scholarly journals What is the impact of drug therapy with antiresorptive agents on the success of dental implants? a literature review

2021 ◽  
Vol 10 (13) ◽  
pp. e211101321074
Author(s):  
Gabriela Sumie Yaguinuma Gonçalves ◽  
Leandro Marcel Soares Alves ◽  
Milena Steluti Marques
Keyword(s):  
Literature Review ◽  
Dental Implants ◽  
Web Of Science ◽  
Osteonecrosis Of The Jaw ◽  
Good Prognosis ◽  
Antiresorptive Agents ◽  
Increased Risk ◽  
Research Findings ◽  
Dental Implant Surgery ◽  
The Impact

Objective: To review the current literature and provide the latest information on anti-resorptive agent-induced osteonecrosis of the jaw (ARONJ), including our basic and clinical research findings, as well as discuss the risks of developing osteonecrosis in patients undergoing dental implant surgery in use of anti-resorptive drugs (ARDs). Methods: A literature review was performed using articles published in indexed journals based on Pubmed, Web of Science, Embase and Scopus databases. Results: Our results show that the placement of dental implants in patients treated with ARDs should be carefully evaluated, these patients are not free from complications and, therefore, the risk assessment should be done individually, as one of the most serious complications, although rare, is the ARONJ. Conclusion: Thus, all patients treated with this type of drug should be informed about the risk of implant loss or the possibility of osteonecrosis, being necessary to inform about the increased risk also patients who already have osteointegrated implants and will start therapy with bisphosphonates (BPT). And, in addition, establishing a relationship and collaboration between doctor, dentist and patient is essential for the good prognosis of these cases.

scholarly journals Focus on Function in Hospitalized Persons With Dementia: The Impact of Hospital-Acquired Complications

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 762-762
Author(s):  
Marie Boltz ◽  
Lorraine Mion
Keyword(s):  
Acute Care ◽  
Goal Attainment ◽  
Functional Decline ◽  
Policy And Practice ◽  
Increased Risk ◽  
Research Findings ◽  
Pharmacologic Management ◽  
Hospitalized Older Adults ◽  
Hospital Acquired ◽  
The Impact

Abstract Persons with dementia (PWD) are two-three times more likely to be hospitalized as persons without dementia and comprise one fourth of hospitalized older adults. Hospitalization often has a dramatic impact upon the health and disposition of the older PWD. They are at increased risk for hospital acquired complications (HAC) such as functional decline, behavioral symptoms of distress, and delirium, all of which contribute to increased disability, mortality, and long-term nursing home stays. Despite the unprecedented number of PWD admitted to acute care, little attention has focused on their specialized needs and HAC, and how they impact functional recovery. The purpose of this symposium is to describe the incidence of common HACs, and factors that influence their occurrence and presentation in PWD. Utilizing baseline findings from the Family-centered Function-focused Care (Fam-FFC) trial, the presentations will address this objective and discuss the ramifications for functional and cognitive post-acute recovery in PWD. The first presentation will describe the incidence and pharmacologic management of pain in PWD, and its association with common HACs. The second presentation will describe physical activity in PWD on medical units and the validity of the Motionwatch8 actigraphy. The third session will describe differences in common HACs between white and black PWD. The final presentation will examine function-focused goals developed in collaboration with family caregivers and patients, and the functional outcomes associated with goal attainment. Our discussant, Dr. Lorraine Mion, will synthesize the research findings and lead a discussion of future directions for policy and practice in dementia-capable acute care.

Development of Antiresorptive Agent-Related Osteonecrosis of the Jaw After Dental Implant Removal: A Case Report

2018 ◽  
Vol 44 (5) ◽  
pp. 359-364
Author(s):  
Shinsuke Yamamoto ◽  
Keigo Maeda ◽  
Izumi Kouchi ◽  
Yuzo Hirai ◽  
Naoki Taniike ◽  
...  
Keyword(s):  
Dental Implants ◽  
Dental Implant ◽  
Osteonecrosis Of The Jaw ◽  
Japanese Woman ◽  
Implant Removal ◽  
Antiresorptive Agent ◽  
Oral Bisphosphonate ◽  
Antiresorptive Agents ◽  
The Right ◽  
Implant Treatment

Dental implant treatment is a highly predictable therapy, but when potentially lethal symptoms or complications occur, dentists must remove the implant fixture. Recently, reports on antiresorptive agent-related osteonecrosis of the jaw have increased in the field of dental implants, although the relationship between dental implant treatment and antiresorptive agents remains unclear. Here, we report a case of antiresorptive agent-related osteonecrosis of the jaw that developed after dental implant removal. A 67-year-old Japanese woman with a medical history of osteoporosis and 7 years of oral bisphosphonate treatment was referred to our hospital with a chief complaint of painful right mandibular bone exposure. A family dentist removed the dental implants from the right mandible using a trephine drill without flap elevation in August 2016. However, the healing was impaired; she was referred to our hospital 3 months after the procedure. We performed a sequestrectomy of the mandible under general anesthesia. In conclusion, this patient's course has two important implications: First, the removal of dental implants from patients who are prescribed oral bisphosphonates for long durations can cause antiresorptive agent-related osteonecrosis of the jaw. Second, meticulous procedures are required to prevent and treat the development of antiresorptive agent-related osteonecrosis of the jaw after dental implant removal.

Trauma-Informed Leadership in the 21st Century

2021 ◽  
pp. 335-355
Author(s):  
Kyna Elliott
Keyword(s):  
Literature Review ◽  
Learning Environment ◽  
21St Century ◽  
Mitigation Strategies ◽  
Relational Leadership ◽  
Physiological Effects ◽  
Global Pandemic ◽  
Research Findings ◽  
Trauma Informed ◽  
The Impact

The 21st century has been marked by war, migration, racial and political tensions, and the COVID-19 global pandemic. The impact of these events on communities is evident in research findings on trauma and education in the 21st century. The purpose of this chapter is to examine the impact of trauma on the learning environment and the ways which trauma-informed leadership may mitigate its effects in the classroom. A literature review will present existing research on trauma, learning in the classroom, educator performance, and trauma-informed relational leadership. A description of the physiological effects of trauma, examples of manifestations in the classroom, and leadership and educator mitigation strategies are provided. The chapter ends with recommendations of leadership's role in modeling trauma-informed practices and mitigation strategies.

scholarly journals Citation bias and selective focus on positive findings in the literature on the serotonin transporter gene (5-HTTLPR), life stress and depression

2016 ◽  
Vol 46 (14) ◽  
pp. 2971-2979 ◽  
Author(s):  
Y. A. de Vries ◽  
A. M. Roest ◽  
M. Franzen ◽  
M. R. Munafò ◽  
J. A. Bastiaansen
Keyword(s):  
Serotonin Transporter ◽  
Life Stress ◽  
Web Of Science ◽  
Evidence Base ◽  
Transporter Gene ◽  
Negative Results ◽  
Research Findings ◽  
Citation Bias ◽  
The Impact ◽  
Positive Focus

BackgroundCaspi et al.'s 2003 report that 5-HTTLPR genotype moderates the influence of life stress on depression has been highly influential but remains contentious. We examined whether the evidence base for the 5-HTTLPR–stress interaction has been distorted by citation bias and a selective focus on positive findings.MethodA total of 73 primary studies were coded for study outcomes and focus on positive findings in the abstract. Citation rates were compared between studies with positive and negative results, both within this network of primary studies and in Web of Science. In addition, the impact of focus on citation rates was examined.ResultsIn all, 24 (33%) studies were coded as positive, but these received 48% of within-network and 68% of Web of Science citations. The 38 (52%) negative studies received 42 and 23% of citations, respectively, while the 11 (15%) unclear studies received 10 and 9%. Of the negative studies, the 16 studies without a positive focus (42%) received 47% of within-network citations and 32% of Web of Science citations, while the 13 (34%) studies with a positive focus received 39 and 51%, respectively, and the nine (24%) studies with a partially positive focus received 14 and 17%.ConclusionsNegative studies received fewer citations than positive studies. Furthermore, over half of the negative studies had a (partially) positive focus, and Web of Science citation rates were higher for these studies. Thus, discussion of the 5-HTTLPR–stress interaction is more positive than warranted. This study exemplifies how evidence-base-distorting mechanisms undermine the authenticity of research findings.

Suicide and assisted dying in dementia: what we know and what we need to know. A narrative literature review

2017 ◽  
Vol 29 (8) ◽  
pp. 1247-1259 ◽  
Author(s):  
J. Diehl-Schmid ◽  
R. Jox ◽  
S. Gauthier ◽  
S. Belleville ◽  
E. Racine ◽  
...  
Keyword(s):  
Risk Factors ◽  
Literature Review ◽  
Cochrane Library ◽  
Assisted Dying ◽  
Increased Risk ◽  
Narrative Literature ◽  
Narrative Literature Review ◽  
And Behavior ◽  
The Impact ◽  
Risk Factors For Suicide

ABSTRACTBackground:Evidence-based data on prevalence and risk factors of suicidal intentions and behavior in dementia are as scarce as the data on assisted dying. The present literature review aimed on summarizing the current knowledge and provides a critical discussion of the results.Methods:A systematic narrative literature review was performed using Medline, Cochrane Library, EMBASE, PSYNDEX, PSYCINFO, Sowiport, and Social Sciences Citation Index literature.Results:Dementia as a whole does not appear to be a risk factor for suicide completion. Nonetheless some subgroups of patients with dementia apparently have an increased risk for suicidal behavior, such as patients with psychiatric comorbidities (particularly depression) and of younger age. Furthermore, a recent diagnosis of dementia, semantic dementia, and previous suicide attempts most probably elevate the risk for suicidal intentions and behavior. The impact of other potential risk factors, such as patient's cognitive impairment profile, behavioral disturbances, social isolation, or a biomarker based presymptomatic diagnosis has not yet been investigated. Assisted dying in dementia is rare but numbers seem to increase in regions where it is legally permitted.Conclusion:Most studies that had investigated the prevalence and risk factors for suicide in dementia had significant methodological limitations. Large prospective studies need to be conducted in order to evaluate risk factors for suicide and assisted suicide in patients with dementia and persons with very early or presymptomatic diagnoses of dementia. In clinical practice, known risk factors for suicide should be assessed in a standardized way so that appropriate action can be taken when necessary.

scholarly journals Towards a Conceptual Development of Industry 4.0, Servitisation, and Circular Economy: A Systematic Literature Review

2021 ◽  
Vol 13 (11) ◽  
pp. 6501
Author(s):  
Sehrish Atif ◽  
Shehzad Ahmed ◽  
Muhammad Wasim ◽  
Bassam Zeb ◽  
Zeeshan Pervez ◽  
...  
Keyword(s):  
Literature Review ◽  
Systematic Literature Review ◽  
Circular Economy ◽  
Industry 4.0 ◽  
Conceptual Development ◽  
Fully Integrated ◽  
Innovative Products ◽  
Research Findings ◽  
The Impact

Industry 4.0 (I4.0) technologies have been highlighted in recent literature as enablers of servitisation. Simultaneously, businesses are advised to implement a circular economy (CE) to bring new opportunities. However, it is pertinent to mention that little attention has been given to assess the role of I4.0 in adopting the CE and servitisation in a fully integrated manner. This research fills this gap by developing a conceptual framework through a systematic literature review of 139 studies investigating the relationship between the I4.0, CE, and servitisation. This study identifies the impact of these variables on a firm’s operational and financial performance (revenue stream, growth, and profitability). Our research findings advocate that adopting I4.0 technologies to the business and manufacturing model enables sustainability, energy and resource efficiency while enhancing performance and offering innovative products through smart services. Thus, firms must systematically adopt I4.0 technologies to support a CE model that creates value through servitisation. This study identifies the research gaps that are unexplored for practitioners and future researchers while providing insight into the role of I4.0 in implementing CE in the servitisation business model.

scholarly journals The Impact of Nandrolone Decanoate in the Osseointegration of Dental Implants in a Rabbit Model: Histological and Micro-Radiographic Results

Materials ◽  
2021 ◽  
Vol 14 (9) ◽  
pp. 2258
Author(s):  
Saturnino Marco Lupi ◽  
Alessandra Nicole Sassi ◽  
Alessandro Addis ◽  
Ruggero Rodriguez y Baena
Keyword(s):  
Dental Implants ◽  
Bone Fractures ◽  
Rabbit Model ◽  
Test Group ◽  
Control Group ◽  
Clinical Effects ◽  
Nandrolone Decanoate ◽  
Implant Placement ◽  
Increased Risk ◽  
The Impact

Despite high rates of osseointegration in healthy patients, complex cases present an increased risk of osseointegration failure when treated with dental implants. Furthermore, if immediate loading of the implants is used, maximizing the response of the host organism would be desirable. Anabolic steroids, such as Nandrolone Decanoate (ND), are reported to have beneficial clinical effects on various bone issues such as osteoporosis and bone fractures. However, their beneficial effects in promoting osseointegration in dental implant placement have not been documented. The study aimed to examine histological changes induced by ND in experimental dental implants in rabbit models. Two dental implants were placed in the tibias of 24 adult rabbits. Rabbits were allocated to one of two groups: control group or test group. Rabbits in the latter group were given nandrolone decanoate (15 mg/kg, immediately after implant placement and after 1 week). Micro-radiographic and histological analyses were assessed to characterize the morphological changes promoted by the nandrolone decanoate use. Total bone volume and fluorescence were significantly higher in the control group after 2 weeks. Such a difference between the two groups might indicate that, initially, nandrolone lengthens the non-specific healing period characteristic of all bone surgeries. However, after the beginning of the reparative processes, the quantity of newly formed bone appears to be significantly higher, indicating a positive stimulation of the androgen molecule on bone metabolism. Based on micro-radiology and fluorescence microscopy, nandrolone decanoate influenced bone regeneration in the implant site. The anabolic steroid nandrolone decanoate affects the healing processes of the peri-implant bone and therefore has the potential to improve the outcomes of implant treatment in medically complex patients.

scholarly journals Approaching the Social Impact of Research Through a Literature Review

2021 ◽  
Vol 20 ◽  
pp. 160940692110521
Author(s):  
Alba Viana-Lora ◽  
Marta Gemma Nel-lo-Andreu
Keyword(s):  
Literature Review ◽  
Social Impact ◽  
Web Of Science ◽  
Point Of View ◽  
Future Research ◽  
Fields Of Study ◽  
The Social ◽  
The Subject ◽  
Key Aspects ◽  
The Impact

The article carries out a systematic literature review on the social impact of research in all fields of study. To this end, this study has compiled the publications on the subject using the Web of Science database, and the most relevant terms have been mapped using the VOSviewer tool. The aim of the article is to advance and provide knowledge on the key aspects to be taken into account for research to generate social benefits and to analyse the main methods and instruments used to assess the social impact of research. At the same time, this article serves as a point of reflection to raise awareness, on a recent topic, of the limitations that arise in evaluation and research gaps that can be addressed in future research. This line of research has been in existence for just over 10 years. International programmes, such as Horizon Europe, highlight the impact channels and, in the field of social sciences, specific methodologies such as communicative communication are being developed. To the best of our knowledge, this is the first study to analyse the subject from a global point of view, without specifying the field of study, providing a conceptual map of the subject.

scholarly journals Impact of Antiresorptive Agents on Maxillary Bones: a Narrative Literature Review

2021 ◽  
Vol 23 (4) ◽  
pp. 268-276
Author(s):  
Maria Luiza da Silva Matos ◽  
Pedro Henrique Bastos de OIiveira ◽  
Ana Carla Barletta Sanches ◽  
Tila Fortuna Costa Freire ◽  
Juliana Borges de Lima Dantas ◽  
...  
Keyword(s):  
Literature Review ◽  
Adverse Effects ◽  
Osteonecrosis Of The Jaw ◽  
Drug Holiday ◽  
Osteonecrosis Of The Jaws ◽  
Antiresorptive Agents ◽  
Antiresorptive Drugs ◽  
Bibliographic Search ◽  
Narrative Literature ◽  
Narrative Literature Review

AbstractAntiresorptive drugs operate in the bone metabolism modulation and are widely used in the treatment of bone metastases and bone losses related to hormonal deficiency. Although this therapy shows satisfactory results, there are adverse effects associated with its use, such as osteonecrosis of the jaws. Medication-related osteonecrosis of the jaws (MRONJ) is, therefore, a serious and challenging condition with important implications in dentistry. The aim was to conduct a narrative literature review on anti-resorptive drugs and their latest repercussions on the maxillary bones. The review was carried out through a bibliographic search using Decs/Mesh descriptors of interest, in Portuguese and English, in the PubMed, Virtual Health Library (VHL) and Scielo databases. After applying the inclusion and exclusion criteria, a total of 33 studies were selected for analysis. It can be noticed that therapy with anti-resorptive agents is complex, especially in dental practice, since MRONJ is a complication that is difficult to manage. Regarding the therapeutic options, these are divided into conservative, surgical or adjuvant therapy, however, there are no protocols in the literature, and there is no consistency regarding the indication of the suspension of the drug administration - "Drug Holiday". Thus, it is important that the multidisciplinary team seeks strategies that minimize complications and promote control over the use of these drugs. In addition, there is a need for investigations that contribute with guidelines for the management and control of adverse effects resulting from therapy with antiresorptive drugs. Keywords: Bone Density Conservation Agents. Diphosphonates. Denosumab. Bisphosphonate-Associated Osteonecrosis of the Jaw. ResumoAs drogas antirreabsortivas atuam na modulação do metabolismo ósseo e são indicadas para o tratamento de metástases ósseas e perdas ósseas relacionadas à deficiência hormonal. Ainda que esta terapia apresente resultados satisfatórios, observam-se efeitos adversos associados ao seu uso, como a osteonecrose dos maxilares. A osteonecrose dos maxilares associada ao uso de medicamentos (OMAM) é, portanto, uma condição séria e desafiadora com implicações importantes na Odontologia. O objetivo foi realizar uma revisão narrativa de literatura sobre as drogas antirreabsortivas e suas respectivas repercussões nos ossos maxilares. A revisão foi realizada através de busca bibliográfica utilizando descritores Decs/Mesh de interesse, em português e inglês, nas bases de dados PubMed, Biblioteca Virtual de Saúde (BVS) e Scielo. Após aplicação dos critérios de inclusão e exclusão, um total de 33 trabalhos foram selecionados para análise. Pode-se constatar que a terapia com agentes antirreabsortivos é complexa, sobretudo na prática odontológica, visto que a OMAM é uma complicação de difícil manejo. Em relação às condutas terapêuticas para esta condição, divide-se em terapia conservadora, cirúrgica ou adjuvante, todavia, não existem protocolos validados na literatura, bem como não há consistência quanto à indicação do intervalo de suspensão da administração da droga - “Drug Holiday”. Desse modo, é importante que a equipe multidisciplinar busque estratégias que minimizem as complicações e promovam o controle no uso dessas drogas. Além disso, nota-se a necessidade de realizar investigações que contribuam com diretrizes para o manejo e controle dos efeitos adversos decorrentes da terapia com medicamentos antirreabsortivos. Palavras-chave: Conservadores da Densidade Óssea. Bisfosfonatos. Denosumabe. Osteonecrose Associada a Bisfosfonatos.  

Medication-Related Osteonecrosis of the Jaw and Dental Implants Failures: A Systematic Review

2017 ◽  
Vol 43 (1) ◽  
pp. 51-57 ◽  
Author(s):  
Riccardo Guazzo ◽  
Luca Sbricoli ◽  
Sara Ricci ◽  
Eriberto Bressan ◽  
Adriano Piattelli ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dental Implants ◽  
Osteonecrosis Of The Jaw ◽  
Implant Failure ◽  
Level Of Evidence ◽  
Antiresorptive Agent ◽  
Antiresorptive Agents ◽  
Real Risk ◽  
Related Risk ◽  
Present Systematic Review

No well-established evidence supporting safe use of bisphosphonates (BPs) or other antiresorptive agents prior, during, or after dentoalveolar surgery, are currently available; moreover, the real risk of osteonecrosis of the jaw (ONJ) development is still unknown. The aim of the present systematic review was to assess the scientific literature concerning the implants placement in antiresorptive agent users and the related risk of implants failure and ONJ development. English papers published from January 2003 until December 2014 were identified on the MEDLINE database. Titles and abstracts retrieved form electronic search were screened separately by 2 examiners; thus, original studies dealing with dental implants placement during or before bone antiresorptive agent therapy and the relative risk of implant failure or development of osteonecrosis were evaluated. Due to the heterogeneity of the included studies and the high risk of bias, there is no evidence of the safe use of oral antiresorptive agents prior or after dental implant surgery. Indeed, implant failure and ONJ development can occur and represent a devastating side effect that should be considered during treatment. Within the limitation of the present systematic review, high quality studies are needed to provide an adequate level of evidence regarding the safety of dentoalveolar surgery during or before bone resorption inhibition therapy and the increase predisposition to osteonecrosis of the jaw (ONJ) development. Therefore, antiresorptive agent therapy should be considered a risk factor until further evidence is prospectively obtained.

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