scholarly journals Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies

2021 ◽  
Vol 12 ◽  
Author(s):  
Joseph A. McQuail ◽  
Amy R. Dunn ◽  
Yaakov Stern ◽  
Carol A. Barnes ◽  
Gerd Kempermann ◽  
...  
Keyword(s):  
Longitudinal Studies ◽  
Cognitive Reserve ◽  
Structure And Function ◽  
Review Article ◽  
Model Systems ◽  
Cross Sectional ◽  
Early Predictors ◽  
Brain Structure And Function ◽  
And Function ◽  
The Relationship

The goal of this review article is to provide a resource for longitudinal studies, using animal models, directed at understanding and modifying the relationship between cognition and brain structure and function throughout life. We propose that forthcoming longitudinal studies will build upon a wealth of knowledge gleaned from prior cross-sectional designs to identify early predictors of variability in cognitive function during aging, and characterize fundamental neurobiological mechanisms that underlie the vulnerability to, and the trajectory of, cognitive decline. Finally, we present examples of biological measures that may differentiate mechanisms of the cognitive reserve at the molecular, cellular, and network level.

scholarly journals Brain structure of perinatally HIV-infected patients on long-term treatment

2019 ◽  
Vol 9 (5) ◽  
pp. 433-442 ◽  
Author(s):  
Malon Van den Hof ◽  
Anne Marleen ter Haar ◽  
Matthan W.A. Caan ◽  
Rene Spijker ◽  
Johanna H. van der Lee ◽  
...  
Keyword(s):  
Brain Structure ◽  
Diffusion Tensor ◽  
Structure And Function ◽  
Resonance Spectroscopy ◽  
Cross Sectional ◽  
Long Term Treatment ◽  
Brain Structure And Function ◽  
And Function ◽  
Hiv Negative

ObjectiveWe aim to give an overview of the available evidence on brain structure and function in PHIV-infected patients (PHIV+) using long-term combination antiretroviral therapy (cART) and how differences change over time.MethodsWe conducted an electronic search using MEDLINE, Embase, and PsycINFO. We used the following selection criteria: cohort and cross-sectional studies that reported on brain imaging differences between PHIV+ of all ages who used cART for at least six months before neuroimaging and HIV-negative controls. Two reviewers independently selected studies, performed data extraction, and assessed quality of studies.ResultsAfter screening 1500 abstracts and 343 full-text articles, we identified 19 eligible articles. All included studies had a cross-sectional design and used MRI with different modalities: structural MRI (n = 7), diffusion tensor imaging (DTI) (n = 6), magnetic resonance spectroscopy (n = 5), arterial spin labeling (n = 1), and resting-state functional neuroimaging (n = 1). Studies showed considerable methodological limitations and heterogeneity, preventing us to perform meta-analyses. DTI data on white matter microstructure suggested poorer directional diffusion in cART-treated PHIV+ compared with controls. Other modalities were inconclusive.ConclusionEvidence may suggest brain structure and function differences in the population of PHIV+ on long-term cART compared with the HIV-negative population. Because of a small study population, and considerable heterogeneity and methodological limitations, the extent of brain structure and function differences on neuroimaging between groups remains unknown.

Longitudinal studies of brain structure and function in MPS disorders: A study of the Lysosomal Disease network

2011 ◽  
Vol 102 (2) ◽  
pp. S41
Author(s):  
Elsa Shapiro ◽  
Julie Eisengart ◽  
Igor Nestrasil ◽  
Alia Ahmed ◽  
Julian Raiman ◽  
...  
Keyword(s):  
Longitudinal Studies ◽  
Brain Structure ◽  
Structure And Function ◽  
Disease Network ◽  
Lysosomal Disease ◽  
Brain Structure And Function ◽  
And Function

scholarly journals Can exercise make our children smarter?

2020 ◽  
Vol 10 (2) ◽  
Author(s):  
Nenad Stojiljković ◽  
Petar Mitić ◽  
Goran Sporiš
Keyword(s):  
White Matter ◽  
Brain Structure ◽  
Methodological Approach ◽  
Brain Structures ◽  
Structure And Function ◽  
Healthy Children ◽  
Cross Sectional ◽  
Brain Structure And Function ◽  
And Function ◽  
The Brain

Purpose. The aim of this study is to reveal the effects of exercise on the brain structure and function in children, and to analyze methodological approach applied in the researches of this topic. Methods. This literature review provides an overview of important findings in this fast growing research domain. Results from cross-sectional, longitudinal, and interventional studies of the influence of exercise on the brain structure and function of healthy children are reviewed and discussed. Results. The majority of researches are done as cross sectional studies based on the exploring correlation between the level of physical activity and characteristics of brain structure and function. Results of the studies indicate that exercise has positive correlation with improved cognition and beneficial changes to brain function in children. Physically active children have greater white matter integrity in several white matter tracts (corpus callosum, corona radiata, and superior longitudinal fasciculus), have greater volume of gray matter in the hippocampus and basal ganglia than their physically inactive counterparts. The longitudinal/interventional studies also showed that exercise (mainly aerobic) improve cognitive performance of children and causes changes observed on functional magnetic resonance imaging scans (fMRI) located in prefrontal and parietal regions. Conclusion. Previous researches undoubtable proved that exercise can make positive changes of the brain structures in children, specifically the volume of the hippocampus which is the center of learning and memory. Finally the researchers agree that the most influential type of exercise on changes of brain structure and functions are the aerobic exercises. 

Beautiful minds (i.e., brains) and the neural basis of intelligence

2007 ◽  
Vol 30 (2) ◽  
pp. 174-178 ◽  
Author(s):  
Richard J. Haier ◽  
Rex E. Jung
Keyword(s):  
Cognitive Neuroscience ◽  
Brain Structure ◽  
Structure And Function ◽  
Neural Basis ◽  
Brain Structure And Function ◽  
And Function ◽  
Relationship Of ◽  
The Relationship ◽  
New Phase ◽  
Empirical Framework

AbstractThe commentaries address conceptual issues ranging from our narrow focus on neuroimaging to the various definitions of intelligence. The integration of the P-FIT and data from cognitive neuroscience is particularly important and considerable consistency is found. Overall, the commentaries affirm that advances in neuroscience techniques have caused intelligence research to enter a new phase. The P-FIT is recognized as a reasonable empirical framework to test hypotheses about the relationship of brain structure and function with intelligence and reasoning.

Longitudinal Studies of Brain Structure and Function in MPS disorders: A Study of the Lysosomal Disease Network

2012 ◽  
Vol 105 (2) ◽  
pp. S57
Author(s):  
Elsa Shapiro ◽  
Kathleen Delaney ◽  
Igor Nestrasil ◽  
Alia Ahmed ◽  
Brianna Yund ◽  
...  
Keyword(s):  
Longitudinal Studies ◽  
Brain Structure ◽  
Structure And Function ◽  
Disease Network ◽  
Lysosomal Disease ◽  
Brain Structure And Function ◽  
And Function
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