scholarly journals Effects of Clostridium butyricum, Sodium Butyrate, and Butyric Acid Glycerides on the Reproductive Performance, Egg Quality, Intestinal Health, and Offspring Performance of Yellow-Feathered Breeder Hens

2021 ◽  
Vol 12 ◽  
Author(s):  
Yibing Wang ◽  
Yang Wang ◽  
Xiajing Lin ◽  
Zhongyong Gou ◽  
Qiuli Fan ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Growth Performance ◽  
Butyric Acid ◽  
Sodium Butyrate ◽  
Reproductive Performance ◽  
Egg Quality ◽  
Intestinal Morphology ◽  
Intestinal Health ◽  
Offspring Performance ◽  
Breeder Hens

Butyrate has been reported to promote the performance and growth of chickens. The specific roles and efficacy of different sources of butyrate remained unclear. Thus, the present study aimed to investigate and compare the effects of Clostridium butyricum (CB), sodium butyrate (SB), and butyric acid glycerides (tributyrin, BAG) on the reproductive performance, egg quality, intestinal health, and offspring performance of yellow-feathered breeder hens. A total of 300 Lingnan yellow-feathered breeder hens were assigned to five treatment groups: control (CL), 1×108CFU/kg CB (CBL), 1×109CFU/kg CB (CBH), 500mg/kg SB, and 300mg/kg BAG. Results showed that the laying performance and egg quality were increased by CBL, CBH, and BAG. Both CB treatments increased the hatchability of fertilized eggs. Maternal supplementation with both levels of CB significantly elevated the growth performance of offspring. Treatment with CBL, CBH, SB, and BAG all improved the oviduct-related variables and reduced the plasmal antioxidant variables. The CBH, CBL, and BAG treatments also improved the intestinal morphology to different degrees. Jejunal contents of IL-6 were decreased by CBH and BAG, while those of IL-4, IL-6, IL-1β, and IgY were decreased by SB. Transcripts of nutrient transporters in jejunal mucosa were also upregulated by CBH, CBL, and SB treatments and expression of Bcl-2-associated X protein was decreased by CBL, CBH, and BAG. In cecal contents, CBL increased the abundance of Firmicutes and Bacillus, while CBH decreased the abundance of Proteobacteria. Also, the co-occurrence networks of intestinal microbes were regulated by CBH and BAG. In conclusion, dietary inclusion of CB and BAG improved the reproductive parameters, egg quality, and intestinal morphology of breeders. CB also influenced the hatching performance of breeders and growth performance of the offspring, while SB improved the oviduct-related variables. These beneficial effects may result from the regulation of cytokines, nutrient transporters, apoptosis, and gut microbiota; high-level CB had more obvious impact. Further study is needed to explore and understand the correlation between the altered gut microbiota induced by butyrate and the performance, egg quality, intestinal health, and also offspring performance.

scholarly journals Protective Effect of Lactobacillus Plantarum P8 on the Growth Performance, Intestinal Health and Microbiota in Eimeria-infected Broilers

2021 ◽  
Author(s):  
Yang Wang ◽  
Xiaoguo Lv ◽  
Xuemin Li ◽  
Jinshan Zhao ◽  
Kai Zhang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gut Microbiota ◽  
Growth Performance ◽  
Lactobacillus Plantarum ◽  
Control Diet ◽  
Intestinal Barrier ◽  
Intestinal Morphology ◽  
Intestinal Health ◽  
Commercial Broiler ◽  
High Level

Abstract Background: Coccidiosis is one of the major parasitic diseases in the commercial broiler industry. Probiotics can protect poultry against Eimeria infection. However, the mechanisms are not fully known. Therefore, Lactobacillus plantarum P8 (P8) was used to investigate its anti-coccidial property and mechanism.Methods: Five hundred broilers were allocated to five treatments: control diet (NC), control diet + Eimeria infection (IC), control diet containing 1 × 107 cfu/g P8 + Eimeria infection (P8L), control diet containing 1 × 108 cfu/g P8 + Eimeria infection (P8H), and control diet + Eimeria infection + Diclazuril (DIC). At day 14, all treatments except NC were inoculated with sporulated oocysts. Results: Eimeria infection increased the mortality and oocysts shedding, and declined the growth performance as well as the intestinal barrier in Eimeria-treated broilers. On the contrary, dietary supplementation of low level P8, high level P8 and DIC decreased the mortality and oocysts shedding, but improved the growth performance and intestinal barrier. The impaired intestinal morphology in the IC group was also improved by P8H and DIC treatments. Besides, the elevated oxidative stress and pro-inflammation in Eimeria-infected broilers were reduced by P8L, P8H and DIC treatments. Metagenomic analysis indicated P8 altered the structure of the gut microbiota, and the alteration was more obvious at day 21 than day 42. Notably, IC also increased the abundances of Eimeriidae, Eimeria and Eimeria tenella at day 21, while P8L and DIC decreased the abundances. Correlation analysis revealed that bacteria in Eimeria-treated broilers positively correlated with the intestinal permeability, oxidative stress and inflammation, while bacteria in broilers receiving P8L and DIC negatively correlated with the aforementioned pathological indices. Functional prediction demonstrated that the metagenomes of Eimeria-infected broilers were involved in several diseases. But the metagenomes of P8L-treated broilers were involved in energy metabolism and replication repair. Conclusions: Dietary P8 supplementation inhibited oocyst shedding and improved the growth performance as well as the intestinal health of broilers infected with Eimeria, which was closely related to the regulation of gut microbiota. Moreover, the effects of P8 may be more effective in the early infection of coccidia.

scholarly journals Protective Effect of Lactobacillus plantarum P8 on Growth Performance, Intestinal Health, and Microbiota in Eimeria-Infected Broilers

2021 ◽  
Vol 12 ◽  
Author(s):  
Yang Wang ◽  
Xiaoguo Lv ◽  
Xuemin Li ◽  
Jinshan Zhao ◽  
Kai Zhang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gut Microbiota ◽  
Growth Performance ◽  
Lactobacillus Plantarum ◽  
Control Diet ◽  
Intestinal Barrier ◽  
Intestinal Morphology ◽  
Intestinal Health ◽  
Commercial Broiler ◽  
High Level

Coccidiosis is one of the major parasitic diseases in the commercial broiler industry. Probiotics can protect poultry against Eimeria infection. However, the mechanisms are not fully known. Therefore, Lactobacillus plantarum P8 (P8) was used to investigate its anti-coccidial property and mechanism. Five hundred broilers were allocated to five treatments: control diet (NC), control diet + Eimeria infection (IC), control diet containing 1 × 107 cfu/g P8 + Eimeria infection (P8L), control diet containing 1 × 108 cfu/g P8 + Eimeria infection (P8H), and control diet + Eimeria infection + Diclazuril (DIC). At day 14, all treatments except NC were inoculated with sporulated oocysts. Results indicated that Eimeria infection increased the mortality and oocysts shedding, and declined the growth performance as well as the intestinal barrier in Eimeria-treated broilers. On the contrary, dietary supplementation of low level P8, high level P8 and DIC decreased the mortality and oocysts shedding, but improved the growth performance and intestinal barrier. The impaired intestinal morphology in the IC group was also improved by P8H and DIC treatments. Besides, the elevated oxidative stress and pro-inflammation in Eimeria-infected broilers were reduced by P8L, P8H, and DIC treatments. Metagenomic analysis indicated P8 altered the structure of the gut microbiota, and the alteration was more obvious at day 21 than day 42. Notably, IC also increased the abundances of Eimeriidae, Eimeria and Eimeria tenella at day 21, while P8L and DIC decreased the abundances. Correlation analysis revealed that bacteria in Eimeria-treated broilers positively correlated with the intestinal permeability, oxidative stress and inflammation, while bacteria in broilers receiving P8L and DIC negatively correlated with the aforementioned pathological indices. Functional prediction demonstrated that the metagenomes of Eimeria-infected broilers were involved in several diseases. But the metagenomes of P8L-treated broilers were involved in energy metabolism and replication repair. In conclusion, dietary P8 supplementation inhibited oocyst shedding and improved the growth performance as well as the intestinal health of broilers infected with Eimeria, which was closely related to the regulation of gut microbiota. Moreover, the effects of P8 may be more effective in the early infection of coccidia.

Growth performance and intestinal morphology in broiler chickens produced from hyperthyroid breeder hens

2013 ◽  
Vol 53 (10) ◽  
pp. 1046 ◽  
Author(s):  
A. Akhlaghi ◽  
M. J. Zamiri ◽  
Y. Jafari Ahangari ◽  
M. R. Mollasalehi ◽  
H. Shojaie ◽  
...  
Keyword(s):  
Ambient Temperature ◽  
Growth Performance ◽  
Goblet Cell ◽  
Broiler Chickens ◽  
Relative Weight ◽  
Cell Number ◽  
Intestinal Morphology ◽  
Early Effect ◽  
Breeder Hens ◽  
Low Ambient Temperature

An association between induced maternal hyperthyroidism and a decreased incidence of cold-induced ascites in broiler chickens has been reported recently. There are also reports suggesting that thyroid hormones have an effect on intestine, a high oxygen-demanding organ. The present study aimed to determine whether the ascites-attenuating effect of maternal hyperthyroidism is associated with morphological changes in intestine and with probable adverse effects on growth performance in progeny chicks. Eighty-eight broiler breeder hens were allotted to control or hyperthyroid [HYPER; thyroxine-treated] groups, and artificially inseminated. Hatching eggs (n = 924) were incubated and day-old male chicks (n = 288) were reared for 42 days under standard or low ambient temperature. Plasma thyroxine was higher in the HYPER hens and their embryos at internal pipping. Maternal hyperthyroidism did not adversely affect the feed : gain ratio and carcass weight, whereas cold stress impaired them. A higher relative weight was found at 42 days of age for all intestinal regions at low ambient temperature. The duodenal and jejunal crypt depths (CD) were lower in HYPER group at 7 days of age. Cold exposure decreased the duodenal and jejunal villus height and CD, and increased the ileal goblet cell number at 21 days. On Day 42, higher values were recorded for CD, goblet cell number, and epithelial thickness of different intestinal regions in cold-exposed birds. In conclusion, growth performance was not adversely influenced by maternal hyperthyroidism and its minimal early effect on intestinal morphology does not appear to be the underlying mechanism for decreased incidence of ascites in broilers.

Dietary xylo-oligosaccharide improves intestinal functions in weaned piglets

2019 ◽  
Vol 10 (5) ◽  
pp. 2701-2709 ◽  
Author(s):  
Jie Yin ◽  
Fengna Li ◽  
Xiangfeng Kong ◽  
Chaoyue Wen ◽  
Qiuping Guo ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Growth Performance ◽  
Tight Junctions ◽  
Intestinal Morphology ◽  
Weaned Piglets ◽  
Intestinal Functions

This study aimed at investigating the effects of dietary xylo-oligosaccharide (XOS) on intestinal functions (i.e., intestinal morphology, tight junctions, gut microbiota and metabolism) and growth performance in weaned piglets.

Effect of supplementation of nicotinamide and sodium butyrate on the growth performance, liver mitochondrial function and gut microbiota of broilers at high stocking density

2019 ◽  
Vol 10 (11) ◽  
pp. 7081-7090 ◽  
Author(s):  
Yuqin Wu ◽  
Youli Wang ◽  
Dafei Yin ◽  
Wei Wu ◽  
Xiaoying Sun ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Antioxidant Capacity ◽  
Growth Performance ◽  
Sodium Butyrate ◽  
Mitochondrial Function ◽  
Stocking Density

Dietary supplemental with nicotinamide and butyrate sodium improve mitochondrial function, antioxidant capacity, and gut microbiota.

scholarly journals Butyric and Citric Acids and Their Salts in Poultry Nutrition: Effects on Gut Health and Intestinal Microbiota

2021 ◽  
Vol 22 (19) ◽  
pp. 10392
Author(s):  
Mebratu Melaku ◽  
Ruqing Zhong ◽  
Hui Han ◽  
Fan Wan ◽  
Bao Yi ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Organic Acids ◽  
Growth Performance ◽  
Pathogenic Bacteria ◽  
Intestinal Inflammation ◽  
Farm Animals ◽  
Gut Health ◽  
Intestinal Health ◽  
Poultry Products ◽  
Poultry Nutrition

Intestinal dysfunction of farm animals, such as intestinal inflammation and altered gut microbiota, is the critical problem affecting animal welfare, performance and farm profitability. China has prohibited the use of antibiotics to improve feed efficiency and growth performance for farm animals, including poultry, in 2020. With the advantages of maintaining gut homeostasis, enhancing digestion, and absorption and modulating gut microbiota, organic acids are regarded as promising antibiotic alternatives. Butyric and citric acids as presentative organic acids positively impact growth performance, welfare, and intestinal health of livestock mainly by reducing pathogenic bacteria and maintaining the gastrointestinal tract (GIT) pH. This review summarizes the discovery of butyric acid (BA), citric acid (CA) and their salt forms, molecular structure and properties, metabolism, biological functions and their applications in poultry nutrition. The research findings about BA, CA and their salts on rats, pigs and humans are also briefly reviewed. Therefore, this review will fill the knowledge gaps of the scientific community and may be of great interest for poultry nutritionists, researchers and feed manufacturers about these two weak organic acids and their effects on intestinal health and gut microbiota community, with the hope of providing safe, healthy and nutrient-rich poultry products to consumers.

scholarly journals Effects of Dietary Histidine on Growth Performance, Serum Amino Acids, and Intestinal Morphology and Microbiota Communities in Low Protein Diet-Fed Piglets

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Meng Kang ◽  
Jie Yin ◽  
Jie Ma ◽  
Xin Wu ◽  
Ke Huang ◽  
...  
Keyword(s):  
Amino Acids ◽  
Gut Microbiota ◽  
Growth Performance ◽  
Biochemical Parameters ◽  
Intestinal Morphology ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Blood Biochemical Parameters ◽  
Blood Biochemical ◽  
Low Protein

Previous study showed that low protein diet-fed pigs are characterized by lower histidine concentration in the serum and muscle, suggesting that histidine may involve in protein-restricted response. Thus, the current study mainly investigated the effects of dietary histidine on growth performance, blood biochemical parameters and amino acids, intestinal morphology, and microbiota communities in low protein diet-challenged-piglets. The results showed that protein restriction inhibited growth performance, blood biochemical parameters and amino acids, and gut microbiota but had little effect on intestinal morphology. Dietary supplementation with histidine markedly enhanced serum histidine level and restored tryptophan concentration in low protein diet-fed piglets, while growth performance and intestinal morphology were not markedly altered in histidine-treated piglets. In addition, histidine exposure failed to affect bacterial diversity (observed species, Shannon, Simpson, Chao1, ACE, and phylogenetic diversity), but histidine-treated piglets exhibited higher abundances of Butyrivibrio and Bacteroides compared with the control and protein-restricted piglets. In conclusion, dietary histidine in low protein diet enhanced histidine concentration and affected gut microbiota (Butyrivibrio and Bacteroides) but failed to improve growth performance and intestinal morphology.

scholarly journals Eucommia ulmoides Flavones as Potential Alternatives to Antibiotic Growth Promoters in a Low-Protein Diet Improve Growth Performance and Intestinal Health in Weaning Piglets

Animals ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 1998
Author(s):  
Daixiu Yuan ◽  
Jing Wang ◽  
Dingfu Xiao ◽  
Jiefeng Li ◽  
Yanhong Liu ◽  
...  
Keyword(s):  
Growth Performance ◽  
Intestinal Morphology ◽  
Coliform Bacteria ◽  
Feed Ratio ◽  
Growth Promoter ◽  
Eucommia Ulmoides ◽  
Intestinal Health ◽  
Villus Height ◽  
Low Protein ◽  
Weanling Piglets

Eucommia ulmoides flavones (EUF) have been demonstrated to attenuate the inflammation and oxidative stress of piglets. This study aimed to test whether EUF could be used as an alternative antibiotic growth promoter to support growth performance and maintain intestinal health in weanling piglets. Weaned piglets (n = 480) were assigned into three groups and fed with a low-protein basal diet (NC), or supplementation with antibiotics (PC) or 0.01% EUF (EUF). Blood, intestinal contents, and intestine were collected on days 15 and 35 after weaning. The results showed the PC and EUF supplementations increased (p < 0.05) body weight on day 35, average daily gain and gain: feed ratio from day 15 to day 35 and day 0 to day 35, whereas decreased (p < 0.05) the diarrhea index of weanling piglets. EUF treatment increased (p < 0.05) jejunal villus height: crypt depth ratio, jejunal and ileal villus height, and population of ileal lactic acid bacteria on day 15 but decreased (p < 0.05) the population of ileal coliform bacteria on day 15 and day 35. These findings indicated the EUF, as the potential alternative to in-feed antibiotic growth promoter, could improve growth performance and intestinal morphology, and decrease colonization of coliform bacteria and diarrhea index in weanling piglets.

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