scholarly journals Microbes in Tumoral In Situ Tissues and in Tumorigenesis

2020 ◽  
Vol 10 ◽  
Author(s):  
Xue Feng ◽  
Lu Han ◽  
Sijia Ma ◽  
Lanbo Zhao ◽  
Lei Wang ◽  
...  
Keyword(s):  
Dna Damage ◽  
Human Health ◽  
Diagnosis And Treatment ◽  
Early Prevention ◽  
Pathogenic Mechanisms ◽  
Etiologic Role

Cancerous tumors are severe diseases affecting human health that have a complicated etiology and pathogenesis. Microbes have been considered to be related to the development and progression of numerous tumors through various pathogenic mechanisms in recent studies. Bacteria, which have so far remained the most studied microbes worldwide, have four major possible special pathogenic mechanisms (modulation of inflammation, immunity, DNA damage, and metabolism) that are related to carcinogenesis. This review aims to macroscopically summarize and verify the relationships between microbes and tumoral in situ tissues from cancers of four major different systems (urinary, respiratory, digestive, and reproductive); the abovementioned four microbial pathogenic mechanisms, as well as some synergistic pathogenic mechanisms, are also discussed. Once the etiologic role of microbes and their precise pathogenic mechanisms in carcinogenesis are known, the early prevention, diagnosis, and treatment of cancers would progress significantly.

Remediation of Contaminated Land

2007 ◽  
Vol 2 (3) ◽  
pp. 173-189
Author(s):  
Masashi Kamon ◽  
Keyword(s):  
Risk Assessment ◽  
Human Health ◽  
Health Risks ◽  
Cost Effective ◽  
Permeable Reactive Barriers ◽  
Organic Chemical ◽  
Contaminated Land ◽  
Human Health Risks

Growing awareness of geoenvironmental hazards has made clear the need to develop better technical knowledge of environmental issues. We are thus studying how to remediate soil and groundwater contaminated by heavy metals and organic chemical substances in natural and man-made disasters. Remediation technology includes containment and risk assessment of contaminated land, with permeable reactive barriers (PRBs) and monitored natural attenuation (MNA) presented as the passive and cost-effective techniques. A case study to assess the effectiveness of a containment facility as a remedial technique in reducing human health risks was introduced. Numerical analyzed results confirm that this significantly reduces potential human health risks from land contaminated by polychlorinated biphenyls (PCB) and dioxin. Risk assessment based on in situ monitored data indicated that no significant health risks were induced. The important projected role of the geoenvironment is developing a sustainable contamination-free society.

The Role of Punch Biopsy and Cervical Smear in the Diagnosis and Treatment of Cervical Carcinoma In Situ

1965 ◽  
Vol 58 (1) ◽  
pp. 79-81
Author(s):  
JOHN B. THOMISON ◽  
ROBERT H. TOSH ◽  
WILLIAM F. JUNG ◽  
WILLIAM H. PRESTON
Keyword(s):  
Cervical Carcinoma ◽  
Carcinoma In Situ ◽  
Punch Biopsy ◽  
Diagnosis And Treatment ◽  
Cervical Smear

scholarly journals Sam68/KHDRBS1-dependent NF-κB activation confers radioprotection to the colon epithelium in γ-irradiated mice

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Kai Fu ◽  
Xin Sun ◽  
Eric M Wier ◽  
Andrea Hodgson ◽  
Ryan P Hobbs ◽  
...  
Keyword(s):  
Dna Damage ◽  
Critical Role ◽  
Genotoxic Stress ◽  
Whole Body ◽  
Colon Tissue ◽  
Γ Irradiation ◽  
Apoptotic Genes

Previously we reported that Src-associated-substrate-during-mitosis-of-68kDa (Sam68/KHDRBS1) is pivotal for DNA damage-stimulated NF-κB transactivation of anti-apoptotic genes (Fu et al., 2016). Here we show that Sam68 is critical for genotoxic stress-induced NF-κB activation in the γ-irradiated colon and animal and that Sam68-dependent NF-κB activation provides radioprotection to colon epithelium in vivo. Sam68 deletion diminishes γ-irradiation-triggered PAR synthesis and NF-κB activation in colon epithelial cells (CECs), thus hampering the expression of anti-apoptotic molecules in situ and facilitating CECs to undergo apoptosis in mice post whole-body γ-irradiation (WBIR). Sam68 knockout mice suffer more severe damage in the colon and succumb more rapidly from acute radiotoxicity than the control mice following WBIR. Our results underscore the critical role of Sam68 in orchestrating genotoxic stress-initiated NF-κB activation signaling in the colon tissue and whole animal and reveal the pathophysiological relevance of Sam68-dependent NF-κB activation in colonic cell survival and recovery from extrinsic DNA damage.

1763: Stage Migration of upper Tract Transitional Cell Carcinoma: An Argument for the Continued Role of Endourologic Diagnosis and Treatment

2004 ◽  
Vol 171 (4S) ◽  
pp. 466-466
Author(s):  
Stephen A. Boorjian ◽  
Casey K. Ng ◽  
Ravi Munver ◽  
R. Ernest Sosa ◽  
E. Darracott Vaughan ◽  
...  
Keyword(s):  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Diagnosis And Treatment ◽  
Stage Migration ◽  
Upper Tract

Cerebral sinovenous thrombosis during asparaginase treatment

2003 ◽  
Vol 23 (03) ◽  
pp. 109-112
Author(s):  
A. Hirt ◽  
C. Zwicky ◽  
W.A. Wuillemin ◽  
K. Leibundgut
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Induction Treatment ◽  
Pathogenic Mechanisms ◽  
Cerebral Sinovenous Thrombosis ◽  
Haemorrhagic Infarction ◽  
Sinovenous Thrombosis

SummaryA boy (age: 71/12 years) with acute lymphoblastic leukaemia developed thrombosis of the sinus sagitalis superior with secondary haemorrhagic infarction while on induction treatment with vincristine, prednisone, and asparaginase. Based on this report, the potential pathogenic mechanisms are discussed with respect to congenital prothrombotic defects as well as to the role of antileukaemic treatment. Current hypotheses on mechanisms for thromboembolism in children and proposed prophylactic strategies are briefly summarized.

Neuromyelitis optica spectrum: novel concept of pathogenesis, diagnosis and treatment of Devic’s disease

2009 ◽  
Vol 150 (46) ◽  
pp. 2101-2109 ◽  
Author(s):  
Péter Csécsei ◽  
Anita Trauninger ◽  
Sámuel Komoly ◽  
Zsolt Illés
Keyword(s):  
Neuromyelitis Optica ◽  
Water Channel ◽  
Diagnostic Procedures ◽  
Diagnosis And Treatment ◽  
Clinical Settings ◽  
Permanent Disability ◽  
Therapeutic Decisions ◽  
Novel Concept ◽  
The Brain

The identification of autoantibodies generated against the brain isoform water channel aquaporin4 in the sera of patients, changed the current diagnostic guidelines and concept of neuromyelitis optica (NMO). In a number of cases, clinical manifestation is spatially limited to myelitis or relapsing optic neuritis creating a diverse. NMO spectrum. Since prevention of relapses provides the only possibility to reduce permanent disability, early diagnosis and treatment is mandatory. In the present study, we discuss the potential role of neuroimaging and laboratory tests in differentiating the NMO spectrum from other diseases, as well as the diagnostic procedures and therapeutic options. We also present clinical cases, to provide examples of different clinical settings, diagnostic procedures and therapeutic decisions.

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