scholarly journals Scientific Advances in Diabetes: The Impact of the Innovative Medicines Initiative

2021 ◽  
Vol 8 ◽  
Author(s):  
Maria de Fátima Brito ◽  
Carla Torre ◽  
Beatriz Silva-Lima
Keyword(s):  
Large Scale ◽  
Individual Variability ◽  
Scientific Data ◽  
World Health ◽  
Scale Production ◽  
Patient Centered ◽  
Clinical Endpoints ◽  
Large Scale Production ◽  
New Biomarkers ◽  
The Impact

Diabetes Mellitus is one of the World Health Organization's priority diseases under research by the first and second programmes of Innovative Medicines Initiative, with the acronyms IMI1 and IMI2, respectively. Up to October of 2019, 13 projects were funded by IMI for Diabetes & Metabolic disorders, namely SUMMIT, IMIDIA, DIRECT, StemBANCC, EMIF, EBiSC, INNODIA, RHAPSODY, BEAT-DKD, LITMUS, Hypo-RESOLVE, IM2PACT, and CARDIATEAM. In general, a total of €447 249 438 was spent by IMI in the area of Diabetes. In order to prompt a better integration of achievements between the different projects, we perform a literature review and used three data sources, namely the official project's websites, the contact with the project's coordinators and co-coordinator, and the CORDIS database. From the 662 citations identified, 185 were included. The data collected were integrated into the objectives proposed for the four IMI2 program research axes: (1) target and biomarker identification, (2) innovative clinical trials paradigms, (3) innovative medicines, and (4) patient-tailored adherence programmes. The IMI funded projects identified new biomarkers, medical and research tools, determinants of inter-individual variability, relevant pathways, clinical trial designs, clinical endpoints, therapeutic targets and concepts, pharmacologic agents, large-scale production strategies, and patient-centered predictive models for diabetes and its complications. Taking into account the scientific data produced, we provided a joint vision with strategies for integrating personalized medicine into healthcare practice. The major limitations of this article were the large gap of data in the libraries on the official project websites and even the Cordis database was not complete and up to date.

scholarly journals Balancing Boutique-Level Quality and Large-Scale Production: The Impact of “More Product, Less Process” on Digitization in Archives and Special Collections

2012 ◽  
Vol 13 (1) ◽  
pp. 50-63 ◽  
Author(s):  
Shan C. Sutton
Keyword(s):  
Large Scale ◽  
Scale Production ◽  
Special Collections ◽  
Professional Journals ◽  
Large Scale Production ◽  
The Subject ◽  
The Impact ◽  
Archival Processing

Introduction Few writings within the realms of archives and special collections have reverberated throughout the field to the degree of Mark A. Greene and Dennis Meissner’s 2005 article “More Product, Less Process: Revamping Traditional Archival Processing.”1 Its clarion call to shift archival arrangement and description away from time-consuming, detailed processes toward rapid, minimalist strategies was met with both cheers and groans that continue unabated. In a sign of its ubiquity, the approach advocated by Greene and Meissner is now simply referred to as “MPLP,” and its implementation is the subject of ongoing discussion in numerous venues, including professional journals, conference . . .

scholarly journals Are Phage Lytic Proteins the Secret Weapon To Kill Staphylococcus aureus?

mBio ◽  
2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Diana Gutiérrez ◽  
Lucía Fernández ◽  
Ana Rodríguez ◽  
Pilar García
Keyword(s):  
Staphylococcus Aureus ◽  
Large Scale ◽  
Bacterial Resistance ◽  
Antibiotic Use ◽  
Legal Framework ◽  
Scientific Data ◽  
Scale Production ◽  
Health Authorities ◽  
Prophylactic Measures ◽  
The Impact

ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most threatening microorganisms for global human health. The current strategies to reduce the impact of S. aureus include a restrictive control of worldwide antibiotic use, prophylactic measures to hinder contamination, and the search for novel antimicrobials to treat human and animal infections caused by this bacterium. The last strategy is currently the focus of considerable research. In this regard, phage lytic proteins (endolysins and virion-associated peptidoglycan hydrolases [VAPGHs]) have been proposed as suitable candidates. Indeed, these proteins display narrow-spectrum antimicrobial activity and a virtual lack of bacterial-resistance development. Additionally, the therapeutic use of phage lytic proteins in S. aureus animal infection models is yielding promising results, showing good efficacy without apparent side effects. Nonetheless, human clinical trials are still in progress, and data are not available yet. This minireview also analyzes the main obstacles for introducing phage lytic proteins as human therapeutics against S. aureus infections. Besides the common technological problems derived from large-scale production of therapeutic proteins, a major setback is the lack of a proper legal framework regulating their use. In that sense, the relevant health authorities should urgently have a timely discussion about these new antimicrobials. On the other hand, the research community should provide data to dispel any doubts regarding their efficacy and safety. Overall, the appropriate scientific data and regulatory framework will encourage pharmaceutical companies to invest in these promising antimicrobials.

The impact of precursor water content on solution-processed organometal halide perovskite films and solar cells

2015 ◽  
Vol 3 (37) ◽  
pp. 19123-19128 ◽  
Author(s):  
Bert Conings ◽  
Aslihan Babayigit ◽  
Tim Vangerven ◽  
Jan D'Haen ◽  
Jean Manca ◽  
...  
Keyword(s):  
Solar Cells ◽  
Water Content ◽  
Large Scale ◽  
Photovoltaic Performance ◽  
Scale Production ◽  
Large Scale Production ◽  
Organometal Halide Perovskite ◽  
Halide Perovskites ◽  
Halide Perovskite ◽  
The Impact

In this paper, the impact of the water content (up to 10 vol%) in DMF-based precursors on organometal halide perovskites is investigated. The photovoltaic performance is found not to be affected, thus relaxing the conditions for large-scale production of this upcoming photovoltaic technology.

scholarly journals New recommended policies for pathogen surveillance testing of researchers and improved stewardship of diagnostic DNA

2020 ◽  
Author(s):  
Lindsey Robinson-McCarthy ◽  
Alexander J. Mijalis ◽  
Gabriel T Filsinger ◽  
Helena de Puig ◽  
Nina M. Donghia ◽  
...  
Keyword(s):  
Public Health ◽  
Nucleic Acids ◽  
Large Scale ◽  
Health Resources ◽  
Scale Production ◽  
Large Scale Production ◽  
Health Strategy ◽  
Highly Sensitive ◽  
The Public Sphere ◽  
The Impact

The SARS-CoV-2 pandemic has brought about the unprecedented expansion of highly sensitive molecular diagnostics as a primary infection control strategy. At the same time, many laboratories have shifted focus to SARS-CoV-2 research and diagnostic development, leading to large-scale production of nucleic acids that can interfere with these tests. We have identified multiple instances, in independent laboratories, in which nucleic acids generated in research settings are suspected to have caused researchers to test positive for SARS-CoV-2 in surveillance testing. In some cases, the affected individuals did not work directly with these nucleic acids, but were exposed via a contaminated surface or object. Though researchers have long been vigilant of DNA contaminants, the transfer of these contaminants in SARS-CoV-2 testing samples results in anomalous test results. The impact of these stretches into the public sphere, placing additional burdens on public health resources, placing affected researchers and their contacts in quarantine, and carrying the potential to trigger shutdowns of classrooms and workplaces. We report our observations as a call for increased stewardship over nucleic acids with the potential to impact both use and development of diagnostics. These experiences highlight a neglected aspect of the test, trace, isolate public health strategy for managing COVID-19: we cannot easily identify and diagnose an erroneous test result. To prevent undue personal and economic strain and maintain faith in the testing process, we propose: a test, isolate, verify, and trace approach to COVID-19 diagnosis in research and clinical diagnostic workplaces.

scholarly journals Economic Performance of BRICS Economies: An Analysis of Pre and Post BRICS Era

2018 ◽  
Vol 5 (2) ◽  
Author(s):  
P. Dhanasekaran ◽  
M. Sumathy
Keyword(s):  
Economic Performance ◽  
Large Scale ◽  
T Test ◽  
Scale Production ◽  
Macroeconomic Factors ◽  
Paired Sample ◽  
Large Scale Production ◽  
The Impact

This paper intends to analyse the impact of some selected macroeconomic factors on the economies of BRICS nations during the pre and post BRICS era. The analysis done based on the paired sample t-test found a significant impact on the imports, exports, GDP, REER and GCF of BRICS economies during the pre and post BRICS era. The impact is very significant in India as well. The study concluded that though these economies have many challenges to sustain and maintain the trend. FDI will facilitate these economies to enhance large scale production, employment and sustainability.

scholarly journals Anaerobic Solid-State Fermentation of Soybean Meal With Bacillus sp. to Improve Nutritional Quality

2021 ◽  
Vol 8 ◽  
Author(s):  
Yanhui Yao ◽  
Hongya Li ◽  
Jia Li ◽  
Baocheng Zhu ◽  
Tongguo Gao
Keyword(s):  
Solid State ◽  
Solid State Fermentation ◽  
Soybean Meal ◽  
Nutritional Quality ◽  
Large Scale ◽  
High Yield ◽  
Scale Production ◽  
Large Scale Production ◽  
The Impact

The study evaluated the impact of fermentation with Bacillus sp. on the nutritional quality of soybean meal (SBM) and the changes of bacterial community structure during fermentation. High protease-producing strains were screened to degrade SBM macromolecular protein and anti-nutritional factors (ANFs). Unsterilized SBM then underwent an anaerobic solid-state fermentation method to evaluate the effects of fermentation. Results showed that for the nine high-producing protease strains that were screened, acid-soluble protein (ASP) contents in fermented SBM increased, with the highest value found to be 13.48%, which was fermented using strain N-11. N-11 was identified as Bacillus subtilis. N-11 fermentation reduced ANFs such as glycinin and β-conglycinin by 82.38 and 88.32%, respectively. During N-11 fermentation, the bacterial richness and diversity in SBM increased but not significantly. The high-yield protease strain B. subtilis N-11 selected in this experiment improved the nutritional quality of SBM through fermentation, and it can be used for industrial large-scale production.

scholarly journals Effect of Mixing on Microorganism Growth in Loop Bioreactors

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
A. M. Al Taweel ◽  
Q. Shah ◽  
B. Aufderheide
Keyword(s):  
Large Scale ◽  
Critical Role ◽  
Single Cell Protein ◽  
Cell Protein ◽  
Scale Production ◽  
Reactor Model ◽  
Forced Circulation ◽  
Capital Costs ◽  
Large Scale Production ◽  
The Impact

The impact of mixing on the promotion of microorganism growth rate has been analyzed using a multiphase forced-circulation pipe-loop reactor model capable of identifying conditions under which it is possible to convert natural gas into Single-Cell Protein. The impact of mixing in the interphase mass transfer was found to exert a critical role in determining the overall productivity of the bioreactor, particularly at the high cell loadings needed to reduce the capital costs associated with the large-scale production needed for the production of relatively low-value SCP in a sustainable manner.

scholarly journals The Perspective of Large-Scale Production of Algae Biodiesel

2020 ◽  
Vol 10 (22) ◽  
pp. 8181
Author(s):  
Mladen Bošnjaković ◽  
Nazaruddin Sinaga
Keyword(s):  
Large Scale ◽  
Diesel Oil ◽  
Biodiesel Production ◽  
Scale Production ◽  
Algae Biomass ◽  
Electric Cars ◽  
Algae Biodiesel ◽  
Large Scale Production ◽  
Algal Biodiesel ◽  
The Impact

We have had high expectations for using algae biodiesel for many years, but the quantities of biodiesel currently produced from algae are tiny compared to the quantities of conventional diesel oil. Furthermore, no comprehensive analysis of the impact of all factors on the market production of algal biodiesel has been made so far. This paper aims to analyze the strengths, weaknesses, opportunities, and threats associated with algal biodiesel, to evaluate its production prospects for the biofuels market. The results of the analysis show that it is possible to increase the efficiency of algae biomass production further. However, because the production of this biodiesel is an energy-intensive process, the price of biodiesel is high. Opportunities for more economical production of algal biodiesel are seen in integration with other processes, such as wastewater treatment, but this does not ensure large-scale production. The impact of state policies and laws is significant in the future of algal biodiesel production. With increasingly stringent environmental requirements, electric cars are a significant threat to biodiesel production. By considering all the influencing factors, it is not expected that algal biodiesel will gain an essential place in the fuel market.

scholarly journals Monitoring the Quality of Laser Cutting

2018 ◽  
Vol 1 (1) ◽  
pp. 137-143
Author(s):  
Rastislav Bernát ◽  
Zoltán Záležák ◽  
Jozef Žarnovský ◽  
Norbert Kecskés ◽  
Milan Peniaško ◽  
...  
Keyword(s):  
Large Scale ◽  
Cutting Speed ◽  
Base Material ◽  
Dimensional Accuracy ◽  
Cutting Edge ◽  
Engineering Industry ◽  
Scale Production ◽  
Large Scale Production ◽  
The Impact

Abstract In engineering industry the production of components begins with separation of the base material and this technological operation can be time consuming, especially in large-scale production. Such production can be made more efficient by means of laser technology focusing on material cutting. Efficiency of cutting is determined not only by shortening of working time or energy saving, but also by the required cutting quality. In the paper we compare the impact of cutting speed changing and laser beam performance on the cutting edge quality. Based on requirements of dimensional accuracy and preset roughness of the cutting edge, we evaluated the cutting quality of laser in samples of different materials. Measured values of sample dimensions and roughness are compared in conclusions of the paper, where we estimate whether the samples meet specified requirements of dimensional accuracy and roughness of the cutting edge in order to make the production process more efficient.

Sign in / Sign up

Export Citation Format

Share Document