scholarly journals ANTIGEN SPECIFIC IgG ANTIBODIES IN CHILDREN WHO HAD NO PAST HISTORY OF ALLERGIC DISEASES

Author(s):  
Atsushi Yamamoto ◽  
Keisuke Fukuoka ◽  
Masami Sugiuchi ◽  
Toshihiko Nemoto ◽  
Akiyoshi Teramichi
2013 ◽  
Vol 142 (7) ◽  
pp. 1559-1565 ◽  
Author(s):  
C. AHLM ◽  
M. ELIASSON ◽  
O. VAPALAHTI ◽  
M. EVANDER

SUMMARYMosquito-borne Sindbis virus (SINV) cause disease characterized by rash, fever and arthritis which often leads to long-lasting arthralgia. To determine the seroprevalence of SINV and associated risk factors in northern Sweden, a randomly selected population aged between 25 and 74 years were invited to join the MONICA study. Serum from 1611 samples were analysed for specific IgG antibodies. Overall, 2·9% had IgG against SINV. More men (3·7%) than women (2·0%) were SINV seropositive (P = 0·047) and it was more common in subjects with a lower educational level (P = 0·013) and living in small, rural communities (P < 0·001). Seropositivity was associated with higher waist circumference (P = 0·1), elevated diastolic blood pressure (P = 0·037), and history of a previous stroke (P = 0·011). In a multiple logistic regression analysis, adjusting for known risk factors for stroke, seropositivity for SINV was an independent predictor of having had a stroke (odds ratio 4·3, 95% confidence interval 1·4–13·0, P = 0·011).


BMJ Open ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. e053791
Author(s):  
S Muhammad Salim Khan ◽  
Mariya Amin Qurieshi ◽  
Inaamul Haq ◽  
Sabhiya Majid ◽  
Javid Ahmad ◽  
...  

ObjectivesWe designed a population-based survey in Kashmir to estimate the seroprevalence of SARS-CoV-2-specific IgG antibodies in the general population aged 18 years and above.SettingThe survey was conducted among 110 villages and urban wards across 10 districts in Kashmir from 17 October 2020 to 4 November 2020.ParticipantsIndividuals aged 18 years and above were eligible to be included in the survey. Serum samples were tested for the presence of SARS-CoV-2-specific IgG antibodies using the Abbott SARS-CoV-2 IgG assay.Primary and secondary outcome measuresWe labelled assay results equal to or above the cut-off index value of 1.4 as positive for SARS-CoV-2-specific IgG antibodies. Seroprevalence estimates were adjusted for the sampling design and assay characteristics.ResultsOut of 6397 eligible individuals enumerated, 6315 (98.7%) agreed to participate. The final analysis was done on 6230 participants. Seroprevalence adjusted for the sampling design and assay characteristics was 36.7% (95% CI 34.3% to 39.2%). Seroprevalence was higher among the older population. Among seropositive individuals, 10.2% (247/2415) reported a history of COVID-19-like symptoms. Out of 474 symptomatic individuals, 233 (49.2%) reported having been tested. We estimated an infection fatality rate of 0.034%.ConclusionsDuring the first 7 months of the COVID-19 epidemic in Kashmir Valley, approximately 37% of individuals were infected. The reported number of COVID-19 cases was only a small fraction of the estimated number of infections. A more efficient surveillance system with strengthened reporting of COVID-19 cases and deaths is warranted.


PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0239303
Author(s):  
S. Muhammad Salim Khan ◽  
Mariya Amin Qurieshi ◽  
Inaamul Haq ◽  
Sabhiya Majid ◽  
Arif Akbar Bhat ◽  
...  

Background Prevalence of IgG antibodies against SARS-CoV-2 infection provides essential information for deciding disease prevention and mitigation measures. We estimate the seroprevalence of SARS-CoV-2 specific IgG antibodies in District Srinagar. Methods 2906 persons >18 years of age selected from hospital visitors across District Srinagar participated in the study. We tested samples for the presence of SARS-CoV-2 specific IgG antibodies using a chemiluminescent microparticle immunoassay-based serologic test. Results Age- and gender-standardized seroprevalence was 3.6% (95% CI 2.9% to 4.3%). Age 30–69 years, a recent history of symptoms of an influenza-like-illness, and a history of being placed under quarantine were significantly related to higher odds of the presence of SARS-CoV-2 specific IgG antibodies. The estimated number of SARS-CoV-2 infections during the two weeks preceding the study, adjusted for test performance, was 32602 with an estimated (median) infection-to-known-case ratio of 46 (95% CI 36 to 57). Conclusions The seroprevalence of SARS-CoV-2 specific IgG antibodies is low in the District. A large proportion of the population is still susceptible to the infection. A sizeable number of infections remain undetected, and a substantial proportion of people with symptoms compatible with COVID-19 are not tested.


Author(s):  
V.T. Akhmetshina ◽  
◽  
L.G. Gizatullina ◽  
L.M. Masyagutova

Abstract: Abstract: Today, a request is being formed to prevent the introduction of infection into organized groups by means of the formation of population immunity by methods of specific prevention. Purpose of the work: To carry out the determination of specific IgG antibodies to SARS-CoV-2 in students of a higher educational institution, to determine the number of students in need of vaccination. Material and research methods: The level of IgG antibodies to SARS-CoV-2 in the blood serum of students of a higher educational institution was analyzed. An analysis of the strength of immunity shows that the average value of the CP of positive samples is 11.3. A more significant diagnostic level of CP was revealed, indicating a pronounced tension of immunity in students with a history of pneumonia. Among those with a diagnostically significant positive CP level, more than a third of the examined subjects have lower IgG antibodies to SARS-CoV-2 than the average in this group. Consequently, these individuals require dynamic observation and monitoring of antibody levels in order to ensure timely vaccination. Thus, specific IgG antibodies to SARS-CoV-2 were detected in half of the examined students, which was 55%. It is this group that is subject to immediate vaccination before undergoing industrial practice. A third of students with low levels of antibodies to SARS-CoV-2 need dynamic monitoring of their content.


2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Tuncay Çelik ◽  
Yüksel Kaplan ◽  
Eser Ataş ◽  
Derya Öztuna ◽  
Said Berilgen

Most cases of idiopathic Parkinson disease (IPD) are believed to be due to a combination of genetic and environmental factors. The purpose of this study is to investigate the relationship between toxocariasis and Parkinson disease (PD). Patients were selected from people who were admitted to the Movement Disorders Branch, Neurology Department of Elazığ University Faculty of Medicine Elazığ, Turkey. We studied specific IgG antibodies againstToxocara canis(T. canis) in 50 patients with idiopathic Parkinson and 50 healthy volunteers. We investigated the clinical history of three patients infected withT. canis. We also studied specific IgG antibodies againstToxoplasma gondiiin these groups. Antibodies anti-Toxocara caniswere found in 3 idiopathic PD (6%) (P=0.121) and antibody titer was not found in control. A patient had history of the presence of dog in current dog ownership. We did not detect any statistically significant association betweenT. canisand IPD. But, we believe that further comprehensive studies are required for understanding whether there is a causal relation between toxocariasis and PD. We didn’t find possible association betweenToxoplasma gondiiand IPD (P=0.617).


2011 ◽  
Vol 76 (2) ◽  
pp. 271-273
Author(s):  
Hongxia Shao ◽  
Hiroshi Tachibana ◽  
Xunjia Cheng

2020 ◽  
Author(s):  
S Muhammad Salim Khan ◽  
Mariya Amin Qurieshi ◽  
Inaamul Haq ◽  
Sabhiya Majid ◽  
Arif Akbar Bhat ◽  
...  

AbstractBackgroundPrevalence of IgG antibodies against SARS-CoV-2 infection provides essential information for deciding disease prevention and mitigation measures. We estimate the seroprevalence of SARS-CoV-2 specific IgG antibodies in District Srinagar.Methods2906 persons >18 years of age selected from hospital visitors across District Srinagar participated in the study. We tested samples for the presence of SARS-CoV-2 specific IgG antibodies using a chemiluminescent microparticle immunoassay-based serologic test.ResultsAge- and gender-standardized seroprevalence was 3.6% (95% CI 2.9% to 4.3%). Age 30-69 years, a recent history of symptoms of an influenza-like-illness, and a history of being placed under quarantine were significantly related to higher odds of the presence of SARS-CoV-2 specific IgG antibodies. The estimated number of SARS-CoV-2 infections during the two weeks preceding the study, adjusted for test performance, was 32602 with an estimated (median) infection-to-known-case ratio of 46 (95% CI 36 to 57).ConclusionsThe seroprevalence of SARS-CoV-2 specific IgG antibodies is low in the District. A large proportion of the population is still susceptible to the infection. A sizeable number of infections remain undetected, and a substantial proportion of people with symptoms compatible with COVID-19 are not tested.


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