scholarly journals A clinicopathological study and management of odontogenic keratocyst

2019 ◽  
Vol 9 (1) ◽  
pp. 8-15
Author(s):  
Mohammad Asifur Rahman ◽  
Tarin Rahman ◽  
Ismat Ara Haider
Keyword(s):  
Conservative Treatment ◽  
Recurrence Rate ◽  
Surgical Resection ◽  
Treatment Options ◽  
Anatomical Structure ◽  
Odontogenic Keratocyst ◽  
High Recurrence Rate ◽  
Odontogenic Cysts ◽  
Odontogenic Keratocysts ◽  
Surgical Methods

Odontogenic Keratocyst is an aggressive odontogenic cyst with a high recurrence rate. After radicular and follicular cysts, odontogenic keratocysts are the third most common cyst of the jaws and approximately 12-14% of all odontogenic cysts. It has been retermed to Keratocystic odontogenic tumour (KCOT) as it better reflects its neoplastic nature but recently it has been re classified and retermed into the cystic category. Various surgical methods have been proposed but comparatively, conservative treatment options such as Dredging methods might be the treatment of choice due to preservation of anatomical structure. Objective: The aim of this study was to analyse the clinical, radiological and histopathological characteristics of Odontogenic Keratocyst and provide a proper management system affected by this type of lesions. Materials and methods: The prospective study was performed in Dhaka Dental College and Hospital from a period of January 2014 to January 2018. A total number of 75 patients were selected for this study based on clinical, radiological and histopathological confirmation of odontogenic keratocysts. The treatment options were enucleation, enucleation with curettage, enucleation with peripheral ostectomy, Dredging method and surgical resection. After treatment patients were followed up 1months, 3 months and 6 months in every year at least for 5 years. Results: Among 75 patient of odontogenic keratocyst; the mean age was 27.69±13.35 and age range was 11 to 66 years. Male were 53(71%) and 22 (29%) were female patients. 53 (70.67%) cases were found in the mandible, 15(20%) cases in the maxilla and in 7(9.33%) cases were involved in both maxilla and mandible; mandibular posterior region was the most specific region involved 37(69.81%).The most common clinical features revealed pain and swelling. Radiologically, 70.66% unilocular, 96% well defined and 94.66% radiolucent area were prominent. Bone expansion 37.38%, root resorption 30.00% and 36% were associated with an impacted tooth. Regarding treatment options enucleation with curatage 12%, enucleation, curettage & peripheral ostectomy 29.33%, Dredging 52% and surgical resection 6.6% was done. Recurrence occurred in 18 patients with recurrence rate of 24%. Conclusion: Odontogenic keratocyst is an aggressive cyst, male predominant, posterior mandible is the commonest site and well defined unilocular radiolucency are commonest radiological feature. Radical treatment options such as resection reduced the recurrences of the tumour but higher morbidity and jaw deformity. Comparatively, conservative treatment options such as Dredging methods might be the treatment of choice due to preservation of anatomical structure. A long term follow up is paramount importance for the research and understanding the clinical pattern, behavior, treatment and recurrence of the lesion. Update Dent. Coll. j: 2019; 9 (1): 8-15

scholarly journals Decompression: a first-intention treatment for “large” non-syndromic odontogenic keratocysts

2021 ◽  
Vol 27 (2) ◽  
pp. 29
Author(s):  
Marjorie Muret ◽  
Eve Malthiéry ◽  
Théo Casenave ◽  
Valérie Costes-Martineau ◽  
Jacques-Henri Torres
Keyword(s):  
Recurrence Rate ◽  
Dentigerous Cyst ◽  
Treatment Options ◽  
Inferior Alveolar Nerve ◽  
Final Diagnosis ◽  
High Recurrence Rate ◽  
Odontogenic Cysts ◽  
Complete Regression ◽  
Odontogenic Keratocysts ◽  
Long Term Follow Up

Though odontogenic keratocysts (OKCs) are benign lesions, they have a high recurrence rate. Because of their aggressive behavior, they have been classified as tumors by the WHO until 2017. Main differential diagnoses are amelobastoma and dentigerous cyst. Anatomopathological examination can reach a final diagnosis. Several treatments have been proposed: curettage, resection, enucleation (alone or together with peripheral ostectomy) and decompression. Decompression aims to decrease the volume of the lesion of “large” OKCs, in order to prevent surgery-related fractures and to preserve the surrounding important anatomical structures such as the inferior alveolar nerve. It could lead to a complete regression. If not, secondary enucleation can be performed in better conditions: a reduced volume to remove, a thicker epithelium to detach, a lower risk to damage neighboring anatomic structures and a lower recurrence rate. Long-term follow-up however remains necessary. Nowadays, minimally invasive surgery prevails. And since OKC was returned into the odontogenic cysts group in the WHO classification, decompression should be considered as the first intention treatment. The purpose of this paper is to provide an update about OKC features and biological mechanisms, to review the different treatment options and to provide a step-by-step protocol for decompression.

scholarly journals Complete Surgical Excision with Keeping Drain Tube in Situ for 2 to 3 Weeks in the Treatment of Cystic Hygroma: A study of 5 years

2016 ◽  
Vol 10 (1) ◽  
pp. 26-28 ◽  
Author(s):  
Swapan Kumar Paul ◽  
Suprotim Howlader ◽  
Diponker Kumar Saha ◽  
Abdur Rahed Khan
Keyword(s):  
Recurrence Rate ◽  
Surgical Resection ◽  
Treatment Options ◽  
Surgical Excision ◽  
Cystic Hygroma ◽  
The Body ◽  
High Recurrence Rate ◽  
Drain Tube ◽  
Complete Surgical Excision

Lymphangiomas are benign hamartomatous lymphatic tumours characterized by multiple communicating lymphatic channels and cystic spaces. Cystic lyphangiomas may be seen anywhere in the body but are common in neck, axilla, mediastinum and groin. Treatment options are surgical resection, radiation, sclerotherapy etc but have got high recurrence rate and complications. In the present study we hypothesized that complete surgical resection along with keeping a drain for 2-3 wks, may reduce recurrence rate. This prospective study was performed from July 2008 to June 2013. Total 21 children treated during this period by the technique of complete surgical excision with keeping drain tube in situ for 2 to 3 weeks. Ultrasound performed in all patients, CT scan and Duplex study performed in some patients, histopathology done in all patients. Patients with intra-abdominal lymphangioma not included in this study. Twenty one patients were operated during the study period and average duration of keeping drain tube was 18.57 days. Among the 21 cases 2 (9.52%) patients developed mild infection, 1 (4.76%) patient developed infection with pus formation and 1 (4.76%) patient developed recurrence. Our success in the treatment warrants further verification of potential benefits of keeping drain tube in situ for 2-3 weeks after surgical excision of lymphangiomas.Faridpur Med. Coll. J. Jan 2015;10(1): 26-28

Modern molecular and biological aspects of endometriosis-associated infertility

GYNECOLOGY ◽  
2019 ◽  
Vol 21 (5) ◽  
pp. 12-15
Author(s):  
Anastasiia S Safronova ◽  
Mikhail Yu Vysokikh ◽  
Vladimir D Chuprynin ◽  
Natalia A Buralkina
Keyword(s):  
Signaling Pathways ◽  
Recurrence Rate ◽  
High Recurrence Rate ◽  
Modern Drug ◽  
Surgical Methods ◽  
Prevention And Treatment ◽  
Biological Aspects ◽  
Methods Of Treatment ◽  
New Strategies

There is currently no consensus on the etiopathogenetic nature of endometriosis. The causes of aggressive, progressive, infiltrative growth of endometrioid tissue also remain unclear. An important problem remains the high recurrence rate of endometriosis, despite the availability of modern drug and surgical methods of treatment. The study of the central signaling pathways and the search for new key molecules is of paramount importance for a better understanding of the pathogenesis of the disease, and is also an important step in the development of new strategies for the diagnosis, prevention and treatment of endometriosis.

A Review of the Odontogenic Keratocyst and Report of a Case

2019 ◽  
pp. 1-7
Author(s):  
M. Chandra Sekhar ◽  
D. Ayesha Thabusum ◽  
M. Charitha ◽  
G. Chandrasekhar ◽  
M. Shalini
Keyword(s):  
Recurrence Rate ◽  
Cystic Lesion ◽  
Soft Tissues ◽  
Clinical History ◽  
Odontogenic Keratocyst ◽  
High Recurrence Rate ◽  
Clinical Behavior ◽  
Clinical Appearance ◽  
Odontogenic Origin ◽  
Aggressive Clinical Behavior

The Odontogenic keratocyst (OKC) is a developmental, non – inflammatory chronic cystic lesion, on radiograph it may be unilocular or multi locular OKC is a cyst of odontogenic origin, usually asymptomatic with an aggressive clinical behavior including a high recurrence rate and tendency to invade bone and adjacent soft tissues. Diagnosis is based on the clinical history, clinical appearance, and radiographs and histology. A case of odontogenic keratocyst involving the ramus of the mandible is presented in this article emphasizing on the characteristics and various features of OKC.

scholarly journals Immunohistochemical expression of ki-67 in odontogenic keratocyst: Evidence of aggressive behavior.

2020 ◽  
Vol 27 (01) ◽  
pp. 74-79
Author(s):  
Rabiya Saif ◽  
Hafiz Majid Jehangir ◽  
Abdul Hannan Nagi ◽  
Nadia Naseem ◽  
Zainab Rizvi ◽  
...  
Keyword(s):  
Aggressive Behavior ◽  
Descriptive Study ◽  
World Health ◽  
Odontogenic Keratocyst ◽  
High Recurrence Rate ◽  
Odontogenic Cysts ◽  
P Value ◽  
Proliferative Potential ◽  
Nuclear Staining ◽  
Ki 67

The odontogenic keratocyst (OKC) well-known for its aggressiveness and high recurrence rate, comprises approximately 11% of all jaw cysts. Due to its aggressive behavior it was placed into category of tumour in 2005 by the World Health Organization (WHO). Objectives: The purpose of this study was to determine the Ki-67 expression in Odontogenic Keratocysts to predict its proliferative potential. Study Design: Descriptive study. Setting: Department of Morbid Anatomy and Histopathology, UHS. Periods: June 2014- June 2018. Material & Methods: This is a descriptive study comprising of 39 cases of odontogenic cysts. These surgically removed samples were processed at University of Health Sciences (UHS) laboratory. Routine staining with Hematoxylin & Eosin stain along with immunohistochemistry (IHC) with Ki-67 antibody was performed. Immunohisto chemical scoring was done on the basis of percentage of the nuclear staining of Ki-67. Data was entered into SPSS 22 and descriptive statistics were measured in the form of percentage and frequency. Quantitative variables such as age of patient, size of the cyst, and Ki-67 score were also measured. P value <0.05 was taken as significant. Results: The mean age of the patients was 25.08 ±14.5 years. Significant association was observed between histological variables with odontogenic keratocyst such as parakeratinized epithelial lining (p = 0.00), epithelial hyperplasia both typical and atypical (p = 0.02) and focal spongiosis (p = 0.04). Foci having epithelial atypia demonstrated stronger staining intensity compared to adjacent normal epithelium. However, no significant association was observed between the histological variables and Ki-67 expression. Conclusion: OKC expressed low Ki-67 expression in most of the cases, however, foci of strong expression were also observed in few cases.

scholarly journals p63 Expression in Solitary and Syndromic Odontogenic Keratocysts: An Immunohistochemical Study

Proceedings ◽  
2019 ◽  
Vol 35 (1) ◽  
pp. 29
Author(s):  
Luconi ◽  
Togni ◽  
Giannatempo ◽  
Caponio ◽  
Mascitti ◽  
...  
Keyword(s):  
Immunohistochemical Study ◽  
Odontogenic Keratocyst ◽  
Odontogenic Cysts ◽  
Odontogenic Keratocysts

In the last years, the classification of odontogenic cysts and tumors has been highly debated, especially regarding odontogenic keratocyst (OKC). [...]

Immediate Implants After Enucleation of an Odontogenic Keratocyst: An Early Return to Function

2012 ◽  
Vol 38 (S1) ◽  
pp. 485-488 ◽  
Author(s):  
Sabri C. Isler ◽  
Sabit Demircan ◽  
Taylan Can ◽  
Zerrin Cebi ◽  
Emrah Baca
Keyword(s):  
Aggressive Behavior ◽  
Dental Implants ◽  
Recurrence Rate ◽  
Male Patient ◽  
Odontogenic Keratocyst ◽  
High Recurrence Rate ◽  
Histologic Appearance ◽  
Early Return ◽  
Immediate Implants

An odontogenic keratocyst is a unique cyst because of its locally aggressive behavior, high recurrence rate, and characteristic histologic appearance. In this article we present the case of a 22-year-old male patient with a large odontogenic keratocyst and describe his treatment with immediate dental implants.

Odontogenic Keratocyst: Diagnosis and Treatment

1983 ◽  
Vol 91 (2) ◽  
pp. 167-172 ◽  
Author(s):  
Stephen J. Wetmore ◽  
James D. Billie ◽  
Arthur Howe ◽  
William Wetzel
Keyword(s):  
Recurrence Rate ◽  
Surgical Therapy ◽  
Basal Cell ◽  
Squamous Epithelium ◽  
Diagnosis And Treatment ◽  
Odontogenic Keratocyst ◽  
Basal Cell Nevus Syndrome ◽  
Odontogenic Keratocysts

The odontogenic keratocyst is a keratinizing squamous epithelium-lined cyst that occurs in the mandible and maxilla. In 5% to 10% of patients the keratocysts may be a manifestation of the basal cell nevus syndrome. The recurrence rate after surgical therapy for odontogenic keratocysts varies from 10% to 63%.

scholarly journals Pterygium: an update on pathophysiology, clinical features, and management

2021 ◽  
Vol 13 ◽  
pp. 251584142110201
Author(s):  
Toktam Shahraki ◽  
Amir Arabi ◽  
Sepehr Feizi
Keyword(s):  
Recurrence Rate ◽  
Ocular Surface ◽  
Treatment Options ◽  
Clinical Aspects ◽  
Surgical Removal ◽  
Vascular Endothelial ◽  
First Choice ◽  
Surgical Methods ◽  
Endothelial Growth Factor

Pterygium is a relatively common ocular surface disease. The clinical aspects and the treatment options have been studied since many years ago, but many uncertainties still exist. The core pathologic pathway and the role of heredity in the development of pterygium are still attractive fields for the researchers. The role of pterygium in corneal irregularities, in addition to the refractive properties of pterygium removal, has been increasingly recognized through numerous studies. The association between pterygium and ocular surface neoplasia is challenging the traditional beliefs regarding the safe profile of the disease. The need for a comprehensive clinical classification system has encouraged homogenization of trials and prediction of the recurrence rate of the pterygium following surgical removal. Evolving surgical methods have been associated with some complications, whose diagnosis and management are necessary for ophthalmic surgeons. According to the review, the main risk factor of pterygium progression remains to be the ultraviolet exposure. A major part of the clinical evaluation should consist of differentiating between typical and atypical pterygia, where the latter may be associated with the risk of ocular surface neoplasia. The effect of pterygium on astigmatism and the aberrations of the cornea may evoke the need for an early removal with a purpose of reducing secondary refractive error. Among the surgical methods, conjunctival or conjunctival-limbal autografting seems to be the first choice for ophthalmic surgeons because the recurrence rate following the procedure has been reported to be lower, compared with other procedures. The use of adjuvant options is supported in the literature, where intraoperative and postoperative mitomycin C has been the adjuvant treatment of choice. The efficacy and safety of anti–vascular endothelial growth factor agents and cyclosporine have been postulated; however, their exact role in the treatment of the pterygium requires further studies.

scholarly journals Maxillary Odontogenic Keratocyst Masquerading a Periapical Cyst

2018 ◽  
Vol 2 (6) ◽  
pp. 133-137
Author(s):  
Jayaprasad Anekar ◽  
Krishna Santhosh Kumar ◽  
Deepika Nappalli ◽  
Ivin Elsa John
Keyword(s):  
Computed Tomography ◽  
Treatment Planning ◽  
Recurrence Rate ◽  
Aggressive Behaviour ◽  
Odontogenic Cyst ◽  
Odontogenic Keratocyst ◽  
High Recurrence Rate ◽  
Keratocystic Odontogenic Tumor ◽  
Advanced Imaging ◽  
Periapical Cyst

Odontogenic keratocysts previously termed, as keratocystic odontogenic tumor is a developmental odontogenic cyst. It is one of the most commonly occurring odontogenic cyst and is characterized by its aggressive behaviour, high recurrence rate and association with syndromes. A case of odontogenic keratocyst occurring in the maxillary anterior region is described here with emphasis on the importance of advanced imaging modalities like computed tomography in the diagnosis and treatment planning.

Sign in / Sign up

Export Citation Format

Share Document