Compatibility Polymorphism Based on Long-Term Host-Parasite Relationships: Cross Talking Between Biomphalaria glabrata and the Trematode Schistosoma mansoni From Endemic Areas in Brazil

SUMMARYThe tegumental surface of Schistosoma mansoni sporocysts is the site of both nutritive and immunological interactions with haemolymph cells and plasma of Biomphalaria glabrata, the schistosome intermediate host. Within minutes of being placed in host plasma, sporocysts acquire plasma antigens, and within 3 h host plasma antigens are present on the surface at near steady state. Though a wide variety of peptides is acquired, there is selection. Furthermore, some differences occur in the peptides acquired from the plasma of susceptible and resistant strains of snail. Acquired antigens are rapidly processed, and are predominantly undetectable in tegumental extracts after a few hours. In contrast, rabbit antibody on sporocysts remains in situ for at least 48 h, so under some conditions there is stable expression of certain tegumental antigenic determinants.These data, obtained using antibodies to snail plasma antigens and to sporocyst tegumental antigens, are discussed in the light of current ideas on the cellular and molecular basis of susceptibility and resistance in this host#parasite system.

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Review: SCHISTOSOMA MANSONI: THE ULTRASTRUCTURE OF LARVAL MORPHOGENESIS IN BIOMPHALARIA GLABRATA AND OF ASSOCIATED HOST-PARASITE INTERACTIONS

Japanese Journal of Medical Science and Biology ◽

10.7883/yoken1952.49.129 ◽

1996 ◽

Vol 49 (4) ◽

pp. 129-149 ◽

Cited By ~ 23

Author(s):

S. Chia-Tung PAN

Keyword(s):

Schistosoma Mansoni ◽

Biomphalaria Glabrata ◽

Host Parasite Interactions ◽

Host Parasite

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Transient non-susceptibility toSchistosoma mansoniassociated with atrial amoebocytic accumulations in the snail hostBiomphalaria glabrata

Parasitology ◽

10.1017/s0031182000057929 ◽

1987 ◽

Vol 95 (3) ◽

pp. 499-505 ◽

Cited By ~ 10

Author(s):

C. S. Richards ◽

D. J. Minchella

Keyword(s):

Population Dynamics ◽

Schistosoma Mansoni ◽

Genetic Control ◽

Old Age ◽

Biomphalaria Glabrata ◽

Egg Laying ◽

Snail Population ◽

Host Parasite ◽

Variable Susceptibility

SUMMARYIn someBiomphalaria glabrata–Schistosoma mansonicombinations snails are susceptible to infection as juveniles, but have variable susceptibility as adults. These snails become non-susceptible at the onset of egg-laying and typically revert to susceptibility in old age. Certain stocks ofB. glabratahave the capacity to form amoebocytic accumulations in the atrium, and this ability is under genetic control. The atrial amoebocytic accumulations are transitory, typically appearing at onset of egg-laying and disappearing after a few months. A snail stock which has genetic tendencies for both adult variable susceptibility and atrial amoebocytic accumulations was studied. An association between the time of occurrence of adult non-susceptibility and atrial accumulation is revealed as snails never became infected withS. mansoniwhen amoebocytic accumulations were present. Developing parasites, however, were not necessarily encapsulated and destroyed by amoebocytes. Some sporocysts were able to delay development until the amoebocytic accumulations disappeared. The timing of atrial amoebocytic accumulations and resulting transient non-susceptibility in this host-parasite combination could influence snail population dynamics.

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Geographical variations in infectivity and susceptibility in the host-parasite system Schistosoma mansoni/Biomphalaria glabrata: no evidence for local adaptation

Parasitology ◽

10.1017/s0031182006000412 ◽

2006 ◽

Vol 133 (3) ◽

pp. 313-319 ◽

Cited By ~ 17

Author(s):

F. PRUGNOLLE ◽

T. DE MEEÛS ◽

J.P. POINTIER ◽

P. DURAND ◽

A. ROGNON ◽

...

Keyword(s):

Schistosoma Mansoni ◽

Local Adaptation ◽

Genetic Factors ◽

Biomphalaria Glabrata ◽

Metapopulation Dynamics ◽

Geographical Variations ◽

Transplantation Experiment ◽

Host Parasite ◽

Parasite Populations ◽

Transplantation Experiments

We investigated local adaptation in the spatially structured natural Biomphalaria glabrata/Schistosoma mansoni host-parasite system in the marshy forest focus of Guadeloupe using cross-transplantation experiments. We demonstrated strong and highly significant variations in susceptibility/infectivity of host and parasite populations, respectively, but found no evidence of local adaptation neither for S. mansoni nor for B. glabrata. Environmental as well as genetic factors are discussed to explain susceptibility/infectivity variations between both host and parasite populations. The absence of local adaptation is discussed in relation to the metapopulation dynamics of both host and parasite, in particular their relative rates of dispersal at the scale under scrutiny. Our study constitutes the first cross-transplantation experiment concerning this host-parasite system of which both hosts and parasites came directly from the wild, excluding laboratory generations and experimental host passages.

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Neither heat pulse, nor multigenerational exposure to a modest increase in water temperature, alters the susceptibility of Guadeloupean Biomphalaria glabrata to Schistosoma mansoni infection

PeerJ ◽

10.7717/peerj.9059 ◽

2020 ◽

Vol 8 ◽

pp. e9059

Author(s):

Euan R.O. Allan ◽

Stephanie Bollmann ◽

Ekaterina Peremyslova ◽

Michael Blouin

Keyword(s):

Schistosoma Mansoni ◽

Elevated Temperatures ◽

Global Climate ◽

Biomphalaria Glabrata ◽

Heat Pulse ◽

Infection Prevalence ◽

Vector Borne Diseases ◽

Temperature Regimes ◽

Vector Borne

There are increasing concerns regarding the role global climate change will have on many vector-borne diseases. Both mathematical models and laboratory experiments suggest that schistosomiasis risk may change as a result of the effects of increasing temperatures on the planorbid snails that host schistosomes. Heat pulse/heat shock of the BS90 strain of Biomphalaria glabrata was shown to increase the rate of infection by Schistosoma mansoni, but the result was not replicable in a follow up experiment by a different lab. We characterised the susceptibility and cercarial shedding of Guadeloupean B. glabrata after infection with S. mansoni under two temperature regimes: multigenerational exposure to small increases in temperature, and extreme heat pulse events. Neither long-term, multigenerational rearing at elevated temperatures, nor transient heat pulse modified the susceptibility of Guadeloupean B. glabrata to infection (prevalence) or shedding of schistosome cercaria (intensity of infection). These findings suggest that heat pulse-induced susceptibility in snail hosts may be dependent on the strain of the snail and/or schistosome, or on some as-yet unidentified environmental co-factor.

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Observations on two biological races of Schistosoma mansoni

Memórias do Instituto Oswaldo Cruz ◽

10.1590/s0074-02761981000300006 ◽

1981 ◽

Vol 76 (3) ◽

pp. 287-291 ◽

Cited By ~ 36

Author(s):

W. Lobato Paraense ◽

Lygia R. Corrêa

Keyword(s):

Comparative Study ◽

Schistosoma Mansoni ◽

Biomphalaria Glabrata ◽

Prepatent Period ◽

Snail Species ◽

Infection Rates ◽

Paulo State ◽

Minas Gerais State ◽

Belo Horizonte ◽

Host Parasite

A comparative study of the BH strain of Schistosoma mansoni from Belo Horizonte, Minas Gerais state, infective to Biomphalaria glabrata from the same locality, and the SJ strain from São José dos Campos, São Paulo state, infective to B. tenagophila from the latter locality, showed the following differences: 1. Length of adult worms and size of eggs significantly larger in the BH strain. 2. Higher infection rates in the B. glabrata-BH strain association than in the B. tenagophila-SJ strain association, following exposure of each snail to 1 or 10 miracidia. 3.Longer prepatent period (from penetration of miracidium to first shedding of cercariae) in the B. tenagophila-SJ strain association. 4. Infection of both Biomphalaria species when exposed to hybrid miracidia from crosses between the two strains, at lower levels than those resulting from exposure of each snail species to miracidia of the pure sympatric strain. (Both Biomphalaria populations are practically refractory to infection with the allopatric strain). These results are interpreted as pointing to a better host-parasite adjustment in the B. glabrata-BH strain association than in the B. tenagophila-SJ association. The interfertility between the two strains, which produced viable hybrids infective to both Biomphalaria species, supports the conclusion that the observed differences are merely intraspecific, and that the two strains may be considered distinct biological races of Schistosoma mansoni.

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Multi-parasite host susceptibility and multi-host parasite infectivity: A new approach of the Biomphalaria glabrata/Schistosoma mansoni compatibility polymorphism

Infection Genetics and Evolution ◽

10.1016/j.meegid.2014.04.025 ◽

2014 ◽

Vol 26 ◽

pp. 80-88 ◽

Cited By ~ 38

Author(s):

A. Theron ◽

A. Rognon ◽

B. Gourbal ◽

G. Mitta

Keyword(s):

Schistosoma Mansoni ◽

Biomphalaria Glabrata ◽

Host Susceptibility ◽

New Approach ◽

Host Parasite

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Compatibility and sex in a snail–schistosome system

Parasitology ◽

10.1017/s0031182001007442 ◽

2001 ◽

Vol 122 (4) ◽

pp. 423-432 ◽

Cited By ~ 15

Author(s):

J. P. WEBSTER

Keyword(s):

Schistosoma Mansoni ◽

Reproductive Strategy ◽

Parasitic Infection ◽

Biomphalaria Glabrata ◽

Parasite Strain ◽

Cross Breeding ◽

Infection Dynamics ◽

Rapd Pcr ◽

Host Parasite ◽

Parasite Strains

Knowledge of the genetics underlying resistance to parasitic infection has important repercussions for our understanding of infection dynamics and the mechanisms of host–parasite co-evolution. The aim here was to determine for a Biomphalaria glabrata–Schistosoma mansoni system whether (1) resistance is dominant over susceptibility, (2) it is possible to crossbreed snails to be simultaneously resistant and/or susceptible to more than one parasite strain and (3) compatibility genotype affects reproductive strategy. Using replicate snail strains artificially selected for either resistance or susceptibility to single replicate parasite strains, individual snails from each line were paired with a selected partner of matched or non-matched compatibility status and cross-breeding was identified by RAPD–PCR. The resulting compatibility phenotype of all offspring was determined. Support for all 3 hypotheses were obtained. The results are discussed in terms of their applied and theoretical implications.

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Long-term controlled field experiment on the competition between two species of Biomphalaria (Mollusca, Basommatophora), the snail vectors of Schistosoma mansoni in Northeastern Brazil

Cadernos de Saúde Pública ◽

10.1590/s0102-311x1993000200008 ◽

1993 ◽

Vol 9 (2) ◽

pp. 170-176 ◽

Cited By ~ 3

Author(s):

Constança S. Barbosa ◽

Frederico S. Barbosa ◽

Francisco Arruda

Keyword(s):

Field Experiment ◽

Schistosoma Mansoni ◽

Target Population ◽

Biomphalaria Glabrata ◽

Current Paper ◽

Northeastern Brazil ◽

Competitive Advantages ◽

Native Population ◽

Marked Influence

A long-term controlled field experiment on the interactions of the populations of Biomphalaria glabrata (target population) and B. straminea (competitor) was carried out in the county of Alhandra, state of Paraíba, Brazil, during the period 1980 through 1989. Results obtained in the current paper show that the snail B. straminea has strong competitive advantages over B. glabrata. In six out of nine streams the native population of B. glabrata were totally excluded and replaced by B. straminea. There is evidence showing that seasonal dryness has marked influence on the phenomenon studied in this paper. In all the streams were B. straminea already predominated, return of B. glabrata was never observed.

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