scholarly journals Toxicological Effect of Monosodium Glutamate in Seasonings on Human Health

Author(s):  
Augustine I Airaodion
Author(s):  
Zahraa Hameed Al-Agili

According to the famous saying of the medieval physician Paracelsus, "There is no substance without poison. Only the dose determines the extent of the toxic effect." Here, the effect of monosodium glutamate (MSG) on human health and the risks to the health of its frequent use in the short term was addressed and the long term was evaluated according to the studies of several researchers specializing in this regard. Monosodium glutamate (MSG) is known as one of the most popular food additives that classified as a flavor enhancer. Parts of the evidence were reviewed from the literature explaining its effect on immune system cells in addition to metabolic disorders by exposing individuals to obesity and what is known as metabolic syndrome, as well as reviewing a lot of evidence indicating the effect of MSG intake on the health of the kidney, liver and other parts of the body through Practical application to laboratory rats and clinical studies in humans.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Na Li ◽  
Xi Tang ◽  
John Yang ◽  
Zhanxiang Sun

AbstractLead (Pb) contamination in environment has been identified as a threat to human health and ecosystems. In an effort to reduce the health and ecological risks associated with Pb mining wastes, a field study was conducted to stabilize Pb using phosphate (P)-enriched biosolid amendments in the contaminated mining wastes (average of 1004 mg Pb kg−1) located within the Jasper County Superfund Site, southwest Missouri. Experiments consisted of six biosolid amendment treatments, including Mizzou Doo compost (MD); Spent mushroom compost (SMC); Turkey litter compost (TLC); Composted chicken litter (CCL); Composted sewage sludge (CSS); and Triple superphosphate (TSP). Kentucky tall fescue seeds were planted following the treatments, and soil and plant samples were collected and analyzed 8–10 years post treatment. Results indicated that, in all cases, the biosolid treatments resulted in significant reductions in bioaccessible Pb (96.5 to 97.5%), leachable Pb (95.0 to 97.1%) and plant tissue Pb (45.5 to 90.1%) in the treated wastes, as compared with the control. The treatments had no significantly toxicological effect to soil microbial community. Analysis of the Pb fractionation revealed that the Pb risk reduction was accomplished by transforming labile Pb fractions to relatively stable species through the chemical stabilization reactions as induced by the treatments. The solid-phase microprobe analysis confirmed the formation of pyromorphite or pyromorphite-like minerals after the treatment. Among the six biosolid amendments examined, SMC and MD treatments were shown most effective in the context of Pb stabilization and risk reduction. This field study demonstrated that the treatment effectiveness of Pb stabilization and risk reduction in mining wastes by P-enriched biosolid amendments was long-term and environmental-sound, which could be potentially applied as a cost-effective remedial technology to restore contaminated mining site and safeguard human health and ecosystems from Pb contamination.


2021 ◽  
Author(s):  
Na Li ◽  
Xi Tang ◽  
John Yang ◽  
Zhanxiang Sun

Abstract Lead (Pb) contamination in environment has been identified as a threat to human health and ecosystems. In an effort to reduce the health and ecological risks associated with Pb mining wastes, a field study was conducted to stabilize Pb using phosphate (P)-enriched biosolid amendments in contaminated mining wastes (average of 1004 mg Pb kg-1) located within the Jasper County Superfund Site, southwest Missouri. Experiments consisted of six treatments, including Mizzou Doo (MD); Spent mushroom compost (SMC); Turkey litter compost (TLC); Composted chicken litter (CCL); Composed sewage sludge (CSS); and Triple superphosphate (TSP). Tall fescue seeds were planted following treatments and soil and plant samples collected and analyzed 8-10 years post treatment. Results indicated that all biosolid treatments resulted in effective reductions of bioaccessible, leachable and phytoavailable Pb in the treated waste. The treatments had no toxicological effect to soil microbial community. Analysis of the Pb fractionation revealed that the Pb risk reduction was acomplished by transforming labile Pb to relatively stable species through chemical stabilization reactions as induced by treatments. The solid-phase microprobe analysis confirmed the formation of pyromorphite or pyromorphite-like minerals after treatment. Among the six amendments examined, SMC and MD treatments were shown most effective in context of Pb stabilization and risk reduction. This study demonstrated that the efficacy of Pb stabilization and risk reduction by P-enriched biosolid amendments was long-term and environmental-sound, which could be potentially applied as a cost-effective remedial technology to restore contaminated mining site and safeguard human health and ecosystems from Pb contamination.


Author(s):  
A. V. Rutska ◽  
N. V. Getsko ◽  
I. Y. Krynytska

The article analyzes the available literature data on the problem of the food additives usage in the food industry. According to many scientists, reducing the amount of fresh foods that are eaten, and increasing of artificial additives may be one of reasons for increased prevalence of diseases such as cancer, diabetes mellitus, obesity, depression and asthma.Number of food additives used in food industry in different countries, is up to five hundred today, not counting the combined additives and flavorings. One of the most common food additive inUkraineand inEuropeis monosodium glutamate (E-621). Studies have shown that excess of sodium glutamate intake can provoke the development of hypertension and stroke, diabetes mellitus, Alzheimer's disease and abnormalities of the nervous system development, erosive lesions of the mucous membrane of the stomach and weight gain.There are no reliable data that showed in what doses and at what conditions monosodium glutamate which is used in foods constantly is harmful to health. On the one hand, there are studies that intake of monosodium glutamate in the dosage of3 gramsper day is dangerous to human health. However, other researchers argue that daily administration of sodium glutamate to rats even in safe for human health doses (15 and 30 mg/kg), corresponding to 1 and2 gramsfor the average adult person, has toxic effects.Thus, based on the large amount of data can be argued that today there is a constant increase in the use of food additives in the food industry of an economically developed countries as well as countries with low intake. And because food additives are foreign substances to the human body (due to the chemical composition or number) investigation of their effect on human health has become relevant. Moreover, small number of data on biochemical and morphological changes in major organs and body systems dictate the need for a detailed study of the problem. In addition, it is necessary to focus not only on the study of established dangerous doses of food additives, but also to study the molecular mechanisms of these substances influence on the living body in "safe" (permitted) doses.


2020 ◽  
Vol 11 (10) ◽  
pp. 8547-8559
Author(s):  
Hongjing Zhao ◽  
Yu Wang ◽  
Mengyao Mu ◽  
Menghao Guo ◽  
Hongxian Yu ◽  
...  

Antibiotics are used worldwide to treat diseases in humans and other animals; most of them and their secondary metabolites are discharged into the aquatic environment, posing a serious threat to human health.


2011 ◽  
Vol 81 (4) ◽  
pp. 238-239 ◽  
Author(s):  
Manfred Eggersdorfer ◽  
Paul Walter

Nutrition is important for human health in all stages of life - from conception to old age. Today we know much more about the molecular basis of nutrition. Most importantly, we have learnt that micronutrients, among other factors, interact with genes, and new science is increasingly providing more tools to clarify this interrelation between health and nutrition. Sufficient intake of vitamins is essential to achieve maximum health benefit. It is well established that in developing countries, millions of people still suffer from micronutrient deficiencies. However, it is far less recognized that we face micronutrient insufficiencies also in developed countries.


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