Knowledge, attitude and practices of pregnant women aged 18-49 years towards pregnancy induced hypertension (PIH) in Bindura district: Zimbabwe: A case control study

Background: Pregnancy induced hypertension (PIH) is a global public health concern as a leading cause of maternal mortality. Lao PDR has a high prevalence of PIH, but little is known about its risk factors. This study aimed to identify risk factors of PIH relating to antenatal care (ANC) in Lao PDR. Methods: This hospital-based age-matched case control study was carried out between July and December 2017 in tertiary and secondary hospitals in Lao PDR. A total of 258 pregnant women (86 hypertensive and 172 normotensive pregnant women) were recruited to join the study based specific inclusion criteria. For each case, two consecutive controls were included in the study with matched maternal age. Data was collected using a structured questionnaire interview to identify the risk factors of PIH relating to ANC. The association between the independent variables and PIH was assessed through bivariable and conditional multiple logistic regression analyses. Results: Mothers with PIH had inadequate ANC (defined as <4 times) (adj. OR= 10.23 , 95%CI: 3.67 – 28.49, p<0.001), excessive maternal weight gain during pregnancy (>13kg) ( adj. OR=7.35, 95%CI: 3.06 -17.69, p<0.001), had a history of abortion (adj. OR=3.54, 95%CI: 1.30-9.59, p=0.013), and had received inadequate information about PIH (adj OR= 2.58 , 95%CI: 1.03 – 6.46 , p=0.043). Conclusion: Inadequate ANC and maternal factors were major risk factors of PIH in Lao PR. National PIH guidelines for effective counseling, ANC and treatment should be promptly developed and implemented at all levels in order to improve pregnancy outcomes.

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Assessment of Renal Function Tests and Serum Total Protein among Pregnant Women with Pregnancy-Induced Hypertension Attending in Asrade Zewudie Memorable Hospital (ASZMPH), Gojjam, Ethiopia: Case-Control Study

Journal of Clinical Medical Research ◽

10.46889/jcmr.2020.1301 ◽

2020 ◽

Vol 01 (03) ◽

Author(s):

Haymanot Tewabe ◽

Mistire Wolde

Keyword(s):

Renal Function ◽

Pregnant Women ◽

Total Protein ◽

Case Control Study ◽

Case Control ◽

Pregnancy Induced Hypertension ◽

Serum Total Protein ◽

Induced Hypertension ◽

Renal Function Tests ◽

Control Study

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Serum Uric Acid Level as a Predictive Biomarker of Gestational Hypertension Severity; A Prospective Observational Case-Control Study

Reviews on Recent Clinical Trials ◽

10.2174/1574887115666200709142119 ◽

2020 ◽

Vol 15 (3) ◽

pp. 227-239 ◽

Cited By ~ 1

Author(s):

Hader I. Sakr ◽

Akef A. Khowailed ◽

Reham S. Al-Fakharany ◽

Dina S. Abdel-Fattah ◽

Ahmed A. Taha

Keyword(s):

Blood Pressure ◽

Pregnant Women ◽

Case Control Study ◽

Serum Urate ◽

Interleukin 1Β ◽

Pregnancy Induced Hypertension ◽

C Reactive Protein ◽

Reactive Protein ◽

Induced Hypertension ◽

Control Study

Background: Pre-eclampsia poses a significant potential risk of hypertensive disorders during pregnancy, a leading cause of maternal deaths. Hyperuricemia is associated with adverse effects on endothelial function, normal cellular metabolism, and platelet aggregation and adhesion. This study was designed to compare serum urate levels in normotensive pregnant women to those with pregnancy-induced hypertension, and to evaluate its value as a potential predictive marker of hypertension severity during pregnancy. Methods: A prospective, observational, case-control study conducted on 100 pregnant women in their third trimester. Pregnant women were classified into two groups (n=50) according to arterial blood pressure measurements: group I had normal blood pressure, and group II had a blood pressure of ≥ 140/90, which was further subdivided according to hypertension severity into IIa (pregnancy- induced hypertension, IIb (mild pre-eclampsia), and IIc (severe pre-eclampsia). Blood samples were obtained on admission. Serum urate, high sensitive C-reactive protein, and interleukin-1β levels, and lipid profile were compared among the groups. Results: A significant increase in the mean values of serum urate, C-reactive protein, and interleukin- 1β levels was detected in gestational hypertensives. In addition, there was a positive correlation between serum urate levels and C-reactive protein and interleukin-1β, as well as between serum urate levels and hypertension severity. Conclusion: Hyperuricemia and increased C-reactive protein and interleukin-1β serum levels correlate with the severity of pregnancy-induced hypertension, and these biomarkers may play a role in the pathogenesis of pre-eclampsia. Serum urate measurement is sensitive, reliable markers that correlate well with the severity of hypertension in pregnant females with pre-eclampsia.

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Determinants of pregnancy-induced hypertension on maternal and foetal outcomes in Hossana town administration, Hadiya zone, Southern Ethiopia: Unmatched case-control study

PLoS ONE ◽

10.1371/journal.pone.0250548 ◽

2021 ◽

Vol 16 (5) ◽

pp. e0250548

Author(s):

Getachew Ossabo Babore ◽

Tsegaye Gebre Aregago ◽

Tadesse Lelago Ermolo ◽

Mangistu Handiso Nunemo ◽

Teshome Tesfaye Habebo

Keyword(s):

Case Control Study ◽

Previous History ◽

Educational Status ◽

Case Control ◽

Health Facilities ◽

Sub Saharan Africa ◽

Pregnancy Induced Hypertension ◽

Induced Hypertension ◽

History Of ◽

Control Study

Background Globally, 292,982 women die due to the complications of pregnancy and childbirth per year, out of those deaths 85% occurs in Sub Saharan Africa. In Ethiopia, pre-eclampsia accounts for 11% of direct maternal deaths. Objective To determine maternal and foetal outcomes of pregnancy-induced hypertension among women who gave birth at health facilities in Hossana town administration. Methods Institutional based unmatched case-control study was conducted among women, who gave birth at health facilities from May 20 to October 30, 2018. By using Epi-Info version 7; 207 sample size was estimated, for each case two controls were selected. Two health facilities were selected using a simple random sampling method. Sample sizes for each facility were allocated proportionally. All cleaned & coded data were entered into Epi-info version 3.5.1 and analysis was carried out using SPSS version 20. Multivariate analysis was performed to determine predictors of pregnancy-induced hypertension at a p-value of <0.05. Result Women between 18 to 41 years old had participated in the study with the mean age of 26.00(SD ±4.42), and 25.87(SD ±5.02) for cases and controls respectively. Out of participants 21(30.4%) among cases and 21(15.2%) among controls had developed at least one complication following delivery. 12 (17.4%) and 8 (5.7%) foetal deaths were found in cases and controls groups respectively whereas 15.6% from cases and 3.6% from controls groups women gave birth to the foetus with intra-uterine growth retardation. Women gravidity AOR = 0.32 [95% CI (0.12 0.86)], Previous history of pregnancy-induced hypertension AOR = 22.50 [95% CI (14.95 16.52)] and educational status AOR = 0.32[95% CI (0.12, 0.85)] were identified as predictor of pregnancy-induced hypertension. Conclusion Women with a previous history of pregnancy-induced hypertension had increased risk of developing pregnancy-induced hypertension, whilst ≥ 3 previous pregnancies and informal educational status decrease odds of developing pregnancy-induced hypertension.

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