scholarly journals Epidemiological Characteristics of Sporadic Nosocomial COVID-19 Infections From June 2020 to June 2021 in China: An Overview of Vaccine Breakthrough Infection Events

2021 ◽  
Vol 8 ◽  
Author(s):  
Zhigang He ◽  
Hongbing Xiang ◽  
Anne Manyande ◽  
Weiguo Xu ◽  
Li Fan ◽  
...  
Keyword(s):  
Healthcare Professional ◽  
Severe Acute Respiratory Syndrome ◽  
Breakthrough Infection ◽  
Management Measures ◽  
The World ◽  
Isolation Ward ◽  
Epidemiological Characteristics

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has wreaked havoc on millions of people around the world. Although China quickly brought the Coronavirus disease (COVID-19) under control, there have been several sporadic outbreaks in different regions of China since June 2020. This article described the chronological nosocomial COVID-19 infection events related to several sporadic outbreaks of SARS-CoV-2 in different regions of China. We have reported epidemiological characteristics and management measures of sporadic nosocomial COVID-19 infections from June 2020 to June 2021 and specially focused on the domestic COVID-19 breakthrough infection in China, such as domestic COVID-19 breakthrough infection—a vaccinated healthcare professional working in the isolation ward of a designated COVID-19 hospital.

scholarly journals SARS-CoV-2: Structure, Biology, and Structure-Based Therapeutics Development

2020 ◽  
Vol 10 ◽  
Author(s):  
Mei-Yue Wang ◽  
Rong Zhao ◽  
Li-Juan Gao ◽  
Xue-Fei Gao ◽  
De-Ping Wang ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Protein Structures ◽  
The Novel ◽  
Recognition Mechanism ◽  
Antiviral Compounds ◽  
The World ◽  
Receptor Recognition ◽  
Epidemiological Characteristics ◽  
Therapeutics Development

The pandemic of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been posing great threats to the world in many aspects. Effective therapeutic and preventive approaches including drugs and vaccines are still unavailable although they are in development. Comprehensive understandings on the life logic of SARS-CoV-2 and the interaction of the virus with hosts are fundamentally important in the fight against SARS-CoV-2. In this review, we briefly summarized the current advances in SARS-CoV-2 research, including the epidemic situation and epidemiological characteristics of the caused disease COVID-19. We further discussed the biology of SARS-CoV-2, including the origin, evolution, and receptor recognition mechanism of SARS-CoV-2. And particularly, we introduced the protein structures of SARS-CoV-2 and structure-based therapeutics development including antibodies, antiviral compounds, and vaccines, and indicated the limitations and perspectives of SARS-CoV-2 research. We wish the information provided by this review may be helpful to the global battle against SARS-CoV-2 infection.

The Study of the Epidemiology and Clinical Features of the Novel Coronavirus (COVID-19)

2021 ◽  
pp. 25-39
Author(s):  
Ranjit Barua ◽  
Sudipto Datta ◽  
Amit Roychowdhury ◽  
Pallab Datta
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Health Outcomes ◽  
Clinical Features ◽  
Spike Protein ◽  
The Novel ◽  
The World ◽  
Novel Coronavirus ◽  
The Individual ◽  
Epidemiological Characteristics ◽  
Treatment Prognosis

Epidemiology is the technique used to detect the origins of health outcomes and diseases in inhabitants. In epidemiology, the patient, the individual, and community are viewed mutually. Epidemiology is not only the analysis of health in inhabitants; it also includes applying the information enlarged by the analysis of public-based practice. In case of medicine, the practice of epidemiology is both an art and science. Currently, COVID-19 has spread all around the world. It is basically a severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Through the binding of receptor in gene region of its spike protein, ACE2 is bounded by corona virus. In this chapter, the authors summarized the epidemiological characteristics, clinical features, diagnosis, and treatment prognosis of COVID-19. A complete consideration will help to control the disease.

scholarly journals Clinical and Epidemiological Characteristics of Coronavirus Disease 2019 in the Early Stage of Outbreak

2020 ◽  
Vol 95 (2) ◽  
pp. 67-73 ◽  
Author(s):  
Jung Yeon Heo
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Large Scale ◽  
Early Stage ◽  
Central China ◽  
First Report ◽  
The World ◽  
Novel Coronavirus ◽  
Epidemiological Characteristics

In December 2019, a novel coronavirus, which is now designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first identified as the etiology of pneumonia of unknown cause in patients from Wuhan of central China. Since the first report of coronavirus disease 2019 (COVID-19), the disease became pandemic causing the large-scale outbreak all over the world. In this review, we discuss the clinical and epidemiological characteristics of COVID-19 in the early stage of outbreak based on recent reports from China.

MANAGING INFORMATION TECHNOLOGY APPLICATION IN TEACHING AT HIGH SCHOOLS IN VINH YEN CITY, VINH PHUC PROVINCE MEETS INDUSTRIAL REVOLUTION 4.0

2018 ◽  
Author(s):  
Vu Kha Thap
Keyword(s):  
Information Technology ◽  
Social Life ◽  
Industrial Revolution ◽  
Strong Impact ◽  
Surface Strength ◽  
Technology Application ◽  
Management Measures ◽  
The World ◽  
The Status ◽  
Information Technology Application

Entering the XXI century and especially in the period of the industrial revolution has entered the era of IT with the knowledge economy in the trend of globalization. The 4.0 mankind development of ICT, especially the Internet has had a strong impact and make changes to all activities profound social life of every country in the world. Through surveys in six high School, interviewed 85 managers and teachers on the status of the management of information technology application in teaching, author of the article used the SWOT method to distribute surface strength, weaknesses, opportunities and challenges from which to export 7 management measures consistent with reality. 7 measures have been conducting trials and the results showed that 07 measures of necessary and feasible.

The relevance of dietetic approach of Ayurveda from the perspective of COVID-19 pandemic

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 748-752
Author(s):  
Swapnali Khabade ◽  
Bharat Rathi ◽  
Renu Rathi
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Healthy Person ◽  
World Health ◽  
Physical And Mental Health ◽  
Leading Role ◽  
Global Pandemic ◽  
The People ◽  
The World ◽  
Health Organization ◽  
The Individual

A novel, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causes severe acute respiratory syndrome and spread globally from Wuhan, China. In March 2020 the World Health Organization declared the SARS-Cov-2 virus as a COVID- 19, a global pandemic. This pandemic happened to be followed by some restrictions, and specially lockdown playing the leading role for the people to get disassociated with their personal and social schedules. And now the food is the most necessary thing to take care of. It seems the new challenge for the individual is self-isolation to maintain themselves on the health basis and fight against the pandemic situation by boosting their immunity. Food organised by proper diet may maintain the physical and mental health of the individual. Ayurveda aims to promote and preserve the health, strength and the longevity of the healthy person and to cure the disease by properly channelling with and without Ahara. In Ayurveda, diet (Ahara) is considered as one of the critical pillars of life, and Langhana plays an important role too. This article will review the relevance of dietetic approach described in Ayurveda with and without food (Asthavidhi visheshaytana & Lanhgan) during COVID-19 like a pandemic.

An approach to the understanding of the clinical-etiopathological aspect of COVID-19 (SARS-CoV-2)

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 862-869
Author(s):  
Meena Kumari ◽  
Monika Agrawal ◽  
Rakesh Kumar Singh ◽  
Parameswarappa S Byadgi
Keyword(s):  
World Health ◽  
Apical Surface ◽  
Therapy Assessment ◽  
Differentiated Cells ◽  
The World ◽  
Polarized Epithelia ◽  
Well Differentiated ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Epidemiological Characteristics

Currently, the world is facing a health and socioeconomic crisis caused by the novel coronavirus disease COVID-19. On 11 March 2020, the World Health Organization (WHO) has declared this disease as a pandemic. The condition (COVID-19) is an infectious disorder triggered by a newly discovered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2. Most of the COVID-19 infected patients will experience mild to moderate respiratory symptoms and recover without any unique therapy. Assessment of the clinical and epidemiological characteristics of SARS-CoV-2 cases suggests the infected patients will not be contagious until the onset of severe symptoms and affects the other organs. Well-differentiated cells of apical airway epithelia communicating with ACE2 were promptly infected to SARS-CoV-2 virus. But the expression of ACE 2 in poorly differentiated epithelia facilitated SARS spike (S) protein-pseudo typed virus entry and it is replicated in polarized epithelia and especially exited via the apical surface. Limiting the transmission of COVID-19 infection & its prevention can be regarded as a hierarchy of controls. In this article, we briefly discuss the most recent advances in respect to aetiology, pathogenesis and clinical progression of the disease COVID-19.

Plasma therapy a possible hope to fight against COVID-19

2020 ◽  
Author(s):  
Ravikant Piyush ◽  
Aroni Chatterjee ◽  
Shashikant Ray
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Viral Disease ◽  
Plasma Therapy ◽  
Therapeutic Drugs ◽  
Wild Fire ◽  
The World ◽  
Short Span ◽  
Game Changer

The world is currently going through a disastrous event and a catastrophic upheaval caused by the coronavirus disease 2019 (COVID-19). The pandemic has resulted in loss of more than 150000 deaths across the globe. Originating from China and spreading across all continents within a short span of time, it has become a matter of international emergency. Different agencies are adopting diverse approaches to stop and spread of this viral disease but still now nothing confirmatory has come up. Due to lack of vaccines and proper therapeutic drugs, the disease is still spreading like wild fire without control. An Old but very promising method- the convalescent plasma therapy could be the key therapy to stop this pandemic. This method has already proven its mettle on several occasions previously and has been found to be effective in curing the pandemics induced by Ebola, severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) belongs to the same group of β-Coronavirus that has resulted in the above diseases. Therefore, the role of plasma therapy is being explored for treatment of this disease. In this review, we have mainly focused on the role of convalescent plasma therapy and why its use should be promoted in fight against COVID-19, as it could turn out to be a game changer.

scholarly journals Deepening of In Silico Evaluation of SARS-CoV-2 Detection RT-qPCR Assays in the Context of New Variants

Genes ◽  
2021 ◽  
Vol 12 (4) ◽  
pp. 565
Author(s):  
Mathieu Gand ◽  
Kevin Vanneste ◽  
Isabelle Thomas ◽  
Steven Van Gucht ◽  
Arnaud Capron ◽  
...  
Keyword(s):  
Performance Evaluation ◽  
Severe Acute Respiratory Syndrome ◽  
In Silico ◽  
The Other ◽  
Viral Rna ◽  
Potential Threat ◽  
The World

For 1 year now, the world is undergoing a coronavirus disease-2019 (COVID-19) pandemic due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The most widely used method for COVID-19 diagnosis is the detection of viral RNA by RT-qPCR with a specific set of primers and probe. It is important to frequently evaluate the performance of these tests and this can be done first by an in silico approach. Previously, we reported some mismatches between the oligonucleotides of publicly available RT-qPCR assays and SARS-CoV-2 genomes collected from GISAID and NCBI, potentially impacting proper detection of the virus. In the present study, 11 primers and probe sets investigated during the first study were evaluated again with 84,305 new SARS-CoV-2 unique genomes collected between June 2020 and January 2021. The lower inclusivity of the China CDC assay targeting the gene N has continued to decrease with new mismatches detected, whereas the other evaluated assays kept their inclusivity above 99%. Additionally, some mutations specific to new SARS-CoV-2 variants of concern were found to be located in oligonucleotide annealing sites. This might impact the strategy to be considered for future SARS-CoV-2 testing. Given the potential threat of the new variants, it is crucial to assess if they can still be correctly targeted by the primers and probes of the RT-qPCR assays. Our study highlights that considering the evolution of the virus and the emergence of new variants, an in silico (re-)evaluation should be performed on a regular basis. Ideally, this should be done for all the RT-qPCR assays employed for SARS-CoV-2 detection, including also commercial tests, although the primer and probe sequences used in these kits are rarely disclosed, which impedes independent performance evaluation.

scholarly journals Optimizing COVID-19 testing capabilities and clinical management using pathology informatics

JAMIA Open ◽  
2020 ◽  
Author(s):  
Srikar Chamala ◽  
Sherri Flax ◽  
Petr Starostik ◽  
Kartikeya Cherabuddi ◽  
Nicole M Iovine ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Clinical Management ◽  
World Health ◽  
University Of Florida ◽  
Pathology Informatics ◽  
Large Numbers ◽  
The World ◽  
Health Organization ◽  
The University ◽  
Reporting Data

Abstract Coronavirus disease 2019, first reported in China in late 2019, has quickly spread across the world. The outbreak was declared a pandemic by the World Health Organization on March 11, 2020. Here, we describe our initial efforts at the University of Florida Health for processing of large numbers of tests, streamlining data collection, and reporting data for optimizing testing capabilities and superior clinical management. Specifically, we discuss clinical and pathology informatics workflows and informatics instruments which we designed to meet the unique challenges of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing. We hope these results benefit institutions preparing to implement SARS-CoV-2 testing.

scholarly journals Do Animals Play a Role in the Transmission of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)? A Commentary

Animals ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 16
Author(s):  
Anna Costagliola ◽  
Giovanna Liguori ◽  
Danila d’Angelo ◽  
Caterina Costa ◽  
Francesca Ciani ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Neutralizing Antibodies ◽  
Experimental Studies ◽  
Infectious Agent ◽  
Human Infection ◽  
Farm Animals ◽  
Partial Protection ◽  
Management Measures ◽  
First Case ◽  
And Behavior

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) belongs to the Beta-coronavirus genus. It is 96.2% homologous to bat CoV RaTG13 and 88% homologous to two bat SARS-like coronaviruses. SARS-CoV-2 is the infectious agent responsible for the coronavirus disease (COVID-19), which was first reported in the Hubei province of Wuhan, China, at the beginning of December 2019. Human transmission from COVID-19 patients or incubation carriers occurs via coughing, sneezing, speaking, discharge from the nose, or fecal contamination. Various strains of the virus have been reported around the world, with different virulence and behavior. In addition, SARS-CoV-2 shares certain epitopes with some taxonomically related viruses, with tropism for the most common synanthropic animals. By elucidating the immunological properties of the circulating SARS-CoV-2, a partial protection due to human–animal interactions could be supposed in some situations. In addition, differential epitopes could be used for the differential diagnosis of SARS-CoV-2 infection. There have been cases of transmission from people with COVID-19 to pets such as cats and dogs. In addition, wild felines were infected. All These animals were either asymptomatic or mildly symptomatic and recovered spontaneously. Experimental studies showed cats and ferrets to be more susceptible to COVID-19. COVID-19 positive dogs and felines do not transmit the infection to humans. In contrast, minks at farms were severely infected from people with COVID-19. A SARS-Cov-2 variant in the Danish farmed mink that had been previously infected by COVID-19 positive workers, spread to mink workers causing the first case of animal-to-human infection transmission that causes a moderate decreased sensitivity to neutralizing antibodies. Thus, more investigations are necessary. It remains important to understand the risk that people with COVID-19 pose to their pets, as well as wild or farm animals so effective recommendations and risk management measures against COVID-19 can be made. A One Health unit that facilitates collaboration between public health and veterinary services is recommended.

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