Meningococcal Carriage in ‘Men Having Sex With Men’ With Pharyngeal Gonorrhoea

We assessed the characteristics of Neisseria meningitidis pharyngeal carriage in a cohort of ‘men having sex with men’, including patients with pharyngeal Neisseria gonorrhoeae infection. In the period 2017-2019, among all the oropharyngeal samples tested for gonorrhoea from MSM attending a STI Clinic in Bologna (Italy), we randomly selected 244 N. gonorrhoeae-positive samples and 403 negatives (n=647). Pharyngeal specimens were tested for N. meningitidis presence, by the detection of sodC gene. N. meningitidis-positive samples were further grouped by PCR tests for the major invasive genogroups (i.e., A, B, C, W, and Y). A molecular assay, targeting capsule transporter gene, was used to determine meningococcal capsular status. Overall, 75.8% (491/647) of samples tested positive for sodC gene, indicating a pharyngeal meningococcal carriage. Meningococcal colonisation was significantly more frequent in younger subjects (P=0.009), with no association with HIV infection. Non-groupable meningococci represented most of pharyngeal carriages (about 71%). The commonest N. meningitidis serogroup was B (23.6%), followed by C (2.1%), Y (1.8%) and W (1.1%). Meningococci were often characterized by the genetic potential of capsule production. Interestingly, a negative association between N. meningitidis and N. gonorrhoeae was found: pharyngeal gonorrhoea was significantly more present in patients without meningococcal carriage (P=0.03). Although preliminary, our data added knowledge on the epidemiology of meningococcal carriage in MSM communities at high risk of gonococcal infections, gaining new insights into the interactions/dynamics between N. meningitidis and N. gonorrhoeae.

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Use of multiple recreational drugs is associated with new HIV infections among men who have sex with men in China: a multicenter cross-sectional survey

BMC Public Health ◽

10.1186/s12889-021-10223-y ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Xiang Mao ◽

Sequoia I. Leuba ◽

Qinghai Hu ◽

Hongjing Yan ◽

Zhe Wang ◽

...

Keyword(s):

High Risk ◽

Hiv Infection ◽

Risk Behaviors ◽

Sexual Behaviors ◽

Hiv Infections ◽

Recreational Drugs ◽

Limited Information ◽

High Risk Behaviors ◽

Sex With Men ◽

Recent Hiv Infection

Abstract Background There is limited information about the types of recreational drugs used by men who have sex with men (MSM) in China or the consequent impact on sexual health and human immunodeficiency virus (HIV) acquisition. Methods We recruited MSM from seven cities in China between 2012 and 2013 using multiple approaches including advertisements on gay websites, collaborating with local MSM community-based organizations, peer referrals, and venues such as gay bars and bathrooms visited by MSM. We divided participants into four subgroups based on the number of recreational drugs (RDs) used in the previous 6 months. We defined use of multiple RDs as use of ≥2 types of RDs. Demographics and HIV-related high-risk behaviors were collected, and blood samples were tested for recent HIV infection by the HIV-1 subtypes B, E, and D immunoglobulin G capture enzyme immunoassay (BED-CEIA). We used multivariable logistic regression adjusted for sociodemographics to determine the adjusted odds ratios (aORs) and associated 95% confidence intervals (CIs) of the subgroups of RD use for recent or established HIV infection. Results A total of 4496 Chinese MSM participated; 28.4% used RDs, and 5% used multiple types of RDs. The prevalence of each RD use was as follows: poppers (25.9%), ecstasy (2.4%), ketamine (1.2%), amphetamine (0.6%), tramadol (0.4%), methamphetamine (3.8%), and codeine (1.9%). Users of multiple RDs commonly used poppers combined with one or more other types of RDs. Multiple RD users were likely to be aged 26–30 years (vs. 18–25 and > 30 years), live in non-local cities (vs. local cities), never married (vs. married), have a high monthly income (vs. no income and 1–599 USD), use versatile positions during anal intercourse (vs. top or bottom), and have inadequate HIV-related prevention knowledge (vs. adequate). As the number of RDs used in the previous 6 months increased, the prevalence of HIV-related high-risk behaviors increased (P < 0.05 for all). The odds of recent HIV infection were higher among those who used one type (aOR = 2.2, 95% CI: 1.5–3.0) or two types of RD (aOR=2.3, 95% CI: 1.0-5.2) in the previous 6 months compared to the odds among those who did not use RDs. Conclusion The level and pattern of multiple RD use among Chinese MSM were different from high-income countries. MSM who used more RDs are more likely to engage in high-risk sexual behaviors, and these behaviors may be associated with increases in new HIV infections.

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A survey of HIV infection and related high-risk factors among men who have sex with men in Suzhou, Jiangsu, China

Journal of Biomedical Research ◽

10.1016/s1674-8301(11)60002-x ◽

2012 ◽

Vol 25 (1) ◽

pp. 17-24 ◽

Cited By ~ 10

Author(s):

Hongling Bai ◽

Xiping Huan ◽

Weiming Tang ◽

Xin Chen ◽

Hongjing Yan ◽

...

Keyword(s):

Risk Factors ◽

High Risk ◽

Hiv Infection ◽

High Risk Factors ◽

Sex With Men

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1630. Voluntary HIV Testing and Self-Realization of Risk of HIV Infection Among Young Men-Who-Have-Sex-with-Men in the Miami-Dade Area

Open Forum Infectious Diseases ◽

10.1093/ofid/ofz360.1494 ◽

2019 ◽

Vol 6 (Supplement_2) ◽

pp. S595-S595

Author(s):

Hampton Ocon ◽

Samir Sabbag

Keyword(s):

Public Health ◽

High Risk ◽

Hiv Infection ◽

Hiv Testing ◽

Hiv Risk ◽

Perceived Risk ◽

Health Initiatives ◽

History Of ◽

Sex With Men ◽

Public Health Initiatives

Abstract Background According to the Centers for Disease Control and Prevention, Miami-Dade County has the highest rate of new HIV diagnoses in the Nation. So far, a large focus of public health initiatives has been spreading awareness of HIV testing locations, but this form of voluntary testing relies on individuals realizing that they are at risk of HIV infection in the first place. Consequently, a major obstacle to encouraging young men-who-have-sex-with-men (YMSM) to test themselves for HIV is their own self-perceived risk of having an undetected infection. Methods In an effort to better understand the discordance between high-risk sexual behavior and HIV testing among this high-risk population, YMSM (18–24) were surveyed through smartphone applications that facilitate sexual encounters in the Miami-Dade area (eg Grindr, Scruff). Users were asked about their history of condomless anal intercourse (CAI), their HIV testing habits, and whether or not they believe it possible that they are currently infected with HIV. An analysis of the relationship between CAI and self-perception of possible HIV infection was performed using Cochran-Mantel–Haenszel testing. Results Of the 843 eligible responses, 667 reported a history of voluntary HIV testing while 176 had never voluntarily tested. 726 respondents reported a history of CAI and 131 of these have never voluntarily tested. Of the 843 total participants, 1.6% were in the highest HIV risk group, which is those who have engaged in CAI with an exchange/casual partner, have never voluntarily tested for HIV, and have no self-perceived risk of being currently infected. According to data analysis, YMSM who have engaged in CAI but have never been tested for HIV were not more likely to have a self-perceived possibility of infection when compared with those who have voluntarily tested (P < 0.595). Conclusion This suggests that many high-risk YMSM are not voluntarily testing themselves for HIV not because they do not have access to testing, but rather because they do not perceive themselves as being possibly infected in the first place. Therefore, in addition to increasing access to HIV testing, new public health initiatives must be designed to facilitate YMSM understanding their own personal HIV risk. Disclosures All authors: No reported disclosures.

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P3.31 High risk behaviours and syphilis/hiv infection among men who have sex with men aged 50 years and older in shenzhen, china

10.1136/sextrans-2017-053264.268 ◽

2017 ◽

Author(s):

Cai Yumao ◽

Hong Fuchang ◽

Wen Lizhang ◽

Lai Yonghui ◽

Yu Weiye ◽

...

Keyword(s):

High Risk ◽

Hiv Infection ◽

Risk Behaviours ◽

Sex With Men

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HIV Testing and Preventive Services Accessibility Among Men Who Have Sex With Men at High Risk of HIV Infection in Beijing, China

Medicine ◽

10.1097/md.0000000000000534 ◽

2015 ◽

Vol 94 (6) ◽

pp. e534 ◽

Cited By ~ 24

Author(s):

Yuejuan Zhao ◽

Li Zhang ◽

Heng Zhang ◽

Dongyan Xia ◽

Stephen W. Pan ◽

...

Keyword(s):

High Risk ◽

Hiv Infection ◽

Hiv Testing ◽

Preventive Services ◽

Sex With Men ◽

Beijing China

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The Prevalence of High Carcinogenic Risk of HPV Genotypes among HIV-Positive and HIV-Negative MSM from Russia

Canadian Journal of Infectious Diseases and Medical Microbiology ◽

10.1155/2021/6641888 ◽

2021 ◽

Vol 2021 ◽

pp. 1-6

Author(s):

Ilia Beliakov ◽

Maria Senina ◽

Yuriy Tyulenev ◽

Elena Novoselova ◽

Viktor Surovtsev ◽

...

Keyword(s):

High Risk ◽

Hiv Infection ◽

Hpv Infection ◽

Carcinogenic Risk ◽

Hiv Positive ◽

Hiv Status ◽

Hpv Genotypes ◽

Hpv Types ◽

Sex With Men ◽

Hiv Negative

Objective. Men who have sex with men (MSM) have a high risk of lifelong anal cancer caused by high-risk human papillomavirus (HR HPV) infections. The aim of this study was to investigate the prevalence of anal canal HR HPV infection among men who have sex with men (MSM) with and without HIV infection in Moscow (Russia). We evaluated associations of some HIV coinfections (HSV and CMV) and HPV distribution among MSM with and without HIV infection. Methods. Two groups of HIV-positive (n = 60) and HIV-negative (n = 60) MSM were evaluated in the study. Fourteen high-risk (HR) HPV types, HSV1/2, and CMV were investigated in men anal swabs. Results. HR HPVs were found with nearly the same frequency of 66.7% in both groups: HIV-positive and HIV-negative MSM. HIV-positive status was statistically associated with the presence of several (more than two) HPV types ( p = 0.044 ). The most prevalent HR HPV genotypes were HPV18, HPV16, HPV56, and HPV33 for HIV-positive MSM and HPV56, HPV51, HPV66, and HPV16 for HIV-negatives. We found a statistically significant association of five HR HPV types with HIV status of MSM: HPV16 ( p = 0.028 ), HPV18 ( p = 0.00006 ), HPV58 ( p = 0.003 ), HPV33 ( p = 0.019 ), and HPV39 ( p = 0.026 ). The frequency of HSV1 (1.7%) and HSV2 (10%) infections and CMV (3.3%) infection was evaluated in the group of HIV-positive MSM. The frequency of HSV1 (5%) and HSV2 (6.7%) infections and CMV (0%) infection was evaluated, as well, in the group of HIV-negative MSM. Conclusion. Multiple HPV genotypes were detected significantly more often than single HPV genotype in the group of HIV-positive MSM. According to our data, 25% of HIV-positive MSM have HPV39; this is the only one of the five types of HR HPV (16, 18, 58, 33, and 39) associated with this group of MSM that has not yet been included in the HPV vaccines available on the market.

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Testing men who have sex with men for Neisseria gonorrhoeae and Chlamydia trachomatis prior to the introduction of guidelines at an STD clinic in Melbourne

Sexual Health ◽

10.1071/sh03005 ◽

2004 ◽

Vol 1 (1) ◽

pp. 47 ◽

Cited By ~ 15

Author(s):

N. A. Lister ◽

A. Smith ◽

T. Read ◽

C. K. Fairley

Keyword(s):

Chlamydia Trachomatis ◽

Neisseria Gonorrhoeae ◽

Hiv Infection ◽

Positive Result ◽

Chlamydia Infection ◽

Site Specific ◽

Pharyngeal Infection ◽

Audit Period ◽

Sex With Men ◽

Specific Symptoms

Background: Guidelines for testing men who have sex with men (MSM) were published in 2002. They did not recommend asymptomatic screening for urethral gonorrhoea or pharyngeal screening for chlamydia. To determine if these guidelines were appropriate, we audited gonorrhoea and chlamydia testing of MSM at our centre. Methods: We carried out two audits at our Centre between August 2001 to July 2002. The first was an audit of testing MSM for gonorrhoea and/ or chlamydia over 12 days. The second was an audit of all positive tests over this 12-month period for gonorrhoea or chlamydia among MSM. Results: During the 12 selected days 89 of 286 men tested (31%) were MSM. Among the MSM testing positive for gonorrhoea and/ or chlamydia infection (15, 17%), symptomatic urethral infection was the most common (n = 8). No rectal and pharyngeal infections had site-specific symptoms. Based on the guidelines, 100 of the 334 tests ordered (30%) were not recommended according to the guidelines, and none of these 100 tests yielded a positive result. Over the 12-month audit period, 135 MSM were diagnosed with gonorrhoea and/ or chlamydia. For gonorrhoea, site specific symptoms were present in 42 of 43 cases of urethral infection (98%), six of 23 cases of rectal infection (26%), and no cases of pharyngeal infection had symptoms. For chlamydia, site-specific symptoms were present in 29 of 48 cases of urethral infection (60%), six of 33 cases of rectal infection (18%), and in one of the two cases of pharyngeal chlamydia identified. A substantial proportion of cases occurred in clients with HIV infection (21, 16%). Conclusions: These findings strongly support screening among MSM and in particular not testing asymptomatic MSM for urethral gonorrhoea or any MSM for pharyngeal Chlamydia.

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HIV PREVALENCE AND SOME CHARACTERISTICS OF MAN WHO HAVE SEX WITH MAN (MSM) IN KHANH HOA PROVINCE 2010

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2012.2.16 ◽

2012 ◽

pp. 114-121

Author(s):

That Toan Ton ◽

Xuan Chuong Tran

Keyword(s):

High Risk ◽

Hiv Infection ◽

Risk Group ◽

Cross Sectional Study ◽

Hiv Prevalence ◽

High Risk Group ◽

Sectional Study ◽

Cross Sectional ◽

Men And Women ◽

Sex With Men

Man who have sex with man (MSM) group is a high risk group of HIV infection. There are very rare studies about HIV infection in this group. Objectives: 1. Determine the rate of HIV infection in MSM in Khanh Hoa province 2010. 2. Study some characteristics of MSM in Khanh Hoa province. Materials and Methods: MSM over 16 yrs. live in Khanh Hoa. Cross-sectional study from June 2010 to June 2011. Results: 1. HIV infection in MSM group in Khanh Hoa 2010: 1.3% (rural 0.6%, urban: 3.7%). Marriaged: 3.9%, single: 0.8%; MSM have sex only with men: 0.3%, MSM have sex with men and women: 3.7%. 2. 83.3% of MSM are single (urban more common than rural). The first sex partner: male 82.2%, female 14.9%. Having sex for pay: urban 29.9%, rural 19.3%. Having sex for enjoying: urban 49.5%, rural 71.8%. Conclusions: HIV infection in MSM group in Khanh Hoa 2010: 1.3% (rural 0.6%, urban: 3.7%). Marriaged: 3.9%, single: 0.8%. 83.3% of MSM are single (urban more common than rural). Having sex for enjoying: urban 49.5%, rural 71.8%.

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The development of an online risk calculator for the prediction of future syphilis among a high-risk cohort of men who have sex with men and transgender women in Lima, Peru

Sexual Health ◽

10.1071/sh17118 ◽

2018 ◽

Vol 15 (3) ◽

pp. 261 ◽

Cited By ~ 3

Author(s):

Lao-Tzu Allan-Blitz ◽

Kelika A. Konda ◽

Silver K. Vargas ◽

Xiaoyan Wang ◽

Eddy R. Segura ◽

...

Keyword(s):

Cohort Study ◽

High Risk ◽

Hiv Infection ◽

Predictive Model ◽

Transgender Women ◽

Risk Calculator ◽

Syphilis Infection ◽

Online Risk ◽

History Of ◽

Sex With Men

Background Syphilis incidence worldwide has rebounded since 2000, particularly among men who have sex with men (MSM). A predictive model for syphilis infection may inform prevention counselling and use of chemoprophylaxis. Methods: Data from a longitudinal cohort study of MSM and transgender women meeting high-risk criteria for syphilis who were followed quarterly for 2 years were analysed. Incidence was defined as a four-fold increase in rapid plasma reagin (RPR) titres or new RPR reactivity if two prior titres were non-reactive. Generalised estimating equations were used to calculate rate ratios (RR) and develop a predictive model for 70% of the dataset, which was then validated in the remaining 30%. An online risk calculator for the prediction of future syphilis was also developed. Results: Among 361 participants, 22.0% were transgender women and 34.6% were HIV-infected at baseline. Syphilis incidence was 19.9 cases per 100-person years (95% confidence interval (CI) 16.3–24.3). HIV infection (RR 2.22; 95% CI 1.54–3.21) and history of syphilis infection (RR 2.23; 95% 1.62–3.64) were significantly associated with incident infection. The final predictive model for syphilis incidence in the next 3 months included HIV infection, history of syphilis, number of male sex partners and sex role for anal sex in the past 3 months, and had an area under the curve of 69%. The online syphilis risk calculator based on those results is available at: www.syphrisk.net. Conclusions: Using data from a longitudinal cohort study among a population at high risk for syphilis infection in Peru, we developed a predictive model and online risk calculator for future syphilis infection. The predictive model for future syphilis developed in this study has a moderate predictive accuracy and may serve as the foundation for future studies.

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