THE CONTENT OF ANTIBODIES TO THE SARS-COV-2 VIRUS IN STUDENTS OF A HIGHER EDUCATIONAL INSTITUTION

2021 ◽  
Author(s):  
V.T. Akhmetshina ◽  
◽  
L.G. Gizatullina ◽  
L.M. Masyagutova
Keyword(s):  
Educational Institution ◽  
Dynamic Monitoring ◽  
Igg Antibodies ◽  
Average Value ◽  
Population Immunity ◽  
History Of ◽  
Specific Igg ◽  
Higher Educational ◽  
Antibody Levels ◽  
Specific Igg Antibodies

Abstract: Abstract: Today, a request is being formed to prevent the introduction of infection into organized groups by means of the formation of population immunity by methods of specific prevention. Purpose of the work: To carry out the determination of specific IgG antibodies to SARS-CoV-2 in students of a higher educational institution, to determine the number of students in need of vaccination. Material and research methods: The level of IgG antibodies to SARS-CoV-2 in the blood serum of students of a higher educational institution was analyzed. An analysis of the strength of immunity shows that the average value of the CP of positive samples is 11.3. A more significant diagnostic level of CP was revealed, indicating a pronounced tension of immunity in students with a history of pneumonia. Among those with a diagnostically significant positive CP level, more than a third of the examined subjects have lower IgG antibodies to SARS-CoV-2 than the average in this group. Consequently, these individuals require dynamic observation and monitoring of antibody levels in order to ensure timely vaccination. Thus, specific IgG antibodies to SARS-CoV-2 were detected in half of the examined students, which was 55%. It is this group that is subject to immediate vaccination before undergoing industrial practice. A third of students with low levels of antibodies to SARS-CoV-2 need dynamic monitoring of their content.

scholarly journals Seroprevalence of Sindbis virus and associated risk factors in northern Sweden

2013 ◽  
Vol 142 (7) ◽  
pp. 1559-1565 ◽  
Author(s):  
C. AHLM ◽  
M. ELIASSON ◽  
O. VAPALAHTI ◽  
M. EVANDER
Keyword(s):  
Risk Factors ◽  
Rural Communities ◽  
Sindbis Virus ◽  
Multiple Logistic Regression Analysis ◽  
Northern Sweden ◽  
Igg Antibodies ◽  
History Of ◽  
Specific Igg ◽  
Associated Risk Factors ◽  
Specific Igg Antibodies

SUMMARYMosquito-borne Sindbis virus (SINV) cause disease characterized by rash, fever and arthritis which often leads to long-lasting arthralgia. To determine the seroprevalence of SINV and associated risk factors in northern Sweden, a randomly selected population aged between 25 and 74 years were invited to join the MONICA study. Serum from 1611 samples were analysed for specific IgG antibodies. Overall, 2·9% had IgG against SINV. More men (3·7%) than women (2·0%) were SINV seropositive (P = 0·047) and it was more common in subjects with a lower educational level (P = 0·013) and living in small, rural communities (P < 0·001). Seropositivity was associated with higher waist circumference (P = 0·1), elevated diastolic blood pressure (P = 0·037), and history of a previous stroke (P = 0·011). In a multiple logistic regression analysis, adjusting for known risk factors for stroke, seropositivity for SINV was an independent predictor of having had a stroke (odds ratio 4·3, 95% confidence interval 1·4–13·0, P = 0·011).

scholarly journals Seroprevalence of SARS-CoV-2-specific IgG antibodies in Kashmir, India, 7 months after the first reported local COVID-19 case: results of a population-based seroprevalence survey from October to November 2020

BMJ Open ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. e053791
Author(s):  
S Muhammad Salim Khan ◽  
Mariya Amin Qurieshi ◽  
Inaamul Haq ◽  
Sabhiya Majid ◽  
Javid Ahmad ◽  
...  
Keyword(s):  
Sampling Design ◽  
Final Analysis ◽  
Population Based ◽  
Secondary Outcome ◽  
Igg Antibodies ◽  
Serum Samples ◽  
History Of ◽  
Specific Igg ◽  
Index Value ◽  
Specific Igg Antibodies

ObjectivesWe designed a population-based survey in Kashmir to estimate the seroprevalence of SARS-CoV-2-specific IgG antibodies in the general population aged 18 years and above.SettingThe survey was conducted among 110 villages and urban wards across 10 districts in Kashmir from 17 October 2020 to 4 November 2020.ParticipantsIndividuals aged 18 years and above were eligible to be included in the survey. Serum samples were tested for the presence of SARS-CoV-2-specific IgG antibodies using the Abbott SARS-CoV-2 IgG assay.Primary and secondary outcome measuresWe labelled assay results equal to or above the cut-off index value of 1.4 as positive for SARS-CoV-2-specific IgG antibodies. Seroprevalence estimates were adjusted for the sampling design and assay characteristics.ResultsOut of 6397 eligible individuals enumerated, 6315 (98.7%) agreed to participate. The final analysis was done on 6230 participants. Seroprevalence adjusted for the sampling design and assay characteristics was 36.7% (95% CI 34.3% to 39.2%). Seroprevalence was higher among the older population. Among seropositive individuals, 10.2% (247/2415) reported a history of COVID-19-like symptoms. Out of 474 symptomatic individuals, 233 (49.2%) reported having been tested. We estimated an infection fatality rate of 0.034%.ConclusionsDuring the first 7 months of the COVID-19 epidemic in Kashmir Valley, approximately 37% of individuals were infected. The reported number of COVID-19 cases was only a small fraction of the estimated number of infections. A more efficient surveillance system with strengthened reporting of COVID-19 cases and deaths is warranted.

scholarly journals Seroprevalence of SARS-CoV-2 specific IgG antibodies in District Srinagar, northern India – A cross-sectional study

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0239303
Author(s):  
S. Muhammad Salim Khan ◽  
Mariya Amin Qurieshi ◽  
Inaamul Haq ◽  
Sabhiya Majid ◽  
Arif Akbar Bhat ◽  
...  
Keyword(s):  
Test Performance ◽  
Cross Sectional Study ◽  
Mitigation Measures ◽  
Igg Antibodies ◽  
Cross Sectional ◽  
Essential Information ◽  
Northern India ◽  
History Of ◽  
Specific Igg ◽  
Specific Igg Antibodies

Background Prevalence of IgG antibodies against SARS-CoV-2 infection provides essential information for deciding disease prevention and mitigation measures. We estimate the seroprevalence of SARS-CoV-2 specific IgG antibodies in District Srinagar. Methods 2906 persons >18 years of age selected from hospital visitors across District Srinagar participated in the study. We tested samples for the presence of SARS-CoV-2 specific IgG antibodies using a chemiluminescent microparticle immunoassay-based serologic test. Results Age- and gender-standardized seroprevalence was 3.6% (95% CI 2.9% to 4.3%). Age 30–69 years, a recent history of symptoms of an influenza-like-illness, and a history of being placed under quarantine were significantly related to higher odds of the presence of SARS-CoV-2 specific IgG antibodies. The estimated number of SARS-CoV-2 infections during the two weeks preceding the study, adjusted for test performance, was 32602 with an estimated (median) infection-to-known-case ratio of 46 (95% CI 36 to 57). Conclusions The seroprevalence of SARS-CoV-2 specific IgG antibodies is low in the District. A large proportion of the population is still susceptible to the infection. A sizeable number of infections remain undetected, and a substantial proportion of people with symptoms compatible with COVID-19 are not tested.

scholarly journals ToxocaraSeroprevalence in Patients with Idiopathic Parkinson's Disease: Chance Association or Coincidence?

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Tuncay Çelik ◽  
Yüksel Kaplan ◽  
Eser Ataş ◽  
Derya Öztuna ◽  
Said Berilgen
Keyword(s):  
Toxoplasma Gondii ◽  
Parkinson Disease ◽  
Causal Relation ◽  
Clinical History ◽  
Toxocara Canis ◽  
Igg Antibodies ◽  
History Of ◽  
Specific Igg ◽  
Genetic And Environmental Factors ◽  
Specific Igg Antibodies

Most cases of idiopathic Parkinson disease (IPD) are believed to be due to a combination of genetic and environmental factors. The purpose of this study is to investigate the relationship between toxocariasis and Parkinson disease (PD). Patients were selected from people who were admitted to the Movement Disorders Branch, Neurology Department of Elazığ University Faculty of Medicine Elazığ, Turkey. We studied specific IgG antibodies againstToxocara canis(T. canis) in 50 patients with idiopathic Parkinson and 50 healthy volunteers. We investigated the clinical history of three patients infected withT. canis. We also studied specific IgG antibodies againstToxoplasma gondiiin these groups. Antibodies anti-Toxocara caniswere found in 3 idiopathic PD (6%) (P=0.121) and antibody titer was not found in control. A patient had history of the presence of dog in current dog ownership. We did not detect any statistically significant association betweenT. canisand IPD. But, we believe that further comprehensive studies are required for understanding whether there is a causal relation between toxocariasis and PD. We didn’t find possible association betweenToxoplasma gondiiand IPD (P=0.617).

scholarly journals ANTIGEN SPECIFIC IgG ANTIBODIES IN CHILDREN WHO HAD NO PAST HISTORY OF ALLERGIC DISEASES

1987 ◽  
Vol 1 (1) ◽  
pp. 94-100
Author(s):  
Atsushi Yamamoto ◽  
Keisuke Fukuoka ◽  
Masami Sugiuchi ◽  
Toshihiko Nemoto ◽  
Akiyoshi Teramichi
Keyword(s):  
Past History ◽  
Allergic Diseases ◽  
Igg Antibodies ◽  
History Of ◽  
Specific Igg ◽  
Specific Igg Antibodies

scholarly journals Prospective Cohort Study of the Kinetics of Specific Antibodies to SARS-CoV-2 Infection and to Four SARS-CoV-2 Vaccines Available in Serbia, and Vaccine Effectiveness: A 3-Month Interim Report

Vaccines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1031
Author(s):  
Olivera Lijeskić ◽  
Ivana Klun ◽  
Marija Stamenov Djaković ◽  
Nenad Gligorić ◽  
Tijana Štajner ◽  
...  
Keyword(s):  
Real Life ◽  
Vaccine Dose ◽  
Igg Antibodies ◽  
Post Vaccination ◽  
Specific Antibodies ◽  
Real Life Data ◽  
Specific Igg ◽  
Antibody Levels ◽  
Kinetics Of ◽  
Specific Igg Antibodies

Real-life data on the performance of vaccines against SARS-CoV-2 are still limited. We here present the rates of detection and levels of antibodies specific for the SARS-CoV-2 spike protein RBD (receptor binding domain) elicited by four vaccines available in Serbia, including BNT-162b2 (BioNTech/Pfizer), BBIBP-CorV (Sinopharm), Gam-COVID-Vac (Gamaleya Research Institute) and ChAdOx1-S (AstraZeneca), compared with those after documented COVID-19, at 6 weeks and 3 months post first vaccine dose or post-infection. Six weeks post first vaccine dose, specific IgG antibodies were detected in 100% of individuals fully vaccinated with BNT-162b2 (n = 100) and Gam-COVID-Vac (n = 12) and in 81.7% of BBIBP-CorV recipients (n = 148), while one dose of ChAdOx1-S (n = 24) induced specific antibodies in 75%. Antibody levels elicited by BNT-162b2 were higher, while those elicited by BBIBP-CorV were lower, than after SARS-CoV-2 infection. By 3 months post-vaccination, antibody levels decreased but remained ≥20-fold above the cut-off in BNT-162b2 but not in BBIBP-CorV recipients, when an additional 30% were seronegative. For all vaccines, antibody levels were higher in individuals with past COVID-19 than in naïve individuals. A total of twelve new infections occurred within the first 3 months post-vaccination, eight after the first dose of BNT-162b2 and ChAdOx1-S (one each) and BBIBP-CorV (six), and four after full vaccination with BBIBP-CorV, but none required hospitalization.

scholarly journals Stable IgG-antibody levels in patients with mild SARS-CoV-2 infection

2021 ◽  
Author(s):  
Thomas Akerlund ◽  
Katherina Zakikhany ◽  
Charlotta Lofstrom ◽  
Evelina Lindmark ◽  
Henrik Kallberg ◽  
...  
Keyword(s):  
Nucleocapsid Protein ◽  
Spike Protein ◽  
Igg Antibodies ◽  
Serum Samples ◽  
Igg Antibody ◽  
Time Period ◽  
Specific Igg ◽  
Antibody Levels ◽  
Over Time ◽  
Specific Igg Antibodies

More knowledge regarding persistence of antibody response to SARS-CoV-2 infections in the general population with mild symptoms is needed. We measured and compared levels of SARS-CoV-2 spike- and nucleocapsid-specific IgG-antibodies in serum samples from 145 laboratory-confirmed COVID-19 cases and 324 non-cases. The IgG-antibody levels against the spike protein in cases were stable over the time-period studied (14 to 256 days), while antibody levels against the nucleocapsid protein decreased over time.

scholarly journals Assessment of S1, S2 and NCP-specific IgM, IgA, and IgG antibody kinetics in acute SARS-CoV-2 infection by a microarray and twelve other immunoassays

2021 ◽  
Author(s):  
Georg Semmler ◽  
Marianna Theresia Traugott ◽  
Marianne Graninger ◽  
Wolfgang Hoepler ◽  
Tamara Seitz ◽  
...  
Keyword(s):  
Rapid Test ◽  
Tracheal Aspirate ◽  
Target Antigen ◽  
Igg Antibodies ◽  
Igg Antibody ◽  
Detection Rates ◽  
Specific Igg ◽  
Antibody Levels ◽  
Antibody Kinetics ◽  
Specific Igg Antibodies

In this study, we comprehensively analyzed multispecific antibody kinetics of different immunoglobulins in hospitalized patients with acute SARS-CoV-2 infection. Three-hundred-fifty-four blood samples longitudinally obtained from 81 IgG seroconverting CoVID-19 patients were quantified for spike (S)1, S2, and nucleocapsid protein (NCP)- specific IgM, IgA, IgG, and total Ig antibodies using a microarray, eleven different ELISAs/CLIAs, and one rapid test by seven manufacturers. The assays’ specificity was assessed in 130 non-CoVID19 pneumonia patients. Using the microarray, NCP-specific IgA and IgG antibodies continuously displayed higher detection rates during acute CoVID-19 than S1- and S2-specific ones. S1-specific IgG antibodies, however, reached higher peak values. Until the 26th-day post symptom onset, all patients developed IgG responses against S1, S2, and NCP, respectively. Although detection rates by ELISAs/CLIAs generally resembled those of the microarray, corresponding to the target antigen, sensitivities and specificities varied among all tests. Notably, patients with more severe CoVID-19 displayed higher IgG and IgA levels, but this difference was mainly observed with S1-specific immunoassays. In patients with high SARS-CoV-2 levels in the lower respiratory tract, we observed high detection rates of IgG and total Ig immunoassays with a particular rise of S1-specific IgG antibodies when viral concentrations in the tracheal aspirate subsequently declined over time. In summary, our study demonstrates that differences in sensitivity among commercial immunoassays during acute SARS-CoV-2 infection are only partly related to the target antigen. Importantly, our data indicate that NCP-specific IgA and IgG antibodies are detected earlier, while higher S1-specific IgA antibody levels occur in severely ill patients.

scholarly journals Seroprevalence of SARS-CoV-2 specific IgG antibodies in District Srinagar, northern India – a cross-sectional study

2020 ◽  
Author(s):  
S Muhammad Salim Khan ◽  
Mariya Amin Qurieshi ◽  
Inaamul Haq ◽  
Sabhiya Majid ◽  
Arif Akbar Bhat ◽  
...  
Keyword(s):  
Test Performance ◽  
Cross Sectional Study ◽  
Mitigation Measures ◽  
Igg Antibodies ◽  
Cross Sectional ◽  
Essential Information ◽  
Northern India ◽  
History Of ◽  
Specific Igg ◽  
Specific Igg Antibodies

AbstractBackgroundPrevalence of IgG antibodies against SARS-CoV-2 infection provides essential information for deciding disease prevention and mitigation measures. We estimate the seroprevalence of SARS-CoV-2 specific IgG antibodies in District Srinagar.Methods2906 persons >18 years of age selected from hospital visitors across District Srinagar participated in the study. We tested samples for the presence of SARS-CoV-2 specific IgG antibodies using a chemiluminescent microparticle immunoassay-based serologic test.ResultsAge- and gender-standardized seroprevalence was 3.6% (95% CI 2.9% to 4.3%). Age 30-69 years, a recent history of symptoms of an influenza-like-illness, and a history of being placed under quarantine were significantly related to higher odds of the presence of SARS-CoV-2 specific IgG antibodies. The estimated number of SARS-CoV-2 infections during the two weeks preceding the study, adjusted for test performance, was 32602 with an estimated (median) infection-to-known-case ratio of 46 (95% CI 36 to 57).ConclusionsThe seroprevalence of SARS-CoV-2 specific IgG antibodies is low in the District. A large proportion of the population is still susceptible to the infection. A sizeable number of infections remain undetected, and a substantial proportion of people with symptoms compatible with COVID-19 are not tested.

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