scholarly journals Real-Life Cause-Effect Relations Between Urinary IL-6 Levels and Specific and Nonspecific Symptoms in a Patient With Mild SLE Disease Activity

2021 ◽  
Vol 12 ◽  
Author(s):  
Christian Schubert ◽  
Lennart Seizer ◽  
Emil Chamson ◽  
Paul König ◽  
Norbert Sepp ◽  
...  
Keyword(s):  
Disease Activity ◽  
Real Time ◽  
Joint Pain ◽  
Real Life ◽  
Urinary Protein ◽  
Oral Ulceration ◽  
Significance Level ◽  
The Real ◽  
Protein Levels ◽  
Evaluation Point

BackgroundLittle is known about the real-time cause-effect relations between IL-6 concentrations and SLE symptoms.MethodsA 52-year-old woman with mild SLE activity collected her entire urine for the determination of IL-6/creatinine and protein/creatinine levels (ELISA, HPLC) for a period of 56 days in 12 h intervals (total: 112 measurements). Additionally, she answered questionnaires (VAS) on oral ulceration, facial rash, joint pain, fatigue and tiredness and measured her temperature orally twice a day. Time-series analyses consisted of ARIMA modeling and cross-correlational analyses (one lag = 12 h, significance level = p < 0.05).ResultsStatistical analyses showed that increased urinary IL-6 concentrations preceded increased urinary protein levels by 36–48 h (lag3: r=+.225; p=.017) and that, in the opposite direction of effect, increased urinary protein preceded urinary IL-6 decreases by 12–24 h (lag1: r=–.322; p<.001). Moreover, urinary IL-6 increases co-occurred with increased oral ulceration (lag0: r=+.186; p=.049); after 48–60 h, however, IL-6 increases showed a strong tendency to precede oral ulceration decreases (lag4: r=–.170; p=.072). Increases in facial rash preceded decreases in urinary IL-6 after 84–96 h (lag7: r=–.215; p=.023). As to fatigue, increases in urinary IL-6 co-occurred with decreased fatigue (lag0: r=–.193; p=.042); after 84–96 h, however, IL-6 increases preceded fatigue increases (+lag7: r=+.189; p=.046). Finally, joint pain, tiredness and body temperature did not significantly correlate with urinary IL-6 concentrations in either direction of effect.ConclusionsThe results of this evaluation point to real-life feedback mechanisms between immune activity and SLE symptoms. Comparison with a previous evaluation of this patient suggests a counterregulatory mechanism between Th1 activity and IL-6. These findings are preliminary and require replication to draw firm conclusions about the real-time relation between IL-6 and SLE disease activity.

scholarly journals EXPLORATION OF E-LEARNING VS TRADITIONAL LEARNING IN INDIA

2020 ◽  
Vol 8 (2) ◽  
pp. 69-76 ◽  
Author(s):  
Gulbir Singh ◽  
Vivek Bhatnagar ◽  
Rajeev Gupta ◽  
Gautam Kumar
Keyword(s):  
Comparative Analysis ◽  
Real Time ◽  
Real Life ◽  
Research Data ◽  
University Education ◽  
Traditional Learning ◽  
Analysis Method ◽  
The Real ◽  
Huge Impact ◽  
E Learning

Purpose of Study: The purpose of the study is to carry out the comparison of traditional learning and e-learning with reference to university education. Methodology: A comparative analysis method that has been selected to fulfill the purpose of the study. The research data has been collected by various sources internet, previous research studies published in the Journal, universities which offer different technical and nontechnical programs .and further analyzed by in-depth understanding approach. Result: The outcome of this study will show the effect of e-learning in the current era. As we have compared e-learning with traditional learning and the result shows us that e-learning has filled the gap between the universities and the real-life industries' demands. Main finding: The result of this study showed that e-learning is the need of the present era in order to fulfill the gap between the universities and the real-life industries' demands. Additionally, e-learning based courses will have more impact and provide more skill and exposure to students as compared to traditional learning mode. Implications/Applications: This article can help the different universities and students to introduce more e-learning courses in their curriculum and they can fill the real-time industries' demands. Novelty/originality of the study: Our research can ensure that e-learning has a huge impact on our students and can help to increase the skills and exposure of them according to the current demands.

scholarly journals Real-Life Implementation of a GPS-Based Path-Following System for an Autonomous Vehicle

Sensors ◽  
2018 ◽  
Vol 18 (11) ◽  
pp. 3940 ◽  
Author(s):  
Alexander de Winter ◽  
Simone Baldi
Keyword(s):  
Real Time ◽  
Autonomous Vehicle ◽  
Tracking Error ◽  
Experimental Studies ◽  
Real Life ◽  
Path Following ◽  
Lateral Acceleration ◽  
The Real ◽  
Gps System ◽  
Toyota Prius

This work is meant to report on activities at TU Delft on the design and implementation of a path-following system for an autonomous Toyota Prius. The design encompasses: finding the vehicle parameters for the actual vehicle to be used for control design; lateral and longitudinal controllers for steering and acceleration, respectively. The implementation covers the real-time aspects via LabVIEW from National Instruments and the real-life tests. The deployment of the system was enabled by a Spatial Dual Global Positioning System (GPS) system providing more accuracy than the regular GPS. The results discussed in this work represent the first autonomous tests on the Toyota Prius at TU Delft, and we expect the proposed system to be a benchmark against which to test more advanced solutions. The tests show that the system is able to perform in real-time while satisfying comfort and trajectory tracking requirements: in particular, the tracking error was within 16 cm, which is compatible with the 13 cm precision of the Spatial Dual GPS, whereas the longitudinal and lateral acceleration are within comfort levels as defined by available experimental studies.

ACO-Based Global Optimal Transportation Path

2012 ◽  
Vol 488-489 ◽  
pp. 1680-1683
Author(s):  
Wei Hua Zhu ◽  
Ying Shen
Keyword(s):  
Ant Colony Optimization ◽  
Real Time ◽  
Shortest Path ◽  
Real Life ◽  
Optimal Transportation ◽  
Time Analysis ◽  
The Real ◽  
Real Time Analysis ◽  
Global Optimal ◽  
Simulation Results

This paper discusses how to address some issues when contemplating the global optimal transportation path (GOTP) such as dynamics, the ability of real-time analysis as well as complexity of prediction. Using shortest path methodology, this paper abstracts the real-life problem to a graphic context. Based on the solution of ant colony optimization (ACO) algorithm, the simulation indicates that this manner is efficient and effective in dealing with these problems. The indicators utilized ACO are achieved through simulation results analysis, providing the range of exact elements.

scholarly journals Rendering the Real-Time Caustics with DirectX Raytracing

2021 ◽  
Author(s):  
Egor Komarov ◽  
Dmitry Zhdanov ◽  
Andrey Zhdanov
Keyword(s):  
Real Time ◽  
Virtual World ◽  
Real Life ◽  
Light Sources ◽  
Arbitrary Geometry ◽  
The Real ◽  
Virtual Camera ◽  
Current Article ◽  
Game Industry ◽  
Rendering Pipeline

Caustic illumination frequently appears in the real life, however, this type of illumination is especially hard to be rendered in real-time. Currently, some solutions allow to render the caustic illumination caused by the water surface, but these methods could not be applied to the arbitrary geometry. In the scope of the current article, we present a method of real-time caustics rendering that uses the DirectX Raytracing API and is integrated into the rendering pipeline. The method is based on using additional forward caustic visibility maps and backward caustics visibility maps that are created for light sources and the virtual camera correspondingly. The article presents the algorithm of the developed real-time caustics rendering method and the results of testing its implementation on test scenes. The analysis of the dependence of the rendering speed on the depth of specular ray tracing, the number of light sources, and the number of rays per pixel is carried out. Testing shows promising results which can be used in the modern game industry to increase the realism of the virtual world visualization.

The Real-Time Wind Turbine Fault Diagnosis Method Based on Safety Evaluation Model

2014 ◽  
Vol 953-954 ◽  
pp. 453-457
Author(s):  
Ming Li Yang ◽  
San Ming Liu ◽  
Yong Hai Lv ◽  
Yang Zou ◽  
Guo Dong Ding
Keyword(s):  
Fault Diagnosis ◽  
Wind Turbine ◽  
Real Time ◽  
Wind Turbines ◽  
Evaluation Model ◽  
Safety Evaluation ◽  
Mean Value ◽  
Safety Level ◽  
Significance Level ◽  
The Real

In order to determine the best maintenance time of wind turbines and identify the fault type when it is the best time to do the diagnosis work immediately. The establishment of 4-level safety status model for critical parts of wind turbines, based on wind turbine parts’ significance level, was proposed. According to the corresponding safety level of the wind turbines in real-time working status, you can decide whether the wind turbine needs diagnosis at the time or not. Therefore, we should take measures to monitor the real-time working conditions of the wind turbine’s critical parts, confirming whether the critical part need the fault diagnosis analysis or not according to its real-time working safety status. If it is the right time, then the corresponding fault diagnosis process will be initiated, through which the real online fault diagnosis can be achieved. The multi-scale wavelet decomposition and Hilbert transformation was employed to get the useful parameters such as amplitude, effective value, mean value, kurtosis value and so on of the corresponding waveform to confirm the concrete diagnosis type.

scholarly journals FRI0268 REMISSION IN AXIAL SPONDYLOARTHRITIS: IS THERE A DIFFERENCE BETWEEN NSAIDS AND BIOLOGICS IN THE REAL LIFE?

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 718.2-719
Author(s):  
C. Baert ◽  
C. Mouafo Toukam ◽  
T. Sokolova ◽  
A. Nzeusseu Toukap
Keyword(s):  
Ankylosing Spondylitis ◽  
Disease Activity ◽  
Axial Spondyloarthritis ◽  
Activity Index ◽  
Remission Rate ◽  
Real Life ◽  
University Hospitals ◽  
Research Support ◽  
Cross Sectional ◽  
The Real

Background:Randomized-controlled trials (RCTs) done in axial spondyloarthritis (AxSpA) patients have shown that remission in AxSpA and nonradiographic axial SpA patients treated without biologics (BIOL) occurs infrequently (Ref 1, 2). Few are known about remission rate (RR) in daily clinical practice.Objectives:Our aim was to assess the remission rate (RR) in AxSpA patients in Real life, and to compare the RR in AxSpA patients on NSAIDs to RR for those on Biologics (TNFα blockers or IL-17A blockers).Methods:This cross-sectional study reviewed clinical data from a single center (St-Luc university hospitals, UCLouvain, Brussels) from 01/2013 to 03/2019. Last visit available for clinical assessment was evaluated. Disease activity was measured using the Bath Ankylosing Spondylitis disease activity index (BASDAI), and the Ankylosing Spondylitis disease activity score (ASDAS) using the C-reactive protein. Remission was defined as BASDAI < 4 and ASDAS < 1.3.Results:Data from 551 AxSpA patients were reviewed. 353 were men (64.3%). In the entire cohort, 478 BASDAI and 317 ASDAS were recorded. The RR according to the BASDAI was 46.7% (n = 223), and 17.3% for the ASDAS (n = 55). To look for the treatment-related RR, we stratified by the treatment (NSAIDs vs Biologics). We had 285 patients on NSAIDs (177 men, 62.5%) and 266 on BIOL (176 men, 66%). 245 BASDAI were available for NSAIDs and 233 for BIOL. 110 patients on NSAIDs (44.9%) and 113 on BIOL (48.5%) were in remission for BASDAI. Regarding ASDAS (table below), data from 172 patients on NSAIDs and 144 on BIOL were available. Out of them, 27 (15.7%) and 28 (19.4%) were in remission for NSAIDs and BIOL respectively. Chi-square test: p = 0.853.Table.Distribution of ASDAS values in both groups.ASDAS<1.3ASDAS≥ 1.3 < 2.1ASDAS≥ 2.1 < 3.5ASDAS> 3.5NSAIDs (n = 172)N = 27 (15.7%)N = 41 (23.8%)N = 70 (40.7%)N = 34 (19.8%)BIOL (n = 144)N = 28 (19.4%)N = 30 (20.8%)N = 57 (39.6%)N = 29 (20.1%)Conclusion:The real life RR in AxSpA seems to be higher on BIOL, even if compared to NSAIDs, the difference is not significant. However, many patients on NSAIDs achieve the remission.References:[1]Deodhar A. et al. Arthritis Rheumatol 2019 Jul;71(7):1101-1111. 2) Sieper J. et al. Rheumatology (Oxford) 2016 Nov; 55(11): 1946-1953.Disclosure of Interests:Charlotte Baert: None declared, Charlene MOUAFO TOUKAM: None declared, Tatiana Sokolova: None declared, Adrien Nzeusseu Toukap Grant/research support from: AbbVie, Celgene Corporation, Janssen, Pfizer, UCB – grant/research support, Consultant of: AbbVie, Eli Lilly, Janssen, Novartis, UCB – consultant, Speakers bureau: AbbVie, Eli Lilly, Janssen, Novartis, UCB – advisory board member

Towards an understanding of real-time continuous feedback from simulation games

2014 ◽  
Vol 11 (1) ◽  
pp. 45-62 ◽  
Author(s):  
Mathews Nkhoma ◽  
Jaime Calbeto ◽  
Narumon Sriratanaviriyakul ◽  
Thu Muang ◽  
Quyen Ha Tran ◽  
...  
Keyword(s):  
Real Time ◽  
Learning Outcomes ◽  
Classroom Environment ◽  
Positive Impact ◽  
Real Life ◽  
Simulation Game ◽  
Simulation Games ◽  
Content Type ◽  
The Real ◽  
Continuous Feedback

Purpose – Simulation games have long been used as a teaching tool in the classroom environment mainly due to the high level of participation and engagement that students are able to generate from these, making the learning process more enjoyable and capable to replicate real-life scenarios. Feedback given during the simulation helps to motivate students to find better solutions to the problems being presented in the games and thus enhance their hands-on knowledge on particular subjects. The purpose of this research is to provide empirical evidence of interrelations and impacts that exist between real-time continuous feedback and simulation game performance as well as the interrelations and impacts that exist between real-time continuous feedback and both students' attitude and engagement towards learning. Design/methodology/approach – The research focused on 60 undergraduate students enrolled at the Centre of Commerce at RMIT University Vietnam who had taken at least three semesters at various programmes. For test purposes, the research employed a 3D IBM business process management (BPM) simulation game, INNOV8 developed by the IBM Academic Initiative (more information about the game is available at: www-01.ibm.com/software/solutions/soa/innov8/index.html). A web-based survey followed at the university grounds for the collection of data. Findings – Students showed a favourable attitude towards learning through the simulation game. In addition, the real-time continuous feedback given during the simulation game had a positive impact on the students' cognitive learning outcomes. Research limitations/implications – The sample size used was relatively small with 60 participants, most unfamiliar with the theories of BPM. Originality/value – The originality of this research stems from the real-time and continuous nature of the feedback being given to students during the gameplay of a computer-based simulation game, and how this type of feedback could positively impact the students' learning outcomes.

Integration of Simulation Modeling and Comparison of Scheduling Methods to Minimize the Makespan in a Printing Industry

2012 ◽  
Vol 488-489 ◽  
pp. 1119-1124
Author(s):  
V. Govindarajalu ◽  
V.S. Senthil Kumar
Keyword(s):  
Real Time ◽  
Completion Time ◽  
Flow Shop ◽  
Discrete Event ◽  
Real Life ◽  
Simulation Software ◽  
Printing Industry ◽  
The Real ◽  
Tardy Jobs ◽  
Maximum Occupancy

This paper considers the problem of scheduling production activities in a real-life printing industry. The problem is modeled as a two-stage flexible flow shop problem with minimization of the makespan and the number of tardy jobs as the objective. Discrete event simulation has been performed using Extend simulation software to depict the real time model of the print industry. The setup time, processing time and completion time of the prioritized customers were obtained and validated with the real time industry inputs. After validation, the output of simulation data has been used to perform preliminary scheduling experiments. This paper deals with the comparison of three scheduling algorithms such as earliest completion time first (ECT), Earliest start time first (EST) and PCmax algorithm for the calculation of maximum occupancy time of various printing jobs. The results obtained using PC max shows the reduced make span of the printing jobs compared to other two algorithms with approximately 12% improvement in minimizing the makespan. Hence the P||Cmax scheduling method can be implemented in the industry to minimize the maximum occupancy time of a particular printing machine. This motivates the actual implementation of the proposed ILP (PCmax scheduling) procedure for the printing industry.

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