scholarly journals Controlling Synthetic Cell-Cell Communication

2022 ◽  
Vol 8 ◽  
Author(s):  
Jefferson M. Smith ◽  
Razia Chowdhry ◽  
Michael J. Booth
Keyword(s):  
Small Molecules ◽  
Cell Communication ◽  
Cellular Function ◽  
Living Cells ◽  
Cellular Communication ◽  
Synthetic Cell ◽  
Synthetic Cells ◽  
Chemical Inputs ◽  
Cell Cell

Synthetic cells, which mimic cellular function within a minimal compartment, are finding wide application, for instance in studying cellular communication and as delivery devices to living cells. However, to fully realise the potential of synthetic cells, control of their function is vital. An array of tools has already been developed to control the communication of synthetic cells to neighbouring synthetic cells or living cells. These tools use either chemical inputs, such as small molecules, or physical inputs, such as light. Here, we examine these current methods of controlling synthetic cell communication and consider alternative mechanisms for future use.

scholarly journals From primal scenes to synthetic cells

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Hub Zwart
Keyword(s):  
Synthetic Biology ◽  
Artificial Life ◽  
Living Cells ◽  
Philosophical Perspective ◽  
Fictional Narratives ◽  
Synthetic Cell ◽  
Synthetic Cells ◽  
Life Projects

Synthetic cells spark intriguing questions about the nature of life. Projects such as BaSyC (Building a Synthetic Cell) aim to build an entity that mimics how living cells work. But what kind of entity would a synthetic cell really be? I assess this question from a philosophical perspective, and show how early fictional narratives of artificial life – such as the laboratory scene in Goethe’s Faust – can help us to understand the challenges faced by synthetic biology researchers.

Synthetic cell–cell communication in a three-species consortium for one-step vitamin C fermentation

2019 ◽  
Vol 41 (8-9) ◽  
pp. 951-961 ◽  
Author(s):  
En-Xu Wang ◽  
Yu Liu ◽  
Qian Ma ◽  
Xiu-Tao Dong ◽  
Ming-Zhu Ding ◽  
...  
Keyword(s):  
Vitamin C ◽  
Cell Communication ◽  
Synthetic Cell ◽  
One Step ◽  
Cell Cell

Small Molecules for Interference with Cell-Cell-Communication Systems in Gram-Negative Bacteria

2008 ◽  
Vol 15 (21) ◽  
pp. 2144-2156 ◽  
Author(s):  
Joost Janssens ◽  
Sigrid De Keersmaecker ◽  
Dirk De Vos ◽  
Jos Vanderleyden
Keyword(s):  
Small Molecules ◽  
Communication Systems ◽  
Cell Communication ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Cell Cell

scholarly journals GLI ESOSOMI NELLA COMUNICAZIONE CELLULA-CELLULA

2020 ◽  
Author(s):  
Stefania Raimondo
Keyword(s):  
Small Molecules ◽  
Extracellular Vesicles ◽  
Cell Communication ◽  
Cell Types ◽  
Cell Contact ◽  
Bioactive Lipids ◽  
Pathological Conditions ◽  
Extracellular Matrix Components ◽  
Different Cell Types ◽  
Cell Cell

Cell to cell communication is essential for the coordination and proper organization of different cell types in multicellular systems. Cells exchange information through a multitude of mechanisms such as secreted growth factors and chemokines, small molecules (peptides, ions, bioactive lipids and nucleotides), cell-cell contact and the secretion of extracellular matrix components. Over the last few years a new and sophisticated mechanism of cell-cell communication based on extracellular vesicles has been described. Extracellular vesicles are specialized vesicles released in the extracellular space by most of cell types, under physiological and pathological conditions. Among different extracellular vesicles subtypes, exosomes (30-100 nm) have recently received most of the attention do to their ability to be messenger in intercellular communication.

scholarly journals New approaches in bioprocess-control: Consortium guidance by synthetic cell-cell communication based on fungal pheromones

2018 ◽  
Vol 18 (6) ◽  
pp. 387-400 ◽  
Author(s):  
Stefan Hennig ◽  
Mandy Wenzel ◽  
Christiane Haas ◽  
Andreas Hoffmann ◽  
Jost Weber ◽  
...  
Keyword(s):  
Cell Communication ◽  
Bioprocess Control ◽  
New Approaches ◽  
Synthetic Cell ◽  
Cell Cell

scholarly journals Chemical communication at the synthetic cell/living cell interface

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Vincent Mukwaya ◽  
Stephen Mann ◽  
Hongjing Dou
Keyword(s):  
Signal Processing ◽  
Chemical Communication ◽  
Living Cell ◽  
Communication Systems ◽  
Cell Communication ◽  
Lipid Vesicles ◽  
Living Cells ◽  
Giant Vesicles ◽  
Synthetic Cell ◽  
Living Organisms

AbstractAlthough the complexity of synthetic cells has continued to increase in recent years, chemical communication between protocell models and living organisms remains a key challenge in bottom-up synthetic biology and bioengineering. In this Review, we discuss how communication channels and modes of signal processing can be established between living cells and cytomimetic agents such as giant unilamellar lipid vesicles, proteinosomes, polysaccharidosomes, polymer-based giant vesicles and membrane-less coacervate micro-droplets. We describe three potential modes of chemical communication in consortia of synthetic and living cells based on mechanisms of distributed communication and signal processing, physical embodiment and nested communication, and network-based contact-dependent communication. We survey the potential for applying synthetic cell/living cell communication systems in biomedicine, including the in situ production of therapeutics and development of new bioreactors. Finally, we present a short summary of our findings.

scholarly journals Cell–cell signalling in plants: Cross-talk among chloroplasts, mitochondria and plasmodesmata

2014 ◽  
Vol 36 (5) ◽  
pp. 11-15
Author(s):  
Jacob O. Brunkard ◽  
Anne M. Runkel ◽  
Patricia C. Zambryski
Keyword(s):  
Cell Death ◽  
Small Molecules ◽  
Developmental Process ◽  
Cell Signalling ◽  
Cell Communication ◽  
Land Plants ◽  
Animal Cells ◽  
Distinct Mechanism ◽  
Septal Pores ◽  
Cell Cell

Multicellularity is central to the stunning diversity of biological forms on earth today. In multicellular species, individual cells become dependent on each other, differentiate to specialize their functions, and may even undergo cell death as the whole organism develops. This developmental process requires intense co-ordination of genetic programs and physiology across the organism, relying on communication between cells. There are only a handful of lineages of obligate multicellular eukaryotes – animals, a few groups of fungi, certain algal lineages, and land plants – but each arose independently, and each employs a distinct mechanism of intercellular communication1. Direct physical cell–cell communication between animal cells occurs via gap junctions, which transport only very small molecules, and via tunnelling nanotubes, which permit exchange of larger molecules. Fungal cells never fully separate after cell division, in a sense, because they leave behind septal pores that connect adjacent cytoplasts. In plants, intercellular communication is primarily facilitated by plasmodesmata (PD).

Gap junctions in the prothoracic glands of the tobacco hornworm, Manduca sexta

1992 ◽  
Vol 50 (1) ◽  
pp. 706-707
Author(s):  
Ji-da Dai ◽  
M. Joseph Costello ◽  
Lawrence I. Gilbert
Keyword(s):  
Gap Junctions ◽  
Small Molecules ◽  
Manduca Sexta ◽  
Freeze Fracture ◽  
Cell Communication ◽  
Cellular Level ◽  
Thin Sections ◽  
Prothoracic Glands ◽  
Polyhydroxylated Steroids ◽  
Stimulation Of

Insect molting and metamorphosis are elicited by a class of polyhydroxylated steroids, ecdysteroids, that originate in the prothoracic glands (PGs). Prothoracicotropic hormone stimulation of steroidogenesis by the PGs at the cellular level involves both calcium and cAMP. Cell-to-cell communication mediated by gap junctions may play a key role in regulating signal transduction by controlling the transmission of small molecules and ions between adjacent cells. This is the first report of gap junctions in the PGs, the evidence obtained by means of SEM, thin sections and freeze-fracture replicas.

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