scholarly journals Economic and Clinical Benefits of Galantamine in the Treatment of Mild to Moderate Alzheimer's Disease in a Korean Population: A 52-Week Prospective Study

2008 ◽  
Vol 23 (1) ◽  
pp. 10 ◽  
Author(s):  
Guk-Hee Suh ◽  
Hee Yeon Jung ◽  
Chang Uk Lee ◽  
Sungku Choi ◽  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Prospective Study ◽  
Korean Population ◽  
Clinical Benefits

scholarly journals Revisiting the Amyloid Cascade Hypothesis: From Anti-Aβ Therapeutics to Auspicious New Ways for Alzheimer’s Disease

2020 ◽  
Vol 21 (16) ◽  
pp. 5858 ◽  
Author(s):  
Md. Sahab Uddin ◽  
Md. Tanvir Kabir ◽  
Md. Sohanur Rahman ◽  
Tapan Behl ◽  
Philippe Jeandet ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Trials ◽  
Clinical Symptoms ◽  
Neurodegenerative Disorder ◽  
Early Stage ◽  
Amyloid Β ◽  
Aβ Oligomers ◽  
Aβ Aggregation ◽  
Clinical Benefits

Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder related to age, characterized by the cerebral deposition of fibrils, which are made from the amyloid-β (Aβ), a peptide of 40–42 amino acids. The conversion of Aβ into neurotoxic oligomeric, fibrillar, and protofibrillar assemblies is supposed to be the main pathological event in AD. After Aβ accumulation, the clinical symptoms fall out predominantly due to the deficient brain clearance of the peptide. For several years, researchers have attempted to decline the Aβ monomer, oligomer, and aggregate levels, as well as plaques, employing agents that facilitate the reduction of Aβ and antagonize Aβ aggregation, or raise Aβ clearance from brain. Unluckily, broad clinical trials with mild to moderate AD participants have shown that these approaches were unsuccessful. Several clinical trials are running involving patients whose disease is at an early stage, but the preliminary outcomes are not clinically impressive. Many studies have been conducted against oligomers of Aβ which are the utmost neurotoxic molecular species. Trials with monoclonal antibodies directed against Aβ oligomers have exhibited exciting findings. Nevertheless, Aβ oligomers maintain equivalent states in both monomeric and aggregation forms; so, previously administered drugs that precisely decrease Aβ monomer or Aβ plaques ought to have displayed valuable clinical benefits. In this article, Aβ-based therapeutic strategies are discussed and several promising new ways to fight against AD are appraised.

Prognosis of Alzheimer's disease today: A two-year prospective study in 686 patients from the REAL-FR Study

2008 ◽  
Vol 4 (1) ◽  
pp. 22-29 ◽  
Author(s):  
Frédéric Cortes ◽  
Fati Nourhashémi ◽  
Olivier Guérin ◽  
Christelle Cantet ◽  
Sophie Gillette-Guyonnet ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Prospective Study ◽  
The Real

scholarly journals Association of Apolipoprotein E genetic variation in Alzheimer's disease in a Korean population

2020 ◽  
Vol 16 (S3) ◽  
Author(s):  
Giau Van Vo ◽  
Eva Bagyinszky ◽  
Seong Soo An ◽  
SangYun Kim
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Variation ◽  
Apolipoprotein E ◽  
Korean Population

362-S: Prospective Study of Diabetes, Gender, and Subsequent Risk of Alzheimer's Disease: The Cache County Study on Memory, Health, and Aging

2005 ◽  
Vol 161 (Supplement_1) ◽  
pp. S91-S91 ◽  
Author(s):  
G Charoonruk ◽  
R Munger ◽  
H Wengreen ◽  
C Corcoran ◽  
K Hayden ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Prospective Study ◽  
Cache County ◽  
Subsequent Risk

Clinical Benefits for Older Alzheimer’s Disease Patients: Okayama Late Dementia Study (OLDS)

2015 ◽  
Vol 46 (3) ◽  
pp. 687-693 ◽  
Author(s):  
Kosuke Matsuzono ◽  
Toru Yamashita ◽  
Yasuyuki Ohta ◽  
Nozomi Hishikawa ◽  
Kota Sato ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Benefits

scholarly journals No association of prion protein gene polymorphisms with Alzheimer's disease in Korean population

2006 ◽  
Vol 38 (6) ◽  
pp. 727-731 ◽  
Author(s):  
Kyungsook Ahn ◽  
Eunkyung Kim ◽  
Young-A Kwon ◽  
Doh Kwan Kim ◽  
Jong-Eun Lee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Prion Protein ◽  
Gene Polymorphisms ◽  
Protein Gene ◽  
Korean Population ◽  
Prion Protein Gene

Lack of association of the interleukin-1? gene polymorphism with Alzheimer's disease in a Korean population

2001 ◽  
Vol 49 (6) ◽  
pp. 817-818 ◽  
Author(s):  
Chang-Seok Ki ◽  
Duk Lyul Na ◽  
Doh Kwan Kim ◽  
Hye Jin Kim ◽  
Jong-Won Kim
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gene Polymorphism ◽  
Interleukin 1 ◽  
Korean Population
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