Risk of cardiovascular diseases with oral contraceptives.

Aim. Identification of risk factors (RF) for myocardial infarction (MI) among women with preserved menstrual function. Material and Methods. 121 Female patients under 55 years of age, who were hospitalized with MI in the cardiology departments of Ryazan in the period 2010-2016, were studied. All patients were divided into 2 groups. The first group included women with a regular menstrual cycle without menopausal symptoms (n=60, mean age 48.0±6.1 years). The second group consisted of postmenopausal women (n=61, mean age 49.8±4.3 years). Of a cohort of studied women a group of women was isolated (n=18 from group 1 and n=15 from group 2) who, during hospitalization with MI in 2015-2016, filled in questionnaires on nutrition and physical activity. Results. In women of group 1 such risk factors as burdened heredity for cardiovascular diseases (58.3%, p=0.02) and smoking (46.7%, p=0.03) were more common than in women of group 2. Only women of group 1 took oral contraceptives before the onset of MI (15%, p=0.005). The most common RFs were: arterial hypertension (˃80% of patients in both groups; overweight and obesity (78.3% of women from group 1 and 83.6% from group 2); type 2 diabetes mellitus (23.3% in group 1 and 24.6% in group 2). According to the results of the questionnaire on food habits, insufficient use of fruit and vegetables was detected among all patients of both groups. In analysis of the results of the International Physical Activity Questionnaire (IPAQ), 72.2% of patients in group 1 experienced insufficient physical activity, and 53.3% of patients in group 2 showed pronounced hypodynamia. Biochemical analysis of blood revealed increased average levels of total cholesterol, low-density lipoproteins and triglycerides, with high-density lipoproteins within the normal range in both groups. Conclusion. The most common risk factors for myocardial infarction in women with preserved menstrual function in comparison with postmenopausal women were: positive heredity for cardiovascular diseases, smoking and taking oral contraceptives. Besides, a wide spread of arterial hypertension, dyslipidemia and diabetes mellitus, overweight and obesity, low physical activity and lack of fruit and vegetables in the diet of women in both groups should be noted.

Download Full-text

Hormones and cardiovascular diseases: oral contraceptives and hormonal replacement therapy: differential effects on coronary heart disease, deep venous thrombosis and stroke. The ESHRE Capri Workshop Group

Human Reproduction ◽

10.1093/humrep/13.8.2325 ◽

1998 ◽

Vol 13 (8) ◽

pp. 2325-2333 ◽

Cited By ~ 5

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Cardiovascular Diseases ◽

Venous Thrombosis ◽

Deep Venous Thrombosis ◽

Replacement Therapy ◽

Oral Contraceptives ◽

Hormonal Replacement Therapy ◽

Differential Effects ◽

Hormonal Replacement

Download Full-text

Evaluation the Relationship between Oral Contraceptives Containing Drospirenone with Dyslipidemia and Risk of Cardiovascular Diseases among Women in Al-kut City

Indian Journal of Forensic Medicine & Toxicology ◽

10.37506/ijfmt.v14i4.11827 ◽

2020 ◽

Keyword(s):

Cardiovascular Diseases ◽

Oral Contraceptives ◽

The Relationship

Download Full-text

COC’s application for decreasing cardiovascular risks

Medical Council ◽

10.21518/2079-701x-2019-6-126-128 ◽

2019 ◽

pp. 126-128

Author(s):

L. Yu. Karakhalis ◽

G. A. Penzhoyan ◽

M. N. Karakhalis

Keyword(s):

Cardiovascular Diseases ◽

Oral Contraceptives ◽

Cardiovascular Risks ◽

Combined Oral Contraceptives ◽

Effective Contraception

Nowadays application of combined oral contraceptives with folates is considered not only as effective contraception, but also as treatment of hyperandrogenic dermopathy and prophylaxis of cardiovascular diseases.

Download Full-text

Inflammageing in the cardiovascular system: mechanisms, emerging targets, and novel therapeutic strategies

Clinical Science ◽

10.1042/cs20191213 ◽

2020 ◽

Vol 134 (17) ◽

pp. 2243-2262

Author(s):

Danlin Liu ◽

Gavin Richardson ◽

Fehmi M. Benli ◽

Catherine Park ◽

João V. de Souza ◽

...

Keyword(s):

Cardiovascular Diseases ◽

Cardiovascular System ◽

Nlrp3 Inflammasome ◽

Molecular Mechanisms ◽

Molecular Targets ◽

Therapeutic Interventions ◽

Low Grade ◽

Cardiovascular Research ◽

Inflammatory Processes ◽

Ach Receptors

Abstract In the elderly population, pathological inflammation has been associated with ageing-associated diseases. The term ‘inflammageing’, which was used for the first time by Franceschi and co-workers in 2000, is associated with the chronic, low-grade, subclinical inflammatory processes coupled to biological ageing. The source of these inflammatory processes is debated. The senescence-associated secretory phenotype (SASP) has been proposed as the main origin of inflammageing. The SASP is characterised by the release of inflammatory cytokines, elevated activation of the NLRP3 inflammasome, altered regulation of acetylcholine (ACh) nicotinic receptors, and abnormal NAD+ metabolism. Therefore, SASP may be ‘druggable’ by small molecule therapeutics targeting those emerging molecular targets. It has been shown that inflammageing is a hallmark of various cardiovascular diseases, including atherosclerosis, hypertension, and adverse cardiac remodelling. Therefore, the pathomechanism involving SASP activation via the NLRP3 inflammasome; modulation of NLRP3 via α7 nicotinic ACh receptors; and modulation by senolytics targeting other proteins have gained a lot of interest within cardiovascular research and drug development communities. In this review, which offers a unique view from both clinical and preclinical target-based drug discovery perspectives, we have focused on cardiovascular inflammageing and its molecular mechanisms. We have outlined the mechanistic links between inflammageing, SASP, interleukin (IL)-1β, NLRP3 inflammasome, nicotinic ACh receptors, and molecular targets of senolytic drugs in the context of cardiovascular diseases. We have addressed the ‘druggability’ of NLRP3 and nicotinic α7 receptors by small molecules, as these proteins represent novel and exciting targets for therapeutic interventions targeting inflammageing in the cardiovascular system and beyond.

Download Full-text