The Association of Metabolic Dysfunction and Mood Across Lifespan Interacts With the Default Mode Network Functional Connectivity

Background: Numerous studies suggest a relationship between depression and metabolic syndrome, which is likely influenced by age. Interestingly, functional imaging analysis has shown an association between functional connectivity in the default mode network (DMN-FC) and components of metabolic syndrome, which is explored in this study.Methods: From a larger longitudinal cohort study on healthy aging, 943 individuals were extensively characterized for mood and cognition. Among these, 120 individuals who were selected for displaying extreme cognitive performance within the normal range (good and poor performers) were further studied. Here, in a cross-sectional design, using confirmatory factor analysis (CFA), the association between metabolic dysfunction and depressive mood as a function of age and its relationship with DMN-FC was studied.Results: Metabolic dysfunction was modeled as a second-order latent variable using CFA. First-order latent variables were obesity, glucose dysmetabolism, lipids imbalance, and blood pressure. Using multiple linear regression models, this study observed that metabolic dysfunction, glucose dysmetabolism, and lipids imbalance were linearly associated with depressive mood, and the association with obesity was U-shaped. The association of metabolic dysfunction, obesity, and glucose dysmetabolism with depressive mood is positive for the younger individuals in our sample and vanishes with aging. The FC of the right superior temporal gyrus with the DMN correlated with both obesity and depressive mood. In participants with higher obesity scores, FC increased with higher GDS scores, while in those with lower GDS scores, FC decreased. Age and blood pressure were associated with a more complex pattern of association between FC of the right supramarginal gyrus and GDS score.Conclusion: The association of metabolic dysfunction with depressive mood is influenced by age and relates with differential patterns of DMN-FC. The combination of the effects of age, mood, and metabolic dysfunction is likely to explain the heterogeneity of DMN-FC, which deserves further investigation with larger and longitudinal studies.

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Metabolic syndrome components moderate the association between executive function and functional connectivity in the default mode network

Brain Imaging and Behavior ◽

10.1007/s11682-020-00409-0 ◽

2020 ◽

Author(s):

Janelle T. Foret ◽

Maria Dekhtyar ◽

Alex C. Birdsill ◽

Hirofumi Tanaka ◽

Andreana P. Haley

Keyword(s):

Metabolic Syndrome ◽

Executive Function ◽

Functional Connectivity ◽

Default Mode Network ◽

Default Mode ◽

Metabolic Syndrome Components

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Poorer Theory of Mind in Amnestic Mild Cognitive Impairment Is Associated with Decreased Functional Connectivity in the Default Mode Network

Journal of Alzheimer s Disease ◽

10.3233/jad-201284 ◽

2021 ◽

pp. 1-13

Author(s):

Johannes C. Michaelian ◽

Shantel L. Duffy ◽

Loren Mowszowski ◽

Adam J. Guastella ◽

Donna McCade ◽

...

Keyword(s):

Older Adults ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Functional Connectivity ◽

Theory Of Mind ◽

Default Mode Network ◽

Amnestic Mild Cognitive Impairment ◽

Default Mode ◽

Left And Right ◽

The Right

Background: Older adults living with amnestic mild cognitive impairment (aMCI) not only demonstrate impairments in Theory of Mind (ToM), relative to adults with non-amnestic MCI (naMCI), but are also at a higher risk of developing dementia. Objective: Our primary objective was to ascertain whether default mode network (DMN) functional connectivity was differentially associated with ToM abilities between MCI subgroups. Methods: Using functional magnetic resonance imaging, we investigated alterations in resting-state functional connectivity within the brain’s DMN in a sample of 43 older adults with aMCI (n = 19) and naMCI (n = 24), previously reported to demonstrate poorer ToM abilities. Results: Compared to naMCI, the aMCI subgroup revealed a significant association between poorer ToM performance and reduced functional connectivity between the bilateral temporal pole (TempP) and the left lateral temporal cortex (LTC) (LTC_L-TempP_L: b = –0.06, t(33) = –3.53, p = 0.02; LTC_L-TempP_R: b = –0.07,t(33) = –3.20, p = 0.03); between the right TempP and the dorsal medial prefrontal cortex (dMPFC) (b = –0.04, t(33) = –3.02, p = 0.03) and between the left and right TempP (b = –0.05, t(33) = –3.26, p = 0.03). In the naMCI subgroup, the opposite relationship was present between the bilateral TempP and the left LTC (Combined correlation: r = –0.47, p = 0.02), however, not between the right TempP and the dMPFC (r = –0.14, p = 0.51) or the left and right TempP (r = –0.31, p = 0.14). Conclusion: Our findings suggest that alterations in functional connectivity within the DMN involving temporal and frontal lobe regions are associated with ToM deficits in aMCI.

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Music Intervention Reduces Persistent Fibromyalgia Pain and Alters Functional Connectivity Between the Insula and Default Mode Network

Pain Medicine ◽

10.1093/pm/pnaa071 ◽

2020 ◽

Vol 21 (8) ◽

pp. 1546-1552

Author(s):

Chie Usui ◽

Eiji Kirino ◽

Shoji Tanaka ◽

Rie Inami ◽

Kenya Nishioka ◽

...

Keyword(s):

Functional Connectivity ◽

Default Mode Network ◽

Network Connectivity ◽

Music Intervention ◽

Default Mode ◽

Pain Scores ◽

Short Period ◽

Before And After ◽

The Difference ◽

The Right

Abstract Objective The aims of the present study were to examine the effects of short-term music interventions among patients with fibromyalgia (FM) and to clarify the alterations in functional connectivity and persistent pain. Design Pilot study. Setting All participants were evaluated at Juntendo University from November 2017 to January 2019. Subjects We enrolled female patients who had been clinically diagnosed with FM (N = 23). Methods All participants listened to Mozart’s Duo for Violin and Viola No. 1, K. 423, in a quiet room for 17 minutes. We compared the degree of pain using resting-state functional magnetic resonance imaging and the numeric rating scale before and after listening to music. Results Pain scores were significantly reduced after listening to music. Further, we observed there was a significant difference in connectivity between the right insular cortex (IC) and posterior cingulate cortex (PCC)/precuneus (PCu) before and after listening to music. We also found that the difference between the right IC-PCu connectivity and the difference in pain scores were significantly correlated. Conclusions We found that a short period of music intervention reduced chronic pain and altered functional IC–default mode network connectivity. Furthermore, music potentially normalized the neural network via IC–default mode network connectivity, yielding temporary pain relief in patients with FM. Further longitudinal studies with larger sample sizes are required to confirm these results.

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Aberrant patterns of default‐mode network functional connectivity associated with metabolic syndrome: A resting‐state study

Brain and Behavior ◽

10.1002/brb3.1333 ◽

2019 ◽

Vol 9 (12) ◽

Cited By ~ 5

Author(s):

Barnaly Rashid ◽

Sheena I. Dev ◽

Michael Esterman ◽

Nicolette F. Schwarz ◽

Tori Ferland ◽

...

Keyword(s):

Metabolic Syndrome ◽

Functional Connectivity ◽

Default Mode Network ◽

Resting State ◽

Default Mode ◽

State Study

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Lateral Asymmetry in Weekly Reproducibility of Resting State Amygdala Functional Connectivity

10.1101/439372 ◽

2018 ◽

Author(s):

Alina Tetereva ◽

Vladislav Balaev ◽

Sergey Kartashov ◽

Vadim Ushakov ◽

Alexey Ivanitsky ◽

...

Keyword(s):

Functional Connectivity ◽

Default Mode Network ◽

Resting State ◽

Right Hemisphere ◽

List Type ◽

Post Traumatic Stress ◽

Lateral Asymmetry ◽

Default Mode ◽

Functional Connections ◽

The Right

AbstractAbnormal functional connectivity of the amygdala with several other brain regions has been observed in patients with higher anxiety or post-traumatic stress disorder, both in a resting state and threatening conditions. However, findings on the specific connections of the amygdala might be varied due to temporal and individual fluctuations in the resting state functional connectivity (rsFC) of the amygdala and its lateral asymmetry, as well as possible variability in anxiety among healthy subjects. We studied reproducibility of rsFC data for the right and left amygdala, obtained by functional magnetic resonance imaging twice in a one-week interval in 20 healthy volunteers with low to moderate anxiety. We found resting-state amygdala network, which included not only areas involved in the emotion circuit, but regions of the default mode network (DMN) associated with memory and other brain areas involved in motor inhibition and emotion suppression. The amygdala network was stable in time and within subjects, but between-session reproducibility was asymmetrical for the right and left amygdala rsFC. The right amygdala had more significant connections with DMN regions and the right ventrolateral prefrontal cortex. The rsFC values of the right amygdala were more sustained across the week than the left amygdala rsFC. Our results support a hypothesis of functional lateralization of the amygdala. The left amygdala is more responsible for the conscious processing of threats, which may produce more variable rsFC; the right amygdala rsFC is more stable due to its greater engagement in continuous automatic evaluation of stimuli.HighlightsAmygdala resting state network included areas of emotion circuit and motor controlDuring rest amygdala was functionally connected with areas of default mode networkFunctional connectivity of the right amygdala was more sustained across the weekFunctional connections of amygdala network were more stable in the right hemisphere

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