Among 54 patients, 40.7% presented with dengue fever (DF), the rest (59.3%)presented with dengue haemorrhagic fever (DHF). Most of the patients presented withhigh grade continued type of fever (75.9%), followed by abdominal pain (59.3%),vomiting (57.4%). Itchy rash and fever were the most important characteristic signs(75.9% each). Flushed appearance observed in 68.4% and 59.3% patients showedbleeding manifestation of which sub-conjunctival haemorrage was the commonestform (33.3%). Leucopenia were present in only 9.3% of the patients. Platelet countless than 100×109/L were found in 68.5% patients. Tourniquet test was positive in31.5% of cases. All of the patients had packed cell volume (PCV) less than 45%.Raised serum alanine aminotransferase (ALT) was observed in 40.7% of children.IgM and/or IgG antibodies for dengue virus were positive in 96.29% patients. Majority(94%) of the patients completely recovered from the disease and only 6% died.Conclusion: High grade continued fever, vomiting with abdominal pain and itchy skinrash (with normal platelet count) were the presenting features. Commonest form ofbleeding manifestation was subconjunctival haemorrhage. Bleeding manifestationhad a significant association with the degree of thrombocytopenia but no corelationwas observed with tourniquet test positivity.Key words: Dengue fever (DF); dengue haemorrhagic fever (DHF); paediatric.DOI: 10.3329/bjch.v33i2.5678Bangladesh Journal of Child Health 2009; Vol.33(2): 55-58

scholarly journals Dengue Fever: Clinical, Laboratory Profile and Outcome in Pediatric Patient

2022 ◽  
Vol 6 (1) ◽  
Author(s):  
Pooja Gandhi ◽  
Pinkal Taral ◽  
Krunal Patel ◽  
Sanketsinh Rathod ◽  
Bhavini Rathwa
Keyword(s):  
Platelet Count ◽  
Dengue Virus ◽  
Dengue Fever ◽  
Care Center ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Clinical Profile ◽  
Severe Dengue ◽  
Diverse Range ◽  
Laboratory Profile

Introduction: Infection with any of the 4 dengue virus serotypes results in a diverse range of symptoms, from mild undifferentiated fever to life-threatening hemorrhagic fever and shock. Given that dengue virus infection elicits such a broad range of clinical symptoms, early and accurate laboratory diagnosis is essential for appropriate patient management. So a study was carried out to know its clinical profile, correlation between the laboratory profile and the severity of dengue fever and outcome in dengue patients. Aim: To study the clinical profile, correlation between the laboratory profile and the severity of dengue fever and outcome in dengue patients at tertiary care center. Method: Retrospective Observational study from 1st May 2019 to 31st April 2021. Result: Total 323 patients were studied during 1st May 2019 to 31st April 2021. Most common presentation was fever (100%), most common clinical finding is hepatomegaly (14.2%). All severe dengue infection has platelet count < 50000/cumm. In study of 323 patients 194(60%) of dengue fever,85(26.4%) of DHF GRADE 1,9(2.8%) of DHF GRADE 2 were discharged .13(4%) patients of DSS were expired.22 patients (6.8%) went DAMA. Conclusion: Reliable diagnosis of dengue fever in endemic areas can be done by clinical parameters like presence of nausea, vomiting, pain abdomen and hepatomegaly. Monitoring platelet count, hematocrit and WBC count is very useful for management of dengue cases. Keywords: dengue fever, platelet count, outcome

scholarly journals ASSESSMENT OF KNOWLEDGE, ATTITUDES AND PRACTICE TOWARD DENGUE FEVER AMONG UNIVERSITY STUDENTS IN MALAYSIA

2021 ◽  
Vol 3 (1) ◽  
pp. 289-300
Keyword(s):  
University Students ◽  
Dengue Fever ◽  
Dengue Infection ◽  
Febrile Illness ◽  
Simple Random Sampling ◽  
Health Concern ◽  
P Value ◽  
Cross Sectional ◽  
Level Of Knowledge ◽  
Dengue Prevention

Introduction: Dengue fever is an acute febrile illness with a significant public health concern in tropical and subtropical countries. Population knowledge and practice play an essential role in the transmission and prevention of the disease. This study aims to evaluate the level of knowledge, attitudes, and practice regarding dengue fever among Malaysian university students. Methods: A cross-sectional descriptive study was conducted in twenty-five randomly selected universities across Malaysia. A total of 1520 respondents were approached by simple random sampling method. A previously validated and published questionnaire was used with little modification. The associations between the level of knowledge, Attitudes, and practice with different risk factors were calculated statistically and the significant association was considered with a p-value <0.05. Results: The data were analysed and showed that most of the students (56.3%, 46.2%, and 43.3%) has a moderate level of knowledge, attitude, and practice respectively toward dengue infection among the respondents. The result shows a significant association between the level of practice and knowledge (p-value <0.001) as well as between the level of practice and attitudes (p-value <0.001). Conclusion: The significant association between the practice and knowledge along with attitudes indicates the more knowledge and attitudes lead to better practice. This study highlighted the important role of university students in dengue prevention-based programs. They should be exposed more to improve and transfer their knowledge and attitude to other community population to reduce the incidence of dengue not only in Malaysia but globally.

scholarly journals Dengue Outbreak in Children During 2019: Experience at A Tertiary Care teaching Hospital

2021 ◽  
Vol 20 (1) ◽  
pp. 46-50
Author(s):  
Mitra Datta ◽  
Asma Ferdousi ◽  
Salina Haque ◽  
Rifat Jahan ◽  
Aparup Das ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Pleural Effusion ◽  
Dengue Fever ◽  
Tertiary Care ◽  
Clinical Manifestations ◽  
Case Fatality ◽  
Warning Signs ◽  
Severe Dengue ◽  
College Hospital ◽  
Dengue Outbreak

 Background: Dengue outbreaks are hitting different geographic locations, different clinical manifestations are being reported recently. This study was aimed to describe the clinico-epidemiological profile and outcome of dengue infected children during 2019 dengue outbreak in Chattogram. Materials and methods: This hospital based prospective observational study was carried out in the Department of Pediatrics in Chattogram Medical College Hospital. Serologically positive dengue cases (Aged £12 years) admitted from July 2019 to December 2019 were enrolled in the study. Hospital outcome of the patient’s was recorded in terms of mortality, Length of Hospital Stay (LOS) need for ICU. Results: Out of total 192 patients as per the National Guideline 66.7% cases were classified as dengue fever without warning signs, 21.9% as dengue fever with warning signs and 11.5% as severe dengue. Overall the mean age was 7.04 (±3.23) years with male preponderance (59%). Along with fever main complaints were abdominal pain (91.7%), vomiting (47.9%) and headache (23.6%). Marked thrombocytopenia (Below 50,000) was present in 37.9%, leucopenia in 27.9% and raised haematocrit in 10.9% of cases. Average LOS was 5.2 (±1.9) days, 18 (9.5%) patients need ICU admission and there was no fatality in this series. Some clinical (Vomiting, flusihing, shock, reduced urinary output) and laboratory (Marked thrombocytopenia, leucopenia, hemoconcentration, pleural effusion and hepatomegaly) variables were associated with severity. Conclusion: Fever with abdominal pain were common presentations of dengue fever. Severe dengue patients presented with vomiting, flashing and shock. Marked thrombocytopenia and pleural effusion and/or ascites were related to shock. Appropriate and timely management is very effective in reducing case fatality. Chatt Maa Shi Hosp Med Coll J; Vol.20 (1); January 2021; Page 46-50

Clinical and Laboratory Profile of Dengue Fever in the Paediatric Age Group at a Tertiary Care Hospital of West Bengal - A Comparison of Two Subsequent Years

2021 ◽  
Vol 8 (25) ◽  
pp. 2162-2167
Author(s):  
Shankar Sikdar ◽  
Ujjwal Bandyopadhyay ◽  
Sutapa Das ◽  
Mala Bhattacharya
Keyword(s):  
Platelet Count ◽  
Dengue Fever ◽  
Dengue Infection ◽  
Warning Signs ◽  
Health Concern ◽  
Care Hospital ◽  
Age Group ◽  
Structural Protein ◽  
Asian Countries ◽  
Paediatric Age

BACKGROUND Dengue is a major public health concern in tropical Asian countries and a most rapidly spreading mosquito borne viral disease with a 30 fold increase in global incidence over the last five decades. Dengue is among the ten leading causes of death in children ranging from 1 to 15 years of age in tropical Asian countries. Complications of dengue fever are common in children. But very limited studies are available on paediatric populations. The virus or non-structural protein (NS1) interacts with platelets and coagulation factors. A combined effect of mild disseminated intravascular coagulation, liver damage and platelet dysfunction results in bleeding in dengue fever. With this scientific knowledge background, the present study was undertaken to identify and document the changing pattern of dengue infection in paediatric age group with a special emphasis on laboratory findings of dengue cases in paediatric age group. METHODS The present descriptive study was conducted for two years in a state run paediatric referral hospital. The sample was purposive by design and consisted of patients who have been diagnosed as having dengue fever with warning signs and admitted. RESULTS Fever was typically high grade (> 103 F) and most patients presented with warning signs within 5 days of illness (64.2 % in year 2016 and 76.6 % in year 2017). Persistent vomiting and abdominal pain were the most common warning signs in both the years. Thrombocytopenia was the commonest laboratory finding. Bleeding in study subjects lead to < 50000 / cu mm platelet count. Most common bleeding was gastrointestinal bleeding (39.2 % of study subjects with platelet count < 50000 / cu mm presented with G. I bleeding). CONCLUSIONS Dengue illness comes with varied presentation. Atypical presentations can delay the diagnosis. Early recognition of warning signs keeping the atypical presentation in mind is important. KEYWORDS Dengue Fever, Paediatric Age Group, Non-Structural Protein (NS1), Thrombocytopenia

A Retrospective Study on Laboratory Profile and Clinical Parameters of Dengue Fever Patients

2021 ◽  
Vol 15 (11) ◽  
pp. 3357-3359
Author(s):  
Ajeet Kumar ◽  
Shahnawaz Sarwari ◽  
Waheed Ahmed Arain ◽  
Suresh Kumar ◽  
Kaneez Fatima ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Dengue Fever ◽  
Dengue Infection ◽  
Laboratory Data ◽  
Gastrointestinal Symptoms ◽  
Clinical Profile ◽  
Mortality And Morbidity ◽  
Number Of Patients ◽  
Laboratory Profile ◽  
Study Laboratory

Introduction: Over the past decade, the number of cases of dengue fever has augmented intensely globally. Half the world's population is now under threat. Pakistan has also very high dengue fever per year, with regular reports of dengue outbreaks compared to other countries. Dengue infection should be treated as a solitary ailment with various clinical pictures, vacillating from symptomless situations to severe clinical sequences, which may result in high mortality and morbidity. Aim: To investigate the laboratory parameters and clinical profile in patients with dengue fever. Study Design: A Retrospective observational study. Place and Duration: In the Department of Medicine of Jalan Bani Bu Ali hospital Oman for one-year duration from July 2020 to July 2021. Methods: At least IgM positive or NS1 positive or IgM with NS1 positive or reactive ELISA assay for dengue fever detection but without any co-infection, bone marrow disease confirmed the cases of dengue without other confounding factors, such as alteration of clinical and laboratory data. The results were analyzed for the study. SPSS 21.0 was applied for Statistical analysis. Results: A total of 52 cases were tested positive for dengue fever. The patients mean age was 27.60 +/- 13.98 years and vacillated from 13 to 75 years. Of the total number of patients, 30 (57.69%) were in the age group 21 to 40 years. Of the 52 cases, 36 (69.23%) were male, 16 (30.77%) were female with M:F ratio was 2.2: 1. 42 (80.77%) of all cases were hospitalized for 5 days or less, and 10 (19.23%) were hospitalized for more than 5 days. The mean hospital stay was 3.67±1.40, ranging from 2 to 8 days. Fever was observed in all (100%) of the total number of cases. Conclusions: In this analysis, all patients have fever, and body pain, headache and malaise were communal signs, but a substantial quantity of cases also had respiratory and gastrointestinal symptoms such as nausea, abdominal pain, vomiting, dry cough and diarrhea. Keywords: Dengue fever, clinical profile, retrospective study, laboratory profile, thrombocytopenia

scholarly journals Frequency and Clinical Manifestations of Dengue in Urban Medellin, Colombia

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Berta Nelly Restrepo ◽  
Mark E. Beatty ◽  
Yenny Goez ◽  
Ruth E. Ramirez ◽  
G. William Letson ◽  
...  
Keyword(s):  
Dengue Virus ◽  
Dengue Fever ◽  
Low Income ◽  
Dengue Infection ◽  
Diagnostic Testing ◽  
Clinical Manifestations ◽  
Febrile Illness ◽  
Hemorrhagic Fever ◽  
Dengue Virus Infection ◽  
Medical Facilities

A dengue fever surveillance study was conducted at three medical facilities located in the low-income district of San Javier in Medellin, Colombia. During March 2008 to 2009, 781 patients with fever regardless of chief complaint were recruited for acute dengue virus infection testing. Of the 781 tested, 73 (9.3%) were positive for dengue infection. Serotypes DENV-2 (77%) and -3 (23%) were detected by PCR. One patient met the diagnostic criteria for dengue hemorrhagic fever. Only 3 out of 73 (4.1%) febrile subjects testing positive for dengue infection were diagnosed with dengue fever by the treating physician. This study confirms dengue virus as an important cause of acute febrile illness in Medellin, Colombia, but it is difficult to diagnose without dengue diagnostic testing.

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