Steroid induced avascular necrosis of femoral head in ALL patients-two case reports

JMS SKIMS ◽  
2020 ◽  
Vol 23 (2) ◽  
Author(s):  
Faisal Guru ◽  
Syed Nisar ◽  
Saquib Zaffar Banday ◽  
Gul Mohammad Bhat ◽  
Saqib Ahmad Shah ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Young Adults ◽  
Side Effects ◽  
Femoral Head ◽  
Children And Adolescents ◽  
Avascular Necrosis ◽  
Case Reports ◽  
Mineral Density ◽  
Necrosis Of Femoral Head ◽  
Avascular Necrosis Of Bone

Avascular necrosis of bone or Osteonecrosis incidence has been increasing in a larger number of surviving ALL patients, especially in adolescents and young adults [1]. Osteonecrosis and decreased bone mineral density(BMD) are well-known side effects of corticosteroids and avascular necrosis has been reported as one of the leading causes of treatment related morbidity in ALL survivors [2]. Symptomatic avascular necrosis has been reported to occur in up to 20% of children and adolescents with ALL [3]. We are reporting two cases of ALL patients who have been treated with steroid and chemotherapy and developed avascular necrosis of bilateral femoral heads.

scholarly journals Avascular Necrosis of Femoral Head in HIV-infected Patients: Case Reports and Review of the Literature

2012 ◽  
Vol 44 (6) ◽  
pp. 508 ◽  
Author(s):  
Jinyong Park ◽  
Kangil Jun ◽  
Min Jae Kim ◽  
Younghee Jung ◽  
Myung Jin Lee ◽  
...  
Keyword(s):  
Femoral Head ◽  
Avascular Necrosis ◽  
Case Reports ◽  
Review Of The Literature ◽  
Necrosis Of Femoral Head

scholarly journals Bipolar hip arthroplasty for avascular necrosis of femoral head in young adults

2015 ◽  
Vol 49 (3) ◽  
pp. 329 ◽  
Author(s):  
AshokK Shyam ◽  
Pankush Arora ◽  
Arjun Veigus ◽  
Baldev Dudani
Keyword(s):  
Young Adults ◽  
Femoral Head ◽  
Avascular Necrosis ◽  
Hip Arthroplasty ◽  
Necrosis Of Femoral Head

scholarly journals The Association between Bone Mineral Density and Periodontal Disease in Middle-Aged Adults

2021 ◽  
Vol 18 (6) ◽  
pp. 3321
Author(s):  
Hsin-Hua Chou ◽  
Sao-Lun Lu ◽  
Sen-Te Wang ◽  
Ting-Hsuan Huang ◽  
Sam Li-Sheng Chen
Keyword(s):  
Bone Mineral Density ◽  
Young Adults ◽  
Bone Mass ◽  
Periodontal Disease ◽  
Bone Mineral ◽  
Intervention Program ◽  
Past History ◽  
Low Bone Mass ◽  
Mineral Density ◽  
Periodontal Index

The association between osteoporosis and periodontal disease (PD) has been revealed by previous studies, but there have been few studies on the association in younger adults. We enrolled a total of 7298 adults aged 40 to 44 who underwent PD screening between 2003 and 2008. Data on quantitative ultrasound for the measurement of bone mineral density (BMD) were collected for the diagnostic criteria of osteopenia and osteoporosis. The Community Periodontal Index (CPI) was measured for defining PD. A multiple logistic regression model was used to assess the effect of low bone mass on the risk of PD. Of 7298 enrollees, 31% had periodontal pockets >3 mm, 36.2% had osteopenia, and 2.1% had osteoporosis. The 39.8% of PD prevalence was high in adults with osteoporosis, followed by 33.3% in osteopenia. A negative association was found between BMD and CPI value (p < 0.0001). Low bone mass was associated with the risk of PD (adjusted OR: 1.13; 95% CI:1.02–1.26) after adjusting the confounding factors, including age, gender, education level, overweight, smoking status, past history of osteoporosis, and diabetes mellitus. An association between BMD and PD among young adults was found. An intervention program for the prevention of PD and osteoporosis could be considered starting in young adults.

scholarly journals Blood lead and cadmium levels are negatively associated with bone mineral density in young female adults

2021 ◽  
Vol 79 (1) ◽  
Author(s):  
Jianfeng Lu ◽  
Ji Lan ◽  
Xiao’e Li ◽  
Zhongxin Zhu
Keyword(s):  
Bone Mineral Density ◽  
Young Adults ◽  
Bone Mineral ◽  
Subgroup Analysis ◽  
Blood Lead ◽  
Negative Association ◽  
Skewed Distribution ◽  
Mineral Density ◽  
Negatively Associated ◽  
Lead And Cadmium

Abstract Background The organ toxicities of lead and cadmium have been extensively studied; however, studies of their toxic effects on bone remain limited, especially in young adults. The objective of this study was to examine the associations of blood lead levels (BLL) and blood cadmium levels (BCL) with bone mineral density (BMD) among young adults. Methods We performed a cross-sectional study using the National Health and Nutrition Examination Survey 2011–2018 database. Because of the skewed distribution, BLL and BCL were Ln-transformed for analysis. Weighted multivariate regressions were performed to evaluate the associations between LnBLL and LnBCL and lumbar BMD. Subgroup analyses were further performed. Results A total of 3234 participants aged 20–35 years were included in this study. No significant association between LnBLL and lumbar BMD was found (β = − 5.6, 95%CI: − 13.5–2.3). However, in the subgroup analysis stratified by sex, this association became negative in women (β = − 18.2, 95%CI: − 29.9– − 6.4). Moreover, this negative association was more prominent in female blacks (β = − 35.5, 95%CI: − 63.4– − 7.6). On the other hand, a negative association between LnBCL and lumbar BMD was found (β = − 7.4, 95%CI: − 14.0– − 0.8). In the subgroup analysis stratified by sex, this negative association only existed in women (β = − 18.7, 95%CI: − 28.0– − 9.5). Moreover, this negative association was more prominent in female whites (β = − 31.1, 95%CI: − 46.2– − 16.1). Conclusions Our finding showed that both BLL and BCL were independently and negatively associated with lumbar BMD among young females, but not among young males.

scholarly journals Nutritional factors associated with femoral neck bone mineral density in children and adolescents

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Guo-Hau Gou ◽  
Feng-Jen Tseng ◽  
Sheng-Hao Wang ◽  
Pao-Ju Chen ◽  
Jia-Fwu Shyu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Femoral Neck ◽  
Children And Adolescents ◽  
Bone Mineral ◽  
Age Group ◽  
Mineral Density ◽  
Nutrient Intakes ◽  
Nutritional Factors ◽  
Daily Total

Abstract Background Nutritional factors including vitamin D, magnesium, and fat are known to affect bone mineral accrual. This study aimed to evaluate associations between dietary nutrient intakes (both macronutrients and micronutrients) and bone mineral density (BMD) in children and adolescents. Methods Data for this cross-sectional, population-based study were derived from the National Health and Nutrition Examination Survey (NHANES). Participants aged from 8 to 19 years were included. The primary outcome was femoral neck BMD. Results Multivariate analyses revealed that for participants aged 8 to 11, daily sodium intake was significantly and positively associated with femoral neck BMD (B = 0.9 ×  10− 5, p = 0.031); in particular, subgroup analyses by sex found that in male participants aged 8–11, daily total cholesterol intake (B = 5.3 × 10− 5, p = 0.030) and calcium intake (B = − 2.0 × 10− 5, p < 0.05) were significantly associated with femoral neck BMD in a positive and negative manner, respectively, but neither were observed in female participants of this age group. In contrast, daily intakes of vitamin D and magnesium were significantly and positively associated with femoral neck BMD in female participants aged 8–11 (B = 246.8 × 10− 5 and 16.3 × 10− 5, p = 0.017 and 0.033, respectively). For participants aged 16 to 19, daily total fat intake was significantly and negatively associated with femoral neck BMD (B = − 58 × 10− 5, p = 0.048); further stratification by sex found that magnesium and sodium intakes were significantly and positively associated with femoral neck BMD only in females of this age group (B = 26.9 × 10− 5 and 2.1 × 10− 5, respectively; both p < 0.05). However, no significant associations between daily nutrient intakes and femoral neck BMD were identified in participants aged 12–15 before or after subgroup stratification. Conclusion The study found that associations of specific nutrition-related variables with BMD of the femoral neck is dependent upon age and gender.

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