Excess Dietary Vitamin A in the Growing Chick: Effect of Fat Source and Vitamin D

AbstractMaternal vitamin intake during pregnancy is crucial for pregnancy outcomes and the child's subsequent health. However, there are few valid instruments for assessing vitamin intake that address the effects of nausea and vomiting during pregnancy (NVP). This study aimed to investigate the validity of a FFQ concerning vitamin intake during early and late pregnancy with and without NVP. The participants comprised 200 Japanese pregnant women who completed the FFQ and from whom blood samples were taken in early and late pregnancy. Energy-adjusted dietary vitamin intakes (vitamin C, folate, vitamin B6, vitamin B12, vitamin A, vitamin E and vitamin D) from FFQ were compared with their blood concentrations. A subgroup of women with NVP was investigated. In early pregnancy, significant correlations between FFQ and biomarkers were observed for vitamin C (r0·27), folate (r0·18) and vitamin D (r0·26) in women with NVP and for vitamin A (r0·18), vitamin B12(r0·24) and vitamin D (r0·23) in women without NVP. No significant correlations were observed in either group for vitamins B6or E. In late pregnancy, similar significant associations were observed for vitamin C (r0·27), folate (r0·22), vitamin B6(r0·18), vitamin B12(r0·27) and vitamin A (r0·15); coefficients were higher among women without NVP. Our study demonstrates that the FFQ is a useful tool for assessing intake of several important vitamins in early and late pregnancy regardless of NVP status.

Download Full-text

Effects of dietary excesses of vitamins A and D on some constituents of the blood of chicks

British Journal Of Nutrition ◽

10.1079/bjn19680081 ◽

1968 ◽

Vol 22 (4) ◽

pp. 713-721 ◽

Cited By ~ 17

Author(s):

T. G. Taylor ◽

K. M. L. Morris ◽

Jean Kirkley

Keyword(s):

Vitamin D ◽

Acid Phosphatase ◽

Vitamin A ◽

Inorganic Phosphorus ◽

Progressive Increase ◽

Dietary Vitamin ◽

Inorganic P ◽

Dietary Requirements ◽

Four Levels ◽

Induced Changes

1. Groups of chicks were given diets containing four levels of vitamins A and D, 1, 10, 100 and 1000 times the basal level, in all sixteen combinations, with the object of investigating a possible antagonism between the two vitamins.2. Only diets containing 1000 times the basal level (approx. 1700 times the dietary requirements) of one or both vitamins depressed growth and induced changes in the blood.3. The packed cell volume was substantially reduced from 4 weeks of age in the chicks given the highest level of vitamin A. It is suggested that this was due to an effect of the vitamin on the fragility of the red cells and thus on their life span.4. Chicks given the toxic level of vitamin D showed an increase in plasma calcium and a decrease in plasma inorganic phosphorus. The highest level of vitamin A depressed plasma Ca without influencing plasma inorganic P. Increasing amounts of vitamin A given in combination with the highest level of vitamin D caused a progressive increase in the plasma inorganic P.5. The highest level of dietary vitamin A significantly increased the activity in the plasma of three lysosomal enzymes: acid phosphatase, β-glucuronidase and arylsulphatase. Excess vitamin D given in conjunction with the basal level of vitamin A significantly depressed the plasma acid phosphatase and the activity of this enzyme increased with increasing amounts of vitamin A. Excess vitamin D had no influence on the other hydrolases studied.6. A marked antagonism between the effects of excessive amounts of the two vitamins occurred only in respect of their actions on the plasma levels of Ca, inorganic P and acid phosphatase, all of which are involved in bone metabolism.

Download Full-text

Adjuvant Effects of Vitamin A and Vitamin D Supplementation on Children With ADHD

Case Medical Research ◽

10.31525/ct1-nct04284059 ◽

2020 ◽

Author(s):

Keyword(s):

Vitamin D ◽

Vitamin A ◽

Vitamin D Supplementation ◽

Children With Adhd ◽

Adjuvant Effects

Download Full-text

Maternal Vitamin D and Newborn Telomere Length

Nutrients ◽

10.3390/nu13062012 ◽

2021 ◽

Vol 13 (6) ◽

pp. 2012

Author(s):

Lisa Daneels ◽

Dries S. Martens ◽

Soumia Arredouani ◽

Jaak Billen ◽

Gudrun Koppen ◽

...

Keyword(s):

Vitamin D ◽

Cord Blood ◽

Telomere Length ◽

First Trimester ◽

Maternal Serum ◽

Adverse Outcomes ◽

Dietary Vitamin ◽

Maternal Vitamin ◽

Vitamin D Intake ◽

Diet Supplements

Nutrition is important during pregnancy for offspring health. Gestational vitamin D intake may prevent several adverse outcomes and might have an influence on offspring telomere length (TL). In this study, we want to assess the association between maternal vitamin D intake during pregnancy and newborn TL, as reflected by cord blood TL. We studied mother–child pairs enrolled in the Maternal Nutrition and Offspring’s Epigenome (MANOE) cohort, Leuven, Belgium. To calculate the dietary vitamin D intake, 108 women were asked to keep track of their diet using the seven-day estimated diet record (EDR) method. TL was assessed in 108 cord blood using a quantitative real-time PCR method. In each trimester of pregnancy, maternal serum 25-hydroxyvitamin D (25-OHD) concentration was measured. We observed a positive association (β = 0.009, p-value = 0.036) between newborn average relative TL and maternal vitamin D intake (diet + supplement) during the first trimester. In contrast, we found no association between average relative TL of the newborn and mean maternal serum 25-OHD concentrations during pregnancy. To conclude, vitamin D intake (diet + supplements), specifically during the first trimester of pregnancy, is an important factor associated with TL at birth.

Download Full-text

Dietary vitamin A supplementation in rats: suppression of leptin and induction of UCP1 mRNA

The Journal of Lipid Research ◽

10.1016/s0022-2275(20)32117-9 ◽

1999 ◽

Vol 40 (5) ◽

pp. 824-829 ◽

Cited By ~ 1

Author(s):

Monica V. Kumar ◽

Gregory D. Sunvold ◽

Philip J. Scarpace

Keyword(s):

Vitamin A ◽

Dietary Vitamin ◽

Vitamin A Supplementation

Download Full-text

The complexity of producing and interpreting dietary vitamin A statistics

Journal of Food Composition and Analysis ◽

10.1016/j.jfca.2021.103926 ◽

2021 ◽

pp. 103926

Author(s):

Ana Moltedo ◽

Cristina Álvarez-Sánchez ◽

Fernanda Grande ◽

Ruth Charrondiere

Keyword(s):

Vitamin A ◽

Dietary Vitamin

Download Full-text

Adjuvant effects of vitamin A and vitamin D supplementation on treatment of children with attention-deficit/hyperactivity disorder: a study protocol for a randomised, double-blinded, placebo-controlled, multicentric trial in China

BMJ Open ◽

10.1136/bmjopen-2021-050541 ◽

2021 ◽

Vol 11 (6) ◽

pp. e050541

Author(s):

Ping Zhou ◽

Mark Lee Wolraich ◽

Ai-hua Cao ◽

Fei-Yong Jia ◽

Bin Liu ◽

...

Keyword(s):

Vitamin D ◽

Attention Deficit Hyperactivity Disorder ◽

Vitamin A ◽

Attention Deficit ◽

Remission Rate ◽

Vitamin D Supplementation ◽

Multicentric Study ◽

Hyperactivity Disorder ◽

Institutional Review ◽

Double Blinded

IntroductionApproximately 7.2% of children in the world suffer from attention-deficit/hyperactivity disorder (ADHD). Due to the availability of the osmotic-release oral-system methylphenidate, ADHD currently has a remission rate of up to 30.72%. Nevertheless, it has been reported that patients with ADHD tend to exhibit vitamin A and vitamin D deficiency, which may aggravate the symptoms of ADHD. This study aims to determine the effect of vitamin A and vitamin D supplementation as adjunctive therapy to methylphenidate on the symptoms of ADHD.Methods and analysisThis is a parallel, prospective, interventional multicentric study. Patients will be enrolled from the southern, central and northern parts of China. A target of 504 patients will be followed for 8 weeks. They will be allocated into three groups (vitamin AD, vitamin D and placebo) and administered the interventions accordingly. Data on changes in the symptoms of ADHD as well as changes in the serum concentrations of vitamin A and vitamin D will be recorded. Both responders and nonresponders based on the sociodemographic and clinical data will also be described to mitigate selection bias.Ethics and disseminationThis study is performed in accordance with the Declaration of Helsinki and was approved by the Institutional Review Board of Children’s Hospital of Chongqing Medical University, China (approval number: (2019) IRB (STUDY) number 262). The results of the trial will be reported in peer-reviewed scientific journals and academic conferences regardless of the outcomes.Trial registration numberNCT04284059.

Download Full-text

Percentile Values for Serum levels of Vitamin A and Vitamin D in Iranian children and adolescents: The CASPIAN-V study

Nutrition ◽

10.1016/j.nut.2021.111307 ◽

2021 ◽

pp. 111307

Author(s):

Mostafa Qorbani ◽

Armita Mahdavi-Gorab ◽

Hanieh-Sadat Ejtahed ◽

Nazli Namazi ◽

Maliheh Khoramdad ◽

...

Keyword(s):

Vitamin D ◽

Vitamin A ◽

Children And Adolescents ◽

Serum Levels ◽

Iranian Children

Download Full-text

Maternal dietary intake of vitamin A during pregnancy was inversely associated with congenital diaphragmatic hernia: the Japan Environment and Children’s Study

British Journal Of Nutrition ◽

10.1017/s0007114519002204 ◽

2019 ◽

Vol 122 (11) ◽

pp. 1295-1302 ◽

Cited By ~ 2

Author(s):

Takehiro Michikawa ◽

Shin Yamazaki ◽

Makiko Sekiyama ◽

Tatsuo Kuroda ◽

Shoji F. Nakayama ◽

...

Keyword(s):

Vitamin A ◽

Congenital Diaphragmatic Hernia ◽

Diaphragmatic Hernia ◽

Dietary Habits ◽

Daily Intake ◽

First Trimester ◽

Dietary Vitamin ◽

Birth Cohort Study ◽

Case Control Studies ◽

Total Vitamin

AbstractThe pathogenesis of congenital diaphragmatic hernia (CDH) is largely unknown; however, vitamin A seems to play a role in diaphragmatic development. Previous case–control studies reported that maternal dietary vitamin A intake was inversely associated with the risk of CDH. To our knowledge, however, there is no prospective evidence regarding this association. Our aim was to examine whether maternal intake of vitamin A was associated with CDH occurrence. Baseline data, from the Japan nationwide birth cohort study (2011–2014) of 89 658 mothers (mean age at delivery = 31·2 years) who delivered singleton live births, were analysed. We assessed dietary habits using an FFQ focused on the first trimester and estimated the daily intake of total vitamin A (retinol activity equivalents), retinol, provitamin A carotenoids and vegetables. The occurrence of CDH was ascertained from medical records. A total of forty cases of CDH were documented. The adjusted OR of CDH occurrence for the high total vitamin A intake category (median = 468 μg/d) was 0·6 (95 % CI 0·3, 1·2) with reference to the low intake category (230 μg/d). When we restricted to mothers with a prepregnancy BMI of 18·5–24·9 kg/m2, vitamin A intake was inversely associated with the risk of their children being born with CDH (OR 0·5, 95 % CI 0·2, 1·0). Even given the limited number of cases in the study, our findings provide additional evidence to link vitamin A with CDH.

Download Full-text