scholarly journals Association Between Endothelial Cell Stabilizing Medication and Small Vessel Disease Stroke: A Case-Control Study

2019 ◽  
Vol 10 ◽  
Author(s):  
Charlotte Elisabeth Becker ◽  
Terence J. Quinn ◽  
Anna Williams
Keyword(s):  
Endothelial Cell ◽  
Case Control Study ◽  
Small Vessel Disease ◽  
Case Control ◽  
Small Vessel ◽  
Vessel Disease ◽  
Control Study

scholarly journals Higher Total Cerebral Small Vessel Disease Burden Was Associated With Mild Cognitive Impairment and Overall Cognitive Dysfunction: A Propensity Score-Matched Case–Control Study

2021 ◽  
Vol 13 ◽  
Author(s):  
Xuanting Li ◽  
Junliang Yuan ◽  
Wei Qin ◽  
Lei Yang ◽  
Shuna Yang ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Case Control Study ◽  
Small Vessel Disease ◽  
Case Control ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Vessel Disease ◽  
Global Cognition ◽  
Control Study

Background and ObjectiveThe combination of neuroimaging and cognition characteristics may provide complementary information for early identification of mild cognitive impairment (MCI). This study aimed to establish the clinical relevance between cerebral small vessel disease (CSVD) burden and MCI and further explored the cognitive characteristics linked to CSVD applying a propensity score matching (PSM) approach.MethodsThe study was designed as a case–control study. All the subjects underwent the standard clinical assessments, neuropsychological testing battery (including global cognition, memory, executive function, and speed and motor control domains), and brain magnetic resonance imaging (MRI). A 1:2 nearest-neighbor matching approach without replacement was employed with a caliper of 0.15 in the PSM approach.ResultsA total of 84 MCI patients and 186 cognitively normal controls were included in this study. After PSM, 74 MCI patients and 129 controls were successfully matched, and the covariate imbalance was well eliminated. Compared with controls, the MCI group had more severe CSVD burden. In the binary logistic regression analysis, CSVD was associated with MCI after adjusting for all confounders. The results of multivariate linear regression analyses showed that higher total MRI CSVD burden was related to the deficit of cognitive performance in global cognition and three important cognitive domains after adjusting for all confounders.ConclusionCerebral small vessel disease was an independent risk factor of MCI. Moreover, higher total MRI CSVD burden was associated with the overall cognitive impairment among middle-aged and elderly Chinese adults.

scholarly journals Association of Silica Exposure with Anti–Neutrophil Cytoplasmic Autoantibody Small-Vessel Vasculitis: A Population-Based, Case-Control Study

2007 ◽  
Vol 2 (2) ◽  
pp. 290-299 ◽  
Author(s):  
Susan L. Hogan ◽  
Glinda S. Cooper ◽  
David A. Savitz ◽  
Leena A. Nylander-French ◽  
Christine G. Parks ◽  
...  
Keyword(s):  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Small Vessel ◽  
Small Vessel Vasculitis ◽  
Silica Exposure ◽  
Control Study

scholarly journals Association between thyroid disease and its treatment with ANCA small-vessel vasculitis: a case control study

2007 ◽  
Vol 22 (12) ◽  
pp. 3508-3515 ◽  
Author(s):  
S. Lionaki ◽  
S. L. Hogan ◽  
R. J. Falk ◽  
M. S. Joy ◽  
H. Chin ◽  
...  
Keyword(s):  
Thyroid Disease ◽  
Case Control Study ◽  
Case Control ◽  
Small Vessel ◽  
Small Vessel Vasculitis ◽  
Control Study

scholarly journals Vitamin D Status in Small Vessel and Large Vessel Ischemic Stroke Patients: A Case–control Study

2017 ◽  
Vol 6 (1) ◽  
pp. 146 ◽  
Author(s):  
Mohammad Saadatnia ◽  
Navid Manouchehri ◽  
Maryam Vakil-Asadollahi ◽  
Alireza Zandifar ◽  
Fereshteh Rasmani
Keyword(s):  
Vitamin D ◽  
Ischemic Stroke ◽  
Case Control Study ◽  
Case Control ◽  
Large Vessel ◽  
Small Vessel ◽  
Vitamin D Status ◽  
Stroke Patients ◽  
Control Study

scholarly journals Endothelial cell–oligodendrocyte interactions in small vessel disease and aging

2017 ◽  
Vol 131 (5) ◽  
pp. 369-379 ◽  
Author(s):  
Rikesh M. Rajani ◽  
Anna Williams
Keyword(s):  
Endothelial Cells ◽  
Endothelial Cell ◽  
Neurological Disease ◽  
Small Vessel Disease ◽  
Cell Types ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Pathological Changes ◽  
Vessel Disease ◽  
Disease States

Cerebral small vessel disease (SVD) is a prevalent, neurological disease that significantly increases the risk of stroke and dementia. The main pathological changes are vascular, in the form of lipohyalinosis and arteriosclerosis, and in the white matter (WM), in the form of WM lesions. Despite this, it is unclear to what extent the key cell types involved–the endothelial cells (ECs) of the vasculature and the oligodendrocytes of the WM–interact. Here, we describe the work that has so far been carried out suggesting an interaction between ECs and oligodendrocytes in SVD. As these interactions have been studied in more detail in other disease states and in development, we explore these systems and discuss the role these mechanisms may play in SVD.

scholarly journals Comparison of Central Corneal Thickness and Endothelial Cell Density in Patients with Various Types of Glaucoma and Patients without Glaucoma: A Case-control Study

2021 ◽  
Author(s):  
Khushboo Chawla ◽  
Shailesh Gadaginamath ◽  
Ashish Kumar Shah
Keyword(s):  
Endothelial Cell ◽  
Case Control Study ◽  
Corneal Thickness ◽  
Normal Tension Glaucoma ◽  
Case Control ◽  
P Value ◽  
Specular Microscopy ◽  
Significant Difference ◽  
Control Study

Introduction: Corneal affection in glaucoma patients is very high due to various risk factors that may lead to unforeseen and unplanned deleterious effects on the cornea leading to vision loss. Accurate intraocular pressure determination requires corneal thickness measurement and uncontrolled intraocular pressures, use of long term medication, intra ocular surgeries including cataract and glaucoma shunt surgeries may cause significant endothelial loss. Therefore, adequate planning and management and follow-up in these patients is required weighing all the long term consequences and emphasis the need for implementing adequate precautions. Aim: To evaluate and compare the Central Corneal Thickness (CCT) and corneal Endothelial Cell Density (ECD) in patients with glaucoma and without glaucoma by specular microscopy. Materials and Methods: A case-control study conducted in a Shekar Eye Hospital, Bengaluru, Karnataka, India, was conducted from August 2016 till April 2018 on a total 182 eyes from 182 patients were evaluated comprising of 91 cases and 91 controls. All participants underwent a detailed ophthalmological examination including slit lamp biomicroscopy, Intraocular Pressure (IOP) measurement, and CCT and ECD measurement by Tomey EM 3000 noncontact specular microscopy. The Statistical analysis was completes using Statistical Package For the Social Sciences (SPSS) 18.0 and R environment version 3.2.2 software’s. Results: The CCT of the glaucoma patients and the controls showed no significant difference (p-value=0.172). The CCT was comparatively thicker in Ocular Hypertension (OHTN) patients and thinner in Normal Tension Glaucoma (NTG) however statistical significance was not established. The mean ECD of controls was 2509.05±298.48 (cells/mm3) and that of cases was 2465.68±392.91 (cells/mm3) (p-value=0.404). The difference in the ECD amongst the glaucoma subgroups was not statistically significant (p-value=0.588). However, a lower ECD were seen in Pseudoexfoliation Glaucoma (PXG) and Primary Angle Closure Glaucoma (PACG) subgroups. Conclusion: No significant difference was found in CCT and endothelial cell in cornea of patients with and without glaucoma. Normal Tension Glaucoma (NTG) patients have comparatively thinner corneas and OHTN patients had thicker corneas. There was no significant correlation established between ECD of Normal corneal vs. Glaucoma and its subgroups.

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