scholarly journals The Prescription Pattern of Acetaminophen and Non-Steroidal Anti-Inflammatory Drugs in Patients with Liver Cirrhosis

2016 ◽  
Vol 31 (10) ◽  
pp. 1604 ◽  
Author(s):  
Young Mi Hong ◽  
Ki Tae Yoon ◽  
Jeong Heo ◽  
Hyun Young Woo ◽  
Won Lim ◽  
...  
2017 ◽  
Vol 6 (4) ◽  
pp. 206
Author(s):  
Zhila Taherzadeh ◽  
Majid Zeinali ◽  
Jamshid Tabeshpour ◽  
SeyedVahid Maziar ◽  
MohammadReza Zirak ◽  
...  

2019 ◽  
Vol 30 (2) ◽  
Author(s):  
Stefanía Hernández Viana ◽  
Natalia Silva Gómez ◽  
David Andrés Gálvis Pareja ◽  
María Cecilia Martínez Pabón

Introduction: dental surgical procedures trigger an inflammatory response, for which dental practitioners prescribe analgesic and anti-inflammatory medications using pharmacological guidelines that require knowledge on the use of medicines in a given environment. The aim of the present study was to identify the analgesics and anti-inflammatory drugs most commonly prescribed at the oral surgery service of the Universidad de Antioquia School of Dentistry. Methods: this retrospective descriptive study reviewed the clinical records of the oral surgery service in the period January 2013-August 2015. A total of 1,177 records were reviewed, and 709 were selected for analysis. Results: 53.1% of the drugs prescribed were non-selective Nonsteroidal Anti-Inflammatory Drugs (NSAIDs). Ibuprofen was formulated in 26.7% of all cases, followed by nimesulide with 24.1% and the combination of acetaminophen plus meloxicam with 10.2%. This same prescription pattern was observed in patients reporting no additional relevant medical history. In the case of gastric history, nimesulide was the drug of choice. 84% of all procedures were surgical extractions of third molars, with ibuprofen 600 mg postoperative for three days as the main therapeutic scheme. Conclusion: ibuprofen, nimesulide, and the combination acetaminophen plus meloxicam were the main analgesics and anti-inflammatory drugs prescribed in this study, according to medical and surgical records.


2018 ◽  
Vol 71 (1-2) ◽  
pp. 27-32
Author(s):  
Zeljka Savic ◽  
Dragomir Damjanov ◽  
Vladimir Vracaric ◽  
Dijana Kosijer ◽  
Dimitrije Damjanov ◽  
...  

Introduction. The occurrence of peptic ulcer in patients with liver cirrhosis is intriguing due to its frequency and complexity. The aim of the present study was to investigate the incidence of peptic ulcer in patients with liver cirrhosis. Results. It was found that in these patients the usual aggressive factors of the gastric environment do not play a major role in ulcerogenesis; however, researches noticed the importance of reduced mucosal defense which, in portal hypertension, has the features of hypertensive portal gastropathy. The presence of Helicobacter pylori infection in these patients is lower, compared to other patients with peptic ulcer. The prevalence of Helicobacter pylori infection decreases with the severity of liver cirrhosis. Non-steroidal anti-inflammatory drugs play an important role in peptic ulcer bleeding in cirrhotic patients, but the data are limited and contradictory. Peptic ulcer bleeding is the most frequent etiology of nonvariceal bleeding and it is associated with a great number of complications. Conclusion. Helicobacter pylori infection cannot be considered the key risk factor for the development of peptic ulcer in patients with liver cirrhosis. The role of non-steroidal anti-inflammatory drugs is accepted, although the data are controversial. The treatment of peptic ulcer in cirrhotic patients is identical to the treatment of peptic ulcer in patients without liver cirrhosis, except in cases of bleeding ulcers. There are specific therapeutic protocols for peptic ulcer bleeding in patients with liver cirrhosis.


2017 ◽  
Vol 5 (03) ◽  
pp. 17-25 ◽  
Author(s):  
Anita P. Antappan ◽  
Bibin Punnoose Micheal ◽  
Merin Anto Thelappilly ◽  
Thazneem Bagum T.D. ◽  
Leo Mathew ◽  
...  

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used medications in the world. NSAID-induced adverse reactions involve upper gastrointestinal (GI) tract complications, which can be life-threatening. Objectives: The study was conducted to explore the current prescription pattern of non-steroidal anti-inflammatory drugs (NSAIDs) and the prevalence of NSAID-induced gastrointestinal(GI) risk factors of orthopedic adult inpatient.Materials and methods: A prospective observational NSAIDs induced GI risk related study was conducted over a period of 6 months by clinical pharmacist. Study cohort included 105 orthopaedic inpatients who are taking or will be taking NSAIDs for more than a week. A self-administered questionnaire was completed by each patient. A simplified risk scoring scale (the Standardized Calculator of Risk for Events; SCORE) was used to measure patients‟ risk for GI complications. The pattern of NSAIDs prescription was identified from medical recordings.Results: The study groups were stratified into four risk groups according to GI SCORE tool, 27.6% of the patients belonged to high risk or very high risk groups for GI complications. Analysis of prescription pattern revealed that 11.4% of the patients aged over 65 yr, 19% with co morbid disease were prescribed with COX-2 selective inhibitor. Conclusion: In this study assessment of prescription pattern and GI risk factors for NSAIDs were evaluated and in conclusion, physician‟s considerate prescription of NSAIDs with well-understanding of each patient‟s GI risk factors is strongly encouraged to prevent serious GI complications


Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
V Francisco ◽  
A Figueirinha ◽  
B Neves ◽  
C Garcia-Rodriguez ◽  
M Lopes ◽  
...  

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