scholarly journals In Utero Chlordecone Exposure and Thyroid, Metabolic, and Sex-Steroid Hormones at the Age of Seven Years: A Study From the TIMOUN Mother-Child Cohort in Guadeloupe

2021 ◽  
Vol 12 ◽  
Author(s):  
Gülen Ayhan ◽  
Florence Rouget ◽  
Frank Giton ◽  
Nathalie Costet ◽  
Léah Michineau ◽  
...  
Keyword(s):  
Linear Trend ◽  
In Utero ◽  
Thyroid Stimulating Hormone ◽  
Sex Steroid ◽  
Organochlorine Insecticide ◽  
Total Testosterone ◽  
Human Beings ◽  
Future Health ◽  
Hormone Levels ◽  
Non Linear

BackgroundChlordecone is an endocrine-disrupting chemical with well recognized estrogenic and progestagenic properties. This organochlorine insecticide was extensively used in the French West Indies from 1973 to 1993 to control the banana root borer. Due to its poor degradation in the environment, permanently polluted soil is responsible for the current contamination of the food chain and human beings. We aimed to examine the relationship of in utero exposure to chlordecone and thyroid (thyroid stimulating hormone [TSH], free tri-iodothyronine [FT3], free thyroxine [FT4]), metabolic (insulin growth-factor 1, leptin, adiponectin), and sex-steroid (dehydroepiandrosterone [DHEA], total testosterone [TT], dihydrotestosterone [DHT], estradiol [E2]) hormone levels in children at the age of seven years who participated in TIMOUN, an ongoing birth cohort in Guadeloupe.MethodsChlordecone concentrations were measured in cord-blood at delivery. Thyroid, metabolic, and sex-steroid hormone levels were determined in the blood of children at seven years of age. Associations between in utero chlordecone exposure and hormone levels at seven years of age were assessed by multiple linear or logistic regression, controlling for confounding factors.ResultsAmong the study population (210 boys and 228 girls), chlordecone and hormone measurements were available for 124 boys and 161 girls. We found the third quartile of in utero chlordecone exposure relative to the lowest quartile to be associated with elevated TSH levels in girls and elevated DHEA, TT, and DHT levels in both sexes. Complementary non-linear analysis (spline regression) confirmed a significant non-linear trend for TSH in girls and DHEA and DHT in boys.ConclusionIn utero chlordecone exposure was associated with elevated levels of selected thyroid (TSH) and sex-steroid (DHEA, TT, and DHT) hormones at seven years in a non-monotonic dose response (inverted U) relationship. The implications for future health and reproductive function in puberty and adulthood should be determined.

scholarly journals Sex Steroid Hormone Levels and Reproductive Development of Eight-Year-Old Children following In Utero and Environmental Exposure to Phthalates

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e102788 ◽  
Author(s):  
Pen-Hua Su ◽  
Jia-Yuh Chen ◽  
Ching-Yi Lin ◽  
Hsiao-Yen Chen ◽  
Pao-Chi Liao ◽  
...  
Keyword(s):  
Environmental Exposure ◽  
Steroid Hormone ◽  
Reproductive Development ◽  
In Utero ◽  
Sex Steroid ◽  
Sex Steroid Hormone ◽  
Hormone Levels

scholarly journals Non-Parametric Generalized Additive Models as a Tool for Evaluating Policy Interventions

Mathematics ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 299
Author(s):  
Jaime Pinilla ◽  
Miguel Negrín
Keyword(s):  
Linear Regression ◽  
Regression Models ◽  
Linear Trend ◽  
Generalized Additive Models ◽  
Additive Models ◽  
Linear Regression Models ◽  
Non Linear ◽  
Nonlinear Trends ◽  
The Impact ◽  
Non Parametric

The interrupted time series analysis is a quasi-experimental design used to evaluate the effectiveness of an intervention. Segmented linear regression models have been the most used models to carry out this analysis. However, they assume a linear trend that may not be appropriate in many situations. In this paper, we show how generalized additive models (GAMs), a non-parametric regression-based method, can be useful to accommodate nonlinear trends. An analysis with simulated data is carried out to assess the performance of both models. Data were simulated from linear and non-linear (quadratic and cubic) functions. The results of this analysis show how GAMs improve on segmented linear regression models when the trend is non-linear, but they also show a good performance when the trend is linear. A real-life application where the impact of the 2012 Spanish cost-sharing reforms on pharmaceutical prescription is also analyzed. Seasonality and an indicator variable for the stockpiling effect are included as explanatory variables. The segmented linear regression model shows good fit of the data. However, the GAM concludes that the hypothesis of linear trend is rejected. The estimated level shift is similar for both models but the cumulative absolute effect on the number of prescriptions is lower in GAM.

Increase in thyroid stimulating hormone levels in patients with gout treated with inhibitors of xanthine oxidoreductase

2015 ◽  
Vol 35 (11) ◽  
pp. 1857-1861 ◽  
Author(s):  
Fernando Perez-Ruiz ◽  
Sandra Pamela Chinchilla ◽  
Joana Atxotegi ◽  
Irati Urionagüena ◽  
Ana Maria Herrero-Beites ◽  
...  
Keyword(s):  
Thyroid Stimulating Hormone ◽  
Xanthine Oxidoreductase ◽  
Hormone Levels ◽  
Stimulating Hormone

scholarly journals Thyroid Hormone Levels in Apparently Euthyroid Subjects with Essential Hypertension in a Tertiary Hospital in Nigeria

2013 ◽  
Vol 5 (01) ◽  
pp. 26-29 ◽  
Author(s):  
Abiodun Mathias Emokpae ◽  
Aliyu Abdu ◽  
Humphrey Benedo Osadolor
Keyword(s):  
Essential Hypertension ◽  
Thyroid Hormone ◽  
Medical Information ◽  
Young Patients ◽  
Thyroid Stimulating Hormone ◽  
Overt Hypothyroidism ◽  
Thyroid Disorder ◽  
Major Health Problem ◽  
Hormone Levels ◽  
Thyroid Hormone Levels

ABSTRACT Background: High blood pressure (BP) is a major health problem in Nigeria and the involvement of thyroid hormones in this condition has not been evaluated in this center. Objective: The objective of this study was to evaluate the proportion of patients with an essential hypertension who had abnormal thyroid hormone levels and the type of thyroid disorders commonly observed in this group of patients. Materials and Methods: A retrospective study of 94 patients (30 males, aged 30.4 ± 2 years and 64 females, aged 43.4 ± 1.3 years) with essential hypertension was carried out between January 2005 and December 2007. Demographic and other medical information were obtained from the health records. Analysis of laboratory results of triiodothyronine (T3), Thyroxine (T4), and thyroid stimulating hormone (TSH) were made. Results: Of the 94 patients evaluated, 26 (27.7%) had abnormal thyroid hormone levels, with 23.4% having hyperthyroidism, 4.3% had sub-clinical hypothyroidism and none had overt hypothyroidism. Of the 26 subjects with abnormal thyroid hormone levels, 18 (69.2%) were females while 8 (30.8%) were males. Out of the 18 female subjects with abnormal thyroid hormone levels, 16 had hyperthyroid levels while 2 had sub-clinical hypothyroid levels. Out of the 8 male patients, 6 had hyperthyroid hormone levels while 2 had sub-clinical hypothyroid levels. Conclusion: Thyroid hormone abnormalities are common in patients with essential hypertension. Hyperthyroidism was the most common thyroid disorder observed. Young patients presenting with essential hypertension should be screened for thyroid hormone abnormalities since they can best be managed by treating the underlying causes.

scholarly journals Normalization of thyroid stimulating hormone levels in acromegalic patients after selective adenomectomy.

1984 ◽  
Vol 31 (6) ◽  
pp. 687-695 ◽  
Author(s):  
HIROYASU TSUCHIYA ◽  
TOSHIO ONISHI ◽  
SHINTARO MORI ◽  
SHOUSHI LEE ◽  
HIROSHI KOHNO ◽  
...  
Keyword(s):  
Thyroid Stimulating Hormone ◽  
Hormone Levels ◽  
Stimulating Hormone

Low Thyroid-stimulating Hormone Levels Are Associated With Annoying Tinnitus in Adult Women

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
So Young Kim ◽  
Chanyang Min ◽  
Hyung-Jong Kim ◽  
Hyo Geun Choi
Keyword(s):  
Thyroid Stimulating Hormone ◽  
Adult Women ◽  
Hormone Levels ◽  
Stimulating Hormone

scholarly journals A potential role for the adrenal gland in autism

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Felwah S. Al-Zaid ◽  
Abdel Fattah A. Alhader ◽  
Laila Y. Al-Ayadhi
Keyword(s):  
Adrenal Gland ◽  
Potential Role ◽  
Free Testosterone ◽  
Sex Hormone ◽  
Control Group ◽  
Total Testosterone ◽  
Published Data ◽  
Strong Positive Correlation ◽  
Hormone Levels ◽  
Autism Group

AbstractAndrogens have been implicated in autism pathophysiology as recently, prenatal exposure to elevated androgens has been proposed as risk factor. However, published data on postnatal sex hormone levels in autistic children are controversial and the source of prenatal androgen exposure in autism remains unknown. Therefore, this study investigated postnatal sex hormone levels and dehydroepiandrosterone (DHEA) to shed light on a potential role for the adrenal gland in autism pathophysiology. A case-control study investigating estradiol (E2), DHEA, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels was conducted with 31 Saudi males with autism and 28 healthy, age-matched boys plasma. Moreover, correlation analysis with measured hormones and previously measured total testosterone (TT) and free testosterone (FT) in the same group of autism was conducted. DHEA was significantly higher (p < 0.05) in the autism group compared to controls. DHEA positively correlated with previously measured TT (r = + 0.79, p < 0.001) and FT (r = + 0.72, p < 0.001) levels in the same autism group. FSH levels were also significantly higher in the autism group than in the control group (p < 0.01). To the best of our knowledge, this is the first study to report a strong positive correlation between TT, FT and DHEA, suggesting an adrenal source for elevated androgen levels.

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