scholarly journals OPTIMASI CAMPURAN AVICEL PH 101 DAN LAKTOSA SEBAGAI BAHAN PENGISI PADA TABLET EKSTRAK BUNGA ROSELLA (Hibiscus sabdariffa L.) SECARA GRANULASI BASAH

2021 ◽  
Vol 3 (2) ◽  
pp. 102-116
Author(s):  
Zila Tjhia Kokafrinsia ◽  
Dwi Saryanti
Keyword(s):  
Design Method ◽  
Test Method ◽  
Wet Granulation ◽  
Lattice Design ◽  
Flower Extract ◽  
Simplex Lattice Design ◽  
Weight Variation ◽  
Significant Difference ◽  
Simplex Lattice ◽  
Optimal Formula

Rosella flower (Hibiscuss sabdariffa L.) in traditional medicine can provide protection against various diseases, such as coronary heart disease, cancer, lowering cholesterol, and liver disorders. This study aims to obtain the optimum formula of tablet of rosella flower extract with a mixture of Avicel PH 101 and lactose as a filler using wet granulation method. Rosella flower extract was obtained by maceration of rosella flower powder using 70% ethanol. The optimization formula for tablets using the Simplex Lattice Design method with Design Expert software version 10. The parameters used in the optimization are weight variation, hardness, friability and disintegration time. Verification of the optimal formula using the SPSS 18 program with the One Sample T-test method with a confidence level of 95%. The results showed that the optimal formula of tablet of rosella flower extract was the Avicel PH 101 97.82%: 2.17% lactose. The optimal formula has weight variation 1.53% ± 0.0073; hardness 5.087 kg ± 0.5135; the friability is 0.3% ± 0.041. The resulting disintegration was 22.99 minutes ± 2.218. The results of the verification of the optimal formula show that there is no significant difference between the predictions of the Simplex Lattice Design method and the results of the tests performed so that it can be said that the method is valid.

scholarly journals OPTIMASI ASAM STEARAT DAN TEA PADA FORMULA SEDIAAN KRIM EKSTRAK KULIT PISANG KEPOK (Musa paradisiaca L.)

2019 ◽  
Vol 1 (3) ◽  
pp. 225-237
Author(s):  
Dwi Saryanti ◽  
Iwan Setiawan ◽  
Romadona Ayu Safitri
Keyword(s):  
Stearic Acid ◽  
Maximum Concentration ◽  
Design Method ◽  
Minimum Concentration ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Significant Difference ◽  
Simplex Lattice ◽  
Optimum Formula ◽  
Optimal Formula

Banana kepok peel has flavonoid compounds used as antioxidants. The aim of this research is to get optimum formula of cream by combination of stearic acid and trietanolamin on good physical propertie of cream. Cream was made with stearic acid 15% minimum concentration and maximum concentration 17%, triethanolamine with minimum concentration 2% and maximum concentration 4%. The optimization of the formula was using the simplex lattice design method with parameters are pH, viscosity, spreadability, adhesion and protection. The optimum cream formula on the combination of stearic acid 16.7 grams and triethanolamine 2.3 grams. Verification results of optimal formula cream for pH got 6.1, viscosity 237.47, adhesion 12.32, power spread 18.11, protection 14.98 which showed no significant difference in the test, and has good stability.

scholarly journals Tablet Formula Optimization From Helminthostachys Zaylanica Extract Using A Simplex Lattice Design

2021 ◽  
Vol 6 (3) ◽  
pp. 131-136
Author(s):  
Fitrya Fitrya ◽  
Najma Annuria Fithri ◽  
Budi Untari ◽  
Aprililianti
Keyword(s):  
Physical Properties ◽  
Toxicity Tests ◽  
Dissolution Time ◽  
Wet Granulation ◽  
Disintegration Time ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Weight Variation ◽  
Simplex Lattice ◽  
Helminthostachys Zeylanica

Helminthostachys zeylanica extract has pharmacological activities such as antioxidant, antiinflamatory, and antihyerucemia. This extract is nontoxic substance from the acute and subchronic toxicity tests. This extract has a potency to be formulated into tablet dosage forms. This study aims to optimize a tablet formula from Helminthostachys zeylanica extract. Disintegrant and binder concentrations were independent variables, while physical properties and dissolution time of the tablets were dependent variables. The tablet was prepared by a wet granulation method. Formula was optimized by Simplex Lattice Design. Physicochemical propertiesof granule, physical properties and dissolution of tablet were then analyzed with One Way ANOVA (p = 0.05). Based on granule analysis, specification of physicochemical parameters, such as hausner’s ratio, compressibility index, flowability, repose angle, and water content, met standard British Pharmacopeia. In addition, the starch and PVA concentrations influenced thickness, weight variation, hardness, friability, disintegration time and dissolution of the tablets (p <0.05), except for friability (p> 0.05). Based on this study, the starch and PVA concentrations for the optimum tablet formula were 19.5% and 1.05%, respectively.

scholarly journals Optimization Formula Tablet Extract of Bengkuang (Pachyrrhizus erosus) Variation Avicel® Ph 101 and Crospovidone

2018 ◽  
Vol 23 (1) ◽  
pp. 9
Author(s):  
Rizki Kharisma ◽  
Ika Puspita Sari ◽  
Angi Nadya Bestari
Keyword(s):  
Design Method ◽  
Wet Granulation ◽  
Flow Properties ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Menopausal Women ◽  
Simplex Lattice ◽  
The Stability ◽  
Optimum Formula ◽  
Tuber Extract

Bengkuang (Pachyrrhizus erosus) contains daidzein which is pro-estrogenic compound, suppressing bone restoration by directing mechanism in bone estrogen receptor. Bengkuang can be developed into a useful source of phytoestrogens as a supplement in menopausal women. This study aims to determine the stability and influence of Avicel® PH 101 and crospovidone on granular flow properties and physical properties of Bengkuang tuber extract. Bengkuang tuber extracts were made into tablet preparations by wet granulation method. Variation of crospovidone composition was between 2-5%, while Avicel® PH 101 was between 38.86 to 41.86%. The tablet formulation is optimized using the Simplex Lattice Design method. The results show that the addition of Avicel® PH 101 can improve the index of determination, water absorption, moisture content, hardness, time of disintegration, and friability of the tablet, as well as crospovidone addition. Avicel® PH 101 and crospovidone interactions increase water content, decrease hardness, and tablet friability. The optimum tablet formula consists of composition of 293 mg of Avicel® PH 101 and 14 mg of crospovidone per tablet. Testing of optimum formula results with SLD method did not differ significantly to the response of the compression index, hardness and friability of the tablet. The tablet was stable at room temperature (30ºC ± 2 ºC) for four weeks.

Application of Simplex Lattice Design in Formulation Development of Lozenges Containing Vernonia cinerea Extract for Smoking Cessation

2019 ◽  
Vol 819 ◽  
pp. 227-232
Author(s):  
Chaowalit Monton ◽  
Thanaporn Sangprapai ◽  
Narathip Mekwimonmas ◽  
Tinnapas Sawangsang ◽  
Natawat Chankana ◽  
...  
Keyword(s):  
Milk Powder ◽  
Angle Of Repose ◽  
Formulation Development ◽  
Disintegration Time ◽  
Powder Mixtures ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Weight Variation ◽  
Simplex Lattice ◽  
Vernonia Cinerea

The aim of this work was to apply the simplex lattice design in the formulation development of lozenges containing Vernonia cinerea extract. The different ratios of three diluents; milk powder, xylitol, and inulin were investigated. The preformulation parameters of powder mixtures were evaluated. The compressed lozenges were evaluated for their weight variation, thickness, hardness, friability, and disintegration time. Results showed that the ratios of the three diluents affected the preformulation parameters. The angle of repose data revealed that all 12 powder mixtures had excellent flow property. The formulation containing milk powder had the highest values of Carr’s index and Hausner ratio, indicating the poor compressibility. While formulation containing inulin had the best compressibility. A formulation containing xylitol had the lowest moisture content. The compressed lozenges had a weight variation of less than 5%, a diameter of 1.5 mm, a thickness of 5-6 mm, and a hardness of 2-12 kP. The 8 of 12 formulations had friability of less than 1%. Use of milk powder provided the longest disintegration time. The desired properties of developed lozenge achieved when the medium amount of xylitol and inulin and low amount of milk powder were used. The optimal diluent ratio providing the weight variation not more than 5%, the hardness of 5-8 kP, friability not more than 1%, and disintegration time not more than 30 min was an equal weight ratio of milk powder, xylitol, and inulin.

scholarly journals Optimasi Formula Gel Antioksidan Ekstrak Etanol Buah Bligo (Benincasa hispida) dengan Metode Simplex Lattice Design (SLD)

2017 ◽  
Vol 3 (2) ◽  
pp. 150-156
Author(s):  
Suryani Suryani ◽  
Andi Nafisah ◽  
Syahrir Mana'an
Keyword(s):  
Antioxidant Activity ◽  
Laboratory Experiments ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Benincasa Hispida ◽  
Dpph Method ◽  
Simplex Lattice ◽  
Dispersive Power ◽  
Carbomer 940 ◽  
Optimal Formula

Benincasa hispida has many benefits including as antioxidant. This study aims to evaluate the effect of Carbomer 940, HPMC and NaOH concentrations in antioxidant gel formula and to determine Carbomer 940, HPMC and NaOH concentrations that could produce the optimal antioxidant gel formula. Benincasa hispida was extracted by maceration method and antioxidant activity was tested by DPPH method. The antioxidant gels were formulated with variety combinations of Carbomer 940, HPMC and NaOH. The optimal gel formula was obtained by Design Expert 7.1.5 with Simplex Lattice Design method. The physical characteristic of optimal gel formula was retested and compared with the results of Simplex Lattice Design .The results showed that antioxidant activity of Benincasa hispida ethanolic extract has potent activity with the IC50 40,28 μg/mL. The increasing concentration of Carbomer 940, HPMC and NaOH possessed the high coefficients viscosity (cPs) with the value of 4366, 4133 and 3750 respectively. The increasing concentration of NaOH possessed pH and dispersive power of the gel with coefficients of 11,0 and 5,21 respectively. The desirability values suggested by Simplex Lattice Design were 1,000 with component variation of the optimal formula were Carbomer 940 1,5%, HPMC 0,5% and NaOH 0,4%. The significance test of the optimal formula  compared to the results of laboratory experiments showed the significance of viscosity of 0,130, the dispersive power of 0,348 and pH of 0,184 that means there was no significant difference between the prediction values by using Simplex Lattice Design and results of laboratory experiments. It was indicated that significance values of each responses were over 0,05 (p>0.05).

scholarly journals Optimasi Formula Tablet Piroksikam Menggunakan Eksipien Laktosa, Avicel pH-101, dan Amprotab dengan Metode Simplex Lattice Design

2020 ◽  
Vol 17 (1) ◽  
pp. 31-44
Author(s):  
Ikhwan Yuda Kusuma ◽  
Rani Prabandari
Keyword(s):  
Physical Properties ◽  
Design Method ◽  
Dominant Factor ◽  
Content Uniformity ◽  
Compression Tests ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Contour Plots ◽  
Simplex Lattice ◽  
Optimum Formula

Piroxicam solubility in water is very small this cause problem in the process of absorption so that it’s required an optimal formula to establish the physical properties of tablet quality for piroxicam tablets. The purpose of this research was creating formulas with the optimal combination of excipients lactose, Avicel pH 101, and piroxicam amprotab to obtain tablets with good physical properties and disolution. Seven piroxicam tablet formulas were made with a combination of lactose, avicel PH-101, and Amprotab on 2 batches. Method for making tablets piroxicam was established by direct compression. Tests included were the physical properties of piroxicam tablets tablets weight uniformity, uniformity of size, hardness, brittleness, disintegration test, as well as dissolution test, and content uniformity. Based on the simplex lattice design method, lactose is a dominant factor to improved the uniformity of tablet’s concentartions. Interaction of two components avicel PH-101 and amprotab is a dominant factor to reduced vulnerability. Interaction of three components lactose, avicel PH-101 and amprotab is a dominant factor to lowered the value coefisien variation of weight uniformity, increased hardness, decreased the disintegration, and improved dissolution of tablets. Selection of the optimum formula was determined by the method of simplex lattice design through diagrams superimposed contour plots and contour plots for obtaining the optimal proportions of each ingredient as follows: lactose (85,154–100%), avicel PH-101 (0–12,437%), and amprotab (0–5,425%).

scholarly journals Characterization and Optimization of Capryol-90, Polysorbate-80, And Peg-400 Proportion in Mefenamic Acid Self Nanoemulsifying Drug Delivery System (SNEDDS) With Simplex-Lattice-Design

2018 ◽  
Vol 3 (4) ◽  
pp. 164
Author(s):  
Mardiyanto Mardiyanto ◽  
Najma Annuria Fithri ◽  
Martina Tandry
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mefenamic Acid ◽  
Polysorbate 80 ◽  
Lattice Design ◽  
Peg 400 ◽  
Simplex Lattice Design ◽  
Simplex Lattice ◽  
Optimal Formula

Mefenamic acid as pain relief drug belongs to the biopharmaceutics classification system (BCS) class II which is practically insoluble in water causing extremely low dissolution in gastrointestinal tract. The self nanoemulsifying drug delivery system (SNEDDS) is a new innovation pharmaceutical dosage form that has effectively known to increase solubilization of hydrophobic drug in polar solvent. In this study the capryol-90 was selected as oil phase in SNEDDS as it showed maximal solubility of mefenamic acid (20 mg/mL). Combination of polysorbate-80 and PEG-400 as a generally regarded as safe (GRAS) excipient were used as surfactant and co-surfactant in SNEDDS due to its high HLB property that can increase mefenamic acid solubility in water. The ternary phase diagram of capryol-90, polysorbate-80, and PEG-400 was constructed in advance to obtain the component concentration of spontaneous nanoemulsion region. Model simplex-lattice-design cooperated in Design-Expert®10 was used to define SNEDDS mefenamic acid formula. Optimized mefenamic acid SNEDDS formula consisted of 20% capryol-90, 31.62% polysorbate-80, and 48.38% PEG-400. Characterization study of Optimized mefenamic acid SNEDDS formula showed improvement of drug content (102.820 ± 4.950)%, emulsification time (421.015 ± 1.290) second, and viscosity (0.927 ± 0.017) mm2/s 30oC. One way ANOVA statistical analysis result of optimal formula SNEDDS (105.210 ± 4.425)% of drug content, commercial generic caplet (0.917 ± 0.094)%, and mefenamic acid powder capsule (10.446 ± 0,333)% gave significant value (sig*) below than 0.05. Optimal formula proved that SNEDDS can significantly increase mefenamic acid dissolution of pH 7.4 (ileum fluid). The optimal formula of mefenamic acid SNEDDS successfully formed an uniformity droplet size (PDI 0.18) with mean size 241.9 nm and  the surface charge has a value of -16.5 mV respectively.

scholarly journals A Modified Scheffe's Simplex Lattice Design Method in Development of Ceramic Carriers for Catalytic Neutralizers of Gas Emissions

2021 ◽  
Author(s):  
Valery Ved ◽  
Hanna Ponomarenko ◽  
Yevhenia Ponomarenko ◽  
Konstantin Gorbunov
Keyword(s):  
Mass Fraction ◽  
Design Method ◽  
Weight Fraction ◽  
Ceramic Materials ◽  
Gas Emissions ◽  
Catalyst Carrier ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Simplex Lattice ◽  
Purification Equipment

A modified Scheffe's simplex lattice design method is proposed to study the properties of multicomponent materials. This modified Scheffe's method allowed determining the optimal compositions of cordierite and corundum based ceramic materials that are used as catalyst carrier for gas purification equipment. The obtained material (0.63-1.25 mm weight fraction of cordierite of 0.35 mass% fraction; < 0.63 mm weight fraction of cordierite of 0.35 mass% fraction; < 0.06 mm weight fraction of corundum of 0.2 mass% fraction; 1.25-2.5 mm weight fraction of cordierite of 0.2 mass% fraction) was used successfully for the manufacturing of catalytic neutralizers of gas emissions.

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