Clinical Diagnostic and Therapeutic Characteristics of COVID-19 in Students of Kyrgyzstan

The study included 747 students. Out of 747 students 399 (53.4%) were women and 348 (46.6%) were men. According to the respondents, 22.6% (n=169) of them had a new coronavirus infection. Different symptoms of COVID-19 were observed in 72.58% of those interviewed. They were loss of taste (82.8%), fever (67.4%) and headache (67.4 %). Chills (47.3%), coughing (40.8%), pain in the throat (36.6%), shortness of breath (23.6%) and nausea (21.3%) were less frequent. 27.4% of respondents can assume asymptomatic course of the disease. A direct weak correlation between smoking and symptoms (cough, shortness of breath) of COVID-19 (r=0.39) has been identified. 59.8% (n=447) of respondents were diagnosed via PCR-test. At the same time, 62.2% (n=278) of the students had no COVID-19 confirmation. Antibodies to SARS-CoV-2 were determined in a total of 28.51% (n=213) of the respondents. Fibrinogen and D-dimer levels were determined in 9.4% and 7.1% of the students surveyed, respectively. Chest X-Rays were done in 22.6% (n=169) of respondents. Antibacterial and anti-inflammatory drugs (75.1%) were clearly prevalent among young students in the structure of therapeutic interventions for new coronavirus infection.

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Ibuprofen safety at the golden anniversary. A commentary and recent developments

10.22514/sv.2020.16.0097 ◽

2020 ◽

Keyword(s):

The World ◽

Recent Developments ◽

Inflammatory Drugs ◽

Coronavirus Infection ◽

Interesting Story ◽

Anti Inflammatory ◽

Short Comment ◽

Published Paper

Ibuprofen is a long lasting non-steroidal anti-inflammatory drugs (NSAIDs) and still represents one of the most diffused analgesics around the world. It has an interesting story started over 50 years ago. In this short comment to an already published paper, the authors try to focus some specific important point. On top, they illustrate the recent, confusing and fake assertion on the potentially dangerous influence that ibuprofen could have, increasing the risk of Coronavirus infection. This is also better illustrated in a previously published paper, where the readers could find more clear responses to eventual doubts.

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Inflammation in the Pathophysiology and Therapy of Cardiometabolic Disease

Endocrine Reviews ◽

10.1210/er.2019-00002 ◽

2019 ◽

Vol 40 (4) ◽

pp. 1080-1091 ◽

Cited By ~ 14

Author(s):

Marc Y Donath ◽

Daniel T Meier ◽

Marianne Böni-Schnetzler

Keyword(s):

Metabolic Syndrome ◽

Clinical Studies ◽

Cell Function ◽

Therapeutic Interventions ◽

Metabolic Inflammation ◽

Inflammatory Conditions ◽

Β Cell Function ◽

Associated Conditions ◽

Inflammatory Drugs ◽

Anti Inflammatory

Abstract The role of chronic inflammation in the pathogenesis of type 2 diabetes mellitus and associated complications is now well established. Therapeutic interventions counteracting metabolic inflammation improve insulin secretion and action and glucose control and may prevent long-term complications. Thus, a number of anti-inflammatory drugs approved for the treatment of other inflammatory conditions are evaluated in patients with metabolic syndrome. Most advanced are clinical studies with IL-1 antagonists showing improved β-cell function and glycemia and prevention of cardiovascular diseases and heart failure. However, alternative anti-inflammatory treatments, alone or in combinations, may turn out to be more effective, depending on genetic predispositions, duration, and manifestation of the disease. Thus, there is a great need for comprehensive and well-designed clinical studies to implement anti-inflammatory drugs in the treatment of patients with metabolic syndrome and its associated conditions.

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DO NSAIDS CAUSE SPECIFIC COMPLICATIONS IN COVID-19 CORONAVIRUS INFECTION?

Rheumatology Science and Practice ◽

10.14412/1995-4484-2020-340-343 ◽

2020 ◽

Vol 58 (3) ◽

pp. 340-343 ◽

Cited By ~ 1

Author(s):

A. E. Karateev ◽

E. L. Nasonov ◽

A. M. Lila

Keyword(s):

Gastrointestinal Tract ◽

Elderly Patients ◽

Cardiovascular System ◽

Clinical Evidence ◽

Correct Diagnosis ◽

Viral Diseases ◽

Inflammatory Drugs ◽

Coronavirus Infection ◽

Anti Inflammatory ◽

Comorbid Diseases

Currently, there is no clear data indicating the risk of specific complications when using non-steroidal anti-inflammatory drugs (NSAIDs), and in particular ibuprofen, for COVID-19 infection. There is also no clear clinical evidence that taking NSAIDs increases the risk of COVID-19 infection. However, when using NSAIDs in patients with acute respiratory viral diseases, keep in mind the possibility of class-specific complications from the gastrointestinal tract, cardiovascular system and kidneys. This risk is quite serious in elderly patients with multiple comorbid diseases. In addition, you should remember that taking NSAIDs and paracetamol can mask important symptoms of COVID-19 infection (in particular, fever) and lengthen the time for making a correct diagnosis.

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Feline coronavirus infection

E3S Web of Conferences ◽

10.1051/e3sconf/202127302025 ◽

2021 ◽

Vol 273 ◽

pp. 02025

Author(s):

Aleksey Ermakov ◽

Tatyana Lipilkina ◽

Pavel Lipilkin ◽

Igor Popov

Keyword(s):

Primary Prevention ◽

Therapeutic Interventions ◽

Feline Infectious Peritonitis ◽

Clinical Diagnostic ◽

Coronavirus Infection ◽

Near Future ◽

Feline Coronavirus ◽

Prevention And Therapy

The main feature of feline coronavirus infection is its manifestation in the form of peritonitis. Feline infectious peritonitis is a highly lethal disease that lacks primary prevention and therapy. Therefore, feline infectious peritonitis is an epizootic problem in the near future. In our review, we demonstrate the current clinical, diagnostic, and therapeutic interventions for feline infectious peritonitis, as well as hypotheses of origin.

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Editorial Commentary: The Efficacy of Nonsteroidal Anti-inflammatory Drugs for Prophylaxis of Heterotopic Ossification in Hip Arthroscopy—Do We Treat Patients or X-rays?

Arthroscopy The Journal of Arthroscopic and Related Surgery ◽

10.1016/j.arthro.2015.12.035 ◽

2016 ◽

Vol 32 (3) ◽

pp. 526-527 ◽

Cited By ~ 5

Author(s):

G. Klaud Miller

Keyword(s):

Heterotopic Ossification ◽

Hip Arthroscopy ◽

X Rays ◽

Editorial Commentary ◽

Inflammatory Drugs ◽

Anti Inflammatory

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Karantina Sonrası COVID-19 Tanısıyla Takip Edilen Hastaların Değerlendirilmesi

Flora the Journal of Infectious Diseases and Clinical Microbiology ◽

10.5578/flora.70119 ◽

2020 ◽

Vol 25 (4) ◽

pp. 499-505

Author(s):

Onur Ural ◽

Şua Sümer ◽

Nazlım Aktuğ Demir ◽

Emine Yalçınkaya ◽

Elif Uçan ◽

...

Keyword(s):

Underlying Disease ◽

Clinical Findings ◽

Lung Involvement ◽

Shortness Of Breath ◽

Rt Pcr ◽

The World ◽

Underlying Diseases ◽

Time Of Admission ◽

Pcr Test ◽

D Dimer

Introduction: The COVID-19 pandemic continues to affect the world with serious number of cases and deaths. For this reason, knowing the clinical findings and course of the disease is important for early diagnosis and treatment. In this article, COVID-19 cases followed up after quarantine were discussed. Materials and Methods: In this study, the data of 99 patients who were followed up during travel and post-Umrah quarantine between 31 March and 15 April 2020 were retrospectively reviewed. Results: Of the 99 patients included in the study, 66 (66.7%) were females, 33 (33.3%) were males, and mean age was 59.8 ± 11.4 years. SARS-CoV-2 RT-PCR test was positive at the time of admission in 97 (98.0%) of the 99 patients. Thirty-nine (39.4%) of the patients were symptomatic and 25.3% of the patients had cough, 8.1% had fever, and 7.1% had shortness of breath. While SARSCoV-2 RT-PCR test was negative in 2 (3.3%) of the 60 patients without complaints, 58 (96.7%) of them were positive for SARS-CoV-2 RT-PCR test. Leukopenia was detected as 3%, lymphopenia 66.7%, D-dimer height 47.5%, LDH elevation 38.4%, CRP elevation 45.5%. Ground glass opacities were present in 81 (81.8%) of the patients with lung involvement, and consolidation areas were present in 40 patients (40.4%). Underlying disease was present in 38 (38.4%) of the patients. Hypertension and diabetes mellitus were the most common underlying diseases. It was observed that 89 (89.4%) of our cases had negative SARS-CoV-2 RT-PCR test on the 5th day. Conclusion: COVID-19 infection is an infectious disease that can present with many different clinics. In asymptomatic COVID-19 cases, lung involvement findings and disorders in laboratory parameters may be observed. It should be kept in mind that asymptomatic cases pose a risk in terms of transmission.

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Pharmacological (or Synthetic) and Nutritional Agonists of PPAR-γ as Candidates for Cytokine Storm Modulation in COVID-19 Disease

Molecules ◽

10.3390/molecules25092076 ◽

2020 ◽

Vol 25 (9) ◽

pp. 2076 ◽

Cited By ~ 31

Author(s):

Carmen Ciavarella ◽

Ilenia Motta ◽

Sabrina Valente ◽

Gianandrea Pasquinelli

Keyword(s):

Peroxisome Proliferator ◽

Cytokine Storm ◽

Disease Treatment ◽

Peroxisome Proliferator Activated Receptor ◽

Dual Approach ◽

Ppar Γ ◽

Inflammatory Drugs ◽

Coronavirus Infection ◽

Anti Inflammatory ◽

Dietary Strategies

The cytokine storm is an abnormal production of inflammatory cytokines, due to the over-activation of the innate immune response. This mechanism has been recognized as a critical mediator of influenza-induced lung disease, and it could be pivotal for COVID-19 infections. Thus, an immunomodulatory approach targeting the over-production of cytokines could be proposed for viral aggressive pulmonary disease treatment. In this regard, the peroxisome proliferator-activated receptor (PPAR)-γ, a member of the PPAR transcription factor family, could represent a potential target. Beside the well-known regulatory role on lipid and glucose metabolism, PPAR-γ also represses the inflammatory process. Similarly, the PPAR-γ agonist thiazolidinediones (TZDs), like pioglitazone, are anti-inflammatory drugs with ameliorating effects on severe viral pneumonia. In addition to the pharmacological agonists, also nutritional ligands of PPAR-γ, like curcuma, lemongrass, and pomegranate, possess anti-inflammatory properties through PPAR-γ activation. Here, we review the main synthetic and nutritional PPAR-γ ligands, proposing a dual approach based on the strengthening of the immune system using pharmacological and dietary strategies as an attempt to prevent/treat cytokine storm in the case of coronavirus infection.

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Experience of using a systemic glucocorticosteroid as an initial therapy for post-COVID-19 arthritis in outpatient practice

Russian Medical Inquiry ◽

10.32364/2587-6821-2021-5-5-252-256 ◽

2021 ◽

Vol 5 (5) ◽

pp. 252-256

Author(s):

V.E. Yershov ◽

◽

A.V. Krivova ◽

V.P. Zakharov ◽

S.V. Bystrov ◽

...

Keyword(s):

Reactive Arthritis ◽

Initial Therapy ◽

Transmitted Infection ◽

Dose Administration ◽

Number Of Patients ◽

Inflammatory Drugs ◽

Coronavirus Infection ◽

Anti Inflammatory ◽

Outpatient Practice ◽

Russian Medical

ABSTRACT Amid the COVID-19 pandemic, a large number of patients with joint lesions resistant to nonsteroidal anti-inflammatory drugs (NSAIDs) was encountered in our clinical practice. The article summarizes the positive experience of outpatient therapy of 916 patients (mean age 47.1±11.3 years), including 774 women, with arthritis of various localization, which occurred on average 45.0±7.1 days after a previously transmitted infection caused by SARS-CoV-2. 709 (77.4%) patients used NSAIDs before going to the clinic, the effect of which was absent or insufficient. In this regard, intramuscular injections of betamethasone prescribed to 823 patients were used as the initial therapy (considering the comorbid background and allergy history). During the drug intake, most of the patients had relief of inflammation, pain reduction, improvement of the disease segment function already on the 7th day. In 69.3% of cases, a single-dose administration was sufficient. The obtained results allow drawing preliminary conclusions about the feasibility of using this technique in the complex treatment of reactive arthritis after the SARS-CoV-2 infection. KEYWORDS: coronavirus infection, COVID-19, glucocorticosteroids, nonsteroidal anti-inflammatory drugs, reactive arthritis. FOR CITATION: Yershov V.E., Krivova A.V., Zakharov V.P., Bystrov S.V. Experience of using a systemic glucocorticosteroid as an initial therapy for post-COVID-19 arthritis in outpatient practice. Russian Medical Inquiry. 2021;5(5):252–256 (in Russ.). DOI: 10.32364/2587- 6821-2021-5-5-252-256.

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