scholarly journals An Association of Serum ferritin and SGPT Level in Transfusion dependent Thalassaemia major Patients-A Cross Sectional Study

2017 ◽  
Vol 8 (1) ◽  
pp. 170-173
Author(s):  
Farida Parvin ◽  
Bepasha Naznin ◽  
Tanzila Tabib Chowdhury ◽  
AFM Ashik Imran ◽  
MST Laizuman Nahar ◽  
...  

Background : The Thalassaemia is an inherited haemoglobulin disorder causes hemolytic anemia which usually requires life-long blood transfusion therapy. Therefore transfusion dependent thalassaemia major patients suffer from the effect of deposition of excess iron in the liver, heart and endocrine glands.Objective : The aim of present study was to find out the association of serum ferritin and SGPT in transfusion dependent thalassaemia major patient.Methodology : This cross sectional study was carried out in Day care unit (DCU) of Transfusion Medicine department, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, during January 2014 to December 2014. Total of 110 clinically diagnosed Thalassaemia major (TM) between (5-35 years) cases of either sex from the above mentioned department attending the DCU were selected purposively for this study. Data were collected on clinical examination findings, laboratory investigations, ABO and Rh Blood Group, Serum ferritin and SGPT (Serum glutamic pyruvic transaminase) after taking informed consent.Results : The following observations and results were obtained in this study. The mean age was found 17.15±8.77 years with range from 5 to 35 years and male to female ratio was 1.2:1 (male 59 and female 51). Sixty eight (68.0%) patients came from rural area, 43.6% patients were student, 77.3% patients had completed primary education, 57.3% of the patients came from middle class family and 72.7% patients were unmarried. About 46.4% of the patients had moderate anaemia, 28.2% had jaundice, 79.1% had hepatomegaly, 82.7% had splenomegaly and 30.9% had complication due to iron overload. Mean haemoglobulin (Hb%) was found 6.65±1.63 gm/dl, mean serum ferritin was found 3785±17637 ?g/L and mean SGPT was found 134.8±77.94 U/L. There was a significant positive correlation (r=0.259; p=0.006) between serum ferritin and SGPT.Conclusion : Considering the study result it can be concluded that there is a positive significant correlation between serum ferritin with SGPT level.Northern International Medical College Journal Vol.8(1) July 2016: 170-173

2019 ◽  
Vol 14 (1) ◽  
pp. 73-77
Author(s):  
Masuma Ahmed Salsabil ◽  
Ashesh Kumar Chowdhury ◽  
Debashish Saha ◽  
Arif Ahmed Khan ◽  
Sazia Sultana

Introduction: The development of anti-RBC antibodies (alloantibodies and/or autoantibodies) can significantly complicate transfusion therapy, particularly in patients needed repeated transfusion. Objectives: To find out the prevalence of alloantibodies and autoantibodies in repeatedly transfused patients so that serious hazards due to immune reaction may be avoided. Materials and Methods: This descriptive cross-sectional study was carried out in Department of Immunology, BIRDEM and Armed Forces Institute of Pathology (AFIP) during the period of July 2015 to June 2016. Total 370 patients who had received at least five units of transfusions were enrolled in this study but known patients of auto immune haemolytic anaemia, patients in whom antibody was previously detected and pregnant women were excluded from the study. Blood grouping and Direct Anti-globulin Test (DAT) were performed with cell suspension using a poly-specific Coombs reagent. In cases of a positive DAT, further investigation using specific monoclonal reagents to detect IgG or a complement (C3d) was carried out. Serum was used to detect red cell alloantibodies using standard blood bank methods. Antibody identification was performed in antibody screening positive samples using red cell Identicells. Results: Maximum 132 (35.7%) patients were in the age group 1-10 years. The male-female ratio was 1.2:1. Among 370 total patients 290 were HHA and 80 were non-HHA. Antibody was detected in only 17(4.59%) patients. Among the Hereditary Haemolytic Anaemia (HHA) patients it was 11 (3.79%) but among the non-HHA patients it was 6(7.5%). Out of 8 auto-antibodies, 5 were anti IgG followed by 3 were anti C3d. Out of 14 alloantibodies, 4(28.6%) were anti E, 3(21.4%) were anti K and in 3(21.4%) cases specificity of alloantibody was not detected. Conclusion: Prevalence of anti-RBC antibodies was not so uncommon in multiple transfused patients. Journal of Armed Forces Medical College Bangladesh Vol.14(1) 2018: 73-77


Author(s):  
Ambika Sood ◽  
Pancham Kumar ◽  
Rakesh Sharma ◽  
Deepak Sharma ◽  
Sanya Sharma

Background: MIS-C as a disease has varied symptoms and signs that affect multiple organs and systems in the body. The present study aimed to describe the clinical presentation among children admitted as a case of multisystem inflammatory syndrome in children in Indira Gandhi Medical College, Shimla.Methods: We conducted a cross sectional study of children with MIS-C from January to July 2021, in the pediatric ward of Indira Gandhi Medical College Shimla in Himachal Pradesh. All children admitted with a diagnosis of MISC were included in the study. Data regarding clinical presentation was extracted and analyzed using Epi Info V7 software.Results: In the present study, a total of 31 children diagnosed and admitted as a case of multisystem inflammatory syndrome in children (MIS-C) were included. Mean age of these children was 7.12±4.78 years. Among the total 16 (51.6%) were males while 15 (48.4%) were females. All 31 patients had presented with fever and 13 (41.9%) patients had fever with rash. 5 (16.1%) had cough, 1 (3.2%) child presented with hematemesis, 18 (58.1%) had tachypnea at presentation and 15 (48.4%) patients had respiratory distress. 16 (51.6%) children had complaints of vomiting, 1 (3.2%) presented with bleeding diathesis and 12 (38.7%) had hematuria, 5 (16.1%) had seizures and 8 (25.8%) presented with encephalopathy. 19 (61.3%) children had hypotension, 15 (48.4%) had hepatomegaly and 15 (48.4%) had splenomegaly.Conclusions: It is very essential to characterize this syndrome to fully understand its spectrum, therefore we need to be continuously watchful for its varied clinical presentations, both for ensuring an early diagnosis and treatment of patients suffering from MIS-C.


2020 ◽  
Vol 27 (10) ◽  
pp. 2253-2259
Author(s):  
Zaid Umer ◽  
Irum Hayat ◽  
Muhammad Waseem ◽  
Nauman Aziz ◽  
Hafiza Swaiba Afzal ◽  
...  

Objectives: To know the frequency of obstructive pattern on spirometry in asymptomatic chronic smokers. Study Design: Cross-sectional study. Settings: Department of Pulmonology, Sahiwal Medical College Sahiwal. Period: 1st Nov, 2019 to 1st May 2020. Materials & Methods: A total of 205 chronic smokers aged 30-60 years were included. Patients with history of Ischemic heart disease, previously diagnosed cases of COPD and asthma were excluded. Spirometry was done by using portable spirometer by consultant pulmonologist (at least 2 years of post-fellowship experience) and obstructive pattern (COPD) was noted. Results: Majority males with ages between 41 to 50 years( mean age 47.78 ± 4.90 years)  out of the 205 patients, 137 (66.83%) were male and 68 (33.17%) were females with male to female ratio of 2:1. Mean duration of smoking was 8.81 ± 4.67 years. Mean height was 161.81 ± 9.23 cm. Mean weight was 78.81 ± 5.67 kg. Mean BMI was 26.21 ± 5.39 kg/m2. In this study, frequency of obstructive COPD on spirometry in asymptomatic chronic smokers was found in 29 (14.15%) patients. Conclusion: This study established that frequency of obstructive pattern on spirometry in asymptomatic chronic smokers is high.


Author(s):  
Kishore S. Gudegowda ◽  
Subathra Vengatesan ◽  
Ranganath T. Sobagiah

Background: Worldwide obesity has more than doubled since 1980. Stress is the major factor which contributes to obesity. Medical education is highly stressful. Even though medical students should be extra conscious about overweight and obesity, its prevalence was found out to be high among them. So this study was done with the aim to estimate the prevalence of overweight and obesity among the Medical College students and also to assess the factors influencing it.Methods: A cross-sectional study was conducted among second and third year medical students of Bangalore Medical College and Research Institute, Bengaluru, from July- September 2014. Informed written consent was obtained from the study participants after explaining the purpose of study. Out of 494 students, 424 had willingly participated in the study. Data was collected using a pre-tested, semi-structured, self administered questionnaire. Anthropometric measurements were taken. Descriptive statistics was used to analyze the data.Results: The prevalence of overweight and obesity were 14.6% and 11.3%. Overweight and obesity were more observed in boys (9.7%, 6.8%) than girls (5%, 4.5%). 25.9% girls & 11.1% boys were considered to have central obesity. 74.5% overweight/obese often feel stress at time of exams and 56.0% among them eat more during exams.Conclusions: The prevalence was found to be high among medical college students which were contributed by various factors. This can be reduced by modifying their diet, engaging in regular physical activity.


1970 ◽  
Vol 40 (1) ◽  
pp. 18-21 ◽  
Author(s):  
MN Hossain ◽  
Z Rahman ◽  
S Akhter

A cross sectional study was carried out at the department of Forensic Medicine in Dhaka Medical College during the period of January 2008 to December 2009. Data were collected from 3rd copy of the post mortem reports which were preserved in the department of Forensic Medicine with the verbal consent of the doctors who performed autopsy report. During this period total 5114 autopsies were conducted. Out of this 970 cases (19%) were suicidal in nature. It was noticed that all suicidal deaths occurred from 10 years to all age group respectively, but top amongst age group of suicidal deaths occurred in between 21 to 30 years of people. Suicidal deaths are more common in female than male. Suicidal deaths due to hanging is highest, next common causes of death due to organophosphorus compund poisoning. Suicidal deaths by hanging is more in female than male but in poisoning cases male are more lvictimised than female. Objectives of our study are to see the occurrence and methods of suicidal death. DOI: http://dx.doi.org/10.3329/bmj.v40i1.9957 BMJ 2011; 40(1): 18-21


2020 ◽  
Vol 22 (3) ◽  
pp. 141-145
Author(s):  
Krishna Chandra Devkota ◽  
S Hamal ◽  
PP Panta

Pleural effusion is present when there is >15ml of fluid is accumulated in the pleural space. It can be divided into two types; exudative and transudative pleural effusion. Tuberculosis and parapneumonic effusion are the common cause of exudative pleural effusion whereas heart failure accounts for most of the cases of transudative pleural effusion. This study was a hospital based cross sectional study performed at Nepal Medical College during the period of January 2016-December 2016. A total of 50 patients who fulfilled the inclusion criteria were enrolled. Pleural effusion was confirmed by clinical examination and radiology. After confirmation of pleural effusion, pleural fluid was aspirated and was analysed for protein, LDH, cholesterol. The Heffner criteria was compared with Light criteria to classify exudative or transudative pleural effusion. Among 50 patients, 30 were male and 20 were female. The mean age of patient was 45.4±21.85 years. The sensitivity and specificity of using Light criteria to detect the two type of pleural effusion was 100% and 90.9%, whereas using Heffner criteria was 94.87%, 100% respectively(P<0.01). There are variety of causes for development of pleural effusion and no one criteria is definite to differentiate between exudative or transudative effusion. In this study Light criteria was more sensitive whereas Heffner criteria was more specific to classify exudative pleural effusion. Hence a combination of criteria might be useful in case where there is difficulty to identify the cause of pleural effusion.


2020 ◽  
Vol 33 (1) ◽  
pp. 59-62
Author(s):  
Lubna Yasmin ◽  
Ferdousi Begum

Objective: The objectives of the study were to find out the prevalence of urinary incontinencein women. Materials and Methods: A cross sectional study was conducted on five hundred one (501)women older than 18 years of age who were admitted in department of obstetrics andgynaecology of Shaheed Suhrawardi Medical College and Hospital from April to December2009, answered a questionnaire about urinary incontinence. They were grouped accordingto presence or absence of urinary incontinence (incontinent and continent) and type ofincontinence present (urge, stress and mixed). Results: Urinary incontinence was found in 104(20.8%) women, out of which 25 (24%)suffered from stress incontinence only, 21 (20.2%) suffered from urge incontinence and58(55.8%) suffered mixed incontinence. Conclusions: One in five women older than 18 years of age suffer from one or other formof urinary Incontinence. Bangladesh J Obstet Gynaecol, 2018; Vol. 33(1) : 59-62


1995 ◽  
Vol 31 (2) ◽  
pp. 83-87 ◽  
Author(s):  
E. Y. W. KWAN ◽  
A. C. W. LEE ◽  
A. M. C. LI ◽  
S. C. F. TAM ◽  
C. F. CHAN ◽  
...  

2021 ◽  
Vol 8 (1) ◽  
pp. 30-33
Author(s):  
Sujit Kumar Sarker ◽  
Geethanjali Bhas ◽  
Priyanka Moitra ◽  
Ratna Paul ◽  
Md. Abdullah Yusuf ◽  
...  

Background: Periodic students’ feedback ensures and enhances the effectiveness of the curriculum of medical subject. Objective: This study was designed to obtain students appraisal of the undergraduate pharmacology curriculum and teaching methodology. Methodology: This cross-sectional study was conducted in the Department of Pharmacology at Colonel Malek Medical College, Manikganj, Bangladesh from May to June, 2019 for a period of two months. Questionnaire-based data were collected from students of both sexes who had completed 3rd Professional examination. Likert Scale was applied to collect students’ feedback on pharmacology. Results: A total number of 40 students were recruited for this study of which 60.0% students were strongly agreed about organized teaching. About 47.5% students were agreed that the course was appropriate at their level and achieved their goals in Pharmacology. However, 55% of them strongly agreed that teacher provided clear constructive feedback during class. Total 60%, were agreed that the course improved their problem-solving skills. Overall, 55% students were agreed regarding their satisfaction on Pharmacology course delivery and conduction. Conclusion: In conclusion, periodic appraisal from students regarding evaluation of the student-centric undergraduate pharmacology curriculum is vital in developing efficient medical graduates. Journal of Current and Advance Medical Research, January 2021;8(1):30-33


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