scholarly journals Circular RNAs in the Central Nervous System

2021 ◽  
Vol 8 ◽  
Author(s):  
Meng-Lan Li ◽  
Wen Wang ◽  
Zi-Bing Jin
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Circular Rnas ◽  
Protein Coding ◽  
Current State ◽  
Specific Distribution ◽  
Evolutionarily Conserved ◽  
Protein Functions ◽  
The Central Nervous System ◽  
Regulate Protein

Circular RNAs (circRNAs) are endogenous single-stranded RNAs characterized by covalently closed loop structures with neither 5′ to 3′ polarity nor poly(A) tails. They are generated most commonly from back-splicing of protein-coding exons. CircRNAs have a tissue-specific distribution and are evolutionarily conserved, and many circRNAs play important biological functions by combining with microRNAs and proteins to regulate protein functions and their own translation. Numerous studies have shown that circRNAs are enriched in the central nervous system (CNS) and play an important role in the development and maintenance of homeostasis. Correspondingly, they also play an important role in the occurrence and progression of CNS diseases. In this review, we highlight the current state of circRNA biogenesis, properties, function and the crucial roles they play in the CNS.

SCO-spondin is evolutionarily conserved in the central nervous system of the chordate phylum

Neuroscience ◽  
1999 ◽  
Vol 88 (2) ◽  
pp. 655-664 ◽  
Author(s):  
S Gobron ◽  
I Creveaux ◽  
R Meiniel ◽  
R Didier ◽  
B Dastugue ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Evolutionarily Conserved ◽  
The Central Nervous System

Surgical Endovascular Neuroradiology in the 21st Century: What Lies Ahead?

Neurosurgery ◽  
2006 ◽  
Vol 59 (suppl_5) ◽  
pp. S3-48-S3-55 ◽  
Author(s):  
Charles J. Prestigiacomo
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Endovascular Therapy ◽  
Neck Surgery ◽  
Cerebrovascular Diseases ◽  
Endovascular Surgery ◽  
Invasive Approach ◽  
Current State ◽  
Push Forward ◽  
The Central Nervous System

Abstract FEW COULD HAVE imagined the tremendous growth of endovascular surgery over the past 40 years. Endovascular therapy has greatly enhanced the care of the patient in neurosurgery, spine surgery, and head and neck surgery. Progress in technology and techniques continue to push forward the boundaries of what is deemed “treatable,” assuming acceptable risk. This article will briefly review the current state of endovascular surgery and speculate about what its role will be in the near and far future. Endovascular therapy provides a minimally invasive approach to the central nervous system and other systems via natural and, at times, highly selective pathways. Maximizing the accessibility of these routes to highly specific regions of the central nervous system provides an elegant and minimalist approach to treating diseases of the central nervous system with almost no “footprints” of ever having accessed the region. In the future, safe, efficient and intelligent delivery systems that may enhance or alter the tissue's response may result in successful treatment of cerebrovascular diseases, as well as other diseases of the craniospinal axis. The growth of nanotechnology, metallurgy, synthetic polymers, imaging, and training will all combine to help grow the technology and the science that is surgical endovascular neuroradiology.

scholarly journals New Insight of Circular RNAs' Roles in Central Nervous System Post-Traumatic Injury

2021 ◽  
Vol 15 ◽  
Author(s):  
Lvwan Xu ◽  
Xin Ye ◽  
Jinjie Zhong ◽  
Ying-ying Chen ◽  
Lin-lin Wang
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Traumatic Injury ◽  
Circular Rnas ◽  
Clinical Value ◽  
Cord Injury ◽  
Second Generation Sequencing ◽  
The Central Nervous System ◽  
Post Traumatic ◽  
Generation Sequencing

The central nervous system (CNS) post-traumatic injury can cause severe nerve damage with devastating consequences. However, its pathophysiological mechanisms remain vague. There is still an urgent need for more effective treatments. Circular RNAs (circRNAs) are non-coding RNAs that can form covalently closed RNA circles. Through second-generation sequencing technology, microarray analysis, bioinformatics, and other technologies, recent studies have shown that a number of circRNAs are differentially expressed after traumatic brain injury (TBI) or spinal cord injury (SCI). These circRNAs play important roles in the proliferation, inflammation, and apoptosis in CNS post-traumatic injury. In this review, we summarize the expression and functions of circRNAs in CNS in recent studies, as well as the circRNA–miRNA–mRNA interaction networks. The potential clinical value of circRNAs as a therapeutic target is also discussed.

scholarly journals Evolutionarily conserved anterior expansion of the central nervous system promoted by a common PcG-Hox program

Development ◽  
2018 ◽  
Vol 145 (7) ◽  
pp. dev160747 ◽  
Author(s):  
Behzad Yaghmaeian Salmani ◽  
Ignacio Monedero Cobeta ◽  
Jonathan Rakar ◽  
Susanne Bauer ◽  
Jesús Rodriguez Curt ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Evolutionarily Conserved ◽  
The Central Nervous System

What are “normal movements” in atypical populations?

1996 ◽  
Vol 19 (1) ◽  
pp. 55-68 ◽  
Author(s):  
Mark L. Latash ◽  
J. Greg Anson
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Structural Changes ◽  
Motor Patterns ◽  
Control Structures ◽  
Current State ◽  
Primary Disorder ◽  
Motor Problems ◽  
The Central Nervous System ◽  
Control Patterns

AbstractRedundancy of the motor control system is an important feature that gives the central control structures options for solving everyday motor problems. The choice of particular control patterns is based on priorities (coordinative rules) that are presently unknown. Motor patterns observed in unimpaired young adults reflect these priorities. We hypothesize that under certain atypical conditions, which may include disorders in perception of the environment and in decision making, structural or biochemical changes within the central nervous system (CNS), and/or structural changes of the effectors, the central nervous system may reconsider its priorities. A new set of priorities will reflect the current state of the system and may lead to different patterns of voluntary movement. Under such conditions, changed motor patterns should be considered not pathological but rather adaptive to a primary disorder and may even be viewed as optimal for a given state of the system of movement production. Therapeutic approaches should not be directed toward restoring the motor patterns to as close to “normal” as possible but rather toward resolving the original underlying problem. We illustrate this approach using, as examples, movements in amputees, in patients with Parkinson's disease, in patients with dystonia, and in persons with Down syndrome.

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