scholarly journals The Association Between Risk Factors And Ultrasound-Based Grades Of Non-Alcoholic Fatty Liver Disease In Type-2 Diabetes Patients

2019 ◽  
Vol 5 (1) ◽  
pp. 47-59
Author(s):  
FX Himawan Haryanto Jong ◽  
Prettysun Ang Mellow
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Liver Disease ◽  
Total Cholesterol ◽  
Fatty Liver Disease ◽  
Density Lipoprotein ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Background: Non-alcoholic fatty liver disease (NAFLD) has become more common as the cause of cirrhosis and liver cancer. The liver disease is highly prevalent in people with type-2 diabetes. Indonesia is not spared from the global epidemic of type-2 diabetes. The ultrasound examination is clinically easy-to-use, economical and non-invasive as a tool to detect NAFLD, compared to the gold standard, liver biopsy. To date, there has been no study in Indonesia to link risk factors and ultrasound-based severity grading of NAFLD. Aim: To understand the association between risk factors and ultrasound-based grades of NAFLD in patients with type-2 diabetes. Method: The present study was an observational study with a cross-sectional design (May-October 2018) that involved 82 type-2 diabetes outpatients of the internal medicine clinic in the Gotong Royong Hospital (Surabaya, Indonesia). The risk factors assessed were gender, age, diabetes duration, obesity (anthropometric measurement: body mass index/ BMI, waist circumference and waist-to-hip ratio), glycemic control (hemoglobin A1c/ HbA1c level) and dyslipidemia (lipid profile: total cholesterol, low-density lipoprotein/ LDL, high-density lipoprotein/ HDL and triglyceride). The ultrasound-based grades of NAFLD consisted of grade 0 (no NAFLD), grade 1 (increased liver echogenicity with normal images of intrahepatic vessel lines and diaphragm), grade 2 (blurred image of intrahepatic vessel lines) and grade 3 (blurred images of intrahepatic vessel lines and diaphragm). Statistical p-value was significant at ≤ 0.05. Results: Seventy-eight subjects (95,1%) had NAFLD. The ultrasound-based NAFLD grades were significantly different across age groups (Kruskal-Wallis) but the Spearman’s rank correlation test result was not significant. Body mass index and total cholesterol were positively correlated (r = 0.390 and 0.237, respectively) with the NAFLD grades. Conclusion: Higher BMI and total cholesterol are associated with increased ultrasound-based NAFLD grades.

Non-alcoholic fatty liver disease is associated with an increased prevalence of atrial fibrillation in hospitalized patients with Type 2 diabetes

2013 ◽  
Vol 125 (6) ◽  
pp. 301-310 ◽  
Author(s):  
Giovanni Targher ◽  
Alessandro Mantovani ◽  
Isabella Pichiri ◽  
Riccardo Rigolon ◽  
Marco Dauriz ◽  
...  
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Type 2 Diabetes ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Hospitalized Patients ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

NAFLD (non-alcoholic fatty liver disease) and AF (atrial fibrillation) are two pathological conditions that are highly prevalent in developed countries and share multiple risk factors. The relationship between NAFLD and AF in Type 2 diabetes is currently unknown. We studied a hospital-based sample of 702 patients with Type 2 diabetes discharged from our Division of Endocrinology during 2007–2011. The diagnosis of AF was confirmed in affected participants on the basis of ECGs and medical history by experienced cardiologists. NAFLD was defined by ultrasonographic detection of hepatic steatosis in the absence of other liver diseases. Of the 702 hospitalized patients included in the study, 514 (73.2%) of them had NAFLD and 85 (12.1%) had persistent or permanent AF. NAFLD was associated with an increased risk of prevalent AF {OR (odds ratio), 3.04 [95% CI (confidence interval), 1.54–6.02]; P<0.001}. Adjustments for age, sex, systolic BP (blood pressure), HbA1c, (glycated haemoglobin), estimated GFR (glomerular filtration rate), total cholesterol, electrocardiographic LVH (left ventricular hypertrophy), COPD (chronic obstructive pulmonary disease), and prior history of HF (heart failure), VHD (valvular heart disease) or hyperthyroidism did not attenuate the association between NAFLD and AF [adjusted OR, 5.88 (95% CI, 2.72–12.7); P<0.001]. In conclusion, our results show that ultrasound-diagnosed NAFLD is strongly associated with an increased prevalence of persistent or permanent AF in patients with Type 2 diabetes, independently of several clinical risk factors for AF. The potential impact of NAFLD on AF deserves particular attention, especially with respect to the implications for screening and surveillance strategies in the growing number of patients with NAFLD.

scholarly journals Frequency of non-alcoholic fatty liver disease in patients with type-2 diabetes mellitus and its associated risk factors

2021 ◽  
Vol 37 (5) ◽  
Author(s):  
Shaista Kanwal ◽  
Tahir Ghaffar ◽  
Azizul Hasan Aamir ◽  
Khalid Usman
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Liver Disease ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Associated Risk Factors ◽  
Alcoholic Fatty Liver Disease

Objective: Non-Alcoholic Fatty Liver Disease (NAFLD) is emerging as a major public health problem globally especially in patients with Type-2 Diabetes mellitus (T2DM). This study aimed to assess the frequency of NAFLD in patients with T2DM and to study its associated risk factors. Methods: This descriptive study was conducted from April 2020 to October 2020 at the Hayatabad Medical Complex, Peshawar. Adult patients with T2DM were included in the study and underwent abdominal ultrasound for the identification of NAFLD. All the relevant clinical and biochemical characteristics were measured. Results: Out of 384 participants, 236 patients (61.5%) had NAFLD on ultrasound. Patients with NAFLD had higher mean BMI, higher HbA1c, increased waist circumference, raised ALT, higher triglyceride, and low HDL. Logistic regression analysis revealed a statistically significant association with central obesity (OR = 5.448, 95% CI = 1.416-20.959, p = 0.014), higher BMI (OR = 4.435, 95% CI = 2.127-9.246, p < 0.0001), higher HbA1c [> 11%] (OR = 3.602, 95% CI = 1.438-9.019, p = 0.006), and elevated ALT (OR = 3.211, 95% CI = 1.509-6.835, p = 0.002). The highest odds for NAFLD were found for hypertriglyceridemia (OR = 11.624, 95% CI = 5.405-24.998, p < 0.0001) and low HDL (OR = 11.543, 95% CI = 2.590-51.439, p = 0.001), respectively. Conclusions: High frequency of NAFLD along with its associated clinical and laboratory risk factors were revealed. This underpins the significance of screening T2DM patients for NAFLD and assessment for and modification of its associated risk factors in routine clinical practice. doi: https://doi.org/10.12669/pjms.37.5.4211 How to cite this:Kanwal S, Ghaffar T, Aamir AH, Usman K. Frequency of non-alcoholic fatty liver disease in patients with type-2 diabetes mellitus and its associated risk factors. Pak J Med Sci. 2021;37(5):---------. doi: https://doi.org/10.12669/pjms.37.5.4211 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Evaluation of Sucrose‐enriched Diet Consumption in the Development of Risk Factors Associated to Type 2 Diabetes, Atherosclerosis and Non‐alcoholic Fatty Liver Disease in a Murine Model

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Carolina Gabriela Plazas-Guerrero ◽  
Selene de Jesùs Acosta-Cota ◽  
Francisco Humberto Castro-Sánchez ◽  
Efrén Rafael Ríos-Burgueño ◽  
Juan Ignacio Sarmiento-Sánchez ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Liver Disease ◽  
Fatty Liver ◽  
Murine Model ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Factors Associated ◽  
Alcoholic Fatty Liver Disease

Evaluation of sucrose-enriched diet consumption in the development of risk factors associated to type 2 diabetes, atherosclerosis and non-alcoholic fatty liver disease in a murine model

2019 ◽  
pp. 1-19
Author(s):  
Carolina Gabriela Plazas Guerrero ◽  
Selene De Jesús Acosta Cota ◽  
Francisco Humberto Castro Sánchez ◽  
Marcela De Jesús Vergara Jiménez ◽  
Efrén Rafael Ríos Burgueño ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Liver Disease ◽  
Fatty Liver ◽  
Murine Model ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Factors Associated ◽  
Alcoholic Fatty Liver Disease

scholarly journals Value of the Triglyceride Glucose index Combined with Body Mass index in Predicting non-Alcoholic Fatty Liver Disease in Patients with Type 2 Diabetes

2020 ◽  
Author(s):  
Nong Li ◽  
Huiwen Tan ◽  
Aixia Xie ◽  
Cheng Li ◽  
Xuan Fu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Regression Analysis ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Tyg Index ◽  
Alcoholic Fatty Liver Disease

Abstract Objective: To explore the predictive value of the triglyceride glucose-body mass index (TyG-BMI) in relation to the occurrence of non-alcoholic fatty liver disease (NAFLD) in the Chinese population with type 2 diabetes (T2D). Methods: We selected 826 patients with T2D who were hospitalized at the Department of Endocrinology and Metabolism of Karamay People's Hospital from September 2016 to October 2018 for this research. The height, weight, fasting blood glucose, serum insulin, and lipid profiles of the subjects were collected. Stepwise logistic regression analysis was performed to calculate the triglyceride glucose (TyG) index, TyG-BMI, and the ratio of the insulin resistance index (HOMA-IR) to triglyceride high-density lipoprotein-cholesterol at risk for non-alcoholic fatty liver disease. The curve method was used to analyze its predictive value for non-alcoholic fatty liver. Results Results of the logistic regression analysis showed that the risk ratios of NAFLD were 6.54 (3.70-11.53) and 4.868 (2.576-9.200) for the TyG-BMI before and after correction. The area under the curve (AUC) for TyG-BMI was 0.727 (0.691–0.764), which was the highest among all the other parameters studied. Conclusion Compared with the TyG index, the TG/HDL-C, HOMA-IR, and the TyG-BMI are more effective predictors of NAFLD in T2D.

scholarly journals Association of non-alcoholic fatty liver disease with anthropometric and metabolic parameters in type 2 diabetes: a retrospective analysis

2016 ◽  
Vol 5 (1) ◽  
pp. 225
Author(s):  
Shiraz S. Khan ◽  
Nishad S. Kannu ◽  
Sagar S. Patil ◽  
Vijay M. Katekhaye
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Metabolic Parameters ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Background: Type 2 diabetes (T2D) is associated with increased prevalence of non-alcoholic fatty liver disease (NAFLD) which mediates increased insulin resistance and is associated with cardiovascular disease (CVD) risk factors. Aim of the study was to understand the association of NAFLD with anthropometric and metabolic parameters in T2DM.Methods: A retrospective observation of data obtained from a private diabetes care centre in non-alcoholic T2D patients was performed. Association of presence of NAFLD with anthropometric, metabolic (glycemic, lipid) parameters, and also blood pressure were assessed. Patients were duly informed that the data collected pertaining to their illness could be used for research purposes. No changes or interventions in the management of the illness were made as part of this study.Results: In total, 300 cases were included in analysis. NAFLD was seen in 38.0% of the cases. Patients with fatty liver were much older than those without fatty liver (P<0.0001). A significant association of NAFLD was seen with all anthropometric (P<0.05 for each) and lipid (p<0.05 for each) parameters and also systolic and diastolic blood pressure measurements (p<0.0001 for both). There was no significant association with glycemic levels in patients with NAFLD. Other factors which had significant association with fatty liver include duration of diabetes, duration of hypertension and a known history of hypertension and dyslipidaemia (p<0.0001 for each).Conclusions: NAFLD has significant association with cardio-metabolic risk factors and may be an independent risk factor for CV disease. Further prospective studies with effect of diabetes treatment and progression/regression of NAFLD and its association with CV outcomes in T2D are warranted.

Risk factors for non-alcoholic fatty liver disease-associated hepatic fibrosis in type 2 diabetes patients

2019 ◽  
Vol 56 (11) ◽  
pp. 1199-1207 ◽  
Author(s):  
Asieh Mansour ◽  
Mohammad Reza Mohajeri-Tehrani ◽  
Majid Samadi ◽  
Hadis Gerami ◽  
Mostafa Qorbani ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Liver Disease ◽  
Fatty Liver ◽  
Hepatic Fibrosis ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease ◽  
Diabetes Patients
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